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| TissGeneSummary for SLC26A3 |
 Gene summary |
| Basic gene information | Gene symbol | SLC26A3 |
| Gene name | solute carrier family 26 (anion exchanger), member 3 | |
| Synonyms | CLD|DRA | |
| Cytomap | UCSC genome browser: 7q31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000111.2, | |
| Description | chloride anion exchangerdown-regulated in adenoma proteinsolute carrier family 26, member 3 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 126650 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000091138 | ||
| HPRD : 00544 | ||
| Vega : OTTHUMG00000154812 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC26A3 | |
| BioGPS: 1811 | ||
| Pathway | NCI Pathway Interaction Database: SLC26A3 | |
| KEGG: SLC26A3 | ||
| REACTOME: SLC26A3 | ||
| Pathway Commons: SLC26A3 | ||
| Context | iHOP: SLC26A3 | |
| ligand binding site mutation search in PubMed: SLC26A3 | ||
| UCL Cancer Institute: SLC26A3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Colon | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COAD | |
| Reference showing the relevant tissue of SLC26A3 | ||
| Description by TissGene annotations | Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SLC26A3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | 5.942193478 | 12.59891655 | -6.656723077 | 7.69E-09 | 7.02E-08 |
| THCA | -2.315573146 | -0.936530773 | -1.379042373 | 1.44E-06 | 5.34E-06 |
| BRCA | -0.172804903 | 2.203183694 | -2.375988596 | 3.56E-09 | 1.23E-08 |
| PRAD | 1.286560785 | 3.045087708 | -1.758526923 | 0.00607 | 0.015475392 |
| KICH | -1.585464061 | -2.742396061 | 1.156932 | 0.00625 | 0.01173339 |
| Top |
| TissGene-miRNA for SLC26A3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-28-3p | MIMAT0004502 | 0.015 | -0.28 | 78 |
| ACC | hsa-miR-28-3p | MIMAT0004502 | 0.015 | -0.28 | 78 |
| Top |
| TissGeneMut for SLC26A3 |
| TissGeneSNV for SLC26A3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G341E | SKCM | 3 |
| p.R566Q | SKCM | 2 |
| p.D742N | SKCM | 2 |
| p.V88I | GBM | 2 |
| p.G199R | UCEC | 1 |
| p.R566Q | COAD | 1 |
| p.Q495K | LUSC | 1 |
| p.L397I | HNSC | 1 |
| p.S122* | LUAD | 1 |
| p.R52I | UCEC | 1 |
| p.G749R | LUAD | 1 |
| p.V340I | COAD | 1 |
| p.L185V | ACC | 1 |
| p.L431I | UCEC | 1 |
| p.Q495K | ESCA | 1 |
| p.E293K | SKCM | 1 |
| p.K705T | STAD | 1 |
| p.L363F | BLCA | 1 |
| p.R752H | DLBC | 1 |
| p.A180E | LUAD | 1 |
| p.F294V | OV | 1 |
| p.E334D | UCEC | 1 |
| p.R566* | GBM | 1 |
| p.E22V | STAD | 1 |
| p.I471F | SKCM | 1 |
| p.E172K | SKCM | 1 |
| p.P112T | ESCA | 1 |
| p.E606K | READ | 1 |
| p.G158E | SKCM | 1 |
| p.R752H | LUAD | 1 |
| p.E533X | PAAD | 1 |
| p.L92S | LUAD | 1 |
| p.E533Q | GBM | 1 |
| p.F213L | UCEC | 1 |
| p.G158R | SKCM | 1 |
| p.H38Y | SKCM | 1 |
| p.E736A | READ | 1 |
| p.A140E | ESCA | 1 |
| p.D660H | BLCA | 1 |
| p.L496M | KIRC | 1 |
| p.R752H | BRCA | 1 |
| p.P328A | LUAD | 1 |
| p.S109F | SKCM | 1 |
| p.D320N | LUAD | 1 |
| p.V184L | LUAD | 1 |
| p.R68Q | PAAD | 1 |
| p.I677F | HNSC | 1 |
| p.L106F | LUAD | 1 |
| p.G450R | SKCM | 1 |
| p.R579Q | SKCM | 1 |
| p.P131L | GBM | 1 |
| p.R502S | LUAD | 1 |
| p.Q326* | BLCA | 1 |
| p.G80D | UCEC | 1 |
| p.M135I | SKCM | 1 |
| p.G750E | SKCM | 1 |
| p.L470X | STAD | 1 |
