TissGeneSummary for KRT24 |
Gene summary |
Basic gene information | Gene symbol | KRT24 |
Gene name | keratin 24 | |
Synonyms | K24|KA24 | |
Cytomap | UCSC genome browser: 17q21.2 | |
Type of gene | protein-coding | |
RefGenes | NM_019016.2, | |
Description | CK-24cytokeratin-24keratin, type I cytoskeletal 24keratin-24type I keratin-24 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607742 | |
HGNC : HGNC | ||
Ensembl : ENSG00000167916 | ||
HPRD : 09668 | ||
Vega : OTTHUMG00000133372 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KRT24 | |
BioGPS: 192666 | ||
Pathway | NCI Pathway Interaction Database: KRT24 | |
KEGG: KRT24 | ||
REACTOME: KRT24 | ||
Pathway Commons: KRT24 | ||
Context | iHOP: KRT24 | |
ligand binding site mutation search in PubMed: KRT24 | ||
UCL Cancer Institute: KRT24 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | EsophagusEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCAUVM | |
Reference showing the relevant tissue of KRT24 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KRT24 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -0.5705798 | 4.937835585 | -5.508415385 | 6.24E-15 | 3.33E-13 |
PRAD | -0.6228298 | 1.159962508 | -1.782792308 | 4.61E-06 | 2.83E-05 |
KICH | -0.746213954 | 0.720162046 | -1.466376 | 4.37E-09 | 2.46E-08 |
HNSC | 3.475362418 | 5.976181023 | -2.500818605 | 0.00997 | 0.024779736 |
LUSC | 0.990025026 | -0.046202425 | 1.036227451 | 0.0132 | 0.020557676 |
BLCA | 0.236958257 | 3.700026678 | -3.463068421 | 2.86E-05 | 0.000426889 |
STAD | 0.491889671 | 3.667949046 | -3.176059375 | 3.06E-05 | 0.000286748 |
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TissGene-miRNA for KRT24 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KRT24 |
TissGeneSNV for KRT24 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.N222K | LIHC | 2 |
p.G62D | COAD | 1 |
p.K171N | SKCM | 1 |
p.K523N | STAD | 1 |
p.Q327H | SKCM | 1 |
p.E393K | HNSC | 1 |
p.R437L | PRAD | 1 |
p.K338N | READ | 1 |
p.I172M | KIRC | 1 |
p.K157T | ESCA | 1 |
p.I206N | OV | 1 |
p.Y321* | BLCA | 1 |
p.E237Q | BLCA | 1 |
p.D247N | LUSC | 1 |
p.E266D | READ | 1 |
p.R491Q | SKCM | 1 |
p.R446H | UCEC | 1 |
p.M267I | COAD | 1 |
p.N236K | UCEC | 1 |
p.R19K | BLCA | 1 |
p.K312E | ESCA | 1 |
p.A152V | STAD | 1 |
p.D201H | BLCA | 1 |
p.R150S | LUAD | 1 |
p.K429E | COAD | 1 |
p.G387R | HNSC | 1 |
p.E412K | SKCM | 1 |
p.Q416H | HNSC | 1 |
p.G184E | SKCM | 1 |
p.G37S | SKCM | 1 |
p.G76V | PRAD | 1 |
p.L431F | LUAD | 1 |
p.G129V | LUAD | 1 |
p.G133R | STAD | 1 |
p.G37D | LGG | 1 |
p.D177N | GBM | 1 |
p.L448M | UCEC | 1 |
p.S91Y | LUAD | 1 |
p.R252W | PAAD | 1 |
p.R335P | HNSC | 1 |
p.S53N | SKCM | 1 |
p.E284K | BLCA | 1 |
p.N222H | ESCA | 1 |
p.L35M | UCEC | 1 |
p.E331G | LIHC | 1 |
p.L135I | READ | 1 |
p.S57G | SKCM | 1 |
p.D450H | BRCA | 1 |
p.S513L | SKCM | 1 |
p.G292E | SKCM | 1 |
p.L151F | STAD | 1 |
p.A223P | LIHC | 1 |
p.P181H | LUAD | 1 |
p.L147I | LGG | 1 |
p.E460X | ESCA | 1 |
p.E274K | CESC | 1 |
p.E333K | BLCA | 1 |
p.S21C | LUSC | 1 |
p.G86V | PAAD | 1 |
p.E162K | SKCM | 1 |
p.G138A | HNSC | 1 |
p.G484E | SKCM | 1 |
p.I442M | KIRP | 1 |
p.A22S | LUAD | 1 |
p.T143N | UCEC | 1 |
p.E212Q | HNSC | 1 |
p.I417V | LUSC | 1 |
p.Q268L | SKCM | 1 |
p.D177N | BLCA | 1 |
p.A214D | THYM | 1 |
p.M287I | ESCA | 1 |
p.F136L | CESC | 1 |
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TissGeneCNV for KRT24 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KRT24 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | HNSC | TCGA-CN-5370-01A | EFTUD2-KRT24 | In-frame | Chr17:42956924 | Chr17:38858185 |
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TissGeneNet for KRT24 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KRT24 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KRT24 |
TissGeneDrug for KRT24 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KRT24 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |