TissGeneSummary for FBXO15 |
Gene summary |
Basic gene information | Gene symbol | FBXO15 |
Gene name | F-box protein 15 | |
Synonyms | FBX15 | |
Cytomap | UCSC genome browser: 18q22.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001142958.1, NM_152676.2, | |
Description | F-box only protein 15 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609093 | |
HGNC : HGNC | ||
Ensembl : ENSG00000141665 | ||
HPRD : 16435 | ||
Vega : OTTHUMG00000132842 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FBXO15 | |
BioGPS: 201456 | ||
Pathway | NCI Pathway Interaction Database: FBXO15 | |
KEGG: FBXO15 | ||
REACTOME: FBXO15 | ||
Pathway Commons: FBXO15 | ||
Context | iHOP: FBXO15 | |
ligand binding site mutation search in PubMed: FBXO15 | ||
UCL Cancer Institute: FBXO15 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FBXO15 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FBXO15 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -0.399885828 | 0.953086585 | -1.352972414 | 1.88E-05 | 5.31E-05 |
THCA | -0.654638312 | 1.189298976 | -1.843937288 | 2.59E-17 | 5.07E-16 |
LUSC | -0.69393336 | 0.740282326 | -1.434215686 | 1.57E-05 | 3.50E-05 |
LIHC | -1.92430238 | -0.55669238 | -1.36761 | 2.54E-09 | 2.55E-08 |
KICH | -2.27567038 | 1.65565362 | -3.931324 | 2.29E-19 | 1.40E-17 |
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TissGene-miRNA for FBXO15 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FBXO15 |
TissGeneSNV for FBXO15 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S373L | SKCM | 4 |
p.E410K | SKCM | 2 |
p.A93T | HNSC | 1 |
p.S329L | CESC | 1 |
p.W335X | SKCM | 1 |
p.D338N | HNSC | 1 |
p.Q17H | ESCA | 1 |
p.V352I | STAD | 1 |
p.P108S | SKCM | 1 |
p.Y153H | STAD | 1 |
p.D268N | SKCM | 1 |
p.Y255H | UCEC | 1 |
p.P450H | UCEC | 1 |
p.P368S | SKCM | 1 |
p.W154C | LUSC | 1 |
p.V109G | STAD | 1 |
p.H295Y | UCEC | 1 |
p.V150A | LUAD | 1 |
p.I420K | LIHC | 1 |
p.H317D | GBM | 1 |
p.K425I | ESCA | 1 |
p.E128X | READ | 1 |
p.V185G | STAD | 1 |
p.P444L | THYM | 1 |
p.N197Y | LUAD | 1 |
p.K155E | SKCM | 1 |
p.S280C | OV | 1 |
p.S119* | BRCA | 1 |
p.R303I | COAD | 1 |
p.P368L | THYM | 1 |
p.I406F | STAD | 1 |
p.G507W | LUSC | 1 |
p.N315S | LIHC | 1 |
p.P158L | SKCM | 1 |
p.S11F | SKCM | 1 |
p.W53* | SKCM | 1 |
p.A424T | ESCA | 1 |
p.M136I | SKCM | 1 |
p.L489I | LUSC | 1 |
p.K271M | UCEC | 1 |
p.G385V | BLCA | 1 |
p.H281Y | SKCM | 1 |
p.S456N | UCEC | 1 |
p.F266L | COAD | 1 |
p.Y229H | STAD | 1 |
p.G121C | PAAD | 1 |
p.W53* | HNSC | 1 |
p.P108S | BLCA | 1 |
p.Y134H | STAD | 1 |
p.K155N | UCEC | 1 |
p.R297C | PAAD | 1 |
p.N397Y | DLBC | 1 |
p.K208Q | UCEC | 1 |
p.R372K | SKCM | 1 |
p.H30N | ESCA | 1 |
p.E357X | READ | 1 |
p.A500T | ESCA | 1 |
p.E150* | UCEC | 1 |
p.F55L | SKCM | 1 |
p.S66F | CESC | 1 |
p.S367F | SKCM | 1 |
p.E232K | SKCM | 1 |
p.S3L | ESCA | 1 |
p.S267C | LUSC | 1 |
p.G197C | PAAD | 1 |
p.G284C | THYM | 1 |
p.S79L | ESCA | 1 |
p.L74P | BRCA | 1 |
p.R373C | PAAD | 1 |
p.S51L | SKCM | 1 |
p.E209* | UCEC | 1 |
p.Y210H | STAD | 1 |
p.V428I | STAD | 1 |
p.K501I | ESCA | 1 |
p.G15C | COAD | 1 |
p.D341N | SKCM | 1 |
p.G359E | SKCM | 1 |
p.D338V | LIHC | 1 |
p.W335* | SKCM | 1 |
p.C440G | LUSC | 1 |
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TissGeneCNV for FBXO15 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FBXO15 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AA906172 | CNN2-FBXO15 | chr19:1039062 | chr18:71813133 | |
TCGAfusionPortal | PRADA | LGG | TCGA-CS-6666-01A | ZBTB7C-FBXO15 | NA | Chr18:45864545 | Chr18:71740965 |
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TissGeneNet for FBXO15 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FBXO15 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FBXO15 |
TissGeneDrug for FBXO15 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FBXO15 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0032285 | Pneumonia | 1 | BeFree |