TissGeneSummary for A2M |
Gene summary |
Basic gene information | Gene symbol | A2M |
Gene name | alpha-2-macroglobulin | |
Synonyms | A2MD|CPAMD5|FWP007|S863-7 | |
Cytomap | UCSC genome browser: 12p13.31 | |
Type of gene | protein-coding | |
RefGenes | NM_000014.4, | |
Description | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5alpha-2-M | |
Modification date | 20141207 | |
dbXrefs | MIM : 103950 | |
HGNC : HGNC | ||
Ensembl : ENSG00000175899 | ||
HPRD : 00072 | ||
Vega : OTTHUMG00000150267 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_A2M | |
BioGPS: 2 | ||
Pathway | NCI Pathway Interaction Database: A2M | |
KEGG: A2M | ||
REACTOME: A2M | ||
Pathway Commons: A2M | ||
Context | iHOP: A2M | |
ligand binding site mutation search in PubMed: A2M | ||
UCL Cancer Institute: A2M | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverLung | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCLUAD,LUSC | |
Reference showing the relevant tissue of A2M | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0001869 | negative regulation of complement activation, lectin pathway | 12538697 | GO:0010951 | negative regulation of endopeptidase activity | 12538697 | GO:0001869 | negative regulation of complement activation, lectin pathway | 12538697 | GO:0010951 | negative regulation of endopeptidase activity | 12538697 |
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TissGeneExp for A2M |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BLCA | 0.530510443 | 3.289015706 | -2.758505263 | 3.37E-09 | 4.23E-07 |
KIRP | 0.9232912 | 2.235719325 | -1.312428125 | 4.55E-09 | 3.74E-08 |
LIHC | 3.838597075 | 5.097181075 | -1.258584 | 8.03E-06 | 3.48E-05 |
LUAD | 2.408551006 | 4.289064799 | -1.880513793 | 1.65E-19 | 3.06E-18 |
COAD | 0.566478459 | 1.753651536 | -1.187173077 | 5.05E-06 | 2.47E-05 |
KICH | 1.063463075 | 2.196391075 | -1.132928 | 4.42E-07 | 1.78E-06 |
BRCA | 1.59441132 | 2.964670092 | -1.370258772 | 1.10E-32 | 1.70E-31 |
LUSC | 1.163616016 | 4.711182682 | -3.547566667 | 4.18E-27 | 1.21E-25 |
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TissGene-miRNA for A2M |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for A2M |
TissGeneSNV for A2M |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R147C | SKCM | 4 |
p.R1031Q | SKCM | 3 |
p.E184K | SKCM | 2 |
p.P36S | SKCM | 2 |
p.E1311K | SKCM | 2 |
p.E153K | SKCM | 2 |
p.G1084R | BLCA | 1 |
p.L1067I | LUSC | 1 |
p.Q1425* | BRCA | 1 |
p.R147C | BLCA | 1 |
p.F229L | STAD | 1 |
p.E197D | STAD | 1 |
p.G27E | SKCM | 1 |
p.P1306Q | KIRC | 1 |
p.S785P | LUAD | 1 |
p.K289T | UCEC | 1 |
p.P29_splice | LUSC | 1 |
p.D282N | SKCM | 1 |
p.D638N | SARC | 1 |
p.R1034S | LUAD | 1 |
p.W739* | SKCM | 1 |
p.I1000V | COAD | 1 |
p.G952E | SKCM | 1 |
p.H446N | STAD | 1 |
p.R1401I | COAD | 1 |
p.R117W | READ | 1 |
p.P799S | SKCM | 1 |
p.P631T | LIHC | 1 |
p.P92T | LUAD | 1 |
p.S63F | SKCM | 1 |
p.R1122H | BLCA | 1 |
p.H1259R | LGG | 1 |
p.N867Y | KIRP | 1 |
p.G69R | SKCM | 1 |
p.E125D | LUAD | 1 |
p.S923L | SKCM | 1 |
p.M713K | HNSC | 1 |
p.A833T | PRAD | 1 |
p.D636N | SKCM | 1 |
p.V551M | PAAD | 1 |
p.Y970* | BLCA | 1 |
p.F352S | SKCM | 1 |
p.C1321Y | UCEC | 1 |
p.G632R | SKCM | 1 |
p.L311P | UCEC | 1 |
p.P799L | COAD | 1 |
p.K1240N | COAD | 1 |
p.A1201D | LUAD | 1 |
p.H156Y | SKCM | 1 |
p.D953G | LUAD | 1 |
p.F1028V | STAD | 1 |
p.E342K | SKCM | 1 |
p.G1094V | HNSC | 1 |
p.L1471F | SKCM | 1 |
p.D1139E | UCEC | 1 |
p.F1430L | KIRP | 1 |
p.L621P | BLCA | 1 |
p.F1248L | UCEC | 1 |
p.D626G | STAD | 1 |
p.R1031X | STAD | 1 |
p.I481S | HNSC | 1 |
p.E886K | LUAD | 1 |
p.R586* | BRCA | 1 |
p.A850V | THYM | 1 |
p.A807V | THYM | 1 |
p.L19P | BLCA | 1 |
p.L1217V | BLCA | 1 |
p.F572L | HNSC | 1 |
p.R719C | LGG | 1 |
p.S66F | SKCM | 1 |
p.S1249F | SKCM | 1 |
p.L1016F | ESCA | 1 |
p.M1314I | UCEC | 1 |
p.T757I | LUAD | 1 |
p.N1413K | STAD | 1 |
p.F229S | COAD | 1 |
p.P140Q | STAD | 1 |
p.N1038T | STAD | 1 |
p.E1198K | SKCM | 1 |
p.K456R | GBM | 1 |
p.R804P | LGG | 1 |
p.E1462K | SKCM | 1 |
p.Q1051H | LIHC | 1 |
p.Q1252_splice | LUSC | 1 |
p.F1049L | LIHC | 1 |
p.T411S | PCPG | 1 |
p.G47S | SARC | 1 |
p.E113Q | BLCA | 1 |
p.T728M | UCEC | 1 |
p.A88T | COAD | 1 |
p.S136X | STAD | 1 |
p.R732Q | STAD | 1 |
p.E65X | ESCA | 1 |
p.A1108T | ESCA | 1 |
p.G141R | LUAD | 1 |
p.W739X | SKCM | 1 |
p.R147H | UCEC | 1 |
p.G1141D | STAD | 1 |
p.S617L | READ | 1 |
p.F495L | ESCA | 1 |
p.L965R | UCEC | 1 |
p.S351A | TGCT | 1 |
p.I1091V | GBM | 1 |
p.P227T | ESCA | 1 |
p.N159Y | UCEC | 1 |
p.P936T | ESCA | 1 |
p.I481N | SKCM | 1 |
p.P529H | UCEC | 1 |
p.L77V | BLCA | 1 |
p.S571R | KIRP | 1 |
p.A176T | UCEC | 1 |
p.A1043T | UCEC | 1 |
p.E1030K | THYM | 1 |
p.S782C | LUSC | 1 |
p.S136* | STAD | 1 |
p.I650F | LUAD | 1 |
p.F385L | STAD | 1 |
p.T1285I | LUAD | 1 |
p.R719H | STAD | 1 |
p.F452L | COAD | 1 |
p.K1162* | HNSC | 1 |
p.E160* | LUAD | 1 |
p.G1310W | LUAD | 1 |
p.K271N | UCEC | 1 |
p.M713I | SKCM | 1 |
p.R147H | THCA | 1 |
p.R117Q | LUAD | 1 |
p.R174H | LUAD | 1 |
p.A1061V | KIRC | 1 |
p.S575* | BLCA | 1 |
p.S525F | SKCM | 1 |
p.Q1220H | STAD | 1 |
p.S94F | LIHC | 1 |
p.E113* | UCEC | 1 |
p.L772M | READ | 1 |
p.C48R | STAD | 1 |
p.M121V | CESC | 1 |
p.F365L | LUSC | 1 |
p.E1137Q | BLCA | 1 |
p.A176T | COAD | 1 |
p.P759T | LUAD | 1 |
p.G69E | DLBC | 1 |
p.D638E | KIRC | 1 |
p.A1215T | STAD | 1 |
p.I984S | LGG | 1 |
p.Y425* | BRCA | 1 |
p.Q284H | UCEC | 1 |
p.G1029V | COAD | 1 |
p.Y1055C | BRCA | 1 |
p.Y1463C | UCS | 1 |
p.D1441E | STAD | 1 |
p.T885A | LUSC | 1 |
p.S801F | SKCM | 1 |
p.L1324I | LUAD | 1 |
p.D1353E | LUAD | 1 |
p.R174H | THYM | 1 |
p.T1064A | COAD | 1 |
p.P380Q | BRCA | 1 |
p.E881* | LUAD | 1 |
p.F495V | ESCA | 1 |
p.F155I | SKCM | 1 |
p.S614L | SKCM | 1 |
p.I175F | SKCM | 1 |
p.L835I | OV | 1 |
p.R174H | UCEC | 1 |
p.R823Q | STAD | 1 |
p.Q310* | BLCA | 1 |
p.M121I | LUSC | 1 |
p.E842Q | SARC | 1 |
p.M1385T | STAD | 1 |
p.R1053* | SKCM | 1 |
p.M713I | STAD | 1 |
p.A23T | STAD | 1 |
p.G714R | SKCM | 1 |
p.I1091T | LUAD | 1 |
p.D1420N | HNSC | 1 |
p.P163S | UCEC | 1 |
p.Q302E | CESC | 1 |
p.S1102C | LUAD | 1 |
p.R645H | LGG | 1 |
p.E184D | BLCA | 1 |
p.Y138* | CHOL | 1 |
p.S276F | SKCM | 1 |
p.V1396M | READ | 1 |
p.Q1074K | READ | 1 |
p.V207L | CESC | 1 |
p.P838T | KIRP | 1 |
p.Y1104D | SARC | 1 |
p.A749S | LIHC | 1 |
p.R174C | COAD | 1 |
p.S660R | KIRC | 1 |
p.G894R | PCPG | 1 |
p.T1229S | LUSC | 1 |
p.V723D | LUAD | 1 |
p.I409M | BLCA | 1 |
p.D897H | BLCA | 1 |
p.S1002Y | COAD | 1 |
p.R1031* | STAD | 1 |
p.L13I | UCEC | 1 |
p.S1304L | SKCM | 1 |
p.T548I | UCEC | 1 |
p.G1138E | HNSC | 1 |
p.A1090T | STAD | 1 |
p.Q132* | SKCM | 1 |
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TissGeneCNV for A2M |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for A2M |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | DB150819 | TUBB4B-A2M | chr9:140136997 | chr12:9246089 | |
Chimerdb3.0 | ChiTaRs | NA | BF923332 | LOC100128682-A2M | chr19:35897573 | chr12:9221369 | |
Chimerdb3.0 | ChiTaRs | NA | W90454 | A2M-AFMID | chr12:9247627 | chr17:76203648 | |
Chimerdb3.0 | ChiTaRs | NA | AA804941 | A2M-A2M | chr12:9230419 | chr12:9230399 | |
Chimerdb3.0 | ChiTaRs | NA | BF849872 | A2M-EPN2 | chr12:9246176 | chr17:19184805 | |
Chimerdb3.0 | ChiTaRs | NA | BF880179 | A2M-A2M | chr12:9248289 | chr12:9251205 | |
TCGAfusionPortal | PRADA | KIRC | TCGA-B4-5378-01A | A2M-FAR1 | NA | Chr12:9220308 | Chr11:13744912 |
TCGAfusionPortal | PRADA | LUAD | TCGA-97-7941-01A | A2M-ARFGEF2 | 3UTR-CDS | Chr12:9220308 | Chr20:47615777 |
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TissGeneNet for A2M |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for A2M |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for A2M |
TissGeneDrug for A2M |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for A2M |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002395 | Alzheimer's Disease | 26 | BeFree,CTD_human,GAD,LHGDN |
umls:C0010674 | Cystic Fibrosis | 5 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 4 | BeFree |
umls:C0600139 | Prostate carcinoma | 4 | BeFree |
umls:C2239176 | Liver carcinoma | 4 | BeFree,CTD_human,RGD |
umls:C0024115 | Lung diseases | 3 | BeFree,CTD_human |
umls:C0025202 | melanoma | 3 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 3 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 2 | BeFree,GAD |
umls:C0011570 | Mental Depression | 2 | BeFree |
umls:C0023903 | Liver neoplasms | 2 | BeFree |
umls:C0024117 | Chronic Obstructive Airway Disease | 2 | BeFree |
umls:C0024121 | Lung Neoplasms | 2 | CTD_human |
umls:C0026769 | Multiple Sclerosis | 2 | BeFree,LHGDN |
umls:C0027051 | Myocardial Infarction | 2 | GAD,LHGDN |
umls:C0027726 | Nephrotic Syndrome | 2 | BeFree,CTD_human,RGD |
umls:C0029408 | Degenerative polyarthritis | 2 | BeFree |
umls:C0034067 | Pulmonary Emphysema | 2 | BeFree |
umls:C0221757 | alpha 1-Antitrypsin Deficiency | 2 | BeFree |
umls:C0243026 | Sepsis | 2 | RGD |
umls:C0333463 | Senile Plaques | 2 | BeFree |
umls:C0524851 | Neurodegenerative Disorders | 2 | BeFree |
umls:C2936349 | Plaque, Amyloid | 2 | BeFree |
umls:C3501835 | alpha-1-Antitrypsin Deficiency, Autosomal Recessive | 2 | BeFree |
umls:C0002726 | Amyloidosis | 1 | GAD,LHGDN |
umls:C0002878 | Anemia, Hemolytic | 1 | RGD |
umls:C0003864 | Arthritis | 1 | GAD |
umls:C0004114 | Astrocytoma | 1 | BeFree |
umls:C0009375 | Colonic Neoplasms | 1 | CTD_human |
umls:C0011847 | Diabetes | 1 | BeFree |
umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
umls:C0014072 | Experimental Autoimmune Encephalomyelitis | 1 | RGD |
umls:C0015814 | Femur Head Necrosis | 1 | RGD |
umls:C0015967 | Fever | 1 | RGD |
umls:C0017665 | Membranous glomerulonephritis | 1 | RGD |
umls:C0018800 | Cardiomegaly | 1 | RGD |
umls:C0019202 | Hepatolenticular Degeneration | 1 | CTD_human |
umls:C0021368 | Inflammation | 1 | RGD |
umls:C0022578 | Keratoconus | 1 | BeFree |
umls:C0023827 | liposarcoma | 1 | BeFree |
umls:C0023890 | Liver Cirrhosis | 1 | GAD |
umls:C0027430 | Nasal Polyps | 1 | BeFree |
umls:C0030305 | Pancreatitis | 1 | LHGDN |
umls:C0030567 | Parkinson Disease | 1 | GAD |
umls:C0031154 | Peritonitis | 1 | RGD |
umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
umls:C0036983 | Septic Shock | 1 | RGD |
umls:C0038454 | Cerebrovascular accident | 1 | BeFree |
umls:C0040038 | Thromboembolism | 1 | BeFree,LHGDN |
umls:C0041227 | Trypanosomiasis | 1 | RGD |
umls:C0042024 | Urinary Incontinence | 1 | LHGDN |
umls:C0085220 | Cerebral Amyloid Angiopathy | 1 | BeFree |
umls:C0149871 | Deep Vein Thrombosis | 1 | BeFree |
umls:C0151950 | Deep thrombophlebitis | 1 | BeFree |
umls:C0153690 | Secondary malignant neoplasm of bone | 1 | BeFree |
umls:C0206669 | Hepatocellular Adenoma | 1 | CTD_human,RGD |
umls:C0238096 | Embolism, Paradoxical | 1 | BeFree |
umls:C0239981 | Hypoalbuminemia | 1 | BeFree,RGD |
umls:C0242383 | Age related macular degeneration | 1 | GAD |
umls:C0338460 | Argyrophilic grain disease | 1 | GAD |
umls:C0340708 | Deep vein thrombosis of lower limb | 1 | BeFree |
umls:C0398623 | Thrombophilia | 1 | BeFree |
umls:C0524910 | Hepatitis C, Chronic | 1 | GAD |
umls:C0600260 | Lung Diseases, Obstructive | 1 | BeFree |
umls:C0746102 | Chronic lung disease | 1 | BeFree |
umls:C0752347 | Lewy Body Disease | 1 | BeFree |
umls:C0853897 | Diabetic Cardiomyopathies | 1 | RGD |
umls:C0948008 | Ischemic stroke | 1 | BeFree |
umls:C0993582 | Arthritis, Experimental | 1 | RGD |
umls:C1704272 | Benign Prostatic Hyperplasia | 1 | BeFree |
umls:C1842937 | AURAL ATRESIA, CONGENITAL | 1 | BeFree |
umls:C2609414 | Acute kidney injury | 1 | CTD_human |
umls:C2937421 | Prostatic Hyperplasia | 1 | LHGDN |
umls:C3272363 | Ischemic Cerebrovascular Accident | 1 | BeFree |
umls:C3279661 | alpha-2-Macroglobulin Deficiency | 1 | BeFree |