TissGeneSummary for FAM47B |
Gene summary |
Basic gene information | Gene symbol | FAM47B |
Gene name | family with sequence similarity 47, member B | |
Synonyms | - | |
Cytomap | UCSC genome browser: Xp21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_152631.2, | |
Description | protein FAM47B | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000189132 | ||
HPRD : 06559 | ||
Vega : OTTHUMG00000021345 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FAM47B | |
BioGPS: 170062 | ||
Pathway | NCI Pathway Interaction Database: FAM47B | |
KEGG: FAM47B | ||
REACTOME: FAM47B | ||
Pathway Commons: FAM47B | ||
Context | iHOP: FAM47B | |
ligand binding site mutation search in PubMed: FAM47B | ||
UCL Cancer Institute: FAM47B | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FAM47B | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FAM47B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for FAM47B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FAM47B |
TissGeneSNV for FAM47B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R524W | UCEC | 2 |
p.R200C | SKCM | 2 |
p.E644K | SKCM | 2 |
p.A244T | UCEC | 2 |
p.A162D | LUAD | 2 |
p.R212H | READ | 2 |
p.V249M | LUAD | 2 |
p.P183S | SKCM | 2 |
p.P300S | SKCM | 2 |
p.S269F | SKCM | 2 |
p.P324H | LUAD | 2 |
p.P297L | PRAD | 2 |
p.R169Q | KIRP | 1 |
p.T617A | STAD | 1 |
p.D493A | LUSC | 1 |
p.G255V | LUAD | 1 |
p.P10S | BRCA | 1 |
p.P227L | SKCM | 1 |
p.C188Y | UCEC | 1 |
p.R533Q | HNSC | 1 |
p.K643Q | UCEC | 1 |
p.E120K | SKCM | 1 |
p.K609N | LGG | 1 |
p.R361W | STAD | 1 |
p.L247V | BLCA | 1 |
p.S27F | SKCM | 1 |
p.P566T | BRCA | 1 |
p.K571N | SARC | 1 |
p.V249M | LUSC | 1 |
p.E310K | SKCM | 1 |
p.R388L | LUAD | 1 |
p.R212C | BLCA | 1 |
p.V175L | PRAD | 1 |
p.V149L | HNSC | 1 |
p.V606I | COAD | 1 |
p.R419Q | UCEC | 1 |
p.P79L | SKCM | 1 |
p.P624A | LUAD | 1 |
p.R532C | UCEC | 1 |
p.A31V | UCEC | 1 |
p.E156* | BRCA | 1 |
p.K614N | LUAD | 1 |
p.R219W | SKCM | 1 |
p.T370K | COAD | 1 |
p.P6T | LUAD | 1 |
p.R224S | LUAD | 1 |
p.M55I | LUAD | 1 |
p.K158R | STAD | 1 |
p.H396N | LUSC | 1 |
p.A244* | LUAD | 1 |
p.G431R | CESC | 1 |
p.P251H | STAD | 1 |
p.E426* | SKCM | 1 |
p.E521K | SKCM | 1 |
p.R248H | COAD | 1 |
p.V573I | LUAD | 1 |
p.A123S | LGG | 1 |
p.L307F | SKCM | 1 |
p.E253K | UCEC | 1 |
p.A162T | PAAD | 1 |
p.Q202X | THYM | 1 |
p.A244E | LUAD | 1 |
p.R243H | LGG | 1 |
p.E565K | SKCM | 1 |
p.P65H | LUAD | 1 |
p.E373K | SKCM | 1 |
p.P6S | STAD | 1 |
p.R165C | HNSC | 1 |
p.P192L | BLCA | 1 |
p.P377T | LUAD | 1 |
p.D44H | BLCA | 1 |
p.P387L | STAD | 1 |
p.E384K | SKCM | 1 |
p.D442Y | UCEC | 1 |
p.E301* | LUAD | 1 |
p.E286* | LUAD | 1 |
p.G615E | SKCM | 1 |
p.P427H | LUAD | 1 |
p.T338S | BRCA | 1 |
p.R530T | LUAD | 1 |
p.E322K | LUAD | 1 |
p.W468* | HNSC | 1 |
p.E286K | SKCM | 1 |
p.Q202H | BLCA | 1 |
p.P19S | COAD | 1 |
p.G138R | SKCM | 1 |
p.T371I | SKCM | 1 |
p.E174K | BLCA | 1 |
p.R530S | LUAD | 1 |
p.K376M | LUAD | 1 |
p.L203I | BLCA | 1 |
p.P189T | LUAD | 1 |
