TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for DRD2

Gene summary

Basic gene information	Gene symbol	DRD2
	Gene name	dopamine receptor D2
	Synonyms	D2DR\|D2R
	Cytomap	UCSC genome browser: 11q23
	Type of gene	protein-coding
	RefGenes	NM_000795.3, NM_016574.3,
	Description	D(2) dopamine receptordopamine D2 receptordopamine receptor D2 isoformseven transmembrane helix receptor
	Modification date	20141222
dbXrefs	MIM : 126450
	HGNC : HGNC
	Ensembl : ENSG00000149295
	HPRD : 00539
	Vega : OTTHUMG00000167717
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_DRD2
	BioGPS: 1813
Pathway	NCI Pathway Interaction Database: DRD2
	KEGG: DRD2
	REACTOME: DRD2
	Pathway Commons: DRD2
Context	iHOP: DRD2
	ligand binding site mutation search in PubMed: DRD2
	UCL Cancer Institute: DRD2
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	HPA,TiGER
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	LungAdrenal gland
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	LUAD,LUSCPCPG,ACC
Reference showing the relevant tissue of DRD2
Description by TissGene annotations	Cancer gene

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0007194	negative regulation of adenylate cyclase activity	2531656
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	1331329
GO:0030814	regulation of cAMP metabolic process	8666994
GO:0034776	response to histamine	16839358
GO:0035556	intracellular signal transduction	1331329
GO:0050482	arachidonic acid secretion	8301582
GO:0050709	negative regulation of protein secretion	16839358
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	1331329
GO:1901386	negative regulation of voltage-gated calcium channel activity	7921596
GO:0007194	negative regulation of adenylate cyclase activity	2531656
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway	1331329
GO:0030814	regulation of cAMP metabolic process	8666994
GO:0034776	response to histamine	16839358
GO:0035556	intracellular signal transduction	1331329
GO:0050482	arachidonic acid secretion	8301582
GO:0050709	negative regulation of protein secretion	16839358
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	1331329
GO:1901386	negative regulation of voltage-gated calcium channel activity	7921596

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TissGeneExp for DRD2

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
BRCA	-1.311570542	1.687782089	-2.999352632	7.07E-30	9.32E-29
PRAD	-1.425210455	0.150062622	-1.575273077	1.91E-08	2.20E-07
HNSC	-2.120878478	-1.075071501	-1.045806977	0.00825	0.020998303
KICH	0.409498545	-2.148365455	2.557864	0.00035	0.000826795

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TissGene-miRNA for DRD2

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for DRD2

TissGeneSNV for DRD2

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.E280K	SKCM	2
p.N143T	SKCM	1
p.R219H	GBM	1
p.D178Y	LUAD	1
p.R227S	THYM	1
p.E62K	STAD	1
p.W18R	STAD	1
p.R268Q	UCEC	1
p.A127V	COAD	1
p.A120V	LIHC	1
p.A64V	COAD	1
p.P297H	COAD	1
p.I394V	LIHC	1
p.E291K	SKCM	1
p.P335T	STAD	1
p.K101T	UCEC	1
p.G173R	UCEC	1
p.R61H	LUAD	1
p.L307F	SKCM	1
p.R269I	UCEC	1
p.P239S	SKCM	1
p.H303N	LUAD	1
p.T345N	LUAD	1
p.I424V	LUAD	1
p.W386L	LUAD	1
p.P335L	THYM	1
p.P187Q	LUAD	1
p.A38V	UCEC	1
p.P247N	LUAD	1
p.A331T	THYM	1
p.A77T	KIRP	1
p.S359G	LUSC	1
p.R217H	SKCM	1
p.R352W	HNSC	1
p.S286N	LUSC	1
p.S419R	LIHC	1
p.V200M	ESCA	1
p.D12E	BLCA	1
p.P247H	LUAD	1
p.P290L	UCEC	1
p.D10N	SKCM	1
p.T42P	SKCM	1
p.N402S	SKCM	1
p.Y34C	UCEC	1
p.S167F	STAD	1
p.G24V	LUAD	1
p.Y408*	LUAD	1
p.F22L	BRCA	1
p.G261E	SKCM	1
p.T392K	LUSC	1
p.G27R	SKCM	1
p.E368Q	BRCA	1
p.P3L	PRAD	1
p.L40Q	HNSC	1
p.V96I	KIRC	1
p.S228N	STAD	1
p.V190E	LUAD	1
p.P89S	OV	1
p.V381M	PAAD	1
p.V381M	SARC	1
p.R217C	STAD	1
p.C118R	LUAD	1
p.A29T	COAD	1
p.P404L	SKCM	1
p.I122N	HNSC	1
p.A120V	LUAD	1
p.Y71F	HNSC	1
p.R31T	BLCA	1
p.A391T	READ	1
p.P247T	LUAD	1
p.R217C	SKCM	1
p.L363H	LUAD	1
p.H316P	LUAD	1
p.R233K	SKCM	1
p.S364F	SKCM	1
p.R230Q	UCEC	1
p.V255F	LUAD	1
p.S321R	LUAD	1
p.N52I	LIHC	1
p.D400Y	LUAD	1
p.P201S	SKCM	1
p.P289L	SKCM	1
p.P299S	SARC	1
p.S167F	SKCM	1
p.V159L	LUAD	1
p.E248K	UCS	1
p.K356R	BLCA	1
p.T42I	SKCM	1
p.P347L	SKCM	1
p.I403T	SKCM	1
p.H316Q	LUSC	1
p.M155I	LUAD	1
p.R217H	OV	1
p.K241E	SKCM	1
p.L216F	SKCM	1
p.R222Q	SKCM	1
p.S364F	LAML	1
p.T205N	LUAD	1
p.A331P	ESCA	1
p.V74D	STAD	1
p.A177T	STAD	1
p.C399S	STAD	1
p.V270L	LUAD	1
p.A323V	STAD	1
p.T39S	LUAD	1
p.R217H	BLCA	1

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TissGeneCNV for DRD2

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for DRD2

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database

Src

Cancer type

Sample

Fusion gene

ORF

5'-gene BP

3'-gene BP

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TissGeneNet for DRD2

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
DRD2, CADPS2, GIPC1, FLNA, GNAZ, CALM1, KCNJ6, PPP1R9B, EPB41, GNAI2, PPP1R9A, EPB41L1, NSF, KCNJ5, KCNJ3, GRIA2, SLC6A3, SSTR5, ADORA2A, NCS1, CLIC6 (tumor)	DRD2, CADPS2, GIPC1, FLNA, GNAZ, KCNJ6, KCNJ9, PPP1R9B, EPB41, GNAI2, PPP1R9A, NSF, KCNJ5, KCNJ3, CALM3, GRIA2, SLC6A3, ADORA2A, NCS1, CADPS, CLIC6 (normal)

COAD (tumor)	COAD (normal)
DRD2, CADPS2, FLNA, GNAZ, KCNJ6, KCNJ9, EPB41, GNAI2, PPP1R9A, EPB41L1, NSF, KCNJ5, CALM3, GNAI3, GRIA2, SLC6A3, SSTR5, ADORA2A, NCS1, CADPS, CLIC6 (tumor)	DRD2, CADPS2, GIPC1, FLNA, GNAZ, CALM1, KCNJ9, PPP1R9B, EPB41, EPB41L1, NSF, KCNJ5, KCNJ3, CALM3, GNAI3, GRIA2, SLC6A3, SSTR5, ADORA2A, NCS1, CADPS (normal)

HNSC (tumor)	HNSC (normal)
DRD2, CADPS2, GIPC1, FLNA, GNAZ, CALM1, KCNJ6, KCNJ9, PPP1R9B, EPB41, GNAI2, PPP1R9A, EPB41L1, KCNJ5, GNAI3, GRIA2, SSTR5, ADORA2A, NCS1, CADPS, CLIC6 (tumor)	DRD2, CADPS2, GIPC1, FLNA, GNAZ, KCNJ6, KCNJ9, PPP1R9B, GNAI2, PPP1R9A, EPB41L1, KCNJ5, KCNJ3, CALM3, GNAI3, GRIA2, SLC6A3, SSTR5, ADORA2A, CADPS, CLIC6 (normal)

KICH (tumor)	KICH (normal)
DRD2, CADPS2, GIPC1, FLNA, GNAZ, CALM1, KCNJ6, KCNJ9, PPP1R9B, GNAI2, PPP1R9A, NSF, KCNJ5, KCNJ3, CALM3, GRIA2, SLC6A3, SSTR5, NCS1, CADPS, CLIC6 (tumor)	DRD2, GIPC1, FLNA, CALM1, KCNJ6, KCNJ9, PPP1R9B, EPB41, GNAI2, PPP1R9A, EPB41L1, NSF, KCNJ5, KCNJ3, CALM3, GNAI3, GRIA2, SLC6A3, ADORA2A, NCS1, CADPS (normal)

KIRC (tumor)	KIRC (normal)
DRD2, GIPC1, FLNA, GNAZ, CALM1, KCNJ6, PPP1R9B, EPB41, GNAI2, PPP1R9A, NSF, KCNJ5, KCNJ3, CALM3, GNAI3, GRIA2, SLC6A3, SSTR5, ADORA2A, NCS1, CLIC6 (tumor)	DRD2, CADPS2, GIPC1, FLNA, GNAZ, CALM1, KCNJ6, PPP1R9B, EPB41, GNAI2, PPP1R9A, NSF, KCNJ3, GNAI3, GRIA2, SLC6A3, SSTR5, ADORA2A, NCS1, CADPS, CLIC6 (normal)

KIRP (tumor)	KIRP (normal)
DRD2, CADPS2, GIPC1, GNAZ, CALM1, KCNJ6, KCNJ9, PPP1R9B, EPB41, GNAI2, PPP1R9A, NSF, KCNJ5, KCNJ3, CALM3, GNAI3, GRIA2, SLC6A3, SSTR5, NCS1, CADPS (tumor)	DRD2, CADPS2, GIPC1, GNAZ, CALM1, KCNJ6, PPP1R9B, EPB41, PPP1R9A, EPB41L1, NSF, KCNJ3, CALM3, GNAI3, GRIA2, SLC6A3, SSTR5, ADORA2A, NCS1, CADPS, CLIC6 (normal)

LIHC (tumor)	LIHC (normal)
DRD2, CADPS2, GIPC1, GNAZ, CALM1, KCNJ6, KCNJ9, PPP1R9B, GNAI2, EPB41L1, NSF, KCNJ5, KCNJ3, CALM3, GNAI3, GRIA2, SLC6A3, ADORA2A, NCS1, CADPS, CLIC6 (tumor)	DRD2, GIPC1, FLNA, GNAZ, CALM1, KCNJ6, KCNJ9, PPP1R9B, EPB41, GNAI2, PPP1R9A, EPB41L1, CALM3, GNAI3, GRIA2, SLC6A3, SSTR5, ADORA2A, NCS1, CADPS, CLIC6 (normal)

LUAD (tumor)	LUAD (normal)
DRD2, CADPS2, GIPC1, FLNA, CALM1, KCNJ6, PPP1R9B, GNAI2, PPP1R9A, EPB41L1, NSF, KCNJ5, KCNJ3, CALM3, GNAI3, GRIA2, SLC6A3, SSTR5, NCS1, CADPS, CLIC6 (tumor)	DRD2, CADPS2, FLNA, GNAZ, CALM1, KCNJ6, KCNJ9, EPB41, PPP1R9A, EPB41L1, NSF, KCNJ5, KCNJ3, CALM3, GRIA2, SLC6A3, SSTR5, ADORA2A, NCS1, CADPS, CLIC6 (normal)

LUSC (tumor)	LUSC (normal)
DRD2, CADPS2, GIPC1, FLNA, CALM1, KCNJ6, KCNJ9, PPP1R9B, EPB41, GNAI2, PPP1R9A, EPB41L1, NSF, KCNJ5, CALM3, GNAI3, SLC6A3, SSTR5, NCS1, CADPS, CLIC6 (tumor)	DRD2, GIPC1, FLNA, GNAZ, CALM1, KCNJ6, KCNJ9, PPP1R9B, EPB41, PPP1R9A, NSF, KCNJ5, KCNJ3, CALM3, GNAI3, GRIA2, SLC6A3, ADORA2A, NCS1, CADPS, CLIC6 (normal)

PRAD (tumor)	PRAD (normal)
DRD2, CADPS2, GIPC1, FLNA, GNAZ, CALM1, KCNJ9, EPB41, GNAI2, PPP1R9A, EPB41L1, NSF, KCNJ5, KCNJ3, CALM3, GNAI3, GRIA2, ADORA2A, NCS1, CADPS, CLIC6 (tumor)	DRD2, CADPS2, GIPC1, FLNA, GNAZ, CALM1, PPP1R9B, EPB41, GNAI2, PPP1R9A, EPB41L1, NSF, KCNJ5, KCNJ3, CALM3, GNAI3, GRIA2, SSTR5, ADORA2A, NCS1, CLIC6 (normal)

