TissGeneSummary for LIPH |
Gene summary |
Basic gene information | Gene symbol | LIPH |
Gene name | lipase, member H | |
Synonyms | AH|ARWH2|HYPT7|LAH2|LPDLR|PLA1B|mPA-PLA1 | |
Cytomap | UCSC genome browser: 3q27 | |
Type of gene | protein-coding | |
RefGenes | NM_139248.2, | |
Description | LPD lipase-related proteinlipase Hlipase member HmPA-PLA1 alphamembrane-associated phosphatidic acid-selective phospholipase A1-alphamembrane-bound phosphatidic acid-selective phospholipase A1phospholipase A1 member B | |
Modification date | 20141207 | |
dbXrefs | MIM : 607365 | |
HGNC : HGNC | ||
Ensembl : ENSG00000163898 | ||
HPRD : 07392 | ||
Vega : OTTHUMG00000156657 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_LIPH | |
BioGPS: 200879 | ||
Pathway | NCI Pathway Interaction Database: LIPH | |
KEGG: LIPH | ||
REACTOME: LIPH | ||
Pathway Commons: LIPH | ||
Context | iHOP: LIPH | |
ligand binding site mutation search in PubMed: LIPH | ||
UCL Cancer Institute: LIPH | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonStomach | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADSTAD | |
Reference showing the relevant tissue of LIPH | ||
Description by TissGene annotations | Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0016042 | lipid catabolic process | 12963729 | GO:0016042 | lipid catabolic process | 12963729 |
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TissGeneExp for LIPH |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 0.200554769 | 2.634327318 | -2.433772549 | 1.68E-12 | 7.55E-12 |
KIRC | -2.883345312 | 1.922450521 | -4.805795833 | 5.94E-24 | 6.43E-23 |
THCA | 1.760798638 | -4.215614921 | 5.976413559 | 1.05E-26 | 2.91E-24 |
KIRP | -0.301721701 | 1.426562674 | -1.728284375 | 0.000337 | 0.001032178 |
KICH | 0.232286299 | 2.083130299 | -1.850844 | 6.68E-05 | 0.000181091 |
HNSC | -0.171498445 | 1.460280624 | -1.63177907 | 3.57E-05 | 0.000178104 |
COAD | 2.698435991 | 3.832251376 | -1.133815385 | 2.56E-05 | 0.000106432 |
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TissGene-miRNA for LIPH |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-let-7c-5p | MIMAT0000064 | 0.0067 | -0.31 | 78 |
ACC | hsa-let-7c-5p | MIMAT0000064 | 0.0067 | -0.31 | 78 |
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TissGeneMut for LIPH |
TissGeneSNV for LIPH |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M413I | SKCM | 3 |
p.S60* | BLCA | 2 |
p.M313I | SKCM | 1 |
p.T348I | SKCM | 1 |
p.S400F | SKCM | 1 |
p.V98G | KIRC | 1 |
p.I335S | PAAD | 1 |
p.H205N | LUSC | 1 |
p.D304Y | LGG | 1 |
p.W302X | SKCM | 1 |
p.A267T | STAD | 1 |
p.S258F | SKCM | 1 |
p.R352T | LUSC | 1 |
p.F134C | COAD | 1 |
p.R412Q | READ | 1 |
p.D310E | SKCM | 1 |
p.S262N | UCEC | 1 |
p.Q371X | SKCM | 1 |
p.G161E | LUAD | 1 |
p.E435K | SKCM | 1 |
p.P188H | UCEC | 1 |
p.E215K | UCEC | 1 |
p.K350T | CESC | 1 |
p.M129I | LUAD | 1 |
p.T320S | LIHC | 1 |
p.Y5X | THYM | 1 |
p.W338* | SKCM | 1 |
p.C281R | CESC | 1 |
p.D168N | OV | 1 |
p.W302* | SKCM | 1 |
p.H374P | SKCM | 1 |
p.S97F | BLCA | 1 |
p.K132E | UCEC | 1 |
p.G308W | LIHC | 1 |
p.G142X | COAD | 1 |
p.P311S | SKCM | 1 |
p.W338X | SKCM | 1 |
p.W338G | SKCM | 1 |
p.G279V | LUSC | 1 |
p.S287P | LIHC | 1 |
p.L39V | OV | 1 |
p.P269H | ESCA | 1 |
p.D107A | COAD | 1 |
p.Q371* | SKCM | 1 |
p.D89N | UCS | 1 |
p.F62L | SKCM | 1 |
p.F184L | ESCA | 1 |
p.S121C | CESC | 1 |
p.D229H | BLCA | 1 |
p.R352K | SKCM | 1 |
p.M150T | UCEC | 1 |
p.G218I | LUAD | 1 |
p.T37M | STAD | 1 |
p.W338X | KIRC | 1 |
p.K245N | STAD | 1 |
p.Q425* | BLCA | 1 |
p.G186W | COAD | 1 |
p.G152R | UCEC | 1 |
p.D221Y | UCEC | 1 |
p.G218R | LUAD | 1 |
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TissGeneCNV for LIPH |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for LIPH |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF375146 | RPS27A-LIPH | chr2:55462629 | chr3:185232431 | |
Chimerdb3.0 | ChiTaRs | NA | AA102322 | LIPH-LIPH | chr3:185252589 | chr3:185236937 |
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TissGeneNet for LIPH |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for LIPH |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for LIPH |
TissGeneDrug for LIPH |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for LIPH |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020678 | Hypotrichosis | 15 | BeFree,CTD_human,LHGDN |
umls:C1836672 | Total Hypotrichosis, Mari type | 10 | BeFree,CLINVAR,UNIPROT |
umls:C3502073 | Woolly Hair, Autosomal Recessive | 9 | BeFree |
umls:C0343073 | Wooly hair | 6 | BeFree,ORPHANET |
umls:C1854310 | Hypotrichosis simplex | 4 | BeFree,ORPHANET |
umls:C0345427 | Woolly hair, congenital | 2 | BeFree,CTD_human,ORPHANET |
umls:C3148823 | WOOLLY HAIR, AUTOSOMAL RECESSIVE 2, WITH OR WITHOUT HYPOTRICHOSIS | 0 | CLINVAR |