| p.V149D | BRCA | 1 |
| p.G446E | SKCM | 1 |
| p.A559D | PAAD | 1 |
| p.R13M | UCEC | 1 |
| p.R752C | READ | 1 |
| p.G371V | COAD | 1 |
| p.S304F | COAD | 1 |
| p.I243V | READ | 1 |
| p.K521E | STAD | 1 |
| p.M1I | SKCM | 1 |
| p.H32N | BLCA | 1 |
| p.D370H | BLCA | 1 |
| p.R752H | HNSC | 1 |
| p.A180T | READ | 1 |
| p.F94L | PCPG | 1 |
| p.G319W | BRCA | 1 |
| p.S122Y | LUAD | 1 |
| p.D76Y | UCEC | 1 |
| p.R152S | LUAD | 1 |
| p.D558N | UCEC | 1 |
| p.L96V | HNSC | 1 |
| p.E293K | LGG | 1 |
| p.A433E | LGG | 1 |
| p.F391C | UCEC | 1 |
| p.L587V | LUAD | 1 |
| p.G319W | BLCA | 1 |
| p.G407E | SKCM | 1 |
| p.R566Q | UCEC | 1 |
| p.D99N | HNSC | 1 |
| p.F709C | ACC | 1 |
| p.V298M | UCEC | 1 |
| p.G593* | UCEC | 1 |
| p.D599Y | UCEC | 1 |
| p.R752C | UCEC | 1 |
| p.E71K | SKCM | 1 |
| p.S273Y | LUAD | 1 |
| p.I499M | LUSC | 1 |
| p.E533* | PAAD | 1 |
| p.S707L | BLCA | 1 |
| p.R696Q | ESCA | 1 |
| p.A260V | SKCM | 1 |
| p.A178V | LUAD | 1 |
| p.V424L | ESCA | 1 |
| p.K573N | KIRP | 1 |
| p.D742H | ACC | 1 |
| p.V340I | OV | 1 |
| p.R389T | BLCA | 1 |
| p.Y204N | LUAD | 1 |
| p.K227* | LUSC | 1 |
| p.V360I | KIRC | 1 |
| p.K49R | CESC | 1 |
| p.V78A | LUSC | 1 |
| p.S142L | CESC | 1 |
| p.S224F | SKCM | 1 |
| p.Y248H | COAD | 1 |
| p.D738N | SKCM | 1 |
| p.L185F | PRAD | 1 |
| p.V340I | LGG | 1 |
| p.G417D | SKCM | 1 |
| p.E334Q | OV | 1 |
| p.L185I | LUAD | 1 |
| p.Y530H | LUAD | 1 |
| p.I2F | LUAD | 1 |
| p.P543S | SKCM | 1 |
| p.V340I | CESC | 1 |
| p.S186C | CESC | 1 |
| p.L470* | STAD | 1 |
| p.R566Q | LGG | 1 |
| p.P532Q | OV | 1 |
| p.R312S | LUSC | 1 |
| p.R696Q | COAD | 1 |
| p.E207Q | HNSC | 1 |
| p.A347T | STAD | 1 |
| p.G120D | UCEC | 1 |
| p.P101L | SKCM | 1 |
| p.R197Q | SKCM | 1 |
| p.R516I | READ | 1 |
| p.R566* | SKCM | 1 |
| p.F594C | UCEC | 1 |
| p.V353M | UCEC | 1 |
| p.L247V | GBM | 1 |
| p.R752C | STAD | 1 |
| p.E757* | BRCA | 1 |
| p.A179V | GBM | 1 |
| p.K737T | SKCM | 1 |
| p.E533K | LUAD | 1 |
| p.I613M | OV | 1 |
| p.D366N | SKCM | 1 |
| Top |
| TissGeneCNV for SLC26A3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SLC26A3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SLC26A3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor) | SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal) |
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| COAD (tumor) | COAD (normal) |
| SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor) | SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor) | SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal) |
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| KICH (tumor) | KICH (normal) |
| SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor) | SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor) | SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor) | SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor) | SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor) | SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor) | SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor) | SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal) |
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| STAD (tumor) | STAD (normal) |
| SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor) | SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal) |
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| THCA (tumor) | THCA (normal) |
| SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor) | SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal) |
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| Top |
| TissGeneProg for SLC26A3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SLC26A3 |
| TissGeneDrug for SLC26A3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SLC26A3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0267662 | Congenital chloride diarrhea | 11 | BeFree,CLINVAR,MGD,ORPHANET,UNIPROT |
| umls:C0011991 | Diarrhea | 10 | BeFree |
| umls:C0009324 | Ulcerative Colitis | 6 | BeFree,CTD_human,GAD |
| umls:C0001430 | Adenoma | 5 | BeFree,LHGDN |
| umls:C0001418 | Adenocarcinoma | 4 | BeFree |
| umls:C0220726 | Diastrophic dysplasia | 3 | BeFree |
| umls:C0271829 | Pendred's syndrome | 3 | BeFree |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C0848676 | Subfertility, Male | 3 | BeFree |
| umls:C0010674 | Cystic Fibrosis | 2 | BeFree |
| umls:C0019163 | Hepatitis B | 2 | BeFree |
| umls:C0019196 | Hepatitis C | 2 | BeFree |
| umls:C0023343 | Leprosy | 2 | BeFree |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 2 | BeFree |
| umls:C0032584 | polyps | 2 | BeFree |
| umls:C0239182 | Watery diarrhoea | 2 | BeFree |
| umls:C0341439 | Chronic liver disease | 2 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | BeFree |
| umls:C0010346 | Crohn Disease | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0014072 | Experimental Autoimmune Encephalomyelitis | 1 | BeFree |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0018213 | Graves Disease | 1 | BeFree |
| umls:C0021831 | Intestinal Diseases | 1 | BeFree |
| umls:C0023890 | Liver Cirrhosis | 1 | BeFree |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0025218 | Chloasma | 1 | BeFree |
| umls:C0025517 | Metabolic Diseases | 1 | BeFree |
| umls:C0026269 | Mitral Valve Stenosis | 1 | BeFree |
| umls:C0026760 | Multiple Epiphyseal Dysplasia | 1 | BeFree |
| umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
| umls:C0027709 | Nephrocalcinosis | 1 | BeFree |
| umls:C0034494 | Rabies (disorder) | 1 | BeFree |
| umls:C0037859 | Spermatocele | 1 | BeFree |
| umls:C0206677 | Adenomatous Polyps | 1 | BeFree |
| umls:C0220983 | Metabolic alkalosis | 1 | BeFree |
| umls:C0242596 | Neoplasm, Residual | 1 | BeFree |
| umls:C0267557 | Secretory diarrhea | 1 | BeFree |
| umls:C0333980 | Focal Nodular Hyperplasia | 1 | BeFree |
| umls:C0343284 | Chondrodysplasia | 1 | BeFree |
| umls:C0346627 | Intestinal Cancer | 1 | BeFree |
| umls:C0376544 | Hematopoietic Neoplasms | 1 | BeFree |
| umls:C0524851 | Neurodegenerative Disorders | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0740898 | Hypokalemic metabolic alkalosis | 1 | BeFree |
| umls:C0751951 | Central Core Myopathy (disorder) | 1 | BeFree |
| umls:C0878555 | Diffuse panbronchiolitis | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C1623038 | Cirrhosis | 1 | BeFree |
| umls:C1840451 | MULTICYSTIC RENAL DYSPLASIA, BILATERAL | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C3697893 | Telangiectatic focal nodular hyperplasia | 1 | BeFree |
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