STAD (tumor)	STAD (normal)
DRD2, CADPS2, GIPC1, FLNA, GNAZ, CALM1, KCNJ6, KCNJ9, PPP1R9B, EPB41, GNAI2, PPP1R9A, NSF, KCNJ5, GRIA2, SLC6A3, SSTR5, ADORA2A, NCS1, CADPS, CLIC6 (tumor)	DRD2, CADPS2, GIPC1, FLNA, GNAZ, CALM1, KCNJ6, KCNJ9, PPP1R9B, EPB41, PPP1R9A, EPB41L1, NSF, CALM3, GNAI3, GRIA2, SLC6A3, SSTR5, NCS1, CADPS, CLIC6 (normal)

THCA (tumor)	THCA (normal)
DRD2, CADPS2, GIPC1, FLNA, GNAZ, CALM1, KCNJ6, KCNJ9, PPP1R9B, EPB41, PPP1R9A, EPB41L1, NSF, KCNJ5, CALM3, GNAI3, GRIA2, SLC6A3, SSTR5, ADORA2A, NCS1 (tumor)	DRD2, CADPS2, GIPC1, FLNA, GNAZ, CALM1, KCNJ6, KCNJ9, EPB41, GNAI2, PPP1R9A, EPB41L1, NSF, KCNJ3, CALM3, GNAI3, GRIA2, SSTR5, NCS1, CADPS, CLIC6 (normal)

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TissGeneProg for DRD2

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for DRD2

TissGeneDrug for DRD2

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID	Drug name	Drug activity	Drug type	Drug status
DB00391	Sulpiride	Antagonist	Small molecule	Approved
DB00458	Imipramine	Binder	Small molecule	Approved
DB00502	Haloperidol	Antagonist	Small molecule	Approved
DB00540	Nortriptyline	Antagonist	Small molecule	Approved
DB00568	Cinnarizine	Other/unknown	Small molecule	Approved
DB00623	Fluphenazine	Antagonist	Small molecule	Approved
DB00850	Perphenazine	Antagonist	Small molecule	Approved
DB00915	Amantadine	Agonist	Small molecule	Approved
DB00933	Mesoridazine	Antagonist	Small molecule	Approved
DB00934	Maprotiline	Binder	Small molecule	Approved
DB01049	Ergoloid mesylate	Agonist\|Antagonist	Small molecule	Approved
DB01063	Acetophenazine	Antagonist	Small molecule	Approved
DB01100	Pimozide	Antagonist	Small molecule	Approved
DB01142	Doxepin	Antagonist	Small molecule	Approved
DB01151	Desipramine	Binder	Small molecule	Approved
DB01235	Levodopa	Agonist	Small molecule	Approved
DB01425	Alizapride	Antagonist	Small molecule	Approved
DB01621	Pipotiazine	Antagonist	Small molecule	Approved
DB01623	Thiothixene	Antagonist	Small molecule	Approved
DB04842	Fluspirilene	Antagonist	Small molecule	Approved
DB04844	Tetrabenazine	Inhibitor	Small molecule	Approved
DB05271	Rotigotine	Agonist	Small molecule	Approved
DB06016	Cariprazine	Agonist\|Partial agonist	Small molecule	Approved
DB06148	Mianserin	Antagonist	Small molecule	Approved
DB08815	Lurasidone	Antagonist	Small molecule	Approved
DB09018	Bromopride	Antagonist	Small molecule	Approved
DB09128	Brexpiprazole	Agonist\|Partial agonist	Small molecule	Approved
DB00182	Amphetamine	Binder	Small molecule	Approved\|Illicit
DB00490	Buspirone	Antagonist	Small molecule	Approved\|Investigational
DB06288	Amisulpride	Antagonist	Small molecule	Approved\|Investigational
DB13025	Tiapride	Blocker	Small molecule	Approved\|Investigational
DB01184	Domperidone	Antagonist	Small molecule	Approved\|Investigational\|Vet_approved
DB00433	Prochlorperazine	Antagonist	Small molecule	Approved\|Vet_approved
DB01221	Ketamine	Agonist\|Partial agonist	Small molecule	Approved\|Vet_approved
DB00409	Remoxipride	Antagonist	Small molecule	Approved\|Withdrawn

