TissGeneSummary for C3orf67 |
Gene summary |
Basic gene information | Gene symbol | C3orf67 |
Gene name | chromosome 3 open reading frame 67 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 3p14.2 | |
Type of gene | protein-coding | |
RefGenes | NM_198463.2, | |
Description | uncharacterized protein C3orf67 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000163689 | ||
HPRD : 13458 | ||
Vega : OTTHUMG00000159151 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C3orf67 | |
BioGPS: 200844 | ||
Pathway | NCI Pathway Interaction Database: C3orf67 | |
KEGG: C3orf67 | ||
REACTOME: C3orf67 | ||
Pathway Commons: C3orf67 | ||
Context | iHOP: C3orf67 | |
ligand binding site mutation search in PubMed: C3orf67 | ||
UCL Cancer Institute: C3orf67 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C3orf67 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C3orf67 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 1.825850543 | -0.946139653 | 2.771990196 | 8.63E-20 | 9.87E-19 |
KICH | -1.987354869 | -0.026102869 | -1.961252 | 1.47E-06 | 5.42E-06 |
BLCA | 1.52995271 | -1.605926237 | 3.135878947 | 1.12E-06 | 3.61E-05 |
BRCA | 1.006234289 | -0.743918342 | 1.750152632 | 3.11E-27 | 3.46E-26 |
LUAD | 0.798657338 | -0.911527144 | 1.710184483 | 5.16E-10 | 2.84E-09 |
KIRC | 1.681569743 | -0.163644146 | 1.845213889 | 1.66E-23 | 1.75E-22 |
KIRP | 1.307455506 | -0.476956994 | 1.7844125 | 2.79E-07 | 1.56E-06 |
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TissGene-miRNA for C3orf67 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C3orf67 |
TissGeneSNV for C3orf67 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P222L | GBM | 1 |
p.R97H | DLBC | 1 |
p.R125W | GBM | 1 |
p.R480H | STAD | 1 |
p.S171P | PAAD | 1 |
p.E301X | THYM | 1 |
p.T272I | UCEC | 1 |
p.S312N | SKCM | 1 |
p.D3N | BLCA | 1 |
p.I6S | KIRC | 1 |
p.I44F | COAD | 1 |
p.A566S | CESC | 1 |
p.R119K | BLCA | 1 |
p.D320N | COAD | 1 |
p.R97C | UCEC | 1 |
p.N46H | LGG | 1 |
p.L223I | BLCA | 1 |
p.P494S | THYM | 1 |
p.L381I | UCEC | 1 |
p.L309V | LUAD | 1 |
p.Q341R | COAD | 1 |
p.M486I | SKCM | 1 |
p.L548V | BLCA | 1 |
p.R125W | ESCA | 1 |
p.E98K | BLCA | 1 |
p.P359S | LIHC | 1 |
p.A210T | LUAD | 1 |
p.S66L | SKCM | 1 |
p.T94A | STAD | 1 |
p.S68C | BLCA | 1 |
p.E436D | STAD | 1 |
p.R76Q | GBM | 1 |
p.R516H | GBM | 1 |
p.R147L | LUAD | 1 |
p.R90Q | LIHC | 1 |
p.E537K | HNSC | 1 |
p.H213Y | SKCM | 1 |
p.D58H | SKCM | 1 |
p.N234D | READ | 1 |
p.G226S | BLCA | 1 |
p.E534V | LUAD | 1 |
p.R516C | COAD | 1 |
p.D464N | READ | 1 |
p.K23R | COAD | 1 |
p.S519F | SKCM | 1 |
p.T82A | STAD | 1 |
p.E250K | SKCM | 1 |
p.E263Q | CESC | 1 |
p.E250A | SKCM | 1 |
p.N385D | COAD | 1 |
p.V456I | KIRP | 1 |
p.S91P | PAAD | 1 |
p.R97L | READ | 1 |
p.S361X | STAD | 1 |
p.Q526* | SKCM | 1 |
p.P512L | PAAD | 1 |
p.F116L | COAD | 1 |
p.R97C | GBM | 1 |
p.Q483K | ESCA | 1 |
p.I318M | PRAD | 1 |
p.S301L | SKCM | 1 |
p.R97S | CHOL | 1 |
p.P300L | BRCA | 1 |
p.F355L | UCEC | 1 |
p.T18S | KIRC | 1 |
p.R360Q | GBM | 1 |
p.P198S | SKCM | 1 |
p.Q478K | ESCA | 1 |
p.P174T | UCEC | 1 |
p.R495W | LAML | 1 |
p.S361* | STAD | 1 |
p.S219N | SKCM | 1 |
p.R150K | LUAD | 1 |
p.H133Y | SKCM | 1 |
p.E242Q | BLCA | 1 |
p.R170Q | LIHC | 1 |
p.P491S | SKCM | 1 |
p.D68N | SKCM | 1 |
p.P266S | LIHC | 1 |
p.R39K | BLCA | 1 |
p.R42W | UCEC | 1 |
p.P638L | PAAD | 1 |
p.R70K | LUAD | 1 |
p.G400S | CESC | 1 |
p.Q424H | STAD | 1 |
p.G319S | BLCA | 1 |
p.H444R | HNSC | 1 |
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TissGeneCNV for C3orf67 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C3orf67 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | KIRC | TCGA-BP-4961-01A | MAP1B-C3orf67 | Out-of-frame | Chr5:71411626 | Chr3:58739590 |
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TissGeneNet for C3orf67 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C3orf67 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C3orf67 |
TissGeneDrug for C3orf67 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C3orf67 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0018799 | Heart Diseases | 1 | GAD |