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| TissGeneSummary for EPHX2 |
 Gene summary |
| Basic gene information | Gene symbol | EPHX2 |
| Gene name | epoxide hydrolase 2, cytoplasmic | |
| Synonyms | CEH|SEH | |
| Cytomap | UCSC genome browser: 8p21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001256482.1, NM_001256483.1,NM_001256484.1,NM_001979.5, | |
| Description | bifunctional epoxide hydrolase 2epoxide hydrataseepoxide hydrolase 2, cytosolicepoxide hydrolase, soluble | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 132811 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000120915 | ||
| HPRD : 00582 | ||
| Vega : OTTHUMG00000102115 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_EPHX2 | |
| BioGPS: 2053 | ||
| Pathway | NCI Pathway Interaction Database: EPHX2 | |
| KEGG: EPHX2 | ||
| REACTOME: EPHX2 | ||
| Pathway Commons: EPHX2 | ||
| Context | iHOP: EPHX2 | |
| ligand binding site mutation search in PubMed: EPHX2 | ||
| UCL Cancer Institute: EPHX2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverProstate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCPRAD | |
| Reference showing the relevant tissue of EPHX2 | ||
| Description by TissGene annotations | Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0010628 | positive regulation of gene expression | 18974052 | GO:0016311 | dephosphorylation | 12574508 | GO:0042632 | cholesterol homeostasis | 18974052 | GO:0046272 | stilbene catabolic process | 8342951 | GO:0046839 | phospholipid dephosphorylation | 12574510 | GO:0010628 | positive regulation of gene expression | 18974052 | GO:0016311 | dephosphorylation | 12574508 | GO:0042632 | cholesterol homeostasis | 18974052 | GO:0046272 | stilbene catabolic process | 8342951 | GO:0046839 | phospholipid dephosphorylation | 12574510 |
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| TissGeneExp for EPHX2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BLCA | -1.218989592 | 1.224668303 | -2.443657895 | 4.04E-06 | 9.76E-05 |
| LUAD | -0.702255653 | 0.680706416 | -1.382962069 | 1.76E-09 | 9.05E-09 |
| KIRP | 2.121747579 | 3.93180383 | -1.81005625 | 4.60E-11 | 5.70E-10 |
| LIHC | 3.223118829 | 5.01802083 | -1.794902 | 2.18E-12 | 4.00E-11 |
| LUSC | -0.434227053 | 0.581986673 | -1.016213725 | 1.56E-06 | 3.80E-06 |
| HNSC | -0.451683961 | 1.812978829 | -2.264662791 | 2.17E-15 | 1.98E-13 |
| KIRC | 2.115094107 | 3.545724663 | -1.430630556 | 2.74E-16 | 1.53E-15 |
| COAD | 1.338205753 | 2.982855753 | -1.64465 | 7.10E-12 | 1.45E-10 |
| STAD | 0.778741329 | 1.990835079 | -1.21209375 | 0.000873 | 0.004800433 |
| KICH | 2.392506829 | 3.55016283 | -1.157656 | 9.34E-05 | 0.000245649 |
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| TissGene-miRNA for EPHX2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for EPHX2 |
| TissGeneSNV for EPHX2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E394K | HNSC | 1 |
| p.P478L | SKCM | 1 |
| p.P512T | LGG | 1 |
| p.V242M | OV | 1 |
| p.R113S | BLCA | 1 |
| p.V498M | HNSC | 1 |
| p.A280S | ESCA | 1 |
| p.A280S | LUSC | 1 |
| p.L281Q | STAD | 1 |
| p.L364S | SKCM | 1 |
| p.S418F | SKCM | 1 |
| p.N223Y | LIHC | 1 |
| p.P459T | LGG | 1 |
| p.K455E | UCEC | 1 |
| p.G461S | ESCA | 1 |
| p.A290D | HNSC | 1 |
| p.R482W | STAD | 1 |
| p.A95V | UCEC | 1 |
| p.Y397C | COAD | 1 |
| p.M293I | CESC | 1 |
| p.V430A | SKCM | 1 |
| p.R234Q | COAD | 1 |
| p.S238T | OV | 1 |
| p.F449L | CESC | 1 |
| p.P379L | DLBC | 1 |
| p.G12E | SKCM | 1 |
| p.T200I | UCEC | 1 |
| p.S418Y | UCEC | 1 |
| p.T208M | UCEC | 1 |
| p.A226T | UCEC | 1 |
| p.E269D | BLCA | 1 |
| p.I511V | OV | 1 |
| p.F149S | UCEC | 1 |
| p.A301V | LGG | 1 |
| p.R410K | SKCM | 1 |
| p.K2R | COAD | 1 |
| p.K540M | SKCM | 1 |
| