TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for AGER

Gene summary

Basic gene information	Gene symbol	AGER
	Gene name	advanced glycosylation end product-specific receptor
	Synonyms	RAGE
	Cytomap	UCSC genome browser: 6p21.3
	Type of gene	protein-coding
	RefGenes	NM_001136.4, NM_001206929.1,NM_001206932.1,NM_001206934.1,NM_001206936.1, NM_001206940.1,NM_001206954.1,NM_001206966.1,NM_172197.2, NR_038190.1,
	Description	RAGE isoform NtRAGE-deltaRAGE isoform sRAGE-deltareceptor for advanced glycation end-products variant 20
	Modification date	20141222
dbXrefs	MIM : 600214
	HGNC : HGNC
	Ensembl : ENSG00000204305
	HPRD : 02568
	Vega : OTTHUMG00000031120
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_AGER
	BioGPS: 177
Pathway	NCI Pathway Interaction Database: AGER
	KEGG: AGER
	REACTOME: AGER
	Pathway Commons: AGER
Context	iHOP: AGER
	ligand binding site mutation search in PubMed: AGER
	UCL Cancer Institute: AGER
Assigned class in TissGDB*	A
Included tissue-specific gene expression resources	HPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	Lung
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	LUAD,LUSC
Reference showing the relevant tissue of AGER	The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling. Lindskog C, Fagerberg L, Hallström B, Edlund K, Hellwig B, Rahnenführer J, Kampf C, Uhlén M, Pontén F, Micke P. FASEB J. 2014 Dec;28(12):5184-96. doi: 10.1096/fj.14-254862. Epub 2014 Aug 28. (pmid:25169055) go to article
Description by TissGene annotations	Cancer gene

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0051092	positive regulation of NF-kappaB transcription factor activity	10391939
GO:0051092	positive regulation of NF-kappaB transcription factor activity	10391939

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TissGeneExp for AGER

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
BRCA	-1.938572571	-0.911222571	-1.02735	1.00E-15	5.47E-15
LUSC	0.986431299	9.013619534	-8.027188235	7.80E-30	3.38E-28
KIRC	-1.14917491	-2.191842966	1.042668056	6.42E-11	2.34E-10
LUAD	2.398395971	9.301227006	-6.902831034	2.23E-29	2.08E-27
KICH	-2.117419132	-0.854411132	-1.263008	3.10E-07	1.28E-06

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TissGene-miRNA for AGER

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for AGER

TissGeneSNV for AGER

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.S190L	STAD	1
p.V233L	LUAD	1
p.P202S	SKCM	1
p.E414Q	CESC	1
p.Q117R	PCPG	1
p.S343N	PAAD	1
p.V11M	PAAD	1
p.R114Q	COAD	1
p.G213V	LUAD	1
p.G90R	PRAD	1
p.A197N	HNSC	1
p.E395K	HNSC	1
p.G29E	SKCM	1
p.E426K	CESC	1
p.Q390*	HNSC	1
p.P196A	HNSC	1
p.A314T	LIHC	1
p.S206L	STAD	1
p.A197D	HNSC	1
p.G349R	STAD	1
p.D201N	SKCM	1
p.E408K	CESC	1
p.E132K	SKCM	1
p.A197T	HNSC	1
p.S129F	READ	1
p.R147I	COAD	1
p.P277S	PRAD	1
p.E94K	BLCA	1
p.E339K	SKCM	1
p.R179T	LUAD	1
p.S359N	PAAD	1
p.G365R	STAD	1
p.S391L	UCEC	1