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TissGeneDisease for DRD2

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0001973	Alcoholic Intoxication, Chronic	163	BeFree,GAD,LHGDN,RGD
umls:C0036341	Schizophrenia	162	BeFree,CTD_human,GAD,LHGDN
umls:C1263846	Attention deficit hyperactivity disorder	34	BeFree,CTD_human,GAD
umls:C0028754	Obesity	30	BeFree,GAD,RGD
umls:C0005586	Bipolar Disorder	27	BeFree,GAD
umls:C0030567	Parkinson Disease	22	BeFree,CTD_human,GAD,RGD
umls:C0152115	Lingual-Facial-Buccal Dyskinesia	19	BeFree,GAD
umls:C0028043	Nicotine Dependence	18	BeFree
umls:C0686347	Tardive Dyskinesia	18	BeFree,GAD
umls:C0004936	Mental disorders	16	BeFree
umls:C0038580	Substance Dependence	16	BeFree
umls:C0525045	Mood Disorders	15	BeFree,GAD
umls:C0003469	Anxiety Disorders	14	BeFree,CTD_human,GAD
umls:C0013146	Drug abuse	14	BeFree
umls:C0149931	Migraine Disorders	14	BeFree,GAD
umls:C0740858	Substance abuse problem	14	BeFree
umls:C0033975	Psychotic Disorders	13	BeFree,GAD
umls:C0040336	Tobacco Use Disorder	13	CTD_human,GAD
umls:C0040517	Gilles de la Tourette syndrome	13	BeFree,GAD,LHGDN,RGD
umls:C0236736	Cocaine-Related Disorders	13	CTD_human,GAD,RGD
umls:C0033375	Prolactinoma	12	BeFree,LHGDN
umls:C0038586	Substance Use Disorders	12	BeFree
umls:C0085762	Alcohol abuse	12	BeFree,GAD
umls:C0349204	Nonorganic psychosis	11	BeFree
umls:C0011570	Mental Depression	10	BeFree,GAD
umls:C0011581	Depressive disorder	10	BeFree,RGD
umls:C0600427	Cocaine Dependence	10	BeFree,GAD
umls:C0038436	Post-Traumatic Stress Disorder	9	BeFree,GAD
umls:C0236969	Substance-Related Disorders	9	CTD_human,GAD
umls:C1269683	Major Depressive Disorder	9	BeFree,GAD
umls:C1510472	Drug Dependence	9	BeFree
umls:C0013384	Dyskinetic syndrome	8	BeFree,CTD_human,LHGDN
umls:C0019337	Heroin Dependence	8	BeFree,CTD_human,GAD
umls:C0032019	Pituitary Neoplasms	8	BeFree,CTD_human,GAD,LHGDN
umls:C0041696	Unipolar Depression	8	BeFree
umls:C0003431	Antisocial Personality Disorder	7	BeFree,GAD
umls:C0004782	Basal Ganglia Diseases	7	CTD_human,GAD
umls:C0020538	Hypertensive disease	7	BeFree,CTD_human
umls:C0024809	Marijuana Abuse	7	BeFree,GAD
umls:C0027849	Neuroleptic Malignant Syndrome	7	BeFree,GAD,LHGDN
umls:C0038587	Substance Withdrawal Syndrome	7	BeFree,CTD_human,GAD
umls:C0242379	Malignant neoplasm of lung	7	BeFree,GAD
umls:C0524662	Opiate Addiction	7	BeFree
umls:C0013421	Dystonia	6	BeFree,GAD,LHGDN
umls:C0020514	Hyperprolactinemia	6	BeFree,CTD_human,GAD
umls:C0027765	nervous system disorder	6	BeFree,GAD
umls:C0032002	Pituitary Diseases	6	BeFree
umls:C0234133	Extrapyramidal sign	6	BeFree
umls:C1834570	Myoclonic dystonia	6	BeFree,CTD_human,ORPHANET
umls:C1839839	MAJOR AFFECTIVE DISORDER 2	6	BeFree,GAD
umls:C0001956	alcohol use disorder	5	BeFree
umls:C0004352	Autistic Disorder	5	BeFree,GAD
umls:C0011860	Diabetes Mellitus, Non-Insulin-Dependent	5	BeFree,GAD
umls:C0013386	Dyskinesia, Drug-Induced	5	CTD_human,GAD,RGD
umls:C0086132	Depressive Symptoms	5	BeFree
umls:C0237123	Alcohol or Other Drugs use	5	BeFree,GAD
umls:C0003944	As If Personality	4	GAD
umls:C0007370	Catalepsy	4	CTD_human
umls:C0009171	Cocaine Abuse	4	BeFree,GAD
umls:C0013473	Eating Disorders	4	BeFree
umls:C0020649	Hypotension	4	CTD_human
umls:C0021122	Disruptive, Impulse Control, and Conduct Disorders	4	CTD_human,GAD
umls:C0026650	Movement Disorders	4	BeFree,CTD_human
umls:C0032000	Pituitary Adenoma	4	BeFree
umls:C0036572	Seizures	4	BeFree,CTD_human
umls:C0038506	Stuttering	4	BeFree,GAD
umls:C0043094	Weight Gain	4	CTD_human,GAD
umls:C0242422	Parkinsonian Disorders	4	CTD_human,RGD
umls:C0338656	Impaired cognition	4	BeFree,GAD
umls:C0393593	Dystonia Disorders	4	BeFree
umls:C0497406	Overweight	4	BeFree
umls:C0600241	Heroin Abuse	4	BeFree,GAD
umls:C1527249	Colorectal Cancer	4	BeFree,GAD
umls:C1842981	NEUROTICISM	4	BeFree
umls:C1852197	MAJOR AFFECTIVE DISORDER 1	4	BeFree,GAD
umls:C1970943	MAJOR AFFECTIVE DISORDER 4	4	BeFree,GAD
umls:C1970944	MAJOR AFFECTIVE DISORDER 5	4	BeFree,GAD
umls:C1970945	MAJOR AFFECTIVE DISORDER 6	4	BeFree,GAD
umls:C2700438	MAJOR AFFECTIVE DISORDER 7	4	BeFree,GAD
umls:C2700439	MAJOR AFFECTIVE DISORDER 8	4	BeFree,GAD
umls:C2700440	MAJOR AFFECTIVE DISORDER 9	4	BeFree,GAD
umls:C2911647	Weight Gain Adverse Event	4	GAD
umls:C0001430	Adenoma	3	BeFree,GAD
umls:C0003125	Anorexia Nervosa	3	BeFree,GAD,LHGDN
umls:C0006142	Malignant neoplasm of breast	3	BeFree,GAD
umls:C0006370	Bulimia	3	BeFree
umls:C0009402	Colorectal Carcinoma	3	BeFree
umls:C0011251	Delusional disorder	3	BeFree
umls:C0020179	Huntington Disease	3	BeFree
umls:C0025202	melanoma	3	BeFree
umls:C0025261	Memory Disorders	3	CTD_human,GAD
umls:C0027796	Neuralgia	3	BeFree,RGD
umls:C0028768	Obsessive-Compulsive Disorder	3	BeFree,LHGDN
umls:C0030193	Pain	3	BeFree,CTD_human,GAD
umls:C0030662	Gambling, Pathological	3	BeFree
umls:C0031212	Personality Disorders	3	BeFree,GAD
umls:C0036337	Schizoaffective Disorder	3	BeFree,GAD
umls:C0039231	Tachycardia	3	CTD_human,RGD
umls:C0040332	Tobacco Dependence	3	BeFree
umls:C0233794	Memory impairment	3	BeFree
umls:C0236733	Amphetamine-Related Disorders	3	CTD_human,GAD
umls:C0242510	Drug usage	3	BeFree
umls:C0600104	Obsessive compulsive behavior	3	BeFree
umls:C1533217	Methamphetamine dependence	3	BeFree,GAD
umls:C0002020	Alexithymia	2	BeFree
umls:C0002395	Alzheimer's Disease	2	GAD
umls:C0004135	Ataxia Telangiectasia	2	BeFree
umls:C0005684	Malignant neoplasm of urinary bladder	2	GAD
umls:C0006012	Borderline Personality Disorder	2	BeFree
umls:C0009241	Cognition Disorders	2	CTD_human,GAD
umls:C0011206	Delirium	2	BeFree,GAD
umls:C0011253	Delusions	2	BeFree
umls:C0013222	Drug Use Disorders	2	BeFree
umls:C0014175	Endometriosis	2	BeFree
umls:C0018681	Headache	2	BeFree
umls:C0019693	HIV Infections	2	BeFree
umls:C0022661	Kidney Failure, Chronic	2	BeFree,GAD
umls:C0028756	Obesity, Morbid	2	BeFree,GAD
umls:C0029421	Osteochondritis Dissecans	2	BeFree
umls:C0030319	Panic Disorder	2	BeFree,GAD
umls:C0031511	Pheochromocytoma	2	BeFree
umls:C0033941	Psychoses, Substance-Induced	2	GAD
umls:C0149654	Conduct Disorder	2	BeFree
umls:C0154723	Migraine with Aura	2	BeFree,GAD
umls:C0233523	Antisocial behavior	2	BeFree
umls:C0233565	Bradykinesia	2	BeFree
umls:C0236663	Alcohol withdrawal syndrome	2	BeFree
umls:C0236788	Bipolar II disorder	2	BeFree
umls:C0270549	Generalized Anxiety Disorder	2	BeFree
umls:C0278076	Behavioral tic	2	GAD
umls:C0282350	Sexual abuse	2	BeFree
umls:C0338480	Common Migraine	2	BeFree
umls:C0392156	Akathisia	2	BeFree
umls:C0403447	Chronic Kidney Insufficiency	2	BeFree
umls:C0424295	Hyperactive behavior	2	CTD_human
umls:C0428977	Bradycardia	2	CTD_human
umls:C0520909	Postoperative Nausea and Vomiting	2	BeFree,GAD,LHGDN
umls:C0522174	Delinquent behavior	2	BeFree
umls:C0524620	Metabolic Syndrome X	2	BeFree,GAD
umls:C0525041	Neurobehavioral Manifestations	2	BeFree
umls:C0678222	Breast Carcinoma	2	BeFree
umls:C0747752	Polysubstance abuse	2	BeFree
umls:C0853193	Bipolar I disorder	2	BeFree
umls:C0917801	Sleeplessness	2	BeFree
umls:C1456624	Methamphetamine abuse	2	BeFree,GAD
umls:C1510586	Autism Spectrum Disorders	2	BeFree
umls:C1863535	INTELLIGENCE QUANTITATIVE TRAIT LOCUS 1	2	BeFree
umls:C2267227	Bulimia Nervosa	2	BeFree
umls:C2362324	Pediatric Obesity	2	BeFree
umls:C0000768	Congenital Abnormality	1	BeFree
umls:C0001314	Acute Disease	1	GAD
umls:C0001957	Alcohol Withdrawal Delirium	1	BeFree,GAD
umls:C0003128	Anovulation	1	BeFree
umls:C0003467	Anxiety	1	GAD
umls:C0004930	Behavior Disorders	1	BeFree
umls:C0006287	Bronchopulmonary Dysplasia	1	BeFree
umls:C0006870	Cannabis Dependence	1	BeFree
umls:C0007131	Non-Small Cell Lung Carcinoma	1	BeFree
umls:C0007222	Cardiovascular Diseases	1	GAD
umls:C0007682	CNS disorder	1	BeFree
umls:C0007786	Brain Ischemia	1	RGD
umls:C0008073	Developmental Disabilities	1	CTD_human
umls:C0008626	Congenital chromosomal disease	1	BeFree
umls:C0009084	Cluster A personality disorder	1	BeFree
umls:C0009324	Ulcerative Colitis	1	BeFree,GAD
umls:C0009404	Colorectal Neoplasms	1	GAD
umls:C0009460	Communication impairment	1	BeFree
umls:C0010346	Crohn Disease	1	BeFree,GAD,LHGDN
umls:C0011847	Diabetes	1	BeFree
umls:C0011849	Diabetes Mellitus	1	BeFree
umls:C0011853	Diabetes Mellitus, Experimental	1	RGD
umls:C0012734	Disruptive Behavior Disorder	1	BeFree
umls:C0013395	Dyspepsia	1	BeFree
umls:C0014544	Epilepsy	1	BeFree
umls:C0014859	Esophageal Neoplasms	1	GAD
umls:C0017636	Glioblastoma	1	BeFree
umls:C0018671	Head and Neck Neoplasms	1	GAD
umls:C0020456	Hyperglycemia	1	BeFree
umls:C0020505	Hyperphagia	1	GAD
umls:C0021390	Inflammatory Bowel Diseases	1	BeFree
umls:C0022116	Ischemia	1	BeFree
umls:C0023015	Language Disorders	1	BeFree,CTD_human
umls:C0023055	Laryngeal neoplasm	1	GAD
umls:C0023267	Fibroid Tumor	1	BeFree,GAD
umls:C0023891	Liver Cirrhosis, Alcoholic	1	GAD
umls:C0024031	Low Back Pain	1	GAD
umls:C0024117	Chronic Obstructive Airway Disease	1	GAD
umls:C0024305	Lymphoma, Non-Hodgkin	1	GAD
umls:C0025958	Microcephaly	1	BeFree
umls:C0026552	Morphine Dependence	1	RGD
