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| TissGeneSummary for EIF2S3 |
 Gene summary |
| Basic gene information | Gene symbol | EIF2S3 |
| Gene name | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | |
| Synonyms | EIF2|EIF2G|EIF2gamma|eIF-2gA | |
| Cytomap | UCSC genome browser: Xp22.2-p22.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001415.3, | |
| Description | eIF-2-gamma XeIF-2gXeukaryotic translation initiation factor 2 subunit 3eukaryotic translation initiation factor 2 subunit gamma Xeukaryotic translation initiation factor 2G | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 300161 | |
| HGNC : HGNC | ||
| HPRD : 02155 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_EIF2S3 | |
| BioGPS: 1968 | ||
| Pathway | NCI Pathway Interaction Database: EIF2S3 | |
| KEGG: EIF2S3 | ||
| REACTOME: EIF2S3 | ||
| Pathway Commons: EIF2S3 | ||
| Context | iHOP: EIF2S3 | |
| ligand binding site mutation search in PubMed: EIF2S3 | ||
| UCL Cancer Institute: EIF2S3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixOvary | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCOV | |
| Reference showing the relevant tissue of EIF2S3 | ||
| Description by TissGene annotations | TissgsLTS Fused withOncogene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006413 | translational initiation | 10900014 | GO:0006413 | translational initiation | 10900014 |
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| TissGeneExp for EIF2S3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for EIF2S3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for EIF2S3 |
| TissGeneSNV for EIF2S3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.T435I | BLCA | 1 |
| p.A363S | SARC | 1 |
| p.D24G | UCEC | 1 |
| p.G3S | UCEC | 1 |
| p.L378F | SKCM | 1 |
| p.R98W | UCEC | 1 |
| p.D423Y | UCEC | 1 |
| p.L157P | THYM | 1 |
| p.I283T | LIHC | 1 |
| p.E205K | UCEC | 1 |
| p.H450Y | HNSC | 1 |
| p.K466N | LUAD | 1 |
| p.H65Y | LUAD | 1 |
| p.G4E | BLCA | 1 |
| p.R385L | ESCA | 1 |
| p.G415W | ESCA | 1 |
| p.D93G | KICH | 1 |
| p.D263H | BLCA | 1 |
| p.R452_splice | UCEC | 1 |
| p.K90N | SARC | 1 |
| p.S302F | SKCM | 1 |
| p.T115M | UCEC | 1 |
| p.A331V | BLCA | 1 |
| p.L81F | SKCM | 1 |
| p.K59N | GBM | 1 |
| p.L378H | SKCM | 1 |
| p.G335S | BLCA | 1 |
| p.R385C | KIRP | 1 |
| p.K449N | KIRC | 1 |
| p.D470Y | LUAD | 1 |
| p.P254T | BRCA | 1 |
| p.E370K | CESC | 1 |
| p.H65Y | ESCA | 1 |
| p.V50I | LGG | 1 |
| p.K397E | COAD | 1 |
| p.E253K | BRCA | 1 |
| p.E295K | BLCA | 1 |
| p.G335S | READ | 1 |
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| TissGeneCNV for EIF2S3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for EIF2S3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI830759 | EIF2S3-HNRNPA3 | chrX:24095226 | chr2:178087487 | |
| Chimerdb3.0 | ChiTaRs | NA | BE177610 | SLC19A2-EIF2S3 | chr1:169434644 | chrX:24086202 | |
| Chimerdb3.0 | ChiTaRs | NA | AW580222 | GFPT1-EIF2S3 | chr2:69560231 | chrX:24080551 | |
| Chimerdb3.0 | ChiTaRs | NA | BG774247 | EIF2S3-H19 | chrX:24095924 | chr11:2018904 | |
| Chimerdb3.0 | ChiTaRs | NA | BM969453 | WDR70-EIF2S3 | chr5:37389308 | chrX:24095045 | |
| Chimerdb3.0 | ChiTaRs | NA | CB131978 | ZNF480-EIF2S3 | chr19:52824975 | chrX:24096214 | |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-44-7667-01A | ZNF480-EIF2S3 | Out-of-Frame | chr19:52819215 | chrX:24094838 |
| Chimerdb3.0 | FusionScan | UCEC | TCGA-AX-A3G4-01A | ZFX-EIF2S3 | 5'UTR-CDS | chrX:24167911 | chrX:24089674 |
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| TissGeneNet for EIF2S3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (tumor) | EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (normal) |
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| COAD (tumor) | COAD (normal) |
| EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (tumor) | EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (tumor) | EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (normal) |
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| KICH (tumor) | KICH (normal) |
| EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (tumor) | EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (tumor) | EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (tumor) | EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (tumor) | EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (tumor) | EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (tumor) | EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (tumor) | EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (normal) |
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| STAD (tumor) | STAD (normal) |
| EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (tumor) | EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (normal) |
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| THCA (tumor) | THCA (normal) |
| EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (tumor) | EIF2S3, IKBKE, CAND1, TRAF6, ELAVL1, UBC, SUMO2, KIAA0101, HLA-B, EIF1B, SUMO1, HDGF, CASP4, RAD21, PRKAB1, GH1, EIF2S2, NDRG1, DCC, METAP2, EIF2S1 (normal) |
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| TissGeneProg for EIF2S3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for EIF2S3 |
| TissGeneDrug for EIF2S3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for EIF2S3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0042769 | Virus Diseases | 3 | BeFree |
| umls:C0019196 | Hepatitis C | 2 | BeFree |
| umls:C1858991 | Childhood Ataxia with Central Nervous System Hypomyelinization | 2 | BeFree |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | GAD |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0022116 | Ischemia | 1 | BeFree |
| umls:C0023827 | liposarcoma | 1 | BeFree |
| umls:C0023890 | Liver Cirrhosis | 1 | BeFree |
| umls:C0025958 | Microcephaly | 1 | BeFree |
| umls:C0027765 | nervous system disorder | 1 | BeFree |
| umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 1 | BeFree |
| umls:C0345904 | Malignant neoplasm of liver | 1 | BeFree |
| umls:C0432217 | Wolcott-Rallison syndrome | 1 | BeFree |
| umls:C0524851 | Neurodegenerative Disorders | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C1623038 | Cirrhosis | 1 | BeFree |
| umls:C3241937 | Nonalcoholic Steatohepatitis | 1 | BeFree |
| umls:C3714756 | Intellectual Disability | 1 | BeFree |
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