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| TissGeneSummary for DPYS |
 Gene summary |
| Basic gene information | Gene symbol | DPYS |
| Gene name | dihydropyrimidinase | |
| Synonyms | DHP|DHPase | |
| Cytomap | UCSC genome browser: 8q22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001385.2, | |
| Description | dihydropyrimidine amidohydrolasehydantoinase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 613326 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000147647 | ||
| HPRD : 01960 | ||
| Vega : OTTHUMG00000164891 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DPYS | |
| BioGPS: 1807 | ||
| Pathway | NCI Pathway Interaction Database: DPYS | |
| KEGG: DPYS | ||
| REACTOME: DPYS | ||
| Pathway Commons: DPYS | ||
| Context | iHOP: DPYS | |
| ligand binding site mutation search in PubMed: DPYS | ||
| UCL Cancer Institute: DPYS | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
| Reference showing the relevant tissue of DPYS | ||
| Description by TissGene annotations | TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006208 | pyrimidine nucleobase catabolic process | 9718352 | GO:0006212 | uracil catabolic process | 10410956 | GO:0006208 | pyrimidine nucleobase catabolic process | 9718352 | GO:0006212 | uracil catabolic process | 10410956 |
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| TissGeneExp for DPYS |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -1.438978238 | 0.578037448 | -2.017015686 | 2.13E-11 | 8.55E-11 |
| LIHC | 8.560766585 | 10.92938859 | -2.368622 | 1.49E-06 | 7.71E-06 |
| LUAD | -0.901098725 | 0.323734034 | -1.224832759 | 4.87E-07 | 1.69E-06 |
| KICH | -1.582387415 | 6.228364585 | -7.810752 | 1.24E-12 | 1.47E-11 |
| BRCA | -1.803041345 | -0.478195731 | -1.324845614 | 2.10E-14 | 1.05E-13 |
| KIRP | 4.36908996 | 7.838430585 | -3.469340625 | 3.66E-05 | 0.00013768 |
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| TissGene-miRNA for DPYS |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for DPYS |
| TissGeneSNV for DPYS |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R475Q | SKCM | 5 |
| p.E177K | SKCM | 3 |
| p.P464L | SKCM | 2 |
| p.R391G | STAD | 2 |
| p.E184K | SKCM | 2 |
| p.R118Q | SKCM | 2 |
| p.G393E | SKCM | 2 |
| p.D402N | BLCA | 1 |
| p.L500M | LUAD | 1 |
| p.G281C | LUAD | 1 |
| p.E496K | COAD | 1 |
| p.M297I | LUAD | 1 |
| p.E371K | SKCM | 1 |
| p.V225A | KIRC | 1 |
| p.I385S | BLCA | 1 |
| p.V455D | COAD | 1 |
| p.M250I | SKCM | 1 |
| p.E271K | SKCM | 1 |
| p.A422T | THYM | 1 |
| p.R355W | UCEC | 1 |
| p.V439M | LUSC | 1 |
| p.I273T | BLCA | 1 |
| p.N195I | SKCM | 1 |
| p.N424T | ESCA | 1 |
| p.R394T | LUSC | 1 |
| p.H217L | LIHC | 1 |
| p.P487H | UCEC | 1 |
| p.P308H | LUAD | 1 |
| p.K165R | HNSC | 1 |
| p.G298V | LUAD | 1 |
| p.G324E | SKCM | 1 |
| p.A237G | LUSC | 1 |
| p.M97I | HNSC | 1 |
| p.I98N | SKCM | 1 |
| p.V488L | LUSC | 1 |
| p.R355W | COAD | 1 |
| p.E449K | SKCM | 1 |
| p.R13C | UCEC | 1 |
| p.K153E | OV | 1 |
| p.L388F | BLCA | 1 |
| p.E215K | ESCA | 1 |
| p.D197N | BLCA | 1 |
| p.G216C | LUSC | 1 |
| p.R465* | UCEC | 1 |
| p.T212A | CESC | 1 |
| p.Y269C | HNSC | 1 |
| p.V452L | UCEC | 1 |
| p.W137L | LUAD | 1 |
| p.D166Y | READ | 1 |
| p.A224S | LUAD | 1 |
| p.H518N | LUAD | 1 |
| p.D128N | READ | 1 |
| p.R475X | STAD | 1 |
| p.S109F | SKCM | 1 |
| p.E288G | BRCA | 1 |
| p.F425V | STAD | 1 |
| p.G435R | ACC | 1 |
| p.R221C | STAD | 1 |
| p.R221C | HNSC | 1 |
| p.M1I | ACC | 1 |
| p.R118Q | BLCA | 1 |
| p.R391G | ESCA | 1 |
| p.A498T | PRAD | 1 |
| p.R490H | COAD | 1 |
| p.E288K | SKCM | 1 |
| p.P487A | HNSC | 1 |
| p.L7V | KIRP | 1 |
| p.E115K | SKCM | 1 |
| p.D128N | SKCM | 1 |
| p.L149F | SKCM | 1 |
| p.R479* | LUSC | 1 |
| p.G210E | SKCM | 1 |
| p.N426S | SKCM | 1 |
| p.V455D | STAD | 1 |
| p.D459Y | STAD | 1 |
| p.A383V | BLCA | 1 |
| p.V240L | LUAD | 1 |
| p.A259S | GBM | 1 |
| p.E470* | BLCA | 1 |
| p.D508Y | LUAD | 1 |
| p.D280Y | BLCA | 1 |
| p.G216S | SKCM | 1 |
| p.Q190H | COAD | 1 |
| p.R262S | BLCA | 1 |
| p.P467L | SKCM | 1 |
| p.S379I | LUAD | 1 |
| p.P123H | LUAD | 1 |
| p.K205N | PAAD | 1 |
| p.R118Q | HNSC | 1 |
| p.H192L | LGG | 1 |
| p.D407N | UCEC | 1 |
| p.G393R | SKCM | 1 |
| p.E226K | ESCA | 1 |
| p.V397A | BLCA | 1 |
| p.S415A | DLBC | 1 |
| p.V446E | SKCM | 1 |
| p.P123H | BLCA | 1 |
| p.R475* | STAD | 1 |
| p.A200S | LUAD | 1 |
| p.G202R | PAAD | 1 |
| p.A259T | LUAD | 1 |
| p.N424I | SKCM | 1 |
| p.K417Q | SKCM | 1 |
| p.A187V | PAAD | 1 |
| p.A90S | LUAD | 1 |
| p.W285C | STAD | 1 |
| p.R465Q | UCEC | 1 |
| p.F425V | BLCA | 1 |
| p.D341G | KIRC | 1 |
| p.T456M | UCEC | 1 |
| p.D326E | SKCM | 1 |
| p.E174K | SKCM | 1 |
| p.A224E | LUAD | 1 |
| p.V446M | SKCM | 1 |
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| TissGeneCNV for DPYS |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for DPYS |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-FC-A4JI-01A | TMEM68-DPYS | Out-of-Frame | chr8:56656039 | chr8:105436616 |
| TCGAfusionPortal | PRADA | LUSC | TCGA-60-2706-01A | VPS13B-DPYS | In-frame | Chr8:100568881 | Chr8:105405219 |
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| TissGeneNet for DPYS |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| DPYS, DPYSL5 (tumor) | DPYS, DPYSL5 (normal) |
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| COAD (tumor) | COAD (normal) |
| DPYS, DPYSL5 (tumor) | DPYS, DPYSL5 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| DPYS, DPYSL5 (tumor) | DPYS, DPYSL5 (normal) |
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| KICH (tumor) | KICH (normal) |
| DPYS, DPYSL5 (tumor) | DPYS, DPYSL5 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| DPYS, DPYSL5 (tumor) | DPYS, DPYSL5 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| DPYS, DPYSL5 (tumor) | DPYS, DPYSL5 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| DPYS, DPYSL5 (tumor) | DPYS, DPYSL5 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| DPYS, DPYSL5 (tumor) | DPYS, DPYSL5 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| DPYS, DPYSL5 (tumor) | DPYS, DPYSL5 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| DPYS, DPYSL5 (tumor) | DPYS, DPYSL5 (normal) |
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| STAD (tumor) | STAD (normal) |
| DPYS, DPYSL5 (tumor) | DPYS, DPYSL5 (normal) |
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| THCA (tumor) | THCA (normal) |
| DPYS, DPYSL5 (tumor) | DPYS, DPYSL5 (normal) |
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| TissGeneProg for DPYS |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for DPYS |
| TissGeneDrug for DPYS |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for DPYS |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0238358 | Hypokalemic periodic paralysis | 9 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 2 | BeFree |
| umls:C0026848 | Myopathy | 2 | BeFree |
| umls:C0699790 | Colon Carcinoma | 2 | BeFree |
| umls:C3495551 | Dihydropyrimidinuria | 2 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | GAD |
| umls:C0013221 | Drug toxicity | 1 | GAD |
| umls:C0018801 | Heart failure | 1 | BeFree |
| umls:C0018802 | Congestive heart failure | 1 | BeFree |
| umls:C0023895 | Liver diseases | 1 | GAD |
| umls:C0024437 | Macular degeneration | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0027819 | Neuroblastoma | 1 | BeFree |
| umls:C0242383 | Age related macular degeneration | 1 | BeFree |
| umls:C0342803 | Dihydropyrimidinase deficiency | 1 | CLINVAR,CTD_human,ORPHANET,UNIPROT |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0700095 | Central neuroblastoma | 1 | BeFree |
| umls:C1832916 | Timothy syndrome | 1 | BeFree |
| umls:C1959620 | Dihydropyrimidine Dehydrogenase Deficiency | 1 | BeFree |
| umls:C3714580 | Hypokalemic periodic paralysis type 1 | 1 | BeFree |
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