TissGeneSummary for DUSP9 |
Gene summary |
Basic gene information | Gene symbol | DUSP9 |
Gene name | dual specificity phosphatase 9 | |
Synonyms | MKP-4|MKP4 | |
Cytomap | UCSC genome browser: Xq28 | |
Type of gene | protein-coding | |
RefGenes | NM_001395.3, | |
Description | dual specificity protein phosphatase 9map kinase phosphatase 4mitogen-activated protein kinase phosphatase 4serine/threonine specific protein phosphatase | |
Modification date | 20141207 | |
dbXrefs | MIM : 300134 | |
HGNC : HGNC | ||
Ensembl : ENSG00000130829 | ||
HPRD : 02136 | ||
Vega : OTTHUMG00000024211 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DUSP9 | |
BioGPS: 1852 | ||
Pathway | NCI Pathway Interaction Database: DUSP9 | |
KEGG: DUSP9 | ||
REACTOME: DUSP9 | ||
Pathway Commons: DUSP9 | ||
Context | iHOP: DUSP9 | |
ligand binding site mutation search in PubMed: DUSP9 | ||
UCL Cancer Institute: DUSP9 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
Reference showing the relevant tissue of DUSP9 | ||
Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for DUSP9 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -2.666761021 | 5.217136201 | -7.883897222 | 1.09E-48 | 8.42E-47 |
LIHC | 1.113934424 | -1.388769576 | 2.502704 | 4.38E-10 | 5.09E-09 |
LUAD | -1.409626059 | -4.463605369 | 3.05397931 | 2.33E-14 | 2.21E-13 |
KIRP | -2.619160326 | 5.758392799 | -8.377553125 | 5.13E-32 | 1.92E-29 |
HNSC | 1.485135168 | -1.721778786 | 3.206913953 | 1.42E-15 | 1.60E-13 |
KICH | -0.895121576 | 5.669118424 | -6.56424 | 1.74E-11 | 1.59E-10 |
LUSC | 1.346613326 | -4.249367066 | 5.595980392 | 4.08E-26 | 1.02E-24 |
ESCA | -0.893987031 | -3.97957794 | 3.085590909 | 0.00187 | 0.022004656 |
COAD | -3.463591576 | -4.849849269 | 1.386257692 | 0.000277 | 0.000909906 |
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TissGene-miRNA for DUSP9 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-98-5p | MIMAT0000096 | 0.0095 | -0.29 | 78 |
ACC | hsa-miR-98-5p | MIMAT0000096 | 0.0095 | -0.29 | 78 |
ACC | hsa-let-7f-5p | MIMAT0000067 | 0.0058 | -0.31 | 78 |
ACC | hsa-let-7f-5p | MIMAT0000067 | 0.0058 | -0.31 | 78 |
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TissGeneMut for DUSP9 |
TissGeneSNV for DUSP9 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D170N | STAD | 2 |
p.Y252* | LUSC | 2 |
p.F243V | STAD | 2 |
p.V159M | COAD | 1 |
p.R200Q | LGG | 1 |
p.R13Q | COAD | 1 |
p.V153G | ESCA | 1 |
p.R145C | LUAD | 1 |
p.Q307H | LGG | 1 |
p.S368Y | COAD | 1 |
p.R349S | THYM | 1 |
p.E139K | BLCA | 1 |
p.F333I | BRCA | 1 |
p.S176Y | LUAD | 1 |
p.E341* | BLCA | 1 |
p.P158L | SKCM | 1 |
p.E223D | UCEC | 1 |
p.F369L | BLCA | 1 |
p.N326Y | OV | 1 |
p.E94* | CESC | 1 |
p.P256L | SKCM | 1 |
p.A220V | STAD | 1 |
p.E175K | SKCM | 1 |
p.N332I | OV | 1 |
p.G335W | PRAD | 1 |
p.V300I | KICH | 1 |
p.R345W | PAAD | 1 |
p.A226S | THYM | 1 |
p.Q352P | HNSC | 1 |
p.P329S | SKCM | 1 |
p.V159M | LIHC | 1 |
p.S343T | LUAD | 1 |
p.Q131K | TGCT | 1 |
p.A360E | LUAD | 1 |
p.P194T | LUAD | 1 |
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TissGeneCNV for DUSP9 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DUSP9 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BQ654128 | DUSP9-UBB | chrX:152916777 | chr17:16285234 |
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TissGeneNet for DUSP9 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DUSP9 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DUSP9 |
TissGeneDrug for DUSP9 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DUSP9 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 5 | BeFree,GAD |
umls:C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 2 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
umls:C0011847 | Diabetes | 1 | BeFree |
umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0028754 | Obesity | 1 | BeFree |
umls:C0524620 | Metabolic Syndrome X | 1 | BeFree |
umls:C1527249 | Colorectal Cancer | 1 | BeFree |