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TissGeneSummary for EPHB3 |
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Basic gene information | Gene symbol | EPHB3 |
Gene name | EPH receptor B3 | |
Synonyms | ETK2|HEK2|TYRO6 | |
Cytomap | UCSC genome browser: 3q27.1 | |
Type of gene | protein-coding | |
RefGenes | NM_004443.3, | |
Description | EK2EPH-like kinase 2EPH-like tyrosine kinase 2EPH-like tyrosine kinase-2embryonic kinase 2ephrin type-B receptor 3human embryo kinase 2tyrosine-protein kinase TYRO6 | |
Modification date | 20141207 | |
dbXrefs | MIM : 601839 | |
HGNC : HGNC | ||
Ensembl : ENSG00000182580 | ||
HPRD : 03502 | ||
Vega : OTTHUMG00000156710 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_EPHB3 | |
BioGPS: 2049 | ||
Pathway | NCI Pathway Interaction Database: EPHB3 | |
KEGG: EPHB3 | ||
REACTOME: EPHB3 | ||
Pathway Commons: EPHB3 | ||
Context | iHOP: EPHB3 | |
ligand binding site mutation search in PubMed: EPHB3 | ||
UCL Cancer Institute: EPHB3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonSkin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADSKCM | |
Reference showing the relevant tissue of EPHB3 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID | GO:0016477 | cell migration | 15536074 | GO:0022407 | regulation of cell-cell adhesion | 8397371 | GO:0032314 | regulation of Rac GTPase activity | 15536074 | GO:0034446 | substrate adhesion-dependent cell spreading | 15536074 | GO:0043088 | regulation of Cdc42 GTPase activity | 15536074 | GO:0046777 | protein autophosphorylation | 15536074 | GO:0048013 | ephrin receptor signaling pathway | 15536074 | GO:0016477 | cell migration | 15536074 | GO:0022407 | regulation of cell-cell adhesion | 8397371 | GO:0032314 | regulation of Rac GTPase activity | 15536074 | GO:0034446 | substrate adhesion-dependent cell spreading | 15536074 | GO:0043088 | regulation of Cdc42 GTPase activity | 15536074 | GO:0046777 | protein autophosphorylation | 15536074 | GO:0048013 | ephrin receptor signaling pathway | 15536074 |
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TissGeneExp for EPHB3 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -2.655389206 | -1.318511428 | -1.336877778 | 2.58E-09 | 8.31E-09 |
KICH | -3.442938984 | -0.969550984 | -2.473388 | 2.21E-06 | 7.82E-06 |
LUAD | 0.11426405 | -1.04579457 | 1.160058621 | 1.18E-10 | 6.95E-10 |
THCA | -0.748502577 | -3.841316137 | 3.092813559 | 2.16E-18 | 5.63E-17 |
KIRP | -4.142323234 | -0.880388859 | -3.261934375 | 1.23E-11 | 1.69E-10 |
LUSC | 1.587844781 | -0.955196396 | 2.543041176 | 1.16E-17 | 1.00E-16 |
BLCA | 0.572885648 | -0.653598563 | 1.226484211 | 0.00653 | 0.032272711 |
COAD | 2.447563785 | 1.159356093 | 1.288207692 | 8.62E-05 | 0.000320652 |
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TissGene-miRNA for EPHB3 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for EPHB3 |
TissGeneSNV for EPHB3 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R813W | SKCM | 2 |
p.R420H | HNSC | 2 |
p.R967L | BLCA | 2 |
p.S795F | SKCM | 2 |
p.W473C | BLCA | 1 |
p.V876G | LIHC | 1 |
p.P300S | SKCM | 1 |
p.G404C | LUAD | 1 |
p.S591L | HNSC | 1 |
p.D370N | HNSC | 1 |
p.Q997K | ACC | 1 |
p.R93C | UCEC | 1 |
p.I709L | STAD | 1 |
p.K894E | LUSC | 1 |
p.N618K | LUSC | 1 |
p.P58L | SKCM | 1 |
p.S788F | SKCM | 1 |
p.D195N | SKCM | 1 |
p.R762C | COAD | 1 |
p.T926I | SKCM | 1 |
p.E495K | LUSC | 1 |
p.C116S | LIHC | 1 |
p.Y292C | COAD | 1 |
p.Y834C | COAD | 1 |
p.R368W | PRAD | 1 |
p.S819T | BRCA | 1 |
p.T993M | PAAD | 1 |
p.V107L | UCEC | 1 |
p.R622W | BLCA | 1 |
p.I888N | LIHC | 1 |
p.R657H | LUAD | 1 |
p.W840L | THYM | 1 |
p.G549W | LIHC | 1 |
p.N726K | STAD | 1 |
p.A566T | SKCM | 1 |
p.D758G | STAD | 1 |
p.E636K | BLCA | 1 |
p.D727N | PRAD | 1 |
p.R941W | COAD | 1 |
p.M738L | LUSC | 1 |
p.D259G | COAD | 1 |
p.T419A | LUAD | 1 |
p.E407K | SKCM | 1 |
p.E643D | HNSC | 1 |
p.S775L | SKCM | 1 |
p.E407* | LUAD | 1 |
p.D789N | STAD | 1 |
p.R391H | READ | 1 |
p.A908T | STAD | 1 |
p.V947L | BLCA | 1 |
p.R705W | SKCM | 1 |
p.S704I | UCEC | 1 |
p.R440H | PRAD | 1 |
p.Q402H | LUAD | 1 |
p.A192T | UCEC | 1 |
p.R460C | PRAD | 1 |
p.Y924C | ESCA | 1 |
p.V947F | BRCA | 1 |
p.G218V | LIHC | 1 |
p.D485Y | STAD | 1 |
p.S681N | LGG | 1 |
p.R649C | HNSC | 1 |
p.E627Q | LUAD | 1 |
p.N991K | KIRP | 1 |
p.P453T | THYM | 1 |
p.D820N | BRCA | 1 |
p.E487* | LUAD | 1 |
p.R326H | BLCA | 1 |
p.P479S | COAD | 1 |
p.R877Q | STAD | 1 |
p.M505I | BLCA | 1 |
p.A217T | PAAD | 1 |
p.E247D | UCEC | 1 |
p.S387L | BLCA | 1 |
p.S953F | SKCM | 1 |
p.A517T | THYM | 1 |
p.R179L | LUAD | 1 |
p.L749Q | LIHC | 1 |
p.R696W | SKCM | 1 |
p.L739F | OV | 1 |
p.P436T | LIHC | 1 |
p.R114H | STAD | 1 |
p.K606N | LUSC | 1 |
p.L749M | UCEC | 1 |
p.E492Q | CESC | 1 |
p.E358K | LUSC | 1 |
p.G950R | SKCM | 1 |
p.E455Q | BLCA | 1 |
p.T94M | LIHC | 1 |
p.M861T | COAD | 1 |
p.A718T | BLCA | 1 |
p.W804C | LUAD | 1 |
p.E541G | STAD | 1 |
p.R813Q | PAAD | 1 |
p.V155A | LIHC | 1 |
p.L513F | SKCM | 1 |
p.P787S | SKCM | 1 |
p.A417T | CESC | 1 |
p.W149C | LUAD | 1 |
p.G778C | LUAD | 1 |
p.M752I | SKCM | 1 |
p.R649P | BRCA | 1 |
p.Q909* | HNSC | 1 |
p.E619K | CESC | 1 |
p.R173C | LUAD | 1 |
p.R622Q | STAD | 1 |
p.A451V | SKCM | 1 |
p.F951C | SKCM | 1 |
p.A718S | LUSC | 1 |
p.P706L | LUAD | 1 |
p.A538S | SARC | 1 |
p.R897C | PAAD | 1 |
p.E358A | STAD | 1 |
p.A171V | SKCM | 1 |
p.A386V | SKCM | 1 |
p.L881H | BRCA | 1 |
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TissGeneCNV for EPHB3 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for EPHB3 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-AQ-A04J-01A | PIGZ-EPHB3 | In-frame | Chr3:196678692 | Chr3:184289106 |
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TissGeneNet for EPHB3 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for EPHB3 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for EPHB3 |
TissGeneDrug for EPHB3 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for EPHB3 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0009402 | Colorectal Carcinoma | 5 | BeFree |
umls:C1527249 | Colorectal Cancer | 5 | BeFree |
umls:C0001430 | Adenoma | 3 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0032580 | Adenomatous Polyposis Coli | 1 | BeFree |
umls:C0079218 | Fibromatosis, Aggressive | 1 | BeFree |
umls:C0149782 | Squamous cell carcinoma of lung | 1 | BeFree |
umls:C0410005 | Nodular fasciitis | 1 | BeFree |
umls:C0518014 | Hematocrit level | 1 | GAD |