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TissGeneCNV for AGER

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for AGER

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	CA435533	AGER-SFTPA2		chr6:3496582	chr10:81315815
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-44-2662-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32150459	chr10:81316167
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-44-2662-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32150458	chr10:81315701
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-44-2662-11A	AGER-SFTPA2	Out-of-Frame	chr6:32150426	chr10:81316985
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-44-6776-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32151763	chr10:81316253
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-44-6777-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32151418	chr10:81316347
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-55-6986-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32148980	chr10:81316621
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-44-2661-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32152028	chr10:81316569
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-44-2661-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32150795	chr10:81316766
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-44-6778-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32150445	chr10:81316181
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-50-5939-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32150764	chr10:81316603
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-49-6743-11A	AGER-SFTPA2	In-Frame	chr6:32150752	chr10:81317035
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-44-6144-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32149237	chr10:81316621
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-50-5939-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32150691	chr10:81315675
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-49-6745-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32150119	chr10:81316068
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-49-6745-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32149153	chr10:81316681
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-91-6847-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32150374	chr10:81316071
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-55-6984-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32149373	chr10:81316256
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-44-6147-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32149382	chr10:81316248
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-50-5935-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32151407	chr10:81315841
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-50-5930-11A	AGER-SFTPA2	In-Frame	chr6:32151343	chr10:81318672
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-55-6983-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32151760	chr10:81316256
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-44-6148-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32150667	chr10:81316764
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-44-2665-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32149376	chr10:81316749
Chimerdb3.0	TopHat-Fusion	LUAD	TCGA-44-2665-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32148779	chr10:81316255
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-33-4587-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32150111	chr10:81316902
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-33-4587-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32151526	chr10:81316920
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-22-5482-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32151760	chr10:81316256
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-90-6837-11A	AGER-SFTPA2	In-Frame	chr6:32150149	chr10:81319169
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-22-5489-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32152002	chr10:81316198
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-56-7580-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32151760	chr10:81316256
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-43-7657-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32151763	chr10:81316254
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-51-4079-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32152027	chr10:81316570
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-22-5472-11A	AGER-SFTPA2	In-Frame	chr6:32151764	chr10:81317844
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-43-6771-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32152003	chr10:81316197
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-56-7731-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32151763	chr10:81316255
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-90-7767-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32149373	chr10:81316256
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-92-7340-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32151761	chr10:81316256
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-22-4593-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32151763	chr10:81316253
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-77-7337-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32151761	chr10:81316255
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-22-5471-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32148973	chr10:81316575
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-22-5471-11A	AGER-SFTPA2	In-Frame	chr6:32148985	chr10:81319114
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-22-5471-11A	AGER-SFTPA2	Out-of-Frame	chr6:32149174	chr10:81317240
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-56-8201-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32149382	chr10:81316248
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-51-4080-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32148861	chr10:81316258
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-51-4080-11A	AGER-SFTPA2	In-Frame	chr6:32148954	chr10:81317853
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-51-4080-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32150640	chr10:81316255
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-43-5670-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32151399	chr10:81316146
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-43-5670-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32151760	chr10:81316256
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-60-2709-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32151756	chr10:81316174
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-22-4609-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32148837	chr10:81316263
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-43-6647-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32150076	chr10:81316048
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-22-4609-11A	AGER-SFTPA2	3'UTR-3'UTR	chr6:32151763	chr10:81316202
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-43-6647-11A	AGER-SFTPA2	Out-of-Frame	chr6:32151765	chr10:81317003
Chimerdb3.0	TopHat-Fusion	LUSC	TCGA-22-5491-11A	AGER-SFTPA2	5'UTR-CDS	chr6:32148897	chr10:81319111

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TissGeneNet for AGER

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (tumor)	AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (normal)

COAD (tumor)	COAD (normal)
AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (tumor)	AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (normal)

HNSC (tumor)	HNSC (normal)
AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (tumor)	AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (normal)

KICH (tumor)	KICH (normal)
AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (tumor)	AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (normal)

KIRC (tumor)	KIRC (normal)
AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (tumor)	AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (normal)

KIRP (tumor)	KIRP (normal)
AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (tumor)	AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (normal)

LIHC (tumor)	LIHC (normal)
AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (tumor)	AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (normal)

LUAD (tumor)	LUAD (normal)
AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (tumor)	AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (normal)

LUSC (tumor)	LUSC (normal)
AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (tumor)	AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (normal)

PRAD (tumor)	PRAD (normal)
AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (tumor)	AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (normal)

STAD (tumor)	STAD (normal)
AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (tumor)	AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (normal)

THCA (tumor)	THCA (normal)
AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (tumor)	AGER, HMGB1, NCK1, S100B, SP1, GRB2, RHOA, TTR, PRKCZ, S100A1, S100A12, IRAK4, TLR9, TIRAP, C1QB, C1QC, MYD88, C1QA, S100P (normal)

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TissGeneProg for AGER

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for AGER

TissGeneDrug for AGER

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for AGER

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	27	BeFree,GAD,LHGDN,RGD
umls:C0011849	Diabetes Mellitus	17	BeFree,LHGDN
umls:C0011884	Diabetic Retinopathy	17	BeFree,GAD,LHGDN,RGD
umls:C0011881	Diabetic Nephropathy	16	BeFree,GAD,LHGDN,RGD
umls:C1956346	Coronary Artery Disease	15	BeFree,LHGDN
umls:C0004153	Atherosclerosis	12	BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0010054	Coronary Arteriosclerosis	12	BeFree
umls:C0011847	Diabetes	12	BeFree
umls:C0010068	Coronary heart disease	10	BeFree
umls:C0011854	Diabetes Mellitus, Insulin-Dependent	8	BeFree,GAD
umls:C0002395	Alzheimer's Disease	7	GAD,LHGDN,RGD
umls:C0011875	Diabetic Angiopathies	7	BeFree,CTD_human,LHGDN
umls:C0003873	Rheumatoid Arthritis	6	BeFree,CTD_human,LHGDN
umls:C0007222	Cardiovascular Diseases	5	BeFree,LHGDN,RGD
umls:C0022658	Kidney Diseases	5	BeFree,LHGDN
umls:C0024117	Chronic Obstructive Airway Disease	5	BeFree,GAD
umls:C0035309	Retinal Diseases	5	BeFree
umls:C0038454	Cerebrovascular accident	5	BeFree,GAD,LHGDN,RGD
umls:C0042373	Vascular Diseases	5	BeFree
umls:C0003850	Arteriosclerosis	4	BeFree
umls:C0020456	Hyperglycemia	4	BeFree,CTD_human
umls:C0020538	Hypertensive disease	4	BeFree,RGD
umls:C0027051	Myocardial Infarction	4	BeFree,GAD,RGD
umls:C0027627	Neoplasm Metastasis	4	BeFree,LHGDN
umls:C0029408	Degenerative polyarthritis	4	BeFree,LHGDN,RGD
umls:C0006142	Malignant neoplasm of breast	3	BeFree
umls:C0007786	Brain Ischemia	3	LHGDN,RGD
umls:C0030297	Pancreatic Neoplasm	3	GAD,LHGDN
umls:C0333186	Restenosis	3	BeFree
umls:C0678222	Breast Carcinoma	3	BeFree
umls:C0948008	Ischemic stroke	3	BeFree
umls:C3160731	Pulmonary function (finding)	3	GAD,GWASCAT
umls:C0001418	Adenocarcinoma	2	BeFree,LHGDN
umls:C0003486	Aortic Aneurysm	2	BeFree
umls:C0007131	Non-Small Cell Lung Carcinoma	2	BeFree,GAD
umls:C0007137	Squamous cell carcinoma	2	LHGDN
umls:C0009404	Colorectal Neoplasms	2	LHGDN,RGD
umls:C0010346	Crohn Disease	2	BeFree
umls:C0011853	Diabetes Mellitus, Experimental	2	RGD
umls:C0016059	Fibrosis	2	LHGDN,RGD
umls:C0019829	Hodgkin Disease	2	BeFree
umls:C0020179	Huntington Disease	2	BeFree
umls:C0020429	Hyperalgesia	2	RGD
umls:C0021368	Inflammation	2	CTD_human,LHGDN
umls:C0024115	Lung diseases	2	BeFree,GAD
umls:C0024121	Lung Neoplasms	2	BeFree,LHGDN
umls:C0025202	melanoma	2	BeFree,LHGDN
umls:C0026769	Multiple Sclerosis	2	BeFree
umls:C0033578	Prostatic Neoplasms	2	LHGDN
umls:C0153381	Malignant neoplasm of mouth	2	BeFree
umls:C0178874	Tumor Progression	2	BeFree
umls:C0220641	Lip and Oral Cavity Carcinoma	2	BeFree
umls:C0242706	Hyperoxia	2	RGD
umls:C0342257	Complications of Diabetes Mellitus	2	GAD,LHGDN
umls:C0596263	Carcinogenesis	2	BeFree
umls:C0699791	Stomach Carcinoma	2	BeFree
umls:C3272363	Ischemic Cerebrovascular Accident	2	BeFree
umls:C0001925	Albuminuria	1	RGD
umls:C0002726	Amyloidosis	1	LHGDN
umls:C0003493	Aortic Diseases	1	RGD
umls:C0004096	Asthma	1	RGD
umls:C0004352	Autistic Disorder	1	BeFree
umls:C0007273	Carotid Artery Diseases	1	RGD
umls:C0007766	Intracranial Aneurysm	1	RGD
umls:C0007787	Transient Ischemic Attack	1	RGD
umls:C0008479	Chondrosarcoma	1	LHGDN
umls:C0009324	Ulcerative Colitis	1	GAD
umls:C0009375	Colonic Neoplasms	1	BeFree
umls:C0010674	Cystic Fibrosis	1	BeFree
umls:C0011065	Cessation of life	1	LHGDN
umls:C0011265	Presenile dementia	1	BeFree
umls:C0011269	Dementia, Vascular	1	LHGDN
umls:C0011633	Dermatomyositis	1	LHGDN
umls:C0011880	Diabetic Ketoacidosis	1	LHGDN
umls:C0011882	Diabetic Neuropathies	1	LHGDN
umls:C0017178	Gastrointestinal Diseases	1	RGD
umls:C0020542	Pulmonary Hypertension	1	RGD
umls:C0022116	Ischemia	1	BeFree
umls:C0022118	Transient ischemia	1	BeFree
umls:C0022661	Kidney Failure, Chronic	1	GAD
umls:C0023473	Myeloid Leukemia, Chronic	1	BeFree
umls:C0024141	Lupus Erythematosus, Systemic	1	GAD
umls:C0024623	Malignant neoplasm of stomach	1	BeFree
umls:C0027055	Myocardial Reperfusion Injury	1	RGD
umls:C0027121	Myositis	1	BeFree
umls:C0027877	Neuronal Ceroid-Lipofuscinoses	1	LHGDN
umls:C0028754	Obesity	1	BeFree
umls:C0029456	Osteoporosis	1	RGD
umls:C0030286	Pancreatic Diseases	1	CTD_human
umls:C0031099	Periodontitis	1	RGD
umls:C0032285	Pneumonia	1	BeFree
umls:C0033860	Psoriasis	1	GAD,LHGDN
umls:C0034067	Pulmonary Emphysema	1	BeFree
umls:C0034069	Pulmonary Fibrosis	1	RGD
umls:C0035222	Respiratory Distress Syndrome, Adult	1	RGD
umls:C0035412	Rhabdomyosarcoma	1	LHGDN
umls:C0036202	Sarcoidosis	1	LHGDN
umls:C0038525	Subarachnoid Hemorrhage	1	RGD
umls:C0040021	Thromboangiitis Obliterans	1	RGD
umls:C0040411	Tongue Neoplasms	1	RGD
umls:C0041296	Tuberculosis	1	LHGDN
umls:C0041948	Uremia	1	RGD
umls:C0085413	Polycystic Kidney, Autosomal Dominant	1	BeFree
umls:C0085655	Polymyositis	1	LHGDN
umls:C0151744	Myocardial Ischemia	1	BeFree,LHGDN
umls:C0153594	Malignant neoplasm of testis	1	BeFree
umls:C0221014	Reactive systemic amyloidosis	1	BeFree
umls:C0238190	Inclusion Body Myositis (disorder)	1	BeFree
umls:C0238461	Anaplastic thyroid carcinoma	1	BeFree
umls:C0242350	Erectile dysfunction	1	RGD
umls:C0242379	Malignant neoplasm of lung	1	BeFree
umls:C0242488	Acute Lung Injury	1	RGD
umls:C0243026	Sepsis	1	RGD
umls:C0266929	Chronic Periodontitis	1	BeFree
umls:C0271650	Impaired glucose tolerance	1	LHGDN
umls:C0273115	Lung Injury	1	RGD
umls:C0346957	Disseminated Malignant Neoplasm	1	BeFree
umls:C0376358	Malignant neoplasm of prostate	1	BeFree
umls:C0497327	Dementia	1	BeFree
umls:C0521607	Peritoneal Fibrosis	1	RGD
umls:C0600139	Prostate carcinoma	1	BeFree
umls:C0677886	Epithelial ovarian cancer	1	BeFree
umls:C0684249	Carcinoma of lung	1	BeFree
umls:C0730345	Microalbuminuria	1	BeFree
umls:C0740392	Infarction, Middle Cerebral Artery	1	RGD
umls:C0752347	Lewy Body Disease	1	CTD_human
umls:C0853897	Diabetic Cardiomyopathies	1	RGD
umls:C0856169	Endothelial dysfunction	1	BeFree
umls:C1458155	Mammary Neoplasms	1	LHGDN
umls:C1512409	Hepatocarcinogenesis	1	BeFree
umls:C1527249	Colorectal Cancer	1	BeFree
umls:C1527336	Sjogren's Syndrome	1	LHGDN
umls:C1800706	Idiopathic Pulmonary Fibrosis	1	LHGDN
umls:C1955869	Malformations of Cortical Development	1	BeFree
umls:C2239176	Liver carcinoma	1	BeFree
umls:C2931822	Nasopharyngeal carcinoma	1	BeFree
umls:C2936349	Plaque, Amyloid	1	BeFree
umls:C3536715	AA amyloidosis	1	BeFree