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| TissGeneSummary for AGXT |
 Gene summary |
| Basic gene information | Gene symbol | AGXT |
| Gene name | alanine-glyoxylate aminotransferase | |
| Synonyms | AGT|AGT1|AGXT1|PH1|SPAT|SPT|TLH6 | |
| Cytomap | UCSC genome browser: 2q37.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000030.2, | |
| Description | L-alanine: glyoxylate aminotransferase 1alanine--glyoxylate aminotransferasehepatic peroxisomal alanine:glyoxylate aminotransferaseserine--pyruvate aminotransferaseserine-pyruvate aminotransferaseserine:pyruvate aminotransferase | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 604285 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000172482 | ||
| HPRD : 05048 | ||
| Vega : OTTHUMG00000133354 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_AGXT | |
| BioGPS: 189 | ||
| Pathway | NCI Pathway Interaction Database: AGXT | |
| KEGG: AGXT | ||
| REACTOME: AGXT | ||
| Pathway Commons: AGXT | ||
| Context | iHOP: AGXT | |
| ligand binding site mutation search in PubMed: AGXT | ||
| UCL Cancer Institute: AGXT | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of AGXT | ||
| Description by TissGene annotations | Cancer gene TissgsKTS CNV gained TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0009436 | glyoxylate catabolic process | 22198249 | GO:0019265 | glycine biosynthetic process, by transamination of glyoxylate | 22198249 | GO:0019448 | L-cysteine catabolic process | 18492492 | GO:0042853 | L-alanine catabolic process | 17696873 | GO:0009436 | glyoxylate catabolic process | 22198249 | GO:0019265 | glycine biosynthetic process, by transamination of glyoxylate | 22198249 | GO:0019448 | L-cysteine catabolic process | 18492492 | GO:0042853 | L-alanine catabolic process | 17696873 |
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| TissGeneExp for AGXT |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 11.1798558 | 13.2687118 | -2.088856 | 1.59E-06 | 8.21E-06 |
| KIRP | -0.144406951 | 5.408471174 | -5.552878125 | 3.70E-14 | 8.13E-13 |
| KICH | -2.345272201 | 3.550699799 | -5.895972 | 1.25E-09 | 7.67E-09 |
| BRCA | -2.222359254 | -0.910120657 | -1.312238596 | 1.07E-14 | 5.44E-14 |
| KIRC | 0.697192354 | 3.396361799 | -2.699169444 | 3.41E-09 | 1.08E-08 |
| ESCA | -0.582851838 | -2.792415474 | 2.209563636 | 0.0054 | 0.0417 |
| COAD | 0.075557953 | 1.601757953 | -1.5262 | 0.000349 | 0.001116291 |
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| TissGene-miRNA for AGXT |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for AGXT |
| TissGeneSNV for AGXT |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E59K | SKCM | 2 |
| p.P30L | SKCM | 2 |
| p.P35S | SKCM | 2 |
| p.E117K | SKCM | 1 |
| p.A294V | COAD | 1 |
| p.K61E | UCEC | 1 |
| p.T369N | LUAD | 1 |
| p.D183N | SKCM | 1 |
| p.L180I | ESCA | 1 |
| p.K209R | LIHC | 1 |
| p.R197L | ACC | 1 |
| p.F68I | BLCA | 1 |
| p.V376M | ESCA | 1 |
| p.V336I | PAAD | 1 |
| p.K228Q | PRAD | 1 |
| p.L25P | KIRC | 1 |
| p.P34L | SKCM | 1 |
| p.P34S | SKCM | 1 |
| p.Q65L | LUAD | 1 |
| p.L163Q | HNSC | 1 |
| p.G47V | LUAD | 1 |
| p.D255N | PAAD | 1 |
| p.W332C | ESCA | 1 |
| p.A112V | UCS | 1 |
| p.G103E | SKCM | 1 |
| p.G47R | SKCM | 1 |
| p.R197Q | ACC | 1 |
| p.P30S | SKCM | 1 |
| p.S275R | UCEC | 1 |
| p.L179M | LUAD | 1 |
| p.D52N | SKCM | 1 |
| p.G356R | SKCM | 1 |
| p.V336I | STAD | 1 |
| p.D58G | HNSC | 1 |
| p.R289H | COAD | 1 |
| p.K225E | LIHC | 1 |
| p.E117K | KIRP | 1 |
| p.S268G | UCEC | 1 |
| p.S205L | LIHC | 1 |
| p.Y338D | STAD | 1 |
| p.G103R | SKCM | 1 |
| p.S79C | CESC | 1 |
| p.G190R | LUAD | 1 |
| p.K12R | KIRP | 1 |
| p.P11A | BRCA | 1 |
| p.Q208H | LUSC | 1 |
| p.G190R | SKCM | 1 |
