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| TissGeneSummary for EMX2 |
 Gene summary |
| Basic gene information | Gene symbol | EMX2 |
| Gene name | empty spiracles homeobox 2 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 10q26.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001165924.1, NM_004098.3, | |
| Description | empty spiracles homolog 2empty spiracles-like protein 2homeobox protein EMX2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600035 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000170370 | ||
| HPRD : 02495 | ||
| Vega : OTTHUMG00000019123 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_EMX2 | |
| BioGPS: 2018 | ||
| Pathway | NCI Pathway Interaction Database: EMX2 | |
| KEGG: EMX2 | ||
| REACTOME: EMX2 | ||
| Pathway Commons: EMX2 | ||
| Context | iHOP: EMX2 | |
| ligand binding site mutation search in PubMed: EMX2 | ||
| UCL Cancer Institute: EMX2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyUterus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHUCEC,UCS | |
| Reference showing the relevant tissue of EMX2 | ||
| Description by TissGene annotations | Protective TissGene in OS Protective TissGene in RFS Have significant anti-correlated miRNA Fused withOncogene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for EMX2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | 0.286364797 | 1.717025323 | -1.430660526 | 1.12E-15 | 6.10E-15 |
| PRAD | -1.824503658 | 1.294969419 | -3.119473077 | 4.51E-08 | 4.66E-07 |
| KICH | 5.338546726 | 6.569182726 | -1.230636 | 0.0141 | 0.024585759 |
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| TissGene-miRNA for EMX2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-302c-3p.2 | 0.0071 | -0.31 | 78 | |
| ACC | hsa-miR-302c-3p.2 | 0.0071 | -0.31 | 78 | |
| ACC | hsa-miR-301a-3p | MIMAT0000688 | 0.0038 | -0.33 | 78 |
| ACC | hsa-miR-301a-3p | MIMAT0000688 | 0.0038 | -0.33 | 78 |
| UCS | hsa-miR-19b-3p | MIMAT0000074 | 0.014 | -0.33 | 56 |
| UCS | hsa-miR-19a-3p | MIMAT0000073 | 0.0043 | -0.38 | 56 |
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| TissGeneMut for EMX2 |
| TissGeneSNV for EMX2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E183X | ESCA | 1 |
| p.R156Q | LUAD | 1 |
| p.Q197E | HNSC | 1 |
| p.L150Q | LUAD | 1 |
| p.A241V | STAD | 1 |
| p.K208N | SARC | 1 |
| p.Q135K | LUAD | 1 |
| p.N80T | TGCT | 1 |
| p.D220Y | LGG | 1 |
| p.A93T | STAD | 1 |
| p.E142D | READ | 1 |
| p.I236N | UCEC | 1 |
| p.S104L | HNSC | 1 |
| p.G218R | SKCM | 1 |
| p.A160T | READ | 1 |
| p.P116L | SKCM | 1 |
| p.E215G | BRCA | 1 |
| p.G62D | PAAD | 1 |
| p.L130M | LGG | 1 |
| p.E142K | PRAD | 1 |
| p.S111L | HNSC | 1 |
| p.D166Y | LUAD | 1 |
| p.A160T | ESCA | 1 |
| p.T228M | COAD | 1 |
| p.S111L | LUAD | 1 |
| p.E216G | COAD | 1 |
| p.Q186X | THYM | 1 |
| p.A172T | PRAD | 1 |
| p.R156W | STAD | 1 |
| p.S111* | STAD | 1 |
| p.190_191SL>RI | LUAD | 1 |
| p.R233Q | UCEC | 1 |
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| TissGeneCNV for EMX2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for EMX2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-94-7557-01A | PTEN-EMX2 | Out-of-Frame | chr10:89653866 | chr10:119305142 |
| Chimerdb3.0 | TopHat-Fusion | OV | TCGA-13-1409-01A | EMX2OS-EMX2 | 3'UTR-3'UTR | chr10:119302373 | chr10:119308258 |
| Chimerdb3.0 | TopHat-Fusion | OV | TCGA-25-1627-01A | EMX2OS-EMX2 | 3'UTR-3'UTR | chr10:119302663 | chr10:119308706 |
| Chimerdb3.0 | TopHat-Fusion | OV | TCGA-04-1519-01A | EMX2OS-EMX2 | 3'UTR-3'UTR | chr10:119303076 | chr10:119307821 |
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| TissGeneNet for EMX2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (tumor) | EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (normal) |
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| COAD (tumor) | COAD (normal) |
| EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (tumor) | EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (tumor) | EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (normal) |
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| KICH (tumor) | KICH (normal) |
| EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (tumor) | EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (tumor) | EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (tumor) | EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (tumor) | EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (tumor) | EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (tumor) | EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (tumor) | EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (normal) |
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| STAD (tumor) | STAD (normal) |
| EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (tumor) | EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (normal) |
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| THCA (tumor) | THCA (normal) |
| EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (tumor) | EMX2, TLE2, GTF2A1L, MEIS1, EIF4E, HOXA10 (normal) |
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| TissGeneProg for EMX2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for EMX2 |
| TissGeneDrug for EMX2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for EMX2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0266484 | Schizencephaly | 6 | BeFree,CLINVAR,GAD,ORPHANET |
| umls:C0596263 | Carcinogenesis | 6 | BeFree |
| umls:C0000768 | Congenital Abnormality | 2 | BeFree |
| umls:C0007103 | Malignant neoplasm of endometrium | 2 | BeFree |
| umls:C0014175 | Endometriosis | 2 | BeFree,GAD,LHGDN |
| umls:C0476089 | Endometrial Carcinoma | 2 | BeFree |
| umls:C1883486 | Uterine Corpus Cancer | 2 | BeFree |
| umls:C2931870 | Familial schizencephaly | 2 | BeFree,CTD_human |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0005586 | Bipolar Disorder | 1 | BeFree |
| umls:C0007120 | Bronchioloalveolar Adenocarcinoma | 1 | BeFree |
| umls:C0011570 | Mental Depression | 1 | GAD |
| umls:C0024121 | Lung Neoplasms | 1 | CTD_human |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0036875 | Disorders of Sex Development | 1 | BeFree |
| umls:C0042580 | Vesico-Ureteral Reflux | 1 | BeFree |
| umls:C0042755 | Virilism | 1 | BeFree |
| umls:C0149654 | Conduct Disorder | 1 | GAD |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0178879 | Urinary tract obstruction | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0266449 | Congenital anomaly of brain | 1 | BeFree |
| umls:C0431380 | Cortical Dysplasia | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0812413 | Malignant Pleural Mesothelioma | 1 | BeFree |
| umls:C0848558 | Hypospadias | 1 | BeFree |
| umls:C1520166 | Xenograft Model | 1 | BeFree |
| umls:C1691215 | Penile hypospadias | 1 | BeFree |
| umls:C1720887 | Female Urogenital Diseases | 1 | CTD_human |
| umls:C2112532 | Postmenopausal endometrium | 1 | BeFree |
| umls:C2930619 | Sex Differentiation Disorders | 1 | BeFree |
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