 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for NUDT10 |
 Gene summary |
| Basic gene information | Gene symbol | NUDT10 |
| Gene name | nudix (nucleoside diphosphate linked moiety X)-type motif 10 | |
| Synonyms | APS2|DIPP3a|hDIPP3alpha | |
| Cytomap | UCSC genome browser: Xp11.23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_153183.2, | |
| Description | DIPP-3-alphaDIPP3-alphadiadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alphadiadenosine hexaphosphate hydrolase (AMP-forming)diphosphoinositol polyphosphate phosphohydrolase 3-alphadiphosphoinositol polyphosphate phosphohydrolase type 3 alphahAp | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 300527 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000122824 | ||
| HPRD : 17651 | ||
| Vega : OTTHUMG00000021530 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NUDT10 | |
| BioGPS: 170685 | ||
| Pathway | NCI Pathway Interaction Database: NUDT10 | |
| KEGG: NUDT10 | ||
| REACTOME: NUDT10 | ||
| Pathway Commons: NUDT10 | ||
| Context | iHOP: NUDT10 | |
| ligand binding site mutation search in PubMed: NUDT10 | ||
| UCL Cancer Institute: NUDT10 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of NUDT10 | ||
| Description by TissGene annotations | Protective TissGene in OS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for NUDT10 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -0.612063191 | -2.497231818 | 1.885168627 | 2.52E-08 | 7.57E-08 |
| PRAD | 2.033619351 | 3.467578966 | -1.433959615 | 8.39E-14 | 6.27E-12 |
| KIRC | -2.832989089 | 0.306885911 | -3.139875 | 2.54E-31 | 5.42E-30 |
| KICH | -3.871107034 | 0.166824966 | -4.037932 | 1.28E-16 | 3.97E-15 |
| LIHC | -4.495969034 | -1.122075034 | -3.373894 | 1.06E-25 | 2.94E-23 |
| KIRP | -2.931021034 | 0.114225841 | -3.045246875 | 6.31E-16 | 2.08E-14 |
| COAD | -2.692682572 | -0.979840265 | -1.712842308 | 3.16E-06 | 1.60E-05 |
| STAD | -2.899080409 | -0.825958534 | -2.073121875 | 6.38E-07 | 1.11E-05 |
| ESCA | -3.030171034 | -0.752116488 | -2.278054545 | 0.00175 | 0.02126776 |
| BLCA | -2.138018402 | -0.331802613 | -1.806215789 | 0.00239 | 0.014806017 |
| Top |
| TissGene-miRNA for NUDT10 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for NUDT10 |
| TissGeneSNV for NUDT10 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.T93M | UCEC | 1 |
| p.G147D | STAD | 1 |
| p.E102V | KIRP | 1 |
| p.A20V | UCEC | 1 |
| p.S159L | SARC | 1 |
| p.V82I | STAD | 1 |
| p.T8I | KIRP | 1 |
| p.E102* | CESC | 1 |
| p.V36A | KIRC | 1 |
| p.P42Q | HNSC | 1 |
| p.E14K | CESC | 1 |
| p.E32K | BLCA | 1 |
| p.P58T | LIHC | 1 |
| p.V82I | BRCA | 1 |
| Top |
| TissGeneCNV for NUDT10 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for NUDT10 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AU125362 | NUDT10-TTC37 | chrX:51079353 | chr5:94877007 |
| Top |
| TissGeneNet for NUDT10 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| NUDT10, RASSF1 (tumor) | NUDT10, RASSF1 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| NUDT10, RASSF1 (tumor) | NUDT10, RASSF1 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| NUDT10, RASSF1 (tumor) | NUDT10, RASSF1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| NUDT10, RASSF1 (tumor) | NUDT10, RASSF1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| NUDT10, RASSF1 (tumor) | NUDT10, RASSF1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| NUDT10, RASSF1 (tumor) | NUDT10, RASSF1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| NUDT10, RASSF1 (tumor) | NUDT10, RASSF1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| NUDT10, RASSF1 (tumor) | NUDT10, RASSF1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| NUDT10, RASSF1 (tumor) | NUDT10, RASSF1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| NUDT10, RASSF1 (tumor) | NUDT10, RASSF1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| NUDT10, RASSF1 (tumor) | NUDT10, RASSF1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| NUDT10, RASSF1 (tumor) | NUDT10, RASSF1 (normal) |
 |  |
| Top |
| TissGeneProg for NUDT10 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for NUDT10 |
| TissGeneDrug for NUDT10 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for NUDT10 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0085409 | Polyendocrinopathies, Autoimmune | 6 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 5 | BeFree |
| umls:C0085859 | Polyglandular Type I Autoimmune Syndrome | 3 | BeFree |
| umls:C0178468 | Autoimmune thyroid disease | 3 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 3 | GAD |
| umls:C0004364 | Autoimmune Diseases | 2 | BeFree |
| umls:C0040147 | Thyroiditis | 2 | BeFree |
| umls:C0042900 | Vitiligo | 1 | BeFree |
| umls:C0085292 | Stiff-Person Syndrome | 1 | BeFree |
| umls:C0271737 | Addison's disease due to autoimmunity | 1 | BeFree |
| umls:C1847835 | VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | 1 | BeFree |
| umls:C2103602 | Autoimmune Primary Adrenal Insufficiency | 1 | BeFree |
| umls:C3494489 | Autoimmune polyendocrinopathy syndrome, type 1 | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |