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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for A2M
check button Gene summary
Basic gene informationGene symbolA2M
Gene namealpha-2-macroglobulin
SynonymsA2MD|CPAMD5|FWP007|S863-7
CytomapUCSC genome browser: 12p13.31
Type of geneprotein-coding
RefGenesNM_000014.4,
DescriptionC3 and PZP-like alpha-2-macroglobulin domain-containing protein 5alpha-2-M
Modification date20141207
dbXrefs MIM : 103950
HGNC : HGNC
Ensembl : ENSG00000175899
HPRD : 00072
Vega : OTTHUMG00000150267
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_A2M
BioGPS: 2
PathwayNCI Pathway Interaction Database: A2M
KEGG: A2M
REACTOME: A2M
Pathway Commons: A2M
ContextiHOP: A2M
ligand binding site mutation search in PubMed: A2M
UCL Cancer Institute: A2M
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)LiverLung
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHCLUAD,LUSC
Reference showing the relevant tissue of A2M
Description by TissGene annotationsTissgsLTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0001869negative regulation of complement activation, lectin pathway12538697
GO:0010951negative regulation of endopeptidase activity12538697
GO:0001869negative regulation of complement activation, lectin pathway12538697
GO:0010951negative regulation of endopeptidase activity12538697


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TissGeneExp for A2M

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
BLCA0.5305104433.289015706-2.7585052633.37E-094.23E-07
KIRP0.92329122.235719325-1.3124281254.55E-093.74E-08
LIHC3.8385970755.097181075-1.2585848.03E-063.48E-05
LUAD2.4085510064.289064799-1.8805137931.65E-193.06E-18
COAD0.5664784591.753651536-1.1871730775.05E-062.47E-05
KICH1.0634630752.196391075-1.1329284.42E-071.78E-06
BRCA1.594411322.964670092-1.3702587721.10E-321.70E-31
LUSC1.1636160164.711182682-3.5475666674.18E-271.21E-25


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TissGene-miRNA for A2M

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for A2M
TissGeneSNV for A2M

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R147CSKCM4
p.R1031QSKCM3
p.E184KSKCM2
p.P36SSKCM2
p.E1311KSKCM2
p.E153KSKCM2
p.G1084RBLCA1
p.L1067ILUSC1
p.Q1425*BRCA1
p.R147CBLCA1
p.F229LSTAD1
p.E197DSTAD1
p.G27ESKCM1
p.P1306QKIRC1
p.S785PLUAD1
p.K289TUCEC1
p.P29_spliceLUSC1
p.D282NSKCM1
p.D638NSARC1
p.R1034SLUAD1
p.W739*SKCM1
p.I1000VCOAD1
p.G952ESKCM1
p.H446NSTAD1
p.R1401ICOAD1
p.R117WREAD1
p.P799SSKCM1
p.P631TLIHC1
p.P92TLUAD1
p.S63FSKCM1
p.R1122HBLCA1
p.H1259RLGG1
p.N867YKIRP1
p.G69RSKCM1
p.E125DLUAD1
p.S923LSKCM1
p.M713KHNSC1
p.A833TPRAD1
p.D636NSKCM1
p.V551MPAAD1
p.Y970*BLCA1
p.F352SSKCM1
p.C1321YUCEC1
p.G632RSKCM1
p.L311PUCEC1
p.P799LCOAD1
p.K1240NCOAD1
p.A1201DLUAD1
p.H156YSKCM1
p.D953GLUAD1
p.F1028VSTAD1
p.E342KSKCM1
p.G1094VHNSC1
p.L1471FSKCM1
p.D1139EUCEC1
p.F1430LKIRP1
p.L621PBLCA1
p.F1248LUCEC1
p.D626GSTAD1
p.R1031XSTAD1
p.I481SHNSC1
p.E886KLUAD1
p.R586*BRCA1
p.A850VTHYM1
p.A807VTHYM1
p.L19PBLCA1
p.L1217VBLCA1
p.F572LHNSC1
p.R719CLGG1
p.S66FSKCM1
p.S1249FSKCM1
p.L1016FESCA1
p.M1314IUCEC1
p.T757ILUAD1
p.N1413KSTAD1
p.F229SCOAD1
p.P140QSTAD1
p.N1038TSTAD1
p.E1198KSKCM1
p.K456RGBM1
p.R804PLGG1
p.E1462KSKCM1
p.Q1051HLIHC1
p.Q1252_spliceLUSC1
p.F1049LLIHC1
p.T411SPCPG1
p.G47SSARC1
p.E113QBLCA1
p.T728MUCEC1
p.A88TCOAD1
p.S136XSTAD1
p.R732QSTAD1
p.E65XESCA1
p.A1108TESCA1
p.G141RLUAD1
p.W739XSKCM1
p.R147HUCEC1
p.G1141DSTAD1
p.S617LREAD1
p.F495LESCA1
p.L965RUCEC1
p.S351ATGCT1
p.I1091VGBM1
p.P227TESCA1
p.N159YUCEC1
p.P936TESCA1
p.I481NSKCM1
p.P529HUCEC1
p.L77VBLCA1
p.S571RKIRP1
p.A176TUCEC1
p.A1043TUCEC1
p.E1030KTHYM1
p.S782CLUSC1
p.S136*STAD1
p.I650FLUAD1
p.F385LSTAD1
p.T1285ILUAD1
p.R719HSTAD1
p.F452LCOAD1
p.K1162*HNSC1
p.E160*LUAD1
p.G1310WLUAD1
p.K271NUCEC1
p.M713ISKCM1
p.R147HTHCA1
p.R117QLUAD1
p.R174HLUAD1
p.A1061VKIRC1
p.S575*BLCA1
p.S525FSKCM1
p.Q1220HSTAD1
p.S94FLIHC1
p.E113*UCEC1
p.L772MREAD1
p.C48RSTAD1
p.M121VCESC1
p.F365LLUSC1
p.E1137QBLCA1
p.A176TCOAD1
p.P759TLUAD1
p.G69EDLBC1
p.D638EKIRC1
p.A1215TSTAD1
p.I984SLGG1
p.Y425*BRCA1
p.Q284HUCEC1
p.G1029VCOAD1
p.Y1055CBRCA1
p.Y1463CUCS1
p.D1441ESTAD1
p.T885ALUSC1
p.S801FSKCM1
p.L1324ILUAD1
p.D1353ELUAD1
p.R174HTHYM1
p.T1064ACOAD1
p.P380QBRCA1
p.E881*LUAD1
p.F495VESCA1
p.F155ISKCM1
p.S614LSKCM1
p.I175FSKCM1
p.L835IOV1
p.R174HUCEC1
p.R823QSTAD1
p.Q310*BLCA1
p.M121ILUSC1
p.E842QSARC1
p.M1385TSTAD1
p.R1053*SKCM1
p.M713ISTAD1
p.A23TSTAD1
p.G714RSKCM1
p.I1091TLUAD1
p.D1420NHNSC1
p.P163SUCEC1
p.Q302ECESC1
p.S1102CLUAD1
p.R645HLGG1
p.E184DBLCA1
p.Y138*CHOL1
p.S276FSKCM1
p.V1396MREAD1
p.Q1074KREAD1
p.V207LCESC1
p.P838TKIRP1
p.Y1104DSARC1
p.A749SLIHC1
p.R174CCOAD1
p.S660RKIRC1
p.G894RPCPG1
p.T1229SLUSC1
p.V723DLUAD1
p.I409MBLCA1
p.D897HBLCA1
p.S1002YCOAD1
p.R1031*STAD1
p.L13IUCEC1
p.S1304LSKCM1
p.T548IUCEC1
p.G1138EHNSC1
p.A1090TSTAD1
p.Q132*SKCM1


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TissGeneCNV for A2M

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for A2M

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNADB150819TUBB4B-A2Mchr9:140136997chr12:9246089
Chimerdb3.0ChiTaRsNABF923332LOC100128682-A2Mchr19:35897573chr12:9221369
Chimerdb3.0ChiTaRsNAW90454A2M-AFMIDchr12:9247627chr17:76203648
Chimerdb3.0ChiTaRsNAAA804941A2M-A2Mchr12:9230419chr12:9230399
Chimerdb3.0ChiTaRsNABF849872A2M-EPN2chr12:9246176chr17:19184805
Chimerdb3.0ChiTaRsNABF880179A2M-A2Mchr12:9248289chr12:9251205
TCGAfusionPortalPRADAKIRCTCGA-B4-5378-01AA2M-FAR1NAChr12:9220308Chr11:13744912
TCGAfusionPortalPRADALUADTCGA-97-7941-01AA2M-ARFGEF23UTR-CDSChr12:9220308Chr20:47615777


