TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for E2F1

Gene summary

Basic gene information	Gene symbol	E2F1
	Gene name	E2F transcription factor 1
	Synonyms	E2F-1\|RBAP1\|RBBP3\|RBP3
	Cytomap	UCSC genome browser: 20q11.2
	Type of gene	protein-coding
	RefGenes	NM_005225.2,
	Description	PBR3PRB-binding protein E2F-1RBAP-1RBBP-3retinoblastoma-associated protein 1retinoblastoma-binding protein 3transcription factor E2F1
	Modification date	20141222
dbXrefs	MIM : 189971
	HGNC : HGNC
	Ensembl : ENSG00000101412
	HPRD : 01806
	Vega : OTTHUMG00000032265
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_E2F1
	BioGPS: 1869
Pathway	NCI Pathway Interaction Database: E2F1
	KEGG: E2F1
	REACTOME: E2F1
	Pathway Commons: E2F1
Context	iHOP: E2F1
	ligand binding site mutation search in PubMed: E2F1
	UCL Cancer Institute: E2F1
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	CervixTestis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	CESCTGCT
Reference showing the relevant tissue of E2F1
Description by TissGene annotations	Cancer gene Have significant anti-correlated miRNA TissgsLTS Fused withTSGene

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0006355	regulation of transcription, DNA-templated	12717439
GO:0010628	positive regulation of gene expression	15766563
GO:0048255	mRNA stabilization	15766563
GO:0006355	regulation of transcription, DNA-templated	12717439
GO:0010628	positive regulation of gene expression	15766563
GO:0048255	mRNA stabilization	15766563

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TissGeneExp for E2F1

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
STAD	0.196605734	-1.862978641	2.059584375	3.39E-12	9.53E-10
LUSC	0.009783431	-1.732577354	1.742360784	6.32E-18	5.69E-17
BRCA	-0.828644485	-2.865362906	2.036718421	2.63E-33	4.30E-32
KICH	-0.757406766	-4.153582766	3.396176	1.18E-16	3.72E-15
KIRP	-1.756631766	-4.502141141	2.745509375	6.99E-16	2.24E-14
THCA	-1.331486427	-3.558535579	2.227049153	2.72E-23	2.08E-21
COAD	0.373381696	-1.248968304	1.62235	5.62E-14	2.05E-12
LUAD	-0.531030903	-1.552901593	1.02187069	3.87E-09	1.84E-08
KIRC	-2.205467877	-4.425653988	2.220186111	1.00E-27	1.52E-26
HNSC	-0.425634672	-1.91498351	1.489348837	2.43E-14	1.40E-12
LIHC	-0.430254766	-4.057524766	3.62727	1.28E-22	1.35E-20
ESCA	-0.16825222	-1.938670402	1.770418182	9.68E-05	0.003175741
BLCA	-0.130154134	-1.975843608	1.845689474	5.06E-05	0.000649306

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TissGene-miRNA for E2F1

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type	miRNA id	miRNA accession	P-val.	Coeff.	# samples
UVM	hsa-miR-93-5p	MIMAT0000093	0.021	-0.26	80
ACC	hsa-miR-362-3p	MIMAT0004683	0.0098	-0.32	78
ACC	hsa-miR-362-3p	MIMAT0004683	0.0098	-0.32	78

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TissGeneMut for E2F1

TissGeneSNV for E2F1

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.R166H	PRAD	1
p.G110S	SKCM	1
p.E280Q	UCEC	1
p.C227F	LUSC	1
p.H98Y	SKCM	1
p.R165Q	UCEC	1
p.F391L	ESCA	1
p.H406Y	SKCM	1
p.Q99*	BLCA	1
p.R232C	STAD	1
p.Q208L	LIHC	1
p.V295D	UCEC	1
p.R165Q	LUAD	1
p.Q189X	SKCM	1
p.Q272L	LIHC	1
p.F437L	LUAD	1
p.G200S	DLBC	1
p.V246A	STAD	1
p.S144R	UCEC	1
p.G291V	LIHC	1
p.E389K	SKCM	1
p.G363R	BLCA	1
p.R165W	BRCA	1
p.E301D	ESCA	1
p.Y168C	BRCA	1
p.R138C	UCS	1
p.D148N	LUSC	1
p.L273H	THYM	1
p.R252C	BRCA	1
p.Q189*	SKCM	1
p.V246A	UCEC	1
p.R252H	PRAD	1
p.S131*	UCEC	1
p.P299H	UCEC	1
p.R166H	UCEC	1
p.D426N	LGG	1
p.D294N	STAD	1
p.P312Q	ESCA	1
p.R91T	BLCA	1
p.D294N	SKCM	1
p.P346S	SKCM	1
p.E321D	UCEC	1
p.I306V	LUAD	1
p.P346L	SKCM	1

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TissGeneCNV for E2F1

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for E2F1

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	BQ962146	E2F1-RDH11		chr20:32274170	chr14:68156930
Chimerdb3.0	ChiTaRs	NA	BG252912	E2F1-E2F1		chr20:32264041	chr20:32263489
Chimerdb3.0	FusionScan	HNSC	TCGA-HD-8314-01A	E2F1-NECAB3	Out-of-Frame	chr20:32264910	chr20:32260228
Chimerdb3.0	FusionScan	CESC	TCGA-MU-A5YI-01A	E2F1-NECAB3	Out-of-Frame	chr20:32264910	chr20:32260228
Chimerdb3.0	FusionScan	BRCA	TCGA-AO-A128-01A	E2F1-NECAB3	Out-of-Frame	chr20:32264910	chr20:32260228
Chimerdb3.0	FusionScan	BRCA	TCGA-AR-A0TS-01A	E2F1-NECAB3	Out-of-Frame	chr20:32264910	chr20:32260228
Chimerdb3.0	FusionScan	ESCA	TCGA-LN-A49L-01A	E2F1-NECAB3	Out-of-Frame	chr20:32264910	chr20:32260228
Chimerdb3.0	FusionScan	ESCA	TCGA-LN-A5U7-01A	E2F1-NECAB3	Out-of-Frame	chr20:32264910	chr20:32260228
Chimerdb3.0	FusionScan	ESCA	TCGA-LN-A49U-01A	E2F1-NECAB3	Out-of-Frame	chr20:32264910	chr20:32260228
Chimerdb3.0	FusionScan	ESCA	TCGA-L5-A88T-01A	E2F1-NECAB3	Out-of-Frame	chr20:32264910	chr20:32260228
Chimerdb3.0	FusionScan	ESCA	TCGA-VR-AA4G-01A	E2F1-NECAB3	Out-of-Frame	chr20:32264910	chr20:32260228

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TissGeneNet for E2F1

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
E2F1, MAP3K5, RBL2, BAX, SETD1A, CDK1, CCNE1, BCL2, PURA, SIRT1, CCNA2, NPDC1, DNMT1, CDT1, FZR1, MYBL2, CDC25A, CTDP1, TERT, TIMELESS, RECQL4 (tumor)	E2F1, CDK1, CDK2, CCNE1, CHEK2, RB1, CCNA2, DNMT1, CDT1, CDKN2C, MYBL2, CDC25A, LAPTM4B, TERT, CYC1, TIMELESS, IGF1, RECQL4, DBF4, ATAD2, PRDM2 (normal)

COAD (tumor)	COAD (normal)
E2F1, BRCA1, HDAC1, NDN, KAT2A, CDK1, CCNE1, SKP2, ATR, CHEK2, CCNA2, DNMT1, CDT1, TFDP1, MYBL2, CDC25A, TOPBP1, TIMELESS, RECQL4, DBF4, ATAD2 (tumor)	E2F1, MAP3K5, BRCA1, E2F4, KAT2A, CDK1, CDK2, CCNE1, CHEK2, RBL1, DNMT1, CDT1, MYBL2, CDC25A, DUSP4, TOPBP1, TIMELESS, MIR17HG, RECQL4, DBF4, ATAD2 (normal)

HNSC (tumor)	HNSC (normal)
E2F1, HDAC3, BAX, E2F4, KAT2A, CDK1, CCNE1, CEBPA, CHEK2, SP4, TRIM28, CCNA2, DDB2, MCPH1, CDT1, MYBL2, CDC25A, PA2G4, TIMELESS, TP53BP1, RECQL4 (tumor)	E2F1, BRCA1, BAX, PIN1, NRIP1, CDK1, CDK2, CHEK2, TRIM28, DDB2, CDK3, CDT1, CDKN2C, MYBL2, CDC25A, NRF1, TIMELESS, TFDP2, CBS, RECQL4, ATAD2 (normal)

KICH (tumor)	KICH (normal)
E2F1, TP53, BRCA1, CDKN2A, CDK1, CCNE1, TCF4, ATR, CHEK2, CCNA2, IFI16, DDB2, DNMT1, ATM, CDT1, MYBL2, DUSP4, TIMELESS, RECQL4, ATAD2, TRIM16 (tumor)	E2F1, MAP3K5, PIN1, NRIP1, CDK1, CCNE1, RAB3GAP2, SIRT1, BECN1, NEDD8, RB1, CCNA2, CDT1, FZR1, CDKN2C, MYBL2, CDC25A, ARID3A, RECQL4, ZMYND10, ATAD2 (normal)

KIRC (tumor)	KIRC (normal)
E2F1, BRCA1, YWHAQ, CDK1, CDK2, CCNE1, TP73, CHEK2, CSNK1A1, CCNA2, DDB2, DNMT1, CDT1, MYBL2, DUSP4, TIMELESS, RECQL4, DBF4, ATAD2, TRIM16, STOML1 (tumor)	E2F1, BAX, CDK1, CCNE1, TP73, BCL2, PURA, RAB3GAP2, SIRT1, CHEK2, TRIM28, RB1, CCNA2, ANAPC5, CDT1, MYBL2, CDC25A, TIMELESS, RECQL4, ATAD2, STOML1 (normal)

KIRP (tumor)	KIRP (normal)
E2F1, TP53, BAX, CDK1, CCNE1, STAT1, PURA, CHEK2, CCNA2, IFI16, DDB2, DNMT1, MYBL2, LAPTM4B, KDM1A, RECQL4, DBF4, ZMYND10, ATAD2, PRMT2, STOML1 (tumor)	E2F1, BRCA1, NFKB1, E2F4, CCND1, CDK1, CCNE1, TP73, TRIM28, CCNA2, NPDC1, DNMT1, CDT1, MYBL2, CDC25A, CHL1, PA2G4, TIMELESS, DIRAS3, RECQL4, ATAD2 (normal)

LIHC (tumor)	LIHC (normal)
E2F1, GADD45B, CDKN2A, BAX, CDK1, CCNE1, STAT1, TP73, PURA, CEBPA, CSNK1A1, CEBPD, CCNA2, CDT1, FZR1, MYBL2, CDC25A, HDAC8, RECQL4, PRMT2, STOML1 (tumor)	E2F1, BRCA1, CDKN2A, CDK1, CDK2, CCNE1, TP73, CCNA2, RBL1, DNMT1, CDT1, CDKN2C, MYBL2, CDC25A, TOPBP1, PA2G4, TIMELESS, RECQL4, DBF4, ZMYND10, ATAD2 (normal)

LUAD (tumor)	LUAD (normal)
E2F1, RBL2, HDAC3, TUBA4A, CDK1, CCNE1, KAT2B, TCF4, CEBPA, RAB3GAP2, SIRT1, SP4, CCNA2, MCPH1, CDT1, MYBL2, CDC25A, RNF144A, HDAC8, TIMELESS, RECQL4 (tumor)	E2F1, BRCA1, RBL2, HDAC2, CDK1, CDK2, CCNE1, KAT2B, SKP2, CHEK2, CCNA2, RBL1, DNMT1, CDT1, MYBL2, CDC25A, TOPBP1, TIMELESS, RECQL4, DBF4, ATAD2 (normal)

LUSC (tumor)	LUSC (normal)
E2F1, HDAC3, BAX, CDK1, CCNE1, BIRC2, CEBPA, SKP2, SIRT1, UBXN1, SP4, CSNK1A1, CCNA2, DNMT1, CDT1, MYBL2, CDC25A, TIMELESS, RECQL4, STOML1, ARID4B (tumor)	E2F1, MAP3K5, BRCA1, KAT2A, CDK1, CDK2, CCNE1, TRIM28, RB1, CCNA2, RBL1, DNMT1, CDT1, MYBL2, CDC25A, TOPBP1, TERT, NRF1, TIMELESS, RECQL4, ATAD2 (normal)

PRAD (tumor)	PRAD (normal)
E2F1, TP53, BRCA1, RBL2, TUBA4A, CDKN2A, CCNE1, KAT2B, BCL2, THBS1, CCNA2, PKIB, CDT1, PAX8, MYBL2, CDC25A, LEF1, PCSK6, TERT, HIST1H2AB, SNX19 (tumor)	E2F1, BRCA1, KAT2A, CDK1, CCNE1, PURA, CHEK2, PDK4, NEDD8, TRIM28, CCNA2, CDT1, CDKN2C, MYBL2, CDC25A, CYC1, TIMELESS, DIRAS3, RECQL4, ZMYND10, PRDM2 (normal)

STAD (tumor)	STAD (normal)
E2F1, CDKN2A, HDAC1, NDN, CDK1, PURA, SIRT1, CHEK2, CCNA2, PKIB, CDT1, MYBL2, CDC25A, DUSP4, CTDP1, TERT, TIMELESS, TFDP2, TEAD3, RECQL4, CWC27 (tumor)	E2F1, BRCA1, KAT2A, CDK1, CDK2, CCNE1, KAT2B, SKP2, CHEK2, TRIM28, CCNA2, RBL1, DNMT1, CDT1, MYBL2, CDC25A, SETD7, TIMELESS, RECQL4, ATAD2, PRMT2 (normal)

THCA (tumor)	THCA (normal)
E2F1, BIRC3, TUBA4A, CDKN2A, BAX, TNFSF11, CDK1, SPIB, CHEK2, CCNA2, DDB2, PARP1, DNMT1, CDT1, CDKN2C, MYBL2, DUSP4, ARID3A, TERT, DRAM1, RECQL4 (tumor)	E2F1, CDKN1A, TUBA4A, BAX, BRD2, PIN1, CCNE1, TP73, UBXN1, SP4, SP3, DDB2, SIN3A, MCPH1, CDT1, MYBL2, TIMELESS, RECQL4, MGA, ARID4B, PRDM2 (normal)

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TissGeneProg for E2F1

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for E2F1

TissGeneDrug for E2F1

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for E2F1

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0035335	Retinoblastoma	29	BeFree
umls:C0596263	Carcinogenesis	26	BeFree
umls:C0678222	Breast Carcinoma	25	BeFree
umls:C0006142	Malignant neoplasm of breast	23	BeFree
umls:C2239176	Liver carcinoma	23	BeFree,CTD_human
umls:C0376358	Malignant neoplasm of prostate	22	BeFree
umls:C0600139	Prostate carcinoma	22	BeFree
umls:C0025202	melanoma	16	BeFree,CTD_human,LHGDN
umls:C0699791	Stomach Carcinoma	14	BeFree
umls:C0027627	Neoplasm Metastasis	13	BeFree
umls:C0007131	Non-Small Cell Lung Carcinoma	12	BeFree
umls:C0024623	Malignant neoplasm of stomach	12	BeFree
umls:C0007102	Malignant tumor of colon	11	BeFree
umls:C0017638	Glioma	11	BeFree,LHGDN
umls:C0699790	Colon Carcinoma	11	BeFree
umls:C0178874	Tumor Progression	9	BeFree
umls:C0009402	Colorectal Carcinoma	8	BeFree
umls:C0025268	Multiple Endocrine Neoplasia Type 2a	8	BeFree
umls:C0017636	Glioblastoma	7	BeFree
umls:C0027819	Neuroblastoma	7	BeFree
umls:C0029925	Ovarian Carcinoma	7	BeFree
umls:C1140680	Malignant neoplasm of ovary	7	BeFree,GAD
umls:C1458155	Mammary Neoplasms	7	BeFree,CTD_human,LHGDN
umls:C1527249	Colorectal Cancer	7	BeFree
umls:C0242379	Malignant neoplasm of lung	6	BeFree
umls:C0279626	Squamous cell carcinoma of esophagus	6	BeFree
umls:C0684249	Carcinoma of lung	6	BeFree
umls:C0700095	Central neuroblastoma	6	BeFree
umls:C1168401	Squamous cell carcinoma of the head and neck	6	BeFree
umls:C0001418	Adenocarcinoma	5	BeFree,LHGDN
umls:C0007137	Squamous cell carcinoma	5	BeFree
umls:C0023467	Leukemia, Myelocytic, Acute	5	BeFree
umls:C0023903	Liver neoplasms	5	BeFree,LHGDN
umls:C0235974	Pancreatic carcinoma	5	BeFree
umls:C0238198	Gastrointestinal Stromal Tumors	5	BeFree
umls:C0005684	Malignant neoplasm of urinary bladder	4	BeFree
umls:C0029463	Osteosarcoma	4	BeFree
umls:C0033578	Prostatic Neoplasms	4	BeFree,LHGDN
umls:C0037286	Skin Neoplasms	4	BeFree
umls:C0038356	Stomach Neoplasms	4	BeFree,LHGDN
umls:C0152013	Adenocarcinoma of lung (disorder)	4	BeFree
umls:C0345904	Malignant neoplasm of liver	4	BeFree
umls:C0346647	Malignant neoplasm of pancreas	4	BeFree
umls:C0585442	Osteosarcoma of bone	4	BeFree
umls:C0677886	Epithelial ovarian cancer	4	BeFree,GAD
umls:C0686619	Secondary malignant neoplasm of lymph node	4	BeFree
umls:C0699885	Carcinoma of bladder	4	BeFree
umls:C0014859	Esophageal Neoplasms	3	BeFree
umls:C0024121	Lung Neoplasms	3	BeFree
umls:C0024299	Lymphoma	3	BeFree
umls:C0032000	Pituitary Adenoma	3	BeFree
umls:C0032002	Pituitary Diseases	3	BeFree
umls:C0152018	Esophageal carcinoma	3	BeFree
umls:C0302592	Cervix carcinoma	3	BeFree
