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| TissGeneSummary for OIT3 |
 Gene summary |
| Basic gene information | Gene symbol | OIT3 |
| Gene name | oncoprotein induced transcript 3 | |
| Synonyms | LZP | |
| Cytomap | UCSC genome browser: 10q22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_152635.2, NR_130125.1, | |
| Description | liver-specific ZP domain-containing proteinliver-specific zona pellucida domain-containing proteinoncoprotein-induced transcript 3 protein | |
| Modification date | 20141218 | |
| dbXrefs | MIM : 609330 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000138315 | ||
| HPRD : 17660 | ||
| Vega : OTTHUMG00000018444 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_OIT3 | |
| BioGPS: 170392 | ||
| Pathway | NCI Pathway Interaction Database: OIT3 | |
| KEGG: OIT3 | ||
| REACTOME: OIT3 | ||
| Pathway Commons: OIT3 | ||
| Context | iHOP: OIT3 | |
| ligand binding site mutation search in PubMed: OIT3 | ||
| UCL Cancer Institute: OIT3 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of OIT3 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for OIT3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 2.258503469 | 0.711032636 | 1.547470833 | 2.85E-05 | 6.40E-05 |
| LIHC | 4.047790414 | 8.112522414 | -4.064732 | 3.69E-24 | 5.85E-22 |
| THCA | 1.39522482 | -1.458617553 | 2.853842373 | 1.29E-20 | 5.83E-19 |
| BRCA | -1.022577306 | -2.275593095 | 1.253015789 | 2.41E-15 | 1.28E-14 |
| LUSC | -1.436668998 | 0.543238845 | -1.979907843 | 1.60E-15 | 1.06E-14 |
| HNSC | -0.585497726 | -1.738214005 | 1.152716279 | 0.000188 | 0.000770492 |
| KIRP | -0.824648961 | 1.442551039 | -2.2672 | 7.37E-05 | 0.000261863 |
| LUAD | -0.189105104 | 0.849062138 | -1.038167241 | 4.69E-05 | 0.000124199 |
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| TissGene-miRNA for OIT3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for OIT3 |
| TissGeneSNV for OIT3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.H384Y | SKCM | 2 |
| p.E248K | SKCM | 1 |
| p.P353L | UCEC | 1 |
| p.S365Y | CESC | 1 |
| p.P85S | LGG | 1 |
| p.R519H | KIRC | 1 |
| p.E392K | SKCM | 1 |
| p.G528S | HNSC | 1 |
| p.P538L | UCEC | 1 |
| p.E446K | SKCM | 1 |
| p.V318M | OV | 1 |
| p.C356X | KIRC | 1 |
| p.R413C | STAD | 1 |
| p.R132C | SKCM | 1 |
| p.C165Y | UCEC | 1 |
| p.E274Q | CESC | 1 |
| p.G170E | BLCA | 1 |
| p.G331S | SKCM | 1 |
| p.D152E | LUAD | 1 |
| p.P337L | ESCA | 1 |
| p.V303A | PRAD | 1 |
| p.R519H | UCEC | 1 |
| p.A84T | STAD | 1 |
| p.R205H | STAD | 1 |
| p.C165Y | THYM | 1 |
| p.G313V | HNSC | 1 |
| p.R295Q | HNSC | 1 |
| p.D317N | LAML | 1 |
| p.R346Q | SKCM | 1 |
| p.K411N | UCEC | 1 |
| p.A66V | STAD | 1 |
| p.G367R | SKCM | 1 |
| p.R373Q | SKCM | 1 |
| p.T290I | SKCM | 1 |
| p.L432F | CESC | 1 |
| p.P333H | LUSC | 1 |
| p.R508S | LUAD | 1 |
| p.W115* | SKCM | 1 |
| p.E242K | SKCM | 1 |
| p.Q103H | LUAD | 1 |
| p.R519C | LGG | 1 |
| p.P278S | SKCM | 1 |
| p.E185D | COAD | 1 |
| p.S507F | SKCM | 1 |
| p.W115X | SKCM | 1 |
| p.C509F | BLCA | 1 |
| p.E153V | LIHC | 1 |
| p.E446V | LUSC | 1 |
| p.N190S | GBM | 1 |
| p.R132H | LUAD | 1 |
| p.S431N | SKCM | 1 |
| p.R496L | COAD | 1 |
| p.E405K | SKCM | 1 |
| p.R469Q | HNSC | 1 |
| p.V447I | ACC | 1 |
| p.R413C | SKCM | 1 |
| p.G226* | PAAD | 1 |
| p.C356* | KIRC | 1 |
| p.L309V | LUSC | 1 |
| p.G174V | LUAD | 1 |
| p.R496L | OV | 1 |
| p.V329M | HNSC | 1 |
| p.P265S | SKCM | 1 |
| p.R515Q | SKCM | 1 |
| p.G232S | LUAD | 1 |
| p.E183K | SKCM | 1 |
| p.E357K | READ | 1 |
| p.I444N | OV | 1 |
| p.D470N | LUSC | 1 |
| p.P479S | SKCM | 1 |
| p.E274K | CESC | 1 |
| p.F476Y | SKCM | 1 |
| p.V447I | BLCA | 1 |
| p.G226X | PAAD | 1 |
| p.D445N | SKCM | 1 |
| p.I541S | KIRP | 1 |
| p.A84T | LUAD | 1 |
| p.Q46E | BLCA | 1 |
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| TissGeneCNV for OIT3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for OIT3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for OIT3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for OIT3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for OIT3 |
| TissGeneDrug for OIT3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for OIT3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0740394 | Hyperuricemia | 1 | LHGDN |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
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