p.R464C | UCEC | 1 |
p.G544R | BRCA | 1 |
p.R532C | GBM | 1 |
p.R9Q | PRAD | 1 |
p.D3N | UCEC | 1 |
p.A432E | HNSC | 1 |
p.L567F | LUAD | 1 |
p.L137M | CESC | 1 |
p.R543S | HNSC | 1 |
p.R393W | LIHC | 1 |
p.R406Q | UCEC | 1 |
p.R59C | HNSC | 1 |
p.H458N | LUAD | 1 |
p.H330N | LUAD | 1 |
p.R547M | UCEC | 1 |
p.D640Y | LUAD | 1 |
p.L145F | UCEC | 1 |
p.D619E | HNSC | 1 |
p.L567F | UCEC | 1 |
p.K497M | GBM | 1 |
p.A116V | PAAD | 1 |
p.E156K | SKCM | 1 |
p.P237L | HNSC | 1 |
p.M394I | LUSC | 1 |
p.R398C | LUAD | 1 |
p.S108L | DLBC | 1 |
p.R291H | OV | 1 |
p.R243C | SKCM | 1 |
p.P335T | LUAD | 1 |
p.P321L | LUAD | 1 |
p.R461K | UCEC | 1 |
p.P323T | ACC | 1 |
p.R90H | COAD | 1 |
p.P25L | COAD | 1 |
p.R224C | SKCM | 1 |
p.R72H | STAD | 1 |
p.V249L | LUAD | 1 |
p.D74E | LUAD | 1 |
p.R248C | BLCA | 1 |
p.W163C | LUAD | 1 |
p.D89E | LUAD | 1 |
p.I590F | UCEC | 1 |
p.P285L | BRCA | 1 |
p.R532C | READ | 1 |
p.R59C | COAD | 1 |
p.E579K | SKCM | 1 |
p.R361W | UCEC | 1 |
p.F58V | SKCM | 1 |
p.R231L | READ | 1 |
p.E156K | STAD | 1 |
p.Q111L | LUAD | 1 |
p.D637E | LUAD | 1 |
p.K99N | LUAD | 1 |
p.D3N | SKCM | 1 |
p.E575K | SKCM | 1 |
p.N136S | LGG | 1 |
p.S506* | CESC | 1 |
p.H339Y | SKCM | 1 |
p.V49L | LUAD | 1 |
p.R602* | LUAD | 1 |
p.A244S | LUAD | 1 |
p.E426* | HNSC | 1 |
p.P192A | LUAD | 1 |
p.H129N | UCEC | 1 |
p.P275H | UCEC | 1 |
p.E503* | LUAD | 1 |
p.D89Y | LUAD | 1 |
p.R33C | STAD | 1 |
p.R419Q | BRCA | 1 |
p.R90S | LUAD | 1 |
p.R398C | STAD | 1 |
p.K526R | SKCM | 1 |
p.G185A | LUAD | 1 |
p.R211H | STAD | 1 |
p.R308C | LGG | 1 |
p.P263H | LUAD | 1 |
p.S453C | OV | 1 |
p.M394I | LUAD | 1 |
p.V606I | LGG | 1 |
p.D640Y | UCEC | 1 |
p.R533W | UCEC | 1 |
p.D515E | LUAD | 1 |
p.P300A | LUAD | 1 |
p.I590F | LIHC | 1 |
p.R543H | LGG | 1 |
p.R524W | STAD | 1 |
p.A534V | PRAD | 1 |
p.E174K | SKCM | 1 |
p.P624S | SKCM | 1 |
p.H434N | HNSC | 1 |
p.R532C | BLCA | 1 |
p.R212S | LUAD | 1 |
p.P26S | COAD | 1 |
p.R169Q | COAD | 1 |
p.L472R | LUSC | 1 |
p.R419W | LUAD | 1 |
p.S305F | SKCM | 1 |
p.L597I | LUAD | 1 |
p.D44N | SKCM | 1 |
p.R243H | HNSC | 1 |
p.A535T | UCEC | 1 |
p.P444S | HNSC | 1 |
p.L107I | COAD | 1 |
p.R219W | COAD | 1 |
p.G544E | SKCM | 1 |
p.G473A | HNSC | 1 |
p.R393Q | HNSC | 1 |
p.D452E | LUAD | 1 |
p.E170* | LUAD | 1 |
p.P195L | READ | 1 |
p.E368K | SKCM | 1 |
p.G14S | BLCA | 1 |
p.D471H | COAD | 1 |
p.R33C | HNSC | 1 |
p.L223I | LUAD | 1 |
p.P192L | UCEC | 1 |
p.S318C | BLCA | 1 |
p.R361Q | COAD | 1 |
p.R59L | LUAD | 1 |
p.R340W | UCEC | 1 |
p.L146I | STAD | 1 |
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TissGeneCNV for FAM47B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FAM47B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FAM47B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FAM47B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FAM47B |
TissGeneDrug for FAM47B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FAM47B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |