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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for AGT
check button Gene summary
Basic gene informationGene symbolAGT
Gene nameangiotensinogen (serpin peptidase inhibitor, clade A, member 8)
SynonymsANHU|SERPINA8
CytomapUCSC genome browser: 1q42.2
Type of geneprotein-coding
RefGenesNM_000029.3,
Descriptionalpha-1 antiproteinase, antitrypsinangiotensin Iangiotensin IIangiotensinogenpre-angiotensinogenserine (or cysteine) proteinase inhibitorserpin A8
Modification date20141222
dbXrefs MIM : 106150
HGNC : HGNC
Ensembl : ENSG00000135744
HPRD : 00106
Vega : OTTHUMG00000037757
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AGT
BioGPS: 183
PathwayNCI Pathway Interaction Database: AGT
KEGG: AGT
REACTOME: AGT
Pathway Commons: AGT
ContextiHOP: AGT
ligand binding site mutation search in PubMed: AGT
UCL Cancer Institute: AGT
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of AGT
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0003014renal system process21183621
GO:0007186G-protein coupled receptor signaling pathway10406457
GO:0010595positive regulation of endothelial cell migration15652490
GO:0010873positive regulation of cholesterol esterification18971559
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling15652490
GO:0032270positive regulation of cellular protein metabolic process18971559
GO:0045742positive regulation of epidermal growth factor receptor signaling pathway15652490
GO:0045893positive regulation of transcription, DNA-templated15153556
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation15652490
GO:0051387negative regulation of neurotrophin TRK receptor signaling pathway10406457
GO:0090190positive regulation of branching involved in ureteric bud morphogenesis18607644
GO:2001238positive regulation of extrinsic apoptotic signaling pathway10406457
GO:0003014renal system process21183621
GO:0007186G-protein coupled receptor signaling pathway10406457
GO:0010595positive regulation of endothelial cell migration15652490
GO:0010873positive regulation of cholesterol esterification18971559
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling15652490
GO:0032270positive regulation of cellular protein metabolic process18971559
GO:0045742positive regulation of epidermal growth factor receptor signaling pathway15652490
GO:0045893positive regulation of transcription, DNA-templated15153556
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation15652490
GO:0051387negative regulation of neurotrophin TRK receptor signaling pathway10406457
GO:0090190positive regulation of branching involved in ureteric bud morphogenesis18607644
GO:2001238positive regulation of extrinsic apoptotic signaling pathway10406457


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TissGeneExp for AGT

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH-2.4925188670.927857133-3.4203769.34E-105.93E-09
LUSC-2.542972749-1.180206083-1.3627666675.91E-071.52E-06
KIRC3.3325942441.6792192441.6533753.62E-081.04E-07
BLCA-2.269151077-0.488440551-1.7807105260.004840.025813333
STAD1.6353018830.0232800081.6120218750.0007940.004420064
HNSC-2.072183146-0.455301751-1.6168813950.0007940.002778383
LUAD-0.197922039-1.538659971.3407379316.35E-050.000165041
COAD0.987386979-0.6363591751.6237461543.35E-050.000136428


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TissGene-miRNA for AGT

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for AGT
TissGeneSNV for AGT

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E299KSKCM2
p.A177VUCEC2
p.E431XCOAD1
p.I428VLUAD1
p.R116CSKCM1
p.V133IKIRP1
p.S427NSKCM1
p.A26SHNSC1
p.A463VLIHC1
p.H129YSKCM1
p.D176NHNSC1
p.S173PSTAD1
p.D64YCOAD1
p.S305NUCEC1
p.N416SKIRC1
p.E441KBLCA1
p.H153NSKCM1
p.K287NLGG1
p.E433AUCEC1
p.V187LBRCA1
p.F223LLUSC1
p.N426SUCEC1
p.K370NUCEC1
p.A74VUCEC1
p.H121LGBM1
p.A150SLGG1
p.G119SSKCM1
p.T231NKIRP1
p.L43FCESC1
p.E423GKIRP1
p.E81KHNSC1
p.M369ISKCM1
p.A479SPAAD1
p.T263PUCEC1
p.A138TCOAD1
p.E338KKIRP1
p.L84PSTAD1
p.E48KCESC1
p.F300LCOAD1
p.L313FCOAD1
p.S351PBLCA1
p.A11DPAAD1
p.P12SSKCM1
p.F336IKIRP1
p.E98KDLBC1
p.R375WSKCM1
p.A177ELUAD1
p.D64YREAD1
p.K61NLUAD1
p.P459ASTAD1
p.D86VBRCA1
p.L366ILUAD1
p.M268TBRCA1
p.G317DBLCA1
p.V209ASKCM1
p.F212LLIHC1
p.V421LHNSC1
p.T76AUCEC1
p.A397VSKCM1


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TissGeneCNV for AGT

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for AGT

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABP347159AGT-GGCTchr1:230849867chr7:30544320


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TissGeneNet for AGT

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
AGT, TP53, GRB2, GSDMB, STAT3, STAT1, ITSN2, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, PREP, CTSG, PRCP, AGTR2, CMA1, PRG2, MAS1, ACE2, ENPEP (tumor)AGT, TP53, HNF4A, GRB2, GSDMB, STAT3, STAT1, ITSN2, EWSR1, NR2F1, KNG1, AGTR1, PREP, CTSG, DNPEP, PRCP, CMA1, PRG2, MAS1, ACE2, ENPEP (normal)
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COAD (tumor)COAD (normal)
AGT, TP53, GRB2, GSDMB, STAT3, STAT1, ITSN2, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, PREP, CTSG, DNPEP, PRCP, AGTR2, PRG2, MAS1, ACE2, ENPEP (tumor)AGT, HNF4A, GSDMB, STAT3, STAT1, ITSN2, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, PREP, CTSG, DNPEP, PRCP, AGTR2, CMA1, PRG2, MAS1, ACE2, ENPEP (normal)
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HNSC (tumor)HNSC (normal)
AGT, TP53, HNF4A, GRB2, GSDMB, STAT1, ITSN2, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, PREP, CTSG, DNPEP, PRCP, AGTR2, CMA1, PRG2, ACE2, ENPEP (tumor)AGT, TP53, HNF4A, GRB2, GSDMB, STAT3, STAT1, ITSN2, EWSR1, NR2F1, KNG1, AGTR1, PREP, CTSG, PRCP, AGTR2, CMA1, PRG2, MAS1, ACE2, ENPEP (normal)
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KICH (tumor)KICH (normal)
AGT, HNF4A, GRB2, GSDMB, STAT3, STAT1, ITSN2, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, PREP, CTSG, DNPEP, PRCP, AGTR2, CMA1, MAS1, ACE2, ENPEP (tumor)AGT, TP53, GRB2, GSDMB, STAT3, ITSN2, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, PREP, CTSG, DNPEP, PRCP, AGTR2, CMA1, PRG2, MAS1, ACE2, ENPEP (normal)
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KIRC (tumor)KIRC (normal)
AGT, TP53, HNF4A, GRB2, GSDMB, STAT3, STAT1, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, PREP, CTSG, DNPEP, PRCP, AGTR2, CMA1, PRG2, ACE2, ENPEP (tumor)AGT, TP53, HNF4A, GRB2, STAT3, STAT1, ITSN2, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, PREP, CTSG, DNPEP, PRCP, CMA1, PRG2, MAS1, ACE2, ENPEP (normal)
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KIRP (tumor)KIRP (normal)
AGT, TP53, HNF4A, GRB2, GSDMB, STAT3, STAT1, ITSN2, EWSR1, NR2F1, KNG1, AGTR1, PREP, CTSG, DNPEP, PRCP, AGTR2, CMA1, PRG2, ACE2, ENPEP (tumor)AGT, TP53, HNF4A, GRB2, STAT3, STAT1, ITSN2, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, PREP, CTSG, DNPEP, PRCP, AGTR2, PRG2, MAS1, ACE2, ENPEP (normal)
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LIHC (tumor)LIHC (normal)
AGT, TP53, HNF4A, GRB2, GSDMB, STAT3, STAT1, ITSN2, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, PREP, CTSG, DNPEP, PRCP, AGTR2, CMA1, PRG2, ENPEP (tumor)AGT, TP53, HNF4A, GRB2, GSDMB, STAT3, STAT1, ITSN2, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, CTSG, DNPEP, AGTR2, CMA1, PRG2, MAS1, ACE2, ENPEP (normal)