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TissGeneNet for A2M

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
A2M, CTSB, CYP2C18, NOS3, MMP2, TGFB1, MYOC, PAXIP1, B2M, LYZ, TGM2, LRP1, GZMA, PDGFB, RAP1B, RPP14, ANXA6, IFIT3, IL10, LEP, TGFBI (tumor)A2M, TP63, GEM, FGF2, NOS3, MMP2, TGFB1, MYOC, PRAM1, LYZ, TGM2, LRP1, GZMA, PDGFA, NGF, ADAMTS1, TGFB2, IL6, LCAT, ADAM19, LEP (normal)
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COAD (tumor)COAD (normal)
A2M, UFD1L, CDKN1A, CDC42, LGALS3, HMOX2, FGF2, NOS3, MMP2, B2M, LRP1, GZMA, PDGFB, NGF, RAP1B, MGEA5, ANXA6, LCAT, NCDN, ELAVL3, TGFBI (tumor)A2M, APOE, CTSB, ELANE, GEM, FGF2, MMP2, TGFB1, MYOC, PRAM1, TGM2, LRP1, PDGFB, NGF, ADAMTS1, TGFB2, ANXA6, IL10, ADAM19, LEP, ELAVL3 (normal)
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HNSC (tumor)HNSC (normal)
A2M, TP63, TK1, APOE, CYP2C18, APP, FGF2, NOS3, MMP2, PRAM1, HSPA5, TGM2, PDGFA, PDGFB, NGF, H2AFX, ADAMTS1, TGFB2, ANXA6, UMPS, KLK13 (tumor)A2M, APOE, TNFRSF14, ELANE, GEM, FGF2, PITX3, NOS3, MMP2, MYOC, PRAM1, LYZ, TGM2, LRP1, PDGFB, ADAMTS1, TGFB2, ANXA6, IL10, UMPS, ADAM19 (normal)
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KICH (tumor)KICH (normal)
A2M, UFD1L, ANXA7, PRDX2, ELANE, MMP2, TGFB1, PRAM1, ECSIT, TGM2, LRP1, C11orf58, GZMA, TGFB2, RPP14, PAEP, ADAM19, MLST8, TRAPPC5, CTSE, TGFBI (tumor)A2M, TSC22D1, TNF, NOS3, MMP2, PRAM1, B2M, LYZ, TGM2, FARSA, PDGFB, NGF, ADAMTS1, GCDH, IL1B, IFIT5, IL10, IL6, NCDN, ADAM19, TGFBI (normal)
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KIRC (tumor)KIRC (normal)
A2M, PRDX2, GEM, MMP2, TGFB1, PRAM1, ECSIT, B2M, LYZ, TGM2, LRP1, GZMA, NGF, ADAMTS1, GCDH, TGFB2, RPP14, IL10, ADAM19, MLST8, TGFBI (tumor)A2M, MAST1, APP, GEM, SHBG, NOS3, MMP2, TGFB1, LRP1, PDGFB, RHEB, NGF, KLK3, ADAMTS1, GCDH, TGFB2, IFIT5, ANXA6, SEPT8, ADAM19, MLST8 (normal)
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KIRP (tumor)KIRP (normal)
A2M, TP63, GRB2, CTSB, CYP2C18, PRDX2, ELANE, GEM, MMP2, TGFB1, NUDT21, LYZ, LRP1, GZMA, NGF, ANXA6, AMBP, IL10, CELA1, ADAM19, TGFBI (tumor)A2M, APOE, CTSB, LGALS3, NOS3, MMP2, TGFB1, PRAM1, B2M, LYZ, LRP1, GZMA, PDGFB, NGF, IL1B, IL8, IL10, IL6, CELA1, ADAM19, TGFBI (normal)
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LIHC (tumor)LIHC (normal)
A2M, CTSB, LGALS3, SHBG, TNF, FGF2, MMP2, TGFB1, MYOC, B2M, LYZ, C11orf58, GZMA, RAP1B, IL1B, MGEA5, RAD23A, ANXA6, IFIT3, IL10, NCDN (tumor)A2M, UFD1L, TK1, APOE, LGALS3, GEM, SHBG, NOS3, MMP2, TGFB1, PAXIP1, HSPA5, TGM2, CPB2, GZMA, RNF32, NGF, ADAMTS1, AMBP, IL6, ADAM19 (normal)
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LUAD (tumor)LUAD (normal)
A2M, APOE, TNFRSF14, LGALS3, APP, GEM, SHBG, FGF2, NOS3, MMP2, MYOC, TGM2, LRP1, FARSA, PDGFB, CDK2AP2, ADAMTS1, TGFB2, ANXA6, EXOSC1, SEPT8 (tumor)A2M, UFD1L, TK1, ELANE, FGF2, MMP2, TGFB1, MYOC, PRAM1, LYZ, TGM2, CPB2, LRP1, PDGFB, RHEB, H2AFX, ADAMTS1, ANXA6, IL10, UMPS, CTSE (normal)
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LUSC (tumor)LUSC (normal)
A2M, LGALS3, APP, TNF, FGF2, NOS3, MMP2, TGFB1, IL2, TGM2, LRP1, C11orf58, RHEB, ADAMTS1, RPP14, ANXA6, EXOSC1, NCDN, SEPT8, CYP2C8, TRAPPC5 (tumor)A2M, TK1, APOE, TNFRSF14, ELANE, GEM, NOS3, MMP2, PRAM1, B2M, LYZ, TGM2, CPB2, LRP1, H2AFX, TGFB2, RAD23A, ANXA6, IL10, ADAM19, CTSE (normal)
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PRAD (tumor)PRAD (normal)
A2M, APOE, ELANE, GEM, FGF2, NOS3, MMP2, LYZ, HSPA5, TGM2, LRP1, FARSA, GZMA, PDGFB, CDK2AP2, TGFB2, ANXA6, IL10, ADAM19, MLST8, TGFBI (tumor)A2M, APOE, CTSB, ELANE, GEM, FGF2, NOS3, MMP2, TGFB1, MYOC, LYZ, LRP1, GZMA, PDGFB, NGF, ADAMTS1, TGFB2, ANXA6, IL10, ADAM19, TGFBI (normal)
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STAD (tumor)STAD (normal)
A2M, TSC22D1, APP, ELANE, GEM, HMOX2, FGF2, NOS3, MMP2, TGM2, PDGFB, NGF, ADAMTS1, TGFB2, ANXA6, LONP1, LCAT, UMPS, NCDN, ADAM19, TGFBI (tumor)A2M, TK1, ELANE, GEM, FGF2, NOS3, MMP2, TGFB1, MYOC, PRAM1, TGM2, LRP1, NGF, H2AFX, ADAMTS1, TGFB2, ANXA6, IL10, UMPS, ADAM19, TGFBI (normal)
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THCA (tumor)THCA (normal)
A2M, TP63, GRB2, TK1, APOE, TNFRSF14, TNF, NOS3, TGFB1, PRAM1, B2M, LYZ, TGM2, C11orf58, GZMA, PDGFB, IFIT3, IL10, UMPS, ADAM19, TGFBI (tumor)A2M, APOE, LGALS3, APP, GEM, PITX3, NOS3, MMP2, TGFB1, MYOC, HSPA5, TGIF1, GZMA, PDGFA, PDGFB, NGF, ADAMTS1, ANXA6, IL10, LONP1, ADAM19 (normal)
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TissGeneProg for A2M

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for A2M
TissGeneDrug for A2M

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for A2M

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0002395Alzheimer's Disease26BeFree,CTD_human,GAD,LHGDN
umls:C0010674Cystic Fibrosis5BeFree
umls:C0376358Malignant neoplasm of prostate4BeFree
umls:C0600139Prostate carcinoma4BeFree
umls:C2239176Liver carcinoma4BeFree,CTD_human,RGD
umls:C0024115Lung diseases3BeFree,CTD_human
umls:C0025202melanoma3BeFree
umls:C0027627Neoplasm Metastasis3BeFree
umls:C0003873Rheumatoid Arthritis2BeFree,GAD
umls:C0011570Mental Depression2BeFree
umls:C0023903Liver neoplasms2BeFree
umls:C0024117Chronic Obstructive Airway Disease2BeFree
umls:C0024121Lung Neoplasms2CTD_human
umls:C0026769Multiple Sclerosis2BeFree,LHGDN
umls:C0027051Myocardial Infarction2GAD,LHGDN
umls:C0027726Nephrotic Syndrome2BeFree,CTD_human,RGD
umls:C0029408Degenerative polyarthritis2BeFree
umls:C0034067Pulmonary Emphysema2BeFree
umls:C0221757alpha 1-Antitrypsin Deficiency2BeFree
umls:C0243026Sepsis2RGD
umls:C0333463Senile Plaques2BeFree
umls:C0524851Neurodegenerative Disorders2BeFree
umls:C2936349Plaque, Amyloid2BeFree
umls:C3501835alpha-1-Antitrypsin Deficiency, Autosomal Recessive2BeFree
umls:C0002726Amyloidosis1GAD,LHGDN
umls:C0002878Anemia, Hemolytic1RGD
umls:C0003864Arthritis1GAD
umls:C0004114Astrocytoma1BeFree
umls:C0009375Colonic Neoplasms1CTD_human
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0014072Experimental Autoimmune Encephalomyelitis1RGD
umls:C0015814Femur Head Necrosis1RGD
umls:C0015967Fever1RGD
umls:C0017665Membranous glomerulonephritis1RGD
umls:C0018800Cardiomegaly1RGD
umls:C0019202Hepatolenticular Degeneration1CTD_human
umls:C0021368Inflammation1RGD
umls:C0022578Keratoconus1BeFree
umls:C0023827liposarcoma1BeFree
umls:C0023890Liver Cirrhosis1GAD
umls:C0027430Nasal Polyps1BeFree
umls:C0030305Pancreatitis1LHGDN
umls:C0030567Parkinson Disease1GAD
umls:C0031154Peritonitis1RGD
umls:C0033578Prostatic Neoplasms1LHGDN
umls:C0036983Septic Shock1RGD
umls:C0038454Cerebrovascular accident1BeFree
umls:C0040038Thromboembolism1BeFree,LHGDN
umls:C0041227Trypanosomiasis1RGD
umls:C0042024Urinary Incontinence1LHGDN
umls:C0085220Cerebral Amyloid Angiopathy1BeFree
umls:C0149871Deep Vein Thrombosis1BeFree
umls:C0151950Deep thrombophlebitis1BeFree
umls:C0153690Secondary malignant neoplasm of bone1BeFree
umls:C0206669Hepatocellular Adenoma1CTD_human,RGD
umls:C0238096Embolism, Paradoxical1BeFree
umls:C0239981Hypoalbuminemia1BeFree,RGD
umls:C0242383Age related macular degeneration1GAD
umls:C0338460Argyrophilic grain disease1GAD
umls:C0340708Deep vein thrombosis of lower limb1BeFree
umls:C0398623Thrombophilia1BeFree
umls:C0524910Hepatitis C, Chronic1GAD
umls:C0600260Lung Diseases, Obstructive1BeFree
umls:C0746102Chronic lung disease1BeFree
umls:C0752347Lewy Body Disease1BeFree
umls:C0853897Diabetic Cardiomyopathies1RGD
umls:C0948008Ischemic stroke1BeFree
umls:C0993582Arthritis, Experimental1RGD
umls:C1704272Benign Prostatic Hyperplasia1BeFree
umls:C1842937AURAL ATRESIA, CONGENITAL1BeFree
umls:C2609414Acute kidney injury1CTD_human
umls:C2937421Prostatic Hyperplasia1LHGDN
umls:C3272363Ischemic Cerebrovascular Accident1BeFree
umls:C3279661alpha-2-Macroglobulin Deficiency1BeFree