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| TissGeneSummary for DNAJC18 |
 Gene summary |
| Basic gene information | Gene symbol | DNAJC18 |
| Gene name | DnaJ (Hsp40) homolog, subfamily C, member 18 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 5q31.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_152686.3, | |
| Description | dnaJ homolog subfamily C member 18 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000170464 | ||
| HPRD : 07130 | ||
| Vega : OTTHUMG00000129225 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DNAJC18 | |
| BioGPS: 202052 | ||
| Pathway | NCI Pathway Interaction Database: DNAJC18 | |
| KEGG: DNAJC18 | ||
| REACTOME: DNAJC18 | ||
| Pathway Commons: DNAJC18 | ||
| Context | iHOP: DNAJC18 | |
| ligand binding site mutation search in PubMed: DNAJC18 | ||
| UCL Cancer Institute: DNAJC18 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of DNAJC18 | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for DNAJC18 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| STAD | -1.950733364 | -0.440758364 | -1.509975 | 4.27E-07 | 8.42E-06 |
| BRCA | -1.260058528 | -0.095279581 | -1.164778947 | 1.12E-41 | 3.77E-40 |
| KICH | -1.026826739 | 0.047681261 | -1.074508 | 8.11E-07 | 3.08E-06 |
| BLCA | -1.58741116 | -0.419790107 | -1.167621053 | 0.000163 | 0.001640326 |
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| TissGene-miRNA for DNAJC18 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-330-5p | MIMAT0004693 | 0.023 | -0.31 | 56 |
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| TissGeneMut for DNAJC18 |
| TissGeneSNV for DNAJC18 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R332Q | CESC | 1 |
| p.D197Y | COAD | 1 |
| p.Y226H | STAD | 1 |
| p.A325V | KIRC | 1 |
| p.D198N | BLCA | 1 |
| p.S242F | SKCM | 1 |
| p.R20K | HNSC | 1 |
| p.V239L | KIRP | 1 |
| p.N177D | UCEC | 1 |
| p.H110Y | SKCM | 1 |
| p.R203S | HNSC | 1 |
| p.T120K | LIHC | 1 |
| p.R288I | PRAD | 1 |
| p.G62R | STAD | 1 |
| p.Y258C | STAD | 1 |
| p.L175M | PRAD | 1 |
| p.V132A | STAD | 1 |
| p.D27G | COAD | 1 |
| p.D305H | CESC | 1 |
| p.S193L | BLCA | 1 |
| p.S50F | SKCM | 1 |
| p.A286V | UCEC | 1 |
| p.R91* | SKCM | 1 |
| p.C311Y | TGCT | 1 |
| p.R141C | SKCM | 1 |
| p.R139T | LUAD | 1 |
| p.S291Y | COAD | 1 |
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| TissGeneCNV for DNAJC18 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for DNAJC18 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for DNAJC18 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for DNAJC18 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for DNAJC18 |
| TissGeneDrug for DNAJC18 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for DNAJC18 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | GAD |
| umls:C0008628 | Chromosome Deletion | 1 | GAD |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
| umls:C0242379 | Malignant neoplasm of lung | 1 | GAD |
| umls:C3463824 | MYELODYSPLASTIC SYNDROME | 1 | GAD |
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