umls:C0026640	Mouth Neoplasms	1	GAD
umls:C0026769	Multiple Sclerosis	1	BeFree
umls:C0026837	Muscle Rigidity	1	BeFree
umls:C0027404	Narcolepsy	1	GAD
umls:C0027412	Opioid-Related Disorders	1	GAD
umls:C0027497	Nausea	1	BeFree
umls:C0027643	Neoplasm Recurrence, Local	1	GAD
umls:C0027819	Neuroblastoma	1	BeFree
umls:C0028047	Nicotine withdrawal	1	BeFree
umls:C0029925	Ovarian Carcinoma	1	BeFree
umls:C0031347	Pharyngeal Neoplasms	1	GAD
umls:C0031572	Phobia, Social	1	BeFree
umls:C0032584	polyps	1	BeFree
umls:C0033054	Prenatal Exposure Delayed Effects	1	GAD
umls:C0036339	Schizoid Personality Disorder	1	BeFree
umls:C0036396	Sciatica	1	GAD
umls:C0036877	organic sexual dysfunction	1	BeFree
umls:C0038435	Stress	1	GAD
umls:C0040188	Tic disorder	1	GAD
umls:C0042133	Uterine Fibroids	1	BeFree
umls:C0042138	Uterine Neoplasms	1	GAD
umls:C0085602	Polydipsia	1	BeFree
umls:C0086209	Emotional Stress	1	BeFree
umls:C0087169	Withdrawal Symptoms	1	BeFree
umls:C0152020	Gastroparesis	1	GAD
umls:C0162316	Iron deficiency anemia	1	GAD
umls:C0162429	Malnutrition	1	GAD
umls:C0162550	Akathisia, Drug-Induced	1	GAD
umls:C0206664	Teratocarcinoma	1	BeFree
umls:C0221480	Recurrent depression	1	BeFree
umls:C0221765	Chronic schizophrenia	1	BeFree
umls:C0233849	Personality Traits	1	GAD
umls:C0234379	Resting Tremor	1	BeFree
umls:C0235032	Neurotoxicity Syndromes	1	RGD
umls:C0235946	Cerebral atrophy	1	BeFree
umls:C0240602	opioid use	1	BeFree
umls:C0242350	Erectile dysfunction	1	BeFree
umls:C0281267	bilateral breast cancer	1	BeFree
umls:C0338908	Mixed anxiety and depressive disorder	1	BeFree
umls:C0344307	Absence of pain sensation	1	BeFree
umls:C0392702	Abnormal involuntary movement	1	BeFree
umls:C0393610	Dystonia, Diurnal	1	BeFree
umls:C0476254	Dyslexia	1	BeFree
umls:C0494463	Alzheimer Disease, Late Onset	1	BeFree
umls:C0497327	Dementia	1	RGD
umls:C0549622	Sexual Dysfunction	1	BeFree
umls:C0586323	Alcohol Withdrawal Seizures	1	BeFree
umls:C0596170	Binge eating disorder	1	GAD
umls:C0684249	Carcinoma of lung	1	BeFree
umls:C0687132	heavy drinking	1	BeFree
umls:C0700095	Central neuroblastoma	1	BeFree
umls:C0730321	Punctate inner choroidopathy	1	BeFree
umls:C0748073	psychosocial stressor	1	BeFree
umls:C0851578	Sleep Disorders	1	GAD
umls:C0856561	Opium addiction	1	BeFree
umls:C0856977	Childhood aggression	1	BeFree
umls:C0857501	Acute schizophrenia	1	BeFree
umls:C0920296	Developmental reading disorder	1	BeFree
umls:C0993582	Arthritis, Experimental	1	RGD
umls:C1140680	Malignant neoplasm of ovary	1	BeFree,GAD
umls:C1302401	Adenoma of large intestine	1	BeFree
umls:C1306214	ACTH-Secreting Pituitary Adenoma	1	BeFree
umls:C1561643	Chronic Kidney Diseases	1	BeFree
umls:C1623038	Cirrhosis	1	GAD
umls:C1709246	Non-Neoplastic Disorder	1	BeFree
umls:C1851920	Dopa-Responsive Dystonia	1	BeFree
umls:C2748208	Executive dysfunction	1	BeFree
umls:C2919828	Chronic ulcerative colitis	1	GAD
umls:C3699402	Alcohol abuse or dependence	1	BeFree
umls:C3714756	Intellectual Disability	1	BeFree
umls:C3825891	Opium abuse	1	GAD