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| TissGeneSummary for LDHD |
 Gene summary |
| Basic gene information | Gene symbol | LDHD |
| Gene name | lactate dehydrogenase D | |
| Synonyms | DLD | |
| Cytomap | UCSC genome browser: 16q23.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_153486.3, NM_194436.2, | |
| Description | D-lactate dehydrogenaseprobable D-lactate dehydrogenase, mitochondrial | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607490 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000166816 | ||
| HPRD : 06318 | ||
| Vega : OTTHUMG00000137605 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LDHD | |
| BioGPS: 197257 | ||
| Pathway | NCI Pathway Interaction Database: LDHD | |
| KEGG: LDHD | ||
| REACTOME: LDHD | ||
| Pathway Commons: LDHD | ||
| Context | iHOP: LDHD | |
| ligand binding site mutation search in PubMed: LDHD | ||
| UCL Cancer Institute: LDHD | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverStomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCSTAD | |
| Reference showing the relevant tissue of LDHD | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for LDHD |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| HNSC | -1.839650936 | 0.541907203 | -2.38155814 | 4.57E-11 | 9.98E-10 |
| LUSC | -2.140352715 | -0.47404095 | -1.666311765 | 2.09E-11 | 8.40E-11 |
| COAD | -1.184238235 | 2.172154072 | -3.356392308 | 1.53E-14 | 6.70E-13 |
| LUAD | -1.431592877 | -0.378191153 | -1.053401724 | 1.26E-06 | 4.17E-06 |
| BRCA | -1.93756644 | -0.115642756 | -1.821923684 | 6.21E-19 | 4.09E-18 |
| LIHC | 2.674532226 | 4.143516226 | -1.468984 | 2.77E-11 | 3.99E-10 |
| THCA | -0.842313333 | 0.624390057 | -1.46670339 | 5.50E-11 | 3.84E-10 |
| KIRC | -0.990034496 | 1.703405782 | -2.693440278 | 2.63E-22 | 2.44E-21 |
| KICH | 2.792684226 | 1.788048226 | 1.004636 | 0.0153 | 0.026552126 |
| ESCA | -1.816308865 | 0.478282044 | -2.294590909 | 0.00109 | 0.015539487 |
| STAD | -0.652134149 | 0.602437726 | -1.254571875 | 0.000371 | 0.00240455 |
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| TissGene-miRNA for LDHD |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for LDHD |
| TissGeneSNV for LDHD |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P94T | LUSC | 1 |
| p.V279F | LUAD | 1 |
| p.R121* | LUAD | 1 |
| p.R232H | UCEC | 1 |
| p.P226L | SKCM | 1 |
| p.R51G | UCS | 1 |
| p.E336K | SKCM | 1 |
| p.V402M | STAD | 1 |
| p.V483M | LUSC | 1 |
| p.P155T | HNSC | 1 |
| p.V485M | STAD | 1 |
| p.R87C | BLCA | 1 |
| p.Q498K | COAD | 1 |
| p.R179H | UCEC | 1 |
| p.V49M | BLCA | 1 |
| p.N372D | ESCA | 1 |
| p.V320L | ESCA | 1 |
| p.F427S | COAD | 1 |
| p.H371R | LUAD | 1 |
| p.G55E | SKCM | 1 |
| p.L431V | HNSC | 1 |
| p.L241F | STAD | 1 |
| p.Q53K | LIHC | 1 |
| p.G55R | SKCM | 1 |
| p.R121Q | SKCM | 1 |
| p.E439K | HNSC | 1 |
| p.W15C | BLCA | 1 |
| p.A438T | STAD | 1 |
| p.G100R | SKCM | 1 |
| p.I217M | LUSC | 1 |
| p.Q474P | DLBC | 1 |
| p.E26Q | LUSC | 1 |
| p.I345V | LUSC | 1 |
| p.E28D | CESC | 1 |
| p.V294L | COAD | 1 |
| p.S59T | LUSC | 1 |
| p.R381W | STAD | 1 |
| p.L500P | HNSC | 1 |
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| TissGeneCNV for LDHD |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for LDHD |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for LDHD |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| LDHD, CAND1, CUL5, CUL3, CSRP3 (tumor) | LDHD, CAND1, CUL5, CUL3, CSRP3 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| LDHD, CAND1, CUL5, CUL3, CSRP3 (tumor) | LDHD, CAND1, CUL5, CUL3, CSRP3 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| LDHD, CAND1, CUL5, CUL3, CSRP3 (tumor) | LDHD, CAND1, CUL5, CUL3, CSRP3 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| LDHD, CAND1, CUL5, CUL3, CSRP3 (tumor) | LDHD, CAND1, CUL5, CUL3, CSRP3 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| LDHD, CAND1, CUL5, CUL3, CSRP3 (tumor) | LDHD, CAND1, CUL5, CUL3, CSRP3 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| LDHD, CAND1, CUL5, CUL3, CSRP3 (tumor) | LDHD, CAND1, CUL5, CUL3, CSRP3 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| LDHD, CAND1, CUL5, CUL3, CSRP3 (tumor) | LDHD, CAND1, CUL5, CUL3, CSRP3 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| LDHD, CAND1, CUL5, CUL3, CSRP3 (tumor) | LDHD, CAND1, CUL5, CUL3, CSRP3 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| LDHD, CAND1, CUL5, CUL3, CSRP3 (tumor) | LDHD, CAND1, CUL5, CUL3, CSRP3 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| LDHD, CAND1, CUL5, CUL3, CSRP3 (tumor) | LDHD, CAND1, CUL5, CUL3, CSRP3 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| LDHD, CAND1, CUL5, CUL3, CSRP3 (tumor) | LDHD, CAND1, CUL5, CUL3, CSRP3 (normal) |
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| THCA (tumor) | THCA (normal) |
| LDHD, CAND1, CUL5, CUL3, CSRP3 (tumor) | LDHD, CAND1, CUL5, CUL3, CSRP3 (normal) |
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| TissGeneProg for LDHD |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for LDHD |
| TissGeneDrug for LDHD |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for LDHD |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0699790 | Colon Carcinoma | 57 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 52 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 35 | BeFree |
| umls:C1527249 | Colorectal Cancer | 26 | BeFree |
| umls:C1319315 | Adenocarcinoma of large intestine | 4 | BeFree |
| umls:C0032580 | Adenomatous Polyposis Coli | 3 | BeFree |
| umls:C0338106 | Adenocarcinoma of colon | 3 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0268193 | NADH cytochrome B5 reductase deficiency | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 1 | BeFree |
| umls:C0014522 | Epidermodysplasia Verruciformis | 1 | BeFree |
| umls:C0016057 | Fibrosarcoma | 1 | BeFree |
| umls:C0024776 | Maple Syrup Urine Disease | 1 | BeFree |
| umls:C0025517 | Metabolic Diseases | 1 | BeFree |
| umls:C0026827 | Muscle hypotonia | 1 | BeFree |
| umls:C0032584 | polyps | 1 | BeFree |
| umls:C0085110 | Severe Combined Immunodeficiency | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0268120 | Adenine phosphoribosyltransferase deficiency | 1 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0948380 | Colorectal cancer metastatic | 1 | BeFree |
| umls:C1333084 | Colon Neuroendocrine Tumor G1 | 1 | BeFree |
| umls:C3665382 | 2,8-Dihydroxyadenine Urolithiasis | 1 | BeFree |
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