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| TissGeneSummary for AHSG |
 Gene summary |
| Basic gene information | Gene symbol | AHSG |
| Gene name | alpha-2-HS-glycoprotein | |
| Synonyms | A2HS|AHS|FETUA|HSGA | |
| Cytomap | UCSC genome browser: 3q27 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001622.2, | |
| Description | alpha-2-Z-globulinba-alpha-2-glycoproteinfetuin-A | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 138680 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000145192 | ||
| HPRD : 00727 | ||
| Vega : OTTHUMG00000156605 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_AHSG | |
| BioGPS: 197 | ||
| Pathway | NCI Pathway Interaction Database: AHSG | |
| KEGG: AHSG | ||
| REACTOME: AHSG | ||
| Pathway Commons: AHSG | ||
| Context | iHOP: AHSG | |
| ligand binding site mutation search in PubMed: AHSG | ||
| UCL Cancer Institute: AHSG | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of AHSG | ||
| Description by TissGene annotations | TissgsKTS CNV gained TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006953 | acute-phase response | 12153747 | GO:0050766 | positive regulation of phagocytosis | 12725640 | GO:0006953 | acute-phase response | 12153747 | GO:0050766 | positive regulation of phagocytosis | 12725640 |
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| TissGeneExp for AHSG |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 12.39019873 | 14.71314073 | -2.322942 | 1.65E-05 | 6.65E-05 |
| LUSC | -0.236154487 | -1.619627036 | 1.383472549 | 2.25E-05 | 4.96E-05 |
| KIRC | -2.046948605 | -0.649784716 | -1.397163889 | 9.64E-12 | 3.78E-11 |
| KICH | -2.454471271 | -0.294575271 | -2.159896 | 2.24E-11 | 1.98E-10 |
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| TissGene-miRNA for AHSG |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for AHSG |
| TissGeneSNV for AHSG |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P336L | SKCM | 1 |
| p.S280F | PRAD | 1 |
| p.R337Q | STAD | 1 |
| p.P261A | LUAD | 1 |
| p.S3F | SKCM | 1 |
| p.L10R | STAD | 1 |
| p.S297Y | LUAD | 1 |
| p.P35S | BLCA | 1 |
| p.E86K | SKCM | 1 |
| p.P278H | COAD | 1 |
| p.R340S | LUSC | 1 |
| p.P279L | UCEC | 1 |
| p.F250L | BLCA | 1 |
| p.G306A | HNSC | 1 |
| p.P269S | SKCM | 1 |
| p.A285T | COAD | 1 |
| p.D315N | UCEC | 1 |
| p.D296N | UCEC | 1 |
| p.Q12X | SKCM | 1 |
| p.E183V | LUAD | 1 |
| p.Q12* | SKCM | 1 |
| p.G331V | SKCM | 1 |
| p.R337W | SKCM | 1 |
| p.A285T | HNSC | 1 |
| p.N172K | LUAD | 1 |
| p.A188V | LUAD | 1 |
| p.A188T | BLCA | 1 |
| p.P278H | STAD | 1 |
| p.E200D | SKCM | 1 |
| p.P136A | BLCA | 1 |
| p.D157Y | LUAD | 1 |
| p.G360E | LUSC | 1 |
| p.R143S | LUAD | 1 |
| p.P294L | SKCM | 1 |
| p.P357L | SKCM | 1 |
| p.G331R | SKCM | 1 |
| p.L42M | STAD | 1 |
| p.G306E | HNSC | 1 |
| p.D148G | BLCA | 1 |
| p.R340H | DLBC | 1 |
| p.P290S | SKCM | 1 |
| p.G284D | LUSC | 1 |
| p.V161M | KIRP | 1 |
| p.V145G | SKCM | 1 |
| p.P304S | SKCM | 1 |
| p.S74F | BLCA | 1 |
| p.E200K | SKCM | 1 |
| p.V127L | KIRC | 1 |
| p.N49T | UCS | 1 |
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| TissGeneCNV for AHSG |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for AHSG |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI133275 | AHSG-CD74 | chr3:186339104 | chr5:149781249 | |
| Chimerdb3.0 | ChiTaRs | NA | AI174759 | AHSG-ALB | chr3:186339075 | chr4:74270015 | |
| Chimerdb3.0 | ChiTaRs | NA | AF130057 | CNOT2-AHSG | chr12:70718054 | chr3:186338832 | |
| Chimerdb3.0 | TopHat-Fusion | CHOL | TCGA-W5-AA2R-11A | AHSG-ALB | 3'UTR-CDS | chr3:186338836 | chr4:74283247 |
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| TissGeneNet for AHSG |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (tumor) | AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (normal) |
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| COAD (tumor) | COAD (normal) |
| AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (tumor) | AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (tumor) | AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (normal) |
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| KICH (tumor) | KICH (normal) |
| AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (tumor) | AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (tumor) | AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (tumor) | AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (tumor) | AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (tumor) | AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (tumor) | AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (tumor) | AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (normal) |
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| STAD (tumor) | STAD (normal) |
| AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (tumor) | AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (normal) |
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| THCA (tumor) | THCA (normal) |
| AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (tumor) | AHSG, HNF4A, GRB2, CDC42, LY96, PITX3, AKT1, ABL1, PSMA3, INSR, HNF1A, TLR4, FBXO2, DCN, RRAS2 (normal) |
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| TissGeneProg for AHSG |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for AHSG |
| TissGeneDrug for AHSG |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for AHSG |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 7 | BeFree,GAD |
| umls:C0006663 | Calcinosis | 6 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0524620 | Metabolic Syndrome X | 6 | BeFree,GAD,LHGDN |
| umls:C0004153 | Atherosclerosis | 5 | BeFree,GAD |
| umls:C0007222 | Cardiovascular Diseases | 5 | BeFree,GAD |
| umls:C0023903 | Liver neoplasms | 5 | BeFree |
| umls:C2239176 | Liver carcinoma | 5 | BeFree |
| umls:C0003850 | Arteriosclerosis | 4 | BeFree |
| umls:C0027051 | Myocardial Infarction | 4 | BeFree,LHGDN |
| umls:C0028754 | Obesity | 4 | BeFree,GAD |
| umls:C0011849 | Diabetes Mellitus | 3 | BeFree,LHGDN |
| umls:C0014175 | Endometriosis | 3 | BeFree,GAD,LHGDN |
| umls:C0015695 | Fatty Liver | 3 | BeFree,LHGDN |
| umls:C0022661 | Kidney Failure, Chronic | 3 | BeFree,GAD |
| umls:C0033847 | Pseudoxanthoma Elasticum | 3 | BeFree |
| umls:C0403447 | Chronic Kidney Insufficiency | 3 | BeFree |
| umls:C0948008 | Ischemic stroke | 3 | BeFree |
| umls:C1561643 | Chronic Kidney Diseases | 3 | BeFree |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 3 | BeFree |
| umls:C0004277 | Tooth Attrition | 2 | BeFree |
| umls:C0007113 | Rectal Carcinoma | 2 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 2 | BeFree |
| umls:C0022658 | Kidney Diseases | 2 | LHGDN |
| umls:C0029456 | Osteoporosis | 2 | BeFree,LHGDN |
| umls:C0038454 | Cerebrovascular accident | 2 | BeFree,LHGDN |
| umls:C0042373 | Vascular Diseases | 2 | GAD,LHGDN |
| umls:C0162429 | Malnutrition | 2 | BeFree,LHGDN |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 2 | BeFree |
| umls:C0524851 | Neurodegenerative Disorders | 2 | BeFree,LHGDN |
| umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
| umls:C1527249 | Colorectal Cancer | 2 | BeFree |
| umls:C2711227 | Steatohepatitis | 2 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | GAD,LHGDN |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0010068 | Coronary heart disease | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011881 | Diabetic Nephropathy | 1 | GAD |
| umls:C0017636 | Glioblastoma | 1 | LHGDN |
| umls:C0020459 | Hyperinsulinism | 1 | BeFree |
| umls:C0021368 | Inflammation | 1 | LHGDN |
| umls:C0024530 | Malaria | 1 | BeFree |
| umls:C0031069 | Familial Mediterranean Fever | 1 | BeFree |
| umls:C0034885 | Rectal Neoplasms | 1 | BeFree |
| umls:C0036572 | Seizures | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0085207 | Gestational Diabetes | 1 | LHGDN |
| umls:C0242339 | Dyslipidemias | 1 | LHGDN |
| umls:C0473583 | Nevus elasticus | 1 | BeFree |
| umls:C0497406 | Overweight | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C1175175 | Severe Acute Respiratory Syndrome | 1 | BeFree |
| umls:C1512981 | Mammary Tumorigenesis | 1 | BeFree |
| umls:C1527408 | Rectal Tumors | 1 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 1 | BeFree |
| umls:C2316810 | Chronic kidney disease stage 5 | 1 | BeFree |
| umls:C3714514 | Infection | 1 | LHGDN |
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