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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for SLC26A3
check button Gene summary
Basic gene informationGene symbolSLC26A3
Gene namesolute carrier family 26 (anion exchanger), member 3
SynonymsCLD|DRA
CytomapUCSC genome browser: 7q31
Type of geneprotein-coding
RefGenesNM_000111.2,
Descriptionchloride anion exchangerdown-regulated in adenoma proteinsolute carrier family 26, member 3
Modification date20141207
dbXrefs MIM : 126650
HGNC : HGNC
Ensembl : ENSG00000091138
HPRD : 00544
Vega : OTTHUMG00000154812
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SLC26A3
BioGPS: 1811
PathwayNCI Pathway Interaction Database: SLC26A3
KEGG: SLC26A3
REACTOME: SLC26A3
Pathway Commons: SLC26A3
ContextiHOP: SLC26A3
ligand binding site mutation search in PubMed: SLC26A3
UCL Cancer Institute: SLC26A3
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Colon
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)COAD
Reference showing the relevant tissue of SLC26A3
Description by TissGene annotationsSignificant down-regulated DEG
TissgsKTS
CNV lost TissGeneKTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for SLC26A3

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
COAD5.94219347812.59891655-6.6567230777.69E-097.02E-08
THCA-2.315573146-0.936530773-1.3790423731.44E-065.34E-06
BRCA-0.1728049032.203183694-2.3759885963.56E-091.23E-08
PRAD1.2865607853.045087708-1.7585269230.006070.015475392
KICH-1.585464061-2.7423960611.1569320.006250.01173339


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TissGene-miRNA for SLC26A3

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
ACChsa-miR-28-3pMIMAT00045020.015-0.2878
ACChsa-miR-28-3pMIMAT00045020.015-0.2878


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TissGeneMut for SLC26A3
TissGeneSNV for SLC26A3

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G341ESKCM3
p.R566QSKCM2
p.D742NSKCM2
p.V88IGBM2
p.G199RUCEC1
p.R566QCOAD1
p.Q495KLUSC1
p.L397IHNSC1
p.S122*LUAD1
p.R52IUCEC1
p.G749RLUAD1
p.V340ICOAD1
p.L185VACC1
p.L431IUCEC1
p.Q495KESCA1
p.E293KSKCM1
p.K705TSTAD1
p.L363FBLCA1
p.R752HDLBC1
p.A180ELUAD1
p.F294VOV1
p.E334DUCEC1
p.R566*GBM1
p.E22VSTAD1
p.I471FSKCM1
p.E172KSKCM1
p.P112TESCA1
p.E606KREAD1
p.G158ESKCM1
p.R752HLUAD1
p.E533XPAAD1
p.L92SLUAD1
p.E533QGBM1
p.F213LUCEC1
p.G158RSKCM1
p.H38YSKCM1
p.E736AREAD1
p.A140EESCA1
p.D660HBLCA1
p.L496MKIRC1
p.R752HBRCA1
p.P328ALUAD1
p.S109FSKCM1
p.D320NLUAD1
p.V184LLUAD1
p.R68QPAAD1
p.I677FHNSC1
p.L106FLUAD1
p.G450RSKCM1
p.R579QSKCM1
p.P131LGBM1
p.R502SLUAD1
p.Q326*BLCA1
p.G80DUCEC1
p.M135ISKCM1
p.G750ESKCM1
p.L470XSTAD1
p.V149DBRCA1
p.G446ESKCM1
p.A559DPAAD1
p.R13MUCEC1
p.R752CREAD1
p.G371VCOAD1
p.S304FCOAD1
p.I243VREAD1
p.K521ESTAD1
p.M1ISKCM1
p.H32NBLCA1
p.D370HBLCA1
p.R752HHNSC1
p.A180TREAD1
p.F94LPCPG1
p.G319WBRCA1
p.S122YLUAD1
p.D76YUCEC1
p.R152SLUAD1
p.D558NUCEC1
p.L96VHNSC1
p.E293KLGG1
p.A433ELGG1
p.F391CUCEC1
p.L587VLUAD1
p.G319WBLCA1
p.G407ESKCM1
p.R566QUCEC1
p.D99NHNSC1
p.F709CACC1
p.V298MUCEC1
p.G593*UCEC1
p.D599YUCEC1
p.R752CUCEC1
p.E71KSKCM1
p.S273YLUAD1
p.I499MLUSC1
p.E533*PAAD1
p.S707LBLCA1
p.R696QESCA1
p.A260VSKCM1
p.A178VLUAD1
p.V424LESCA1
p.K573NKIRP1
p.D742HACC1
p.V340IOV1
p.R389TBLCA1
p.Y204NLUAD1
p.K227*LUSC1
p.V360IKIRC1
p.K49RCESC1
p.V78ALUSC1
p.S142LCESC1
p.S224FSKCM1
p.Y248HCOAD1
p.D738NSKCM1
p.L185FPRAD1
p.V340ILGG1
p.G417DSKCM1
p.E334QOV1
p.L185ILUAD1
p.Y530HLUAD1
p.I2FLUAD1
p.P543SSKCM1
p.V340ICESC1
p.S186CCESC1
p.L470*STAD1
p.R566QLGG1
p.P532QOV1
p.R312SLUSC1
p.R696QCOAD1
p.E207QHNSC1
p.A347TSTAD1
p.G120DUCEC1
p.P101LSKCM1
p.R197QSKCM1
p.R516IREAD1
p.R566*SKCM1
p.F594CUCEC1
p.V353MUCEC1
p.L247VGBM1
p.R752CSTAD1
p.E757*BRCA1
p.A179VGBM1
p.K737TSKCM1
p.E533KLUAD1
p.I613MOV1
p.D366NSKCM1


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TissGeneCNV for SLC26A3

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for SLC26A3

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for SLC26A3

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor)SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal)
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COAD (tumor)COAD (normal)
SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor)SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal)
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HNSC (tumor)HNSC (normal)
SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor)SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal)
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KICH (tumor)KICH (normal)
SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor)SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal)
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KIRC (tumor)KIRC (normal)
SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor)SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal)
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KIRP (tumor)KIRP (normal)
SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor)SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal)
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LIHC (tumor)LIHC (normal)
SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor)SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal)
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LUAD (tumor)LUAD (normal)
SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor)SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal)
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LUSC (tumor)LUSC (normal)
SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor)SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal)
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PRAD (tumor)PRAD (normal)
SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor)SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal)
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STAD (tumor)STAD (normal)
SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor)SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal)
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THCA (tumor)THCA (normal)
SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (tumor)SLC26A3, CFTR, SLC9A3R1, SLC9A3R2 (normal)
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TissGeneProg for SLC26A3

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for SLC26A3
TissGeneDrug for SLC26A3

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for SLC26A3

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0267662Congenital chloride diarrhea11BeFree,CLINVAR,MGD,ORPHANET,UNIPROT
umls:C0011991Diarrhea10BeFree
umls:C0009324Ulcerative Colitis6BeFree,CTD_human,GAD
umls:C0001430Adenoma5BeFree,LHGDN
umls:C0001418Adenocarcinoma4BeFree
umls:C0220726Diastrophic dysplasia3BeFree
umls:C0271829Pendred's syndrome3BeFree
umls:C0596263Carcinogenesis3BeFree
umls:C0848676Subfertility, Male3BeFree
umls:C0010674Cystic Fibrosis2BeFree
umls:C0019163Hepatitis B2BeFree
umls:C0019196Hepatitis C2BeFree
umls:C0023343Leprosy2BeFree
umls:C0023434Chronic Lymphocytic Leukemia2BeFree
umls:C0032584polyps2BeFree
umls:C0239182Watery diarrhoea2BeFree
umls:C0341439Chronic liver disease2BeFree
umls:C0007102Malignant tumor of colon1BeFree
umls:C0009375Colonic Neoplasms1BeFree
umls:C0009402Colorectal Carcinoma1BeFree
umls:C0009404Colorectal Neoplasms1BeFree
umls:C0010346Crohn Disease1BeFree
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0014072Experimental Autoimmune Encephalomyelitis1BeFree
umls:C0017636Glioblastoma1BeFree
umls:C0018213Graves Disease1BeFree
umls:C0021831Intestinal Diseases1BeFree
umls:C0023890Liver Cirrhosis1BeFree
umls:C0024299Lymphoma1BeFree
umls:C0025218Chloasma1BeFree
umls:C0025517Metabolic Diseases1BeFree
umls:C0026269Mitral Valve Stenosis1BeFree
umls:C0026760Multiple Epiphyseal Dysplasia1BeFree
umls:C0026769Multiple Sclerosis1BeFree
umls:C0027709Nephrocalcinosis1BeFree
umls:C0034494Rabies (disorder)1BeFree
umls:C0037859Spermatocele1BeFree
umls:C0206677Adenomatous Polyps1BeFree
umls:C0220983Metabolic alkalosis1BeFree
umls:C0242596Neoplasm, Residual1BeFree
umls:C0267557Secretory diarrhea1BeFree
umls:C0333980Focal Nodular Hyperplasia1BeFree
umls:C0343284Chondrodysplasia1BeFree
umls:C0346627Intestinal Cancer1BeFree
umls:C0376544Hematopoietic Neoplasms1BeFree
umls:C0524851Neurodegenerative Disorders1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0740898Hypokalemic metabolic alkalosis1BeFree
umls:C0751951Central Core Myopathy (disorder)1BeFree
umls:C0878555Diffuse panbronchiolitis1BeFree
umls:C1527249Colorectal Cancer1BeFree
umls:C1623038Cirrhosis1BeFree
umls:C1840451MULTICYSTIC RENAL DYSPLASIA, BILATERAL1BeFree
umls:C2239176Liver carcinoma1BeFree
umls:C3697893Telangiectatic focal nodular hyperplasia1BeFree