umls:C0546837	Malignant neoplasm of esophagus	3	BeFree
umls:C0919267	ovarian neoplasm	3	BeFree,LHGDN
umls:C1512409	Hepatocarcinogenesis	3	BeFree
umls:C0001486	Adenovirus Infections	2	BeFree
umls:C0002395	Alzheimer's Disease	2	BeFree,LHGDN
umls:C0005695	Bladder Neoplasm	2	BeFree
umls:C0006118	Brain Neoplasms	2	BeFree,LHGDN
umls:C0007134	Renal Cell Carcinoma	2	BeFree,LHGDN
umls:C0007847	Malignant tumor of cervix	2	BeFree
umls:C0011265	Presenile dementia	2	BeFree
umls:C0019693	HIV Infections	2	BeFree
umls:C0023434	Chronic Lymphocytic Leukemia	2	BeFree
umls:C0024141	Lupus Erythematosus, Systemic	2	BeFree
umls:C0026764	Multiple Myeloma	2	BeFree
umls:C0031511	Pheochromocytoma	2	BeFree
umls:C0035334	Retinitis Pigmentosa	2	BeFree
umls:C0149925	Small cell carcinoma of lung	2	BeFree
umls:C0156312	Atrophy of testis	2	BeFree
umls:C0279000	Liver and Intrahepatic Biliary Tract Carcinoma	2	BeFree
umls:C0497327	Dementia	2	BeFree,LHGDN
umls:C0555198	Malignant Glioma	2	BeFree
umls:C0854723	Retinal Dystrophies	2	BeFree
umls:C1261473	Sarcoma	2	BeFree
umls:C1335302	Pancreatic Ductal Adenocarcinoma	2	BeFree
umls:C1621958	Glioblastoma Multiforme	2	BeFree
umls:C0000768	Congenital Abnormality	1	BeFree
umls:C0004135	Ataxia Telangiectasia	1	LHGDN
umls:C0006413	Burkitt Lymphoma	1	BeFree
umls:C0007121	Bronchogenic Carcinoma	1	BeFree
umls:C0007138	Carcinoma, Transitional Cell	1	BeFree
umls:C0007873	Uterine Cervical Neoplasm	1	LHGDN
umls:C0009375	Colonic Neoplasms	1	LHGDN
umls:C0011065	Cessation of life	1	LHGDN
umls:C0011875	Diabetic Angiopathies	1	LHGDN
umls:C0011881	Diabetic Nephropathy	1	BeFree
umls:C0013264	Muscular Dystrophy, Duchenne	1	BeFree
umls:C0014072	Experimental Autoimmune Encephalomyelitis	1	BeFree
umls:C0015672	Fatigue	1	BeFree
umls:C0016057	Fibrosarcoma	1	BeFree
umls:C0019163	Hepatitis B	1	BeFree
umls:C0019196	Hepatitis C	1	LHGDN
umls:C0020179	Huntington Disease	1	RGD
umls:C0021367	Mammary Ductal Carcinoma	1	BeFree
umls:C0022116	Ischemia	1	BeFree
umls:C0022665	Kidney Neoplasm	1	BeFree
umls:C0023269	leiomyosarcoma	1	BeFree
umls:C0023418	leukemia	1	BeFree
umls:C0023440	Acute Erythroblastic Leukemia	1	BeFree
umls:C0023448	Lymphoid leukemia	1	BeFree
umls:C0023473	Myeloid Leukemia, Chronic	1	BeFree
umls:C0023890	Liver Cirrhosis	1	BeFree
umls:C0024305	Lymphoma, Non-Hodgkin	1	LHGDN
umls:C0025149	Medulloblastoma	1	BeFree
umls:C0025500	Mesothelioma	1	BeFree
umls:C0025517	Metabolic Diseases	1	BeFree
umls:C0026010	Microphthalmos	1	BeFree
umls:C0026640	Mouth Neoplasms	1	LHGDN
umls:C0026850	Muscular Dystrophy	1	BeFree
umls:C0026948	Mycosis Fungoides	1	BeFree
umls:C0026985	Myelodysplasia	1	BeFree
umls:C0027019	Myelomonocytic leukemia	1	BeFree
umls:C0027051	Myocardial Infarction	1	BeFree
umls:C0027126	Myotonic Dystrophy	1	BeFree
umls:C0030521	Parathyroid Neoplasms	1	BeFree
umls:C0030567	Parkinson Disease	1	LHGDN
umls:C0032019	Pituitary Neoplasms	1	BeFree
umls:C0032584	polyps	1	BeFree
umls:C0032927	Precancerous Conditions	1	BeFree
umls:C0033027	Preleukemia	1	BeFree
umls:C0033375	Prolactinoma	1	BeFree
umls:C0035309	Retinal Diseases	1	BeFree
umls:C0040136	Thyroid Neoplasm	1	BeFree
umls:C0079744	Diffuse Large B-Cell Lymphoma	1	BeFree
umls:C0079773	Lymphoma, T-Cell, Cutaneous	1	BeFree
umls:C0085669	Acute leukemia	1	BeFree
umls:C0151468	Thyroid Gland Follicular Adenoma	1	BeFree
umls:C0151779	Cutaneous Melanoma	1	BeFree
umls:C0153633	Malignant neoplasm of brain	1	BeFree
umls:C0205647	Follicular adenoma	1	BeFree
umls:C0206655	Alveolar rhabdomyosarcoma	1	BeFree
umls:C0206682	Follicular thyroid carcinoma	1	BeFree
umls:C0220633	Uveal melanoma	1	BeFree
umls:C0238461	Anaplastic thyroid carcinoma	1	BeFree
umls:C0238462	Medullary carcinoma of thyroid	1	BeFree
umls:C0239946	Fibrosis, Liver	1	BeFree
umls:C0263641	Epithelial hyperplasia of skin	1	BeFree
umls:C0271183	Severe myopia	1	BeFree
umls:C0271933	Congenital dyserythropoietic anemia, type I	1	BeFree
umls:C0275524	Coinfection	1	BeFree
umls:C0278484	Malignant neoplasm of colon stage IV	1	BeFree
umls:C0278838	Prostate cancer recurrent	1	BeFree
umls:C0278883	Metastatic melanoma	1	BeFree
umls:C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	1	BeFree
umls:C0334634	Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse	1	BeFree
umls:C0346429	Multiple malignancy	1	BeFree
umls:C0374997	Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site	1	BeFree
umls:C0409974	Lupus Erythematosus	1	BeFree
umls:C0410226	Congenital Myotonic Dystrophy	1	BeFree
umls:C0494165	Secondary malignant neoplasm of liver	1	BeFree
umls:C0520571	Fibrosis of bile duct	1	BeFree
umls:C0598766	Leukemogenesis	1	BeFree
umls:C0730321	Punctate inner choroidopathy	1	BeFree
umls:C0850741	Smoker's lung	1	BeFree
umls:C0877373	Advanced cancer	1	BeFree
umls:C1336077	Sporadic Burkitt's lymphoma	1	BeFree
umls:C1337012	Well Differentiated Papillary Mesothelioma	1	BeFree
umls:C1377610	Peritoneal Mesothelioma	1	BeFree
umls:C1510885	Angiogenic Switch	1	BeFree
umls:C1518296	Neuropathogenesis	1	BeFree
umls:C1519670	Tumor Angiogenesis	1	BeFree
umls:C1520166	Xenograft Model	1	BeFree
umls:C1527349	Ductal Breast Carcinoma	1	BeFree
umls:C1623038	Cirrhosis	1	BeFree
umls:C1709246	Non-Neoplastic Disorder	1	BeFree
umls:C1847540	Azoospermia, Nonobstructive	1	BeFree
umls:C2349952	Oropharyngeal Carcinoma	1	BeFree
umls:C2931822	Nasopharyngeal carcinoma	1	BeFree
umls:C3241937	Nonalcoholic Steatohepatitis	1	BeFree
umls:C3463824	MYELODYSPLASTIC SYNDROME	1	LHGDN
umls:C3539878	Triple Negative Breast Neoplasms	1	BeFree
umls:C3714514	Infection	1	LHGDN
umls:C0011854	Diabetes Mellitus, Insulin-Dependent	0	MGD
umls:C1527336	Sjogren's Syndrome	0	MGD