| p.A213V | UCEC | 1 |
| p.S271N | LGG | 1 |
| p.R233L | LUAD | 1 |
| p.A383V | UCEC | 1 |
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| TissGeneCNV for AGXT |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for AGXT |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for AGXT |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (tumor) | AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (normal) |
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| COAD (tumor) | COAD (normal) |
| AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (tumor) | AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (tumor) | AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (normal) |
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| KICH (tumor) | KICH (normal) |
| AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (tumor) | AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (tumor) | AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (tumor) | AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (tumor) | AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (tumor) | AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (tumor) | AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (tumor) | AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (tumor) | AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (tumor) | AGXT, YWHAE, SNCAIP, BMI1, PEX5, ACAT1 (normal) |
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| TissGeneProg for AGXT |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for AGXT |
| TissGeneDrug for AGXT |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00133 | L-Serine | Small molecule | Approved|Nutraceutical |
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| TissGeneDisease for AGXT |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0268164 | Primary hyperoxaluria, type I | 73 | BeFree,CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT |
| umls:C0020538 | Hypertensive disease | 42 | BeFree |
| umls:C0085580 | Essential Hypertension | 15 | BeFree |
| umls:C0020501 | Primary Hyperoxaluria | 11 | BeFree,LHGDN |
| umls:C2239176 | Liver carcinoma | 9 | BeFree |
| umls:C0011847 | Diabetes | 8 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 8 | BeFree |
| umls:C0035078 | Kidney Failure | 8 | BeFree |
| umls:C0004096 | Asthma | 7 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 7 | BeFree |
| umls:C0011881 | Diabetic Nephropathy | 7 | BeFree |
| umls:C0020500 | Hyperoxaluria | 7 | BeFree,GAD |
| umls:C1956346 | Coronary Artery Disease | 7 | BeFree |
| umls:C0022650 | Kidney Calculi | 6 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 5 | BeFree |
| umls:C0010068 | Coronary heart disease | 5 | BeFree |
| umls:C0022661 | Kidney Failure, Chronic | 5 | BeFree |
| umls:C0025517 | Metabolic Diseases | 5 | BeFree |
| umls:C2316810 | Chronic kidney disease stage 5 | 5 | BeFree |
| umls:C0022658 | Kidney Diseases | 4 | BeFree |
| umls:C0451641 | Urolithiasis | 4 | BeFree |
| umls:C0028754 | Obesity | 3 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 3 | BeFree |
| umls:C0392525 | Nephrolithiasis | 3 | BeFree |
| umls:C0730345 | Microalbuminuria | 3 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 2 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 2 | BeFree |
| umls:C0013537 | Eclampsia | 2 | BeFree |
| umls:C0013595 | Eczema | 2 | BeFree |
| umls:C0020443 | Hypercholesterolemia | 2 | BeFree |
| umls:C0021390 | Inflammatory Bowel Diseases | 2 | BeFree |
| umls:C0025521 | Inborn Errors of Metabolism | 2 | BeFree |
| umls:C0027051 | Myocardial Infarction | 2 | BeFree |
| umls:C0035222 | Respiratory Distress Syndrome, Adult | 2 | BeFree |
