TissGeneSummary for SPAG17 |
Gene summary |
Basic gene information | Gene symbol | SPAG17 |
Gene name | sperm associated antigen 17 | |
Synonyms | CT143|PF6 | |
Cytomap | UCSC genome browser: 1p12 | |
Type of gene | protein-coding | |
RefGenes | NM_206996.2, | |
Description | projection protein PF6 homologsperm-associated antigen 17 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000155761 | ||
HPRD : 10146 | ||
Vega : OTTHUMG00000012198 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SPAG17 | |
BioGPS: 200162 | ||
Pathway | NCI Pathway Interaction Database: SPAG17 | |
KEGG: SPAG17 | ||
REACTOME: SPAG17 | ||
Pathway Commons: SPAG17 | ||
Context | iHOP: SPAG17 | |
ligand binding site mutation search in PubMed: SPAG17 | ||
UCL Cancer Institute: SPAG17 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCTGCT | |
Reference showing the relevant tissue of SPAG17 | ||
Description by TissGene annotations | Cancer gene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SPAG17 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.098252512 | 1.469487488 | -2.56774 | 1.48E-07 | 6.59E-07 |
HNSC | 0.544506744 | 2.049564883 | -1.50505814 | 0.0037 | 0.010471698 |
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TissGene-miRNA for SPAG17 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SPAG17 |
TissGeneSNV for SPAG17 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E851K | SKCM | 4 |
p.E594K | SKCM | 4 |
p.G1400E | SKCM | 3 |
p.M652I | BLCA | 2 |
p.G1651R | SKCM | 2 |
p.E1205K | SKCM | 2 |
p.E1946K | SKCM | 2 |
p.K540N | BLCA | 2 |
p.H1368Y | SKCM | 2 |
p.E1054K | SKCM | 2 |
p.E1080K | SKCM | 2 |
p.P1315T | LUAD | 1 |
p.Q1592_splice | GBM | 1 |
p.G2054E | SKCM | 1 |
p.L1104F | READ | 1 |
p.L487F | SKCM | 1 |
p.W940* | SKCM | 1 |
p.L1714R | SKCM | 1 |
p.P1211L | SKCM | 1 |
p.D1436Y | LUAD | 1 |
p.K148N | BLCA | 1 |
p.S2005Y | LUAD | 1 |
p.V807F | LUAD | 1 |
p.W940X | SKCM | 1 |
p.P1586S | LUSC | 1 |
p.H1373Y | LUSC | 1 |
p.T1855K | LUAD | 1 |
p.W558X | SKCM | 1 |
p.E1250K | BLCA | 1 |
p.P1586S | SKCM | 1 |
p.P790Q | PAAD | 1 |
p.Q1677* | SKCM | 1 |
p.P1425H | LGG | 1 |
p.R2218C | COAD | 1 |
p.F1959S | GBM | 1 |
p.L1916W | LUAD | 1 |
p.L1191P | LUAD | 1 |
p.R427G | STAD | 1 |
p.N304Y | STAD | 1 |
p.E1564Q | CESC | 1 |
p.R62H | READ | 1 |
p.C1505S | COAD | 1 |
p.S1041F | ESCA | 1 |
p.K1747E | DLBC | 1 |
p.I348T | SKCM | 1 |
p.G1407V | GBM | 1 |
p.C492Y | COAD | 1 |
p.W558* | SKCM | 1 |
p.L736P | HNSC | 1 |
p.A1522S | BRCA | 1 |
p.S15Y | COAD | 1 |
p.Q1767P | SKCM | 1 |
p.E1479D | LIHC | 1 |
p.K1871N | READ | 1 |
p.S1724L | SKCM | 1 |
p.I900M | UCEC | 1 |
p.T294S | LGG | 1 |
p.Y810H | STAD | 1 |
p.F560C | UCEC | 1 |
p.K893I | GBM | 1 |
p.E1670X | COAD | 1 |
p.A288V | LIHC | 1 |
p.P2116Q | DLBC | 1 |
p.P1684L | LUSC | 1 |
p.V247M | UCEC | 1 |
p.K127X | COAD | 1 |
p.W1719X | SKCM | 1 |
p.E187K | CESC | 1 |
p.E995Q | BLCA | 1 |
p.R1881C | READ | 1 |
p.P715S | SKCM | 1 |
p.E1409V | KIRC | 1 |
p.P1733L | SKCM | 1 |
p.D1413Y | READ | 1 |
p.N974S | HNSC | 1 |
p.E949K | LUAD | 1 |
p.E611V | ESCA | 1 |
p.D808N | BLCA | 1 |
p.M1825I | THYM | 1 |
p.F1868L | UCS | 1 |
p.R828K | LUAD | 1 |
p.K1084R | STAD | 1 |
p.R143* | LGG | 1 |
p.M826I | LUSC | 1 |
p.G622A | GBM | 1 |
p.D1077N | SKCM | 1 |
p.S1785F | SKCM | 1 |
p.E2137K | SARC | 1 |
p.S275L | BLCA | 1 |
p.S1999F | READ | 1 |
p.P930S | SKCM | 1 |
p.S1936F | SKCM | 1 |
p.L1664I | UCEC | 1 |
p.R2188Q | SKCM | 1 |
p.L1608M | ESCA | 1 |
p.E512K | SKCM | 1 |
p.R472K | BLCA | 1 |
p.Q1487K | CESC | 1 |
p.M1901V | READ | 1 |
p.Q1897* | HNSC | 1 |
p.M369I | HNSC | 1 |
p.E1201D | BRCA | 1 |
p.T2013N | OV | 1 |
p.V1166F | GBM | 1 |
p.T1896A | STAD | 1 |
p.L1305I | UCEC | 1 |
p.P2117L | CESC | 1 |
p.L1603S | LUSC | 1 |
p.S88L | SKCM | 1 |
p.A2065S | ESCA | 1 |
p.R62C | UCEC | 1 |
p.E147K | SKCM | 1 |
p.A396V | LGG | 1 |
p.N708D | BRCA | 1 |
p.H502Y | SKCM | 1 |
p.I1390R | LGG | 1 |
p.A839V | COAD | 1 |
p.M1573I | BLCA | 1 |
p.D1474N | SKCM | 1 |
p.S21P | LIHC | 1 |
p.Q858K | PAAD | 1 |
p.A1379V | UCEC | 1 |
p.S982F | SKCM | 1 |
p.E1979Q | CESC | 1 |
p.D357N | UCEC | 1 |
p.E1095K | LUSC | 1 |
p.V1439D | UCEC | 1 |
p.P1733L | KICH | 1 |
p.A1817T | LUSC | 1 |
p.E1194Q | LUAD | 1 |
p.V1383L | HNSC | 1 |
p.F584C | BLCA | 1 |
p.E1942Q | CESC | 1 |
p.L272F | HNSC | 1 |
p.S1953F | COAD | 1 |
p.S1419F | SKCM | 1 |
p.E765Q | BLCA | 1 |
p.Y1558X | COAD | 1 |
p.M321K | HNSC | 1 |
p.T245N | ACC | 1 |
p.G1515E | SKCM | 1 |
p.A92T | SKCM | 1 |
p.E1720K | SKCM | 1 |
p.K1084N | SKCM | 1 |
p.K1267N | HNSC | 1 |
p.Q649E | HNSC | 1 |
p.Y431D | DLBC | 1 |
p.K1112N | COAD | 1 |
p.I1520T | LUAD | 1 |
p.K1822E | UCEC | 1 |
p.Q723L | LUSC | 1 |
p.K957T | COAD | 1 |
p.H448Y | LGG | 1 |
p.T1855M | COAD | 1 |
p.N78S | LUAD | 1 |
p.E1884Q | BLCA | 1 |
p.E1215K | SKCM | 1 |
p.K957N | BLCA | 1 |
p.N1941S | KIRC | 1 |
p.S871Y | UCEC | 1 |
p.T1846I | SKCM | 1 |
p.F1868L | UCEC | 1 |
p.P1978L | SKCM | 1 |
p.A2V | PAAD | 1 |
p.S1419C | BRCA | 1 |
