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TissGeneSummary for OIT3 |
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Basic gene information | Gene symbol | OIT3 |
Gene name | oncoprotein induced transcript 3 | |
Synonyms | LZP | |
Cytomap | UCSC genome browser: 10q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_152635.2, NR_130125.1, | |
Description | liver-specific ZP domain-containing proteinliver-specific zona pellucida domain-containing proteinoncoprotein-induced transcript 3 protein | |
Modification date | 20141218 | |
dbXrefs | MIM : 609330 | |
HGNC : HGNC | ||
Ensembl : ENSG00000138315 | ||
HPRD : 17660 | ||
Vega : OTTHUMG00000018444 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_OIT3 | |
BioGPS: 170392 | ||
Pathway | NCI Pathway Interaction Database: OIT3 | |
KEGG: OIT3 | ||
REACTOME: OIT3 | ||
Pathway Commons: OIT3 | ||
Context | iHOP: OIT3 | |
ligand binding site mutation search in PubMed: OIT3 | ||
UCL Cancer Institute: OIT3 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of OIT3 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for OIT3 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 2.258503469 | 0.711032636 | 1.547470833 | 2.85E-05 | 6.40E-05 |
LIHC | 4.047790414 | 8.112522414 | -4.064732 | 3.69E-24 | 5.85E-22 |
THCA | 1.39522482 | -1.458617553 | 2.853842373 | 1.29E-20 | 5.83E-19 |
BRCA | -1.022577306 | -2.275593095 | 1.253015789 | 2.41E-15 | 1.28E-14 |
LUSC | -1.436668998 | 0.543238845 | -1.979907843 | 1.60E-15 | 1.06E-14 |
HNSC | -0.585497726 | -1.738214005 | 1.152716279 | 0.000188 | 0.000770492 |
KIRP | -0.824648961 | 1.442551039 | -2.2672 | 7.37E-05 | 0.000261863 |
LUAD | -0.189105104 | 0.849062138 | -1.038167241 | 4.69E-05 | 0.000124199 |
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TissGene-miRNA for OIT3 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for OIT3 |
TissGeneSNV for OIT3 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.H384Y | SKCM | 2 |
p.E248K | SKCM | 1 |
p.P353L | UCEC | 1 |
p.S365Y | CESC | 1 |
p.P85S | LGG | 1 |
p.R519H | KIRC | 1 |
p.E392K | SKCM | 1 |
p.G528S | HNSC | 1 |
p.P538L | UCEC | 1 |
p.E446K | SKCM | 1 |
p.V318M | OV | 1 |
p.C356X | KIRC | 1 |
p.R413C | STAD | 1 |
p.R132C | SKCM | 1 |
p.C165Y | UCEC | 1 |
p.E274Q | CESC | 1 |
p.G170E | BLCA | 1 |
p.G331S | SKCM | 1 |
p.D152E | LUAD | 1 |
p.P337L | ESCA | 1 |
p.V303A | PRAD | 1 |
p.R519H | UCEC | 1 |
p.A84T | STAD | 1 |
p.R205H | STAD | 1 |
p.C165Y | THYM | 1 |
p.G313V | HNSC | 1 |
p.R295Q | HNSC | 1 |
p.D317N | LAML | 1 |
p.R346Q | SKCM | 1 |
p.K411N | UCEC | 1 |
p.A66V | STAD | 1 |
p.G367R | SKCM | 1 |
p.R373Q | SKCM | 1 |
p.T290I | SKCM | 1 |
p.L432F | CESC | 1 |
p.P333H | LUSC | 1 |
p.R508S | LUAD | 1 |
p.W115* | SKCM | 1 |
p.E242K | SKCM | 1 |
p.Q103H | LUAD | 1 |
p.R519C | LGG | 1 |
p.P278S | SKCM | 1 |
p.E185D | COAD | 1 |
p.S507F | SKCM | 1 |
p.W115X | SKCM | 1 |
p.C509F | BLCA | 1 |
p.E153V | LIHC | 1 |
p.E446V | LUSC | 1 |
p.N190S | GBM | 1 |
p.R132H | LUAD | 1 |
p.S431N | SKCM | 1 |
p.R496L | COAD | 1 |
p.E405K | SKCM | 1 |
p.R469Q | HNSC | 1 |
p.V447I | ACC | 1 |
p.R413C | SKCM | 1 |
p.G226* | PAAD | 1 |
p.C356* | KIRC | 1 |
p.L309V | LUSC | 1 |
p.G174V | LUAD | 1 |
p.R496L | OV | 1 |
p.V329M | HNSC | 1 |
p.P265S | SKCM | 1 |
p.R515Q | SKCM | 1 |
p.G232S | LUAD | 1 |
p.E183K | SKCM | 1 |
p.E357K | READ | 1 |
p.I444N | OV | 1 |
p.D470N | LUSC | 1 |
p.P479S | SKCM | 1 |
p.E274K | CESC | 1 |
p.F476Y | SKCM | 1 |
p.V447I | BLCA | 1 |
p.G226X | PAAD | 1 |
p.D445N | SKCM | 1 |
p.I541S | KIRP | 1 |
p.A84T | LUAD | 1 |
p.Q46E | BLCA | 1 |
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TissGeneCNV for OIT3 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for OIT3 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for OIT3 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for OIT3 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for OIT3 |
TissGeneDrug for OIT3 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for OIT3 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0740394 | Hyperuricemia | 1 | LHGDN |
umls:C2239176 | Liver carcinoma | 1 | BeFree |