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LUAD (tumor)LUAD (normal)
AGT, TP53, HNF4A, GRB2, GSDMB, STAT3, STAT1, ITSN2, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, PREP, CTSG, DNPEP, PRCP, PRG2, MAS1, ACE2, ENPEP (tumor)AGT, TP53, HNF4A, GRB2, GSDMB, STAT3, STAT1, ITSN2, MEP1A, NR2F1, AGTR1, PREP, CTSG, DNPEP, PRCP, AGTR2, CMA1, PRG2, MAS1, ACE2, ENPEP (normal)
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LUSC (tumor)LUSC (normal)
AGT, HNF4A, GRB2, GSDMB, STAT3, ITSN2, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, PREP, CTSG, DNPEP, PRCP, AGTR2, CMA1, PRG2, MAS1, ACE2, ENPEP (tumor)AGT, TP53, HNF4A, GRB2, GSDMB, STAT3, STAT1, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, PREP, CTSG, PRCP, AGTR2, CMA1, PRG2, MAS1, ACE2, ENPEP (normal)
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PRAD (tumor)PRAD (normal)
AGT, TP53, HNF4A, GRB2, GSDMB, STAT3, STAT1, ITSN2, EWSR1, MEP1A, KNG1, AGTR1, PREP, CTSG, DNPEP, PRCP, AGTR2, PRG2, MAS1, ACE2, ENPEP (tumor)AGT, TP53, HNF4A, GRB2, GSDMB, STAT3, ITSN2, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, PREP, CTSG, DNPEP, PRCP, CMA1, PRG2, MAS1, ACE2, ENPEP (normal)
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STAD (tumor)STAD (normal)
AGT, TP53, HNF4A, GRB2, GSDMB, STAT3, STAT1, ITSN2, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, PREP, CTSG, DNPEP, PRCP, CMA1, PRG2, ACE2, ENPEP (tumor)AGT, TP53, HNF4A, GRB2, GSDMB, STAT3, STAT1, ITSN2, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, PREP, CTSG, PRCP, AGTR2, CMA1, PRG2, ACE2, ENPEP (normal)
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THCA (tumor)THCA (normal)
AGT, TP53, HNF4A, GRB2, GSDMB, STAT3, STAT1, ITSN2, EWSR1, MEP1A, NR2F1, AGTR1, PREP, CTSG, DNPEP, AGTR2, CMA1, PRG2, MAS1, ACE2, ENPEP (tumor)AGT, TP53, HNF4A, GRB2, GSDMB, STAT1, ITSN2, EWSR1, MEP1A, NR2F1, KNG1, AGTR1, PREP, CTSG, PRCP, AGTR2, CMA1, PRG2, MAS1, ACE2, ENPEP (normal)
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TissGeneProg for AGT

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for AGT
TissGeneDrug for AGT

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for AGT

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0020538Hypertensive disease546BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0085580Essential Hypertension149BeFree,CTD_human,GAD
umls:C0004153Atherosclerosis57BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0011881Diabetic Nephropathy56BeFree,CTD_human,GAD
umls:C0022658Kidney Diseases56BeFree,CTD_human,GAD
umls:C0027051Myocardial Infarction53BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0007222Cardiovascular Diseases51BeFree,CTD_human,GAD,LHGDN
umls:C0149721Left Ventricular Hypertrophy49BeFree,CTD_human,GAD,LHGDN
umls:C0003850Arteriosclerosis45BeFree
umls:C0010068Coronary heart disease44BeFree,GAD,LHGDN
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent44BeFree,GAD,LHGDN
umls:C0022661Kidney Failure, Chronic42BeFree,GAD
umls:C0010054Coronary Arteriosclerosis41BeFree,GAD
umls:C1956346Coronary Artery Disease38BeFree,GAD,LHGDN
umls:C0011849Diabetes Mellitus32BeFree,GAD
umls:C0018801Heart failure32BeFree,CTD_human,GAD,RGD
umls:C0018802Congestive heart failure32BeFree
umls:C0028754Obesity30BeFree,GAD
umls:C0011847Diabetes27BeFree
umls:C0017661IGA Glomerulonephritis23BeFree,CTD_human,GAD,LHGDN
umls:C0035078Kidney Failure23BeFree,GAD
umls:C0003486Aortic Aneurysm21BeFree,CTD_human
umls:C0032914Pre-Eclampsia20CTD_human,GAD,LHGDN
umls:C0162871Aortic Aneurysm, Abdominal20BeFree,CTD_human,GAD
umls:C0038454Cerebrovascular accident18BeFree,GAD,LHGDN
umls:C0006142Malignant neoplasm of breast17BeFree,GAD
umls:C0678222Breast Carcinoma17BeFree
umls:C0018800Cardiomegaly16CTD_human,RGD
umls:C0151744Myocardial Ischemia16BeFree,CTD_human,GAD,LHGDN
umls:C2239176Liver carcinoma15BeFree
umls:C2316810Chronic kidney disease stage 515BeFree
umls:C0002940Aneurysm14BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent13BeFree,GAD
umls:C0013537Eclampsia13BeFree,GAD
umls:C1561643Chronic Kidney Diseases13BeFree
umls:C0007194Hypertrophic Cardiomyopathy12BeFree,GAD
umls:C0878544Cardiomyopathies12BeFree,CTD_human,GAD
umls:C0151650Renal fibrosis11BeFree
umls:C0178664Glomerulosclerosis (disorder)11BeFree
umls:C0856169Endothelial dysfunction10BeFree
umls:C0033687Proteinuria9CTD_human,GAD
umls:C0042373Vascular Diseases9BeFree,GAD
umls:C0268164Primary hyperoxaluria, type I9BeFree
umls:C0403447Chronic Kidney Insufficiency9BeFree
umls:C0524620Metabolic Syndrome X9BeFree,GAD,RGD
umls:C0565599Maternal hypertension9BeFree
umls:C1272641Systemic arterial pressure9GAD
umls:C0001925Albuminuria8CTD_human,GAD
umls:C0011884Diabetic Retinopathy8BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0155626Acute myocardial infarction8BeFree
umls:C0333186Restenosis8BeFree,GAD
umls:C0376358Malignant neoplasm of prostate8BeFree
umls:C0600139Prostate carcinoma8BeFree
umls:C0852036Pregnancy associated hypertension8GAD,LHGDN,RGD
umls:C0016059Fibrosis7CTD_human,GAD,LHGDN,RGD
umls:C0017658Glomerulonephritis7BeFree,CTD_human,GAD
umls:C0018799Heart Diseases7BeFree,CTD_human,LHGDN
umls:C0020540Malignant Hypertension7BeFree,CTD_human,LHGDN
umls:C0023890Liver Cirrhosis7BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0730345Microalbuminuria7BeFree
umls:C0947751Vascular inflammations7BeFree
umls:C0948008Ischemic stroke7BeFree
umls:C3272363Ischemic Cerebrovascular Accident7BeFree
umls:C0007785Cerebral Infarction6BeFree,GAD,LHGDN
umls:C0007786Brain Ischemia6GAD
umls:C0024623Malignant neoplasm of stomach6BeFree
umls:C0239946Fibrosis, Liver6BeFree
umls:C0596263Carcinogenesis6BeFree
umls:C0699791Stomach Carcinoma6BeFree
umls:C1397307Cardiac fibrosis6BeFree
umls:C1565489Renal Insufficiency6BeFree,CTD_human,GAD
umls:C0002395Alzheimer's Disease5BeFree,GAD
umls:C0004238Atrial Fibrillation5GAD,LHGDN
umls:C0017668Focal glomerulosclerosis5BeFree,CTD_human,LHGDN,RGD
umls:C0019196Hepatitis C5BeFree,GAD
umls:C0027627Neoplasm Metastasis5BeFree
umls:C0232197Fibrillation5BeFree
umls:C0577631Carotid Atherosclerosis5BeFree
umls:C0003469Anxiety Disorders4BeFree
umls:C0003507Aortic Valve Stenosis4BeFree
umls:C0004096Asthma4BeFree
umls:C0007820Cerebrovascular Disorders4GAD
umls:C0020428Hyperaldosteronism4BeFree
umls:C0020443Hypercholesterolemia4BeFree,GAD,LHGDN
umls:C0020445Hypercholesterolemia, Familial4BeFree,GAD,LHGDN
umls:C0020544Renal hypertension4CTD_human,GAD
umls:C0022116Ischemia4BeFree
umls:C0023903Liver neoplasms4BeFree
umls:C0024141Lupus Erythematosus, Systemic4BeFree,GAD
umls:C0026267Mitral Valve Prolapse Syndrome4BeFree,GAD
umls:C0026769Multiple Sclerosis4BeFree,LHGDN
umls:C0027726Nephrotic Syndrome4BeFree,GAD,LHGDN
umls:C0035309Retinal Diseases4BeFree,GAD
umls:C0042580Vesico-Ureteral Reflux4BeFree,GAD
umls:C0085413Polycystic Kidney, Autosomal Dominant4BeFree
umls:C0162872Aortic Aneurysm, Thoracic4BeFree,GAD
umls:C0235974Pancreatic carcinoma4BeFree
umls:C0268790Renal vascular disorder4BeFree
umls:C0340629Aortic aneurysm without mention of rupture NOS4BeFree
umls:C0346647Malignant neoplasm of pancreas4BeFree
umls:C0403592Chronic rejection of renal transplant4BeFree
umls:C0524910Hepatitis C, Chronic4BeFree,GAD
umls:C0598428genetic hypertension4BeFree
umls:C0751955Brain Infarction4BeFree,GAD
umls:C1527249Colorectal Cancer4BeFree,GAD
umls:C1962972Proteinuria Adverse Event4GAD
umls:C0000832Abruptio Placentae3GAD,LHGDN
umls:C0001430Adenoma3BeFree
umls:C0001624Adrenal Gland Neoplasms3BeFree
umls:C0002965Angina, Unstable3BeFree,GAD,LHGDN
umls:C0005684Malignant neoplasm of urinary bladder3BeFree
umls:C0007134Renal Cell Carcinoma3BeFree
umls:C0007193Cardiomyopathy, Dilated3BeFree,RGD
umls:C0007273Carotid Artery Diseases3CTD_human,GAD
umls:C0009402Colorectal Carcinoma3BeFree
umls:C0011570Mental Depression3BeFree,GAD
umls:C0011581Depressive disorder3BeFree
umls:C0011853Diabetes Mellitus, Experimental3CTD_human
umls:C0019163Hepatitis B3BeFree
umls:C0020456Hyperglycemia3BeFree
umls:C0020473Hyperlipidemia3BeFree,GAD
umls:C0020488Hypernatremia3BeFree
umls:C0020501Primary Hyperoxaluria3BeFree
umls:C0020542Pulmonary Hypertension3BeFree,GAD,LHGDN,RGD
umls:C0020615Hypoglycemia3BeFree,GAD
umls:C0020649Hypotension3CTD_human
umls:C0021368Inflammation3CTD_human,GAD
umls:C0021390Inflammatory Bowel Diseases3BeFree
umls:C0029456Osteoporosis3BeFree
umls:C0034069Pulmonary Fibrosis3BeFree
umls:C0034152Henoch-Schoenlein Purpura3BeFree,GAD
umls:C0035222Respiratory Distress Syndrome, Adult3BeFree,GAD
umls:C0085096Peripheral Vascular Diseases3BeFree,GAD
umls:C0149931Migraine Disorders3BeFree,GAD
umls:C0178874Tumor Progression3BeFree
umls:C0240035Interstitial fibrosis3BeFree
umls:C0242231Coronary Stenosis3BeFree,GAD
umls:C0242379Malignant neoplasm of lung3BeFree,GAD
umls:C0266313Allanson Pantzar McLeod syndrome3BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT
umls:C0268731Renal glomerular disease3BeFree
umls:C0524909Hepatitis B, Chronic3BeFree,GAD,LHGDN
umls:C0684249Carcinoma of lung3BeFree
umls:C0699885Carcinoma of bladder3BeFree
umls:C0848548hypertensive nephropathy3BeFree,RGD
umls:C0948089Acute Coronary Syndrome3BeFree,GAD
umls:C0949658Cardiomyopathy, Hypertrophic, Familial3BeFree,GAD
umls:C1271104Blood pressure finding3GAD
umls:C1277187Left ventricular systolic dysfunction3BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma3BeFree
umls:C1519670Tumor Angiogenesis3BeFree
umls:C1800706Idiopathic Pulmonary Fibrosis3BeFree,GAD,LHGDN
umls:C2711227Steatohepatitis3BeFree
umls:C0001418Adenocarcinoma2BeFree
umls:C0001973Alcoholic Intoxication, Chronic2BeFree,GAD
umls:C0002949Aneurysm, Dissecting2CTD_human,GAD
umls:C0003811Cardiac Arrhythmia2CTD_human
umls:C0007137Squamous cell carcinoma2BeFree,GAD
umls:C0007282Carotid Stenosis2GAD
umls:C0007766Intracranial Aneurysm2BeFree
umls:C0007771Intracranial Arteriosclerosis2GAD
umls:C0008628Chromosome Deletion2GAD
umls:C0010709Cyst2BeFree
umls:C0011269Dementia, Vascular2BeFree,GAD,LHGDN
umls:C0011875Diabetic Angiopathies2GAD,LHGDN
umls:C0014556Epilepsy, Temporal Lobe2BeFree,RGD
umls:C0015934Fetal Growth Retardation2CTD_human,GAD
umls:C0017601Glaucoma2BeFree,GAD
umls:C0017636Glioblastoma2BeFree
umls:C0019189Hepatitis, Chronic2BeFree
umls:C0019284Diaphragmatic Hernia2CTD_human,LHGDN
umls:C0021308Infarction2LHGDN
umls:C0021655Insulin Resistance2GAD
umls:C0022660Kidney Failure, Acute2BeFree,GAD
umls:C0022680Polycystic Kidney Diseases2BeFree,GAD
umls:C0023895Liver diseases2BeFree,GAD
umls:C0024143Lupus Nephritis2BeFree,GAD
umls:C0024796Marfan Syndrome2BeFree,GAD
umls:C0025517Metabolic Diseases2BeFree
umls:C0026269Mitral Valve Stenosis2BeFree
umls:C0026846Muscular Atrophy2BeFree
umls:C0027055Myocardial Reperfusion Injury2CTD_human
umls:C0027540Necrosis2CTD_human
umls:C0027719Nephrosclerosis2BeFree
umls:C0027819Neuroblastoma2BeFree
umls:C0031099Periodontitis2BeFree,GAD
umls:C0031511Pheochromocytoma2BeFree
umls:C0032460Polycystic Ovary Syndrome2BeFree,GAD,LHGDN
umls:C0032962Pregnancy Complications2BeFree,GAD
umls:C0032963Pregnancy Complications, Cardiovascular2GAD
umls:C0036202Sarcoidosis2BeFree
umls:C0036421Systemic Scleroderma2BeFree
umls:C0036572Seizures2BeFree,CTD_human
umls:C0037315Sleep Apnea Syndromes2BeFree,GAD
umls:C0041948Uremia2BeFree,GAD
umls:C0042420Vasovagal syncope2GAD
umls:C0149939Obstructive nephropathy2BeFree
umls:C0151526Premature Birth2GAD
umls:C0152451Chronic glomerulonephritis2BeFree,GAD
umls:C0155616Secondary hypertension2BeFree
umls:C0155765Disease of capillaries2BeFree
umls:C0206667Adrenal Cortical Adenoma2BeFree
umls:C0206686Adrenocortical carcinoma2BeFree
umls:C0221155Systolic hypertension2BeFree
umls:C0242339Dyslipidemias2BeFree,GAD
umls:C0242383Age related macular degeneration2GAD
umls:C0264716Chronic heart failure2BeFree
umls:C0265004Dilatation of aorta2BeFree
umls:C0266929Chronic Periodontitis2BeFree,GAD
umls:C0333291Bleeding ulcer2BeFree
umls:C0333497Segmental glomerulosclerosis2BeFree
umls:C0333559Infarction, Lacunar2BeFree
umls:C0340279Ventricular hypertrophy2BeFree
umls:C0340643Dissection of aorta2BeFree
umls:C0344911Left ventricular dilatation2BeFree
umls:C0398623Thrombophilia2GAD
umls:C0400966Non-alcoholic Fatty Liver Disease2BeFree
umls:C0476089Endometrial Carcinoma2BeFree
umls:C0497406Overweight2BeFree
umls:C0546817Fluid overload2BeFree
umls:C0595921Intraocular pressure disorder2BeFree
umls:C0597048Neurogenic hypertension2BeFree
umls:C0597854renin induced hypertension2BeFree
umls:C0598608Hyperhomocysteinemia2BeFree
umls:C0700095Central neuroblastoma2BeFree
umls:C0852949Arteriopathic disease2BeFree,GAD
umls:C0877008Enzyme inhibition disorder2BeFree
umls:C0917996Cerebral Aneurysm2BeFree
umls:C1135191Heart Failure, Systolic2BeFree,GAD
umls:C1135196Heart Failure, Diastolic2BeFree,GAD
umls:C1260386Glucocorticoid-remediable aldosteronism2BeFree
umls:C1384514Conn Syndrome2BeFree
umls:C1458155Mammary Neoplasms2BeFree,GAD
umls:C1536220ST segment elevation myocardial infarction2BeFree
umls:C2607914Allergic rhinitis (disorder)2BeFree,GAD
umls:C2936179Obesity, Visceral2BeFree
umls:C3495426Homocysteinemia2BeFree
umls:C0001206Acromegaly1BeFree,GAD
umls:C0001339Acute pancreatitis1BeFree
umls:C0002063Alkalosis1CTD_human
umls:C0002351Altitude Sickness1GAD
umls:C0002736Amyotrophic Lateral Sclerosis1GAD
umls:C0002792anaphylaxis1GAD
umls:C0002871Anemia1CTD_human
umls:C0002875Cooley's anemia1BeFree
umls:C0002895Anemia, Sickle Cell1BeFree
umls:C0002986Fabry Disease1BeFree
umls:C0003460Anuria1CTD_human
umls:C0003496Aortic Rupture1BeFree
umls:C0003504Aortic Valve Insufficiency1BeFree
umls:C0004135Ataxia Telangiectasia1BeFree
umls:C0005586Bipolar Disorder1BeFree,GAD
umls:C0006111Brain Diseases1BeFree
umls:C0006266Bronchial Spasm1BeFree
umls:C0006663Calcinosis1GAD
umls:C0007103Malignant neoplasm of endometrium1BeFree
umls:C0007114Malignant neoplasm of skin1BeFree
umls:C0007166Low Cardiac Output1GAD
umls:C0007192Cardiomyopathy, Alcoholic1CTD_human
umls:C0007370Catalepsy1CTD_human
umls:C0007787Transient Ischemic Attack1RGD
umls:C0007789Cerebral Palsy1GAD
umls:C0007847Malignant tumor of cervix1BeFree
umls:C0008495Chorioamnionitis1GAD
umls:C0008497Choriocarcinoma1BeFree
umls:C0009782Connective Tissue Diseases1GAD
umls:C0010072Coronary Thrombosis1GAD
umls:C0010346Crohn Disease1BeFree
umls:C0011053Deafness1GAD
umls:C0011071Sudden death1CTD_human
umls:C0011882Diabetic Neuropathies1GAD
umls:C0012860DNA Damage1GAD
umls:C0013295Duodenal Ulcer1BeFree
umls:C0013336Dwarfism1BeFree
umls:C0013604Edema1GAD
umls:C0014078Venezuelan equine encephalomyelitis1BeFree
umls:C0014867Esophageal Varices1GAD
umls:C0015695Fatty Liver1GAD
umls:C0015944Fetal Membranes, Premature Rupture1GAD
umls:C0016052Fibromuscular Dysplasia1BeFree,GAD
umls:C0017178Gastrointestinal Diseases1GAD
umls:C0017181Gastrointestinal Hemorrhage1GAD
umls:C0017612Glaucoma, Open-Angle1BeFree
umls:C0017665Membranous glomerulonephritis1BeFree
umls:C0017921Glycogen storage disease type II1BeFree
umls:C0018133Graft-vs-Host Disease1GAD
umls:C0018772Hearing Loss, Partial1GAD
umls:C0018784Sensorineural Hearing Loss (disorder)1BeFree
umls:C0018798Congenital Heart Defects1GAD
umls:C0018813Myocardial rupture1BeFree
umls:C0018995Hemochromatosis1GAD
umls:C0019061Hemolytic-Uremic Syndrome1GAD
umls:C0019080Hemorrhage1GAD
umls:C0019158Hepatitis1BeFree
umls:C0019159Hepatitis A1BeFree
umls:C0020429Hyperalgesia1CTD_human
umls:C0020452Hyperemia1CTD_human
umls:C0020459Hyperinsulinism1BeFree
umls:C0020541Hypertension, Portal1BeFree
umls:C0020545Hypertension, Renovascular1BeFree
umls:C0020621Hypokalemia1CTD_human
umls:C0020651Hypotension, Orthostatic1LHGDN
umls:C0022548Keloid1BeFree
umls:C0022876Premature Obstetric Labor1GAD
umls:C0023817Hyperlipoproteinemia Type I1GAD
umls:C0023891Liver Cirrhosis, Alcoholic1GAD
umls:C0023892Biliary cirrhosis1RGD
umls:C0023893Liver Cirrhosis, Experimental1CTD_human
umls:C0023896Alcoholic Liver Diseases1GAD
umls:C0023976Long QT Syndrome1GAD
umls:C0024117Chronic Obstructive Airway Disease1GAD
umls:C0024530Malaria1BeFree
umls:C0024534Malaria, Cerebral1BeFree
umls:C0024667Animal Mammary Neoplasms1GAD
umls:C0024668Mammary Neoplasms, Experimental1RGD
umls:C0025202melanoma1BeFree
umls:C0025303Meningococcal Infections1GAD
umls:C0026266Mitral Valve Insufficiency1BeFree
umls:C0026640Mouth Neoplasms1GAD
umls:C0027707Nephritis, Interstitial1BeFree,GAD
umls:C0027720Nephrosis1CTD_human
umls:C0028756Obesity, Morbid1GAD
umls:C0029899Otosclerosis1BeFree,GAD
umls:C0029925Ovarian Carcinoma1BeFree
umls:C0029928Ovarian Diseases1BeFree
umls:C0029944Drug Overdose1CTD_human
umls:C0030319Panic Disorder1BeFree
umls:C0030920Peptic Ulcer1GAD
umls:C0030922Peptic Ulcer Hemorrhage1CTD_human,GAD
umls:C0031269Peutz-Jeghers Syndrome1BeFree
umls:C0032002Pituitary Diseases1BeFree
umls:C0032045Placenta Disorders1GAD
umls:C0032787Postoperative Complications1GAD
umls:C0033578Prostatic Neoplasms1GAD
umls:C0033999Pterygium1BeFree
umls:C0034150Purpura1LHGDN
umls:C0035066Renal Artery Obstruction1GAD
umls:C0035067Renal Artery Stenosis1BeFree
umls:C0035126Reperfusion Injury1CTD_human
umls:C0035344Retinopathy of Prematurity1CTD_human
umls:C0035439Rheumatic Heart Disease1GAD
umls:C0036690Septicemia1BeFree
umls:C0038356Stomach Neoplasms1GAD,LHGDN
umls:C0038525Subarachnoid Hemorrhage1BeFree
umls:C0039231Tachycardia1BeFree
umls:C0040053Thrombosis1CTD_human
umls:C0041408Turner Syndrome1BeFree
umls:C0041956Ureteral obstruction1BeFree
umls:C0042487Venous Thrombosis1GAD,LHGDN
umls:C0042514Tachycardia, Ventricular1LHGDN
umls:C0042721Viral hepatitis1BeFree
umls:C0079487Helicobacter Infections1GAD
umls:C0085215Ovarian Failure, Premature1BeFree
umls:C0085298Sudden Cardiac Death1GAD
umls:C0149940Sciatic Neuropathy1RGD
umls:C0152105Hypertensive heart disease1BeFree
umls:C0153676Secondary malignant neoplasm of lung1BeFree
umls:C0154723Migraine with Aura1BeFree
umls:C0155733Atherosclerosis of aorta1BeFree
umls:C0155800Chronic hypotension1BeFree
umls:C0175754Agenesis of corpus callosum1BeFree
umls:C0206708Cervical Intraepithelial Neoplasia1BeFree
umls:C0221043Liddle Syndrome1BeFree
umls:C0221505Lesion of brain1BeFree
umls:C0235222Diastolic hypertension1BeFree
umls:C0235989Renal interstitial fibrosis1BeFree
umls:C0238506Congenital posterior urethral valves1BeFree
umls:C0242129Thrombotic stroke1BeFree
umls:C0242350Erectile dysfunction1RGD
umls:C0242510Drug usage1BeFree
umls:C0242698Ventricular Dysfunction, Left1GAD
umls:C0243026Sepsis1BeFree
umls:C0243050Cardiovascular Abnormalities1BeFree
umls:C0264638Low-renin essential hypertension1BeFree
umls:C0264641Endocrine hypertension1BeFree
umls:C0264652Hypertensive heart failure1BeFree
umls:C0278601Inflammatory Breast Carcinoma1BeFree
umls:C0279000Liver and Intrahepatic Biliary Tract Carcinoma1BeFree
umls:C0280100Solid tumour1BeFree
umls:C0282666Very Low Birth Weight1BeFree
umls:C0302592Cervix carcinoma1BeFree
umls:C0311277Obesity, Abdominal1BeFree
umls:C0342751Generalized glycogen storage disease of infants1BeFree
umls:C0345904Malignant neoplasm of liver1BeFree
umls:C0362046Prediabetes syndrome1RGD
umls:C0374997Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site1BeFree
umls:C0392514Hereditary hemochromatosis1BeFree
umls:C0392707Atopy1GAD
umls:C0403529Anti-Glomerular Basement Membrane Disease1RGD
umls:C0428977Bradycardia1CTD_human
umls:C0451641Urolithiasis1BeFree
umls:C0520679Sleep Apnea, Obstructive1LHGDN
umls:C0521173Granulomatosis1BeFree
umls:C0553980Endomyocardial Fibrosis1CTD_human
umls:C0567312Menopause present (finding)1GAD
umls:C0683382renin-dependent hypertension1BeFree
umls:C0686619Secondary malignant neoplasm of lymph node1BeFree
umls:C0740392Infarction, Middle Cerebral Artery1RGD
umls:C0751674Lymphangioleiomyomatosis1BeFree
umls:C0850666Helicobacter pylori infection1BeFree
umls:C0853662Oestrogen deficiency1BeFree
umls:C0853897Diabetic Cardiomyopathies1BeFree
umls:C0867389Chronic graft-versus-host disease1BeFree
umls:C0917798Cerebral Ischemia1BeFree
umls:C0920646Renal ischaemia1BeFree
umls:C0948163Leukoaraiosis1GAD
umls:C0948480Coronary Restenosis1GAD
umls:C1096293Macroangiopathy1BeFree
umls:C1140680Malignant neoplasm of ovary1BeFree
umls:C1142276Renal anemia1BeFree
umls:C1175175Severe Acute Respiratory Syndrome1BeFree
umls:C1263846Attention deficit hyperactivity disorder1GAD
umls:C1299432Multi vessel coronary artery disease1BeFree
umls:C1332860Cauda Equina Paraganglioma1BeFree
umls:C1334274Invasive Carcinoma1BeFree
umls:C1384666hearing impairment1GAD
umls:C1512409Hepatocarcinogenesis1BeFree
umls:C1516170Cancer Cell Growth1BeFree
umls:C1621958Glioblastoma Multiforme1BeFree
umls:C1623038Cirrhosis1BeFree
umls:C1709246Non-Neoplastic Disorder1BeFree
umls:C1839839MAJOR AFFECTIVE DISORDER 21BeFree,GAD
umls:C1852197MAJOR AFFECTIVE DISORDER 11BeFree,GAD
umls:C1860224ABLEPHARON-MACROSTOMIA SYNDROME1BeFree
umls:C1861172Venous Thromboembolism1GAD
umls:C1868649PANIC DISORDER 11BeFree
umls:C1883486Uterine Corpus Cancer1BeFree
umls:C1970943MAJOR AFFECTIVE DISORDER 41BeFree,GAD
umls:C1970944MAJOR AFFECTIVE DISORDER 51BeFree,GAD
umls:C1970945MAJOR AFFECTIVE DISORDER 61BeFree,GAD
umls:C2062593Mesial temporal sclerosis1BeFree
umls:C2076596Influenza A/H5N11BeFree
umls:C2675929Cerebral white matter lesion1GAD
umls:C2697932Loeys-Dietz Syndrome1BeFree
umls:C2700438MAJOR AFFECTIVE DISORDER 71BeFree,GAD
umls:C2700439MAJOR AFFECTIVE DISORDER 81BeFree,GAD
umls:C2700440MAJOR AFFECTIVE DISORDER 91BeFree,GAD
umls:C2732979Acquired long QT syndrome1BeFree
umls:C2919032Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified1GAD
umls:C2931132Crigler Najjar syndrome, type 21BeFree
umls:C2931822Nasopharyngeal carcinoma1BeFree
umls:C2936380Neointima1CTD_human
umls:C2937358Cerebral Hemorrhage1GAD
umls:C3178782Aortic Stiffness1GAD
umls:C3495801Granulomatosis with polyangiitis1BeFree
umls:C3542024AORTIC VALVE DISEASE 21BeFree
umls:C3658248Hypertriglyceridemic Waist1GAD
umls:C3695318Chronic kidney disease due to hypertension1BeFree
umls:C3887873Hearing Loss1GAD
umls:C1862886IgA NEPHROPATHY, PROGRESSION TO RENAL FAILURE IN, SUSCEPTIBILITY TO0CLINVAR