| umls:C0149721 | Left Ventricular Hypertrophy | 2 | BeFree |
| umls:C0155626 | Acute myocardial infarction | 2 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree |
| umls:C0333186 | Restenosis | 2 | BeFree |
| umls:C0476227 | pricking of skin | 2 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C0684249 | Carcinoma of lung | 2 | BeFree |
| umls:C0948008 | Ischemic stroke | 2 | BeFree |
| umls:C1561643 | Chronic Kidney Diseases | 2 | BeFree |
| umls:C1833683 | NEPHROLITHIASIS, CALCIUM OXALATE | 2 | BeFree |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | BeFree |
| umls:C0002875 | Cooley's anemia | 1 | BeFree |
| umls:C0002940 | Aneurysm | 1 | BeFree |
| umls:C0003469 | Anxiety Disorders | 1 | BeFree |
| umls:C0007114 | Malignant neoplasm of skin | 1 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0014122 | Subacute Bacterial Endocarditis | 1 | BeFree |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0017921 | Glycogen storage disease type II | 1 | BeFree |
| umls:C0018784 | Sensorineural Hearing Loss (disorder) | 1 | BeFree |
| umls:C0019158 | Hepatitis | 1 | BeFree |
| umls:C0019159 | Hepatitis A | 1 | BeFree |
| umls:C0019163 | Hepatitis B | 1 | BeFree |
| umls:C0019880 | Homocystinuria | 1 | BeFree |
| umls:C0020071 | Hereditary Sensory Autonomic Neuropathy, Type 1 | 1 | BeFree |
| umls:C0020428 | Hyperaldosteronism | 1 | BeFree |
| umls:C0023269 | leiomyosarcoma | 1 | BeFree |
| umls:C0026267 | Mitral Valve Prolapse Syndrome | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0027726 | Nephrotic Syndrome | 1 | BeFree |
| umls:C0029928 | Ovarian Diseases | 1 | BeFree |
| umls:C0031099 | Periodontitis | 1 | BeFree |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | BeFree |
| umls:C0035309 | Retinal Diseases | 1 | BeFree |
| umls:C0041408 | Turner Syndrome | 1 | BeFree |
| umls:C0042721 | Viral hepatitis | 1 | BeFree |
| umls:C0080233 | Tooth Loss | 1 | BeFree |
| umls:C0085215 | Ovarian Failure, Premature | 1 | BeFree |
| umls:C0149931 | Migraine Disorders | 1 | BeFree |
| umls:C0151779 | Cutaneous Melanoma | 1 | BeFree |
| umls:C0152105 | Hypertensive heart disease | 1 | BeFree |
| umls:C0152451 | Chronic glomerulonephritis | 1 | BeFree |
| umls:C0154723 | Migraine with Aura | 1 | BeFree |
| umls:C0155616 | Secondary hypertension | 1 | BeFree |
| umls:C0155733 | Atherosclerosis of aorta | 1 | BeFree |
| umls:C0155877 | Allergic asthma | 1 | BeFree |
| umls:C0205898 | pineoblastoma | 1 | BeFree |
| umls:C0268165 | Primary hyperoxaluria type 2 | 1 | BeFree |
| umls:C0278601 | Inflammatory Breast Carcinoma | 1 | BeFree |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0333291 | Bleeding ulcer | 1 | BeFree |
| umls:C0342751 | Generalized glycogen storage disease of infants | 1 | BeFree |
| umls:C0403592 | Chronic rejection of renal transplant | 1 | BeFree |
| umls:C0565599 | Maternal hypertension | 1 | BeFree |
| umls:C0577631 | Carotid Atherosclerosis | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0687120 | Nephronophthisis | 1 | BeFree |
| umls:C0751483 | Familial Retinoblastoma | 1 | BeFree |
| umls:C1135191 | Heart Failure, Systolic | 1 | BeFree |
| umls:C1277187 | Left ventricular systolic dysfunction | 1 | BeFree |
| umls:C1332860 | Cauda Equina Paraganglioma | 1 | BeFree |
| umls:C1512409 | Hepatocarcinogenesis | 1 | BeFree |
| umls:C1621958 | Glioblastoma Multiforme | 1 | BeFree |
| umls:C1709246 | Non-Neoplastic Disorder | 1 | BeFree |
| umls:C1860224 | ABLEPHARON-MACROSTOMIA SYNDROME | 1 | BeFree |
| umls:C2607914 | Allergic rhinitis (disorder) | 1 | BeFree |
| umls:C2931132 | Crigler Najjar syndrome, type 2 | 1 | BeFree |
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