p.G1138A | LUAD | 1 |
p.D716H | STAD | 1 |
p.E1100A | KIRC | 1 |
p.D1983Y | CESC | 1 |
p.S1340Y | LUAD | 1 |
p.E1831K | SKCM | 1 |
p.K2122E | BLCA | 1 |
p.C1511F | LUSC | 1 |
p.Q1475* | LUSC | 1 |
p.E1206D | STAD | 1 |
p.C1549* | UCEC | 1 |
p.K1562R | LUSC | 1 |
p.P568Q | LUSC | 1 |
p.C492F | LIHC | 1 |
p.M654I | HNSC | 1 |
p.D1424G | STAD | 1 |
p.Q1950R | PRAD | 1 |
p.E2090K | SKCM | 1 |
p.V1639D | GBM | 1 |
p.P2174T | READ | 1 |
p.Q61R | STAD | 1 |
p.E1093Q | BLCA | 1 |
p.E1706K | THYM | 1 |
p.D115N | SKCM | 1 |
p.R1492W | PAAD | 1 |
p.P1167S | UCEC | 1 |
p.E1270Q | LUSC | 1 |
p.H841Y | SKCM | 1 |
p.L49V | HNSC | 1 |
p.E1215D | READ | 1 |
p.Y1269* | SKCM | 1 |
p.G1588E | SKCM | 1 |
p.K984N | COAD | 1 |
p.M652L | BRCA | 1 |
p.D477H | HNSC | 1 |
p.M826I | SKCM | 1 |
p.W1719* | SKCM | 1 |
p.R946X | READ | 1 |
p.D613N | BLCA | 1 |
p.R946X | STAD | 1 |
p.R437* | UCEC | 1 |
p.S252L | SKCM | 1 |
p.K1562R | GBM | 1 |
p.G98C | MESO | 1 |
p.E1479K | READ | 1 |
p.E580K | BLCA | 1 |
p.E865X | COAD | 1 |
p.D184N | SKCM | 1 |
p.R200Q | HNSC | 1 |
p.Q1240H | COAD | 1 |
p.A34V | BRCA | 1 |
p.R946Q | READ | 1 |
p.P1586H | LUSC | 1 |
p.K1885N | READ | 1 |
p.K772N | STAD | 1 |
p.E309K | BLCA | 1 |
p.L937H | LUAD | 1 |
p.G519C | LUAD | 1 |
p.S888T | BRCA | 1 |
p.S906P | DLBC | 1 |
p.R1259H | PRAD | 1 |
p.L2079I | LGG | 1 |
p.G1043E | LUAD | 1 |
p.R1715W | COAD | 1 |
p.A238T | BLCA | 1 |
p.H483N | HNSC | 1 |
p.D1334Y | STAD | 1 |
p.L371H | LIHC | 1 |
p.S1133L | READ | 1 |
p.S368T | LUAD | 1 |
p.V1165L | LIHC | 1 |
p.R1656* | LUAD | 1 |
p.R946* | STAD | 1 |
p.L1900Q | LUAD | 1 |
p.R1715L | HNSC | 1 |
p.E923D | COAD | 1 |
p.P1712L | SKCM | 1 |
p.N1504S | SKCM | 1 |
p.S1878F | SKCM | 1 |
p.S778G | COAD | 1 |
p.P1211T | LUAD | 1 |
p.M873I | SKCM | 1 |
p.T1938K | LUAD | 1 |
p.Q376* | PRAD | 1 |
p.T1274M | DLBC | 1 |
p.E1812K | UCEC | 1 |
p.I1073M | BRCA | 1 |
p.S368I | LUSC | 1 |
p.E1832K | ESCA | 1 |
p.I289M | GBM | 1 |
p.P715A | LUSC | 1 |
p.N2184S | BLCA | 1 |
p.Q1030E | HNSC | 1 |
p.K1355N | THCA | 1 |
p.R1410I | READ | 1 |
p.P1197T | LUAD | 1 |
p.K1858R | STAD | 1 |
p.E1185K | SKCM | 1 |
p.R670K | BLCA | 1 |
p.A1843T | STAD | 1 |
p.A530T | STAD | 1 |
p.D1648N | SKCM | 1 |
p.S1577L | SKCM | 1 |
p.L831S | CESC | 1 |
p.Q657* | SKCM | 1 |
p.D1445H | PRAD | 1 |
p.E1678G | PAAD | 1 |
p.A238T | STAD | 1 |
p.P308H | LGG | 1 |
p.K403N | READ | 1 |
p.Q1677X | SKCM | 1 |
p.V1773D | KIRP | 1 |
p.V1579I | SKCM | 1 |
p.P410S | STAD | 1 |
p.V1172L | BLCA | 1 |
p.Y1571F | LIHC | 1 |
p.Y1269X | SKCM | 1 |
p.A1667T | LUAD | 1 |
p.H1389Y | SKCM | 1 |
p.D1150N | SKCM | 1 |
p.T577I | LUAD | 1 |
p.L312F | UCEC | 1 |
p.T1876I | HNSC | 1 |
p.R437X | COAD | 1 |
p.M352L | LUSC | 1 |
p.S2042Y | UCEC | 1 |
p.P1760L | LIHC | 1 |
p.S1971G | LGG | 1 |
p.W1254* | LUAD | 1 |
p.P566L | SKCM | 1 |
p.T1396A | SKCM | 1 |
p.H1631N | ACC | 1 |
p.N1401T | LIHC | 1 |
p.R1486K | LUAD | 1 |
p.I1709S | READ | 1 |
p.W296* | LUSC | 1 |
p.E1506Q | LUAD | 1 |
p.P231S | STAD | 1 |
p.D1099A | READ | 1 |
p.L1714I | UCEC | 1 |
p.G2120R | SKCM | 1 |
p.K290Q | READ | 1 |
p.I113V | UCEC | 1 |
p.L720Q | GBM | 1 |
p.R946* | SKCM | 1 |
p.Q795R | STAD | 1 |
p.P544S | SKCM | 1 |
p.C1510S | LUSC | 1 |
p.K876N | KIRC | 1 |
p.E291Q | COAD | 1 |
p.K1369* | LUAD | 1 |
p.T310K | HNSC | 1 |
p.H1360P | LIHC | 1 |
p.N1076H | COAD | 1 |
p.E1152K | LUSC | 1 |
p.S987L | BLCA | 1 |
p.L937H | KICH | 1 |
p.R1563C | UCEC | 1 |
p.R689G | BLCA | 1 |
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TissGeneCNV for SPAG17 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SPAG17 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BQ429818 | SPAG17-NDUFV2 | chr1:118640816 | chr18:9126067 | |
TCGAfusionPortal | PRADA | BRCA | TCGA-A7-A2KD-01A | MAGI3-SPAG17 | In-frame | Chr1:113933971 | Chr1:118550821 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A8-A07L-01A | GDAP2-SPAG17 | 5UTR-CDS | Chr1:118472071 | Chr1:118539366 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AC-A5XU-01A | CERS4-SPAG17 | 5UTR-CDS | Chr19:8275746 | Chr1:118550821 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A1AU-01A | SPAG17-PCF11 | In-frame | Chr1:118727694 | Chr11:82872369 |
TCGAfusionPortal | PRADA | BRCA | TCGA-E9-A1NI-01A | SPAG17-RABGAP1L | In-frame | Chr1:118693166 | Chr1:174926594 |
TCGAfusionPortal | PRADA | HNSC | TCGA-CQ-7065-01A | NOTCH2-SPAG17 | In-frame | Chr1:120611948 | Chr1:118524024 |
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TissGeneNet for SPAG17 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SPAG17 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SPAG17 |
TissGeneDrug for SPAG17 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SPAG17 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0010346 | Crohn Disease | 1 | GAD |
umls:C0013336 | Dwarfism | 1 | BeFree |
umls:C0018273 | Growth Disorders | 1 | GAD |
umls:C0040136 | Thyroid Neoplasm | 1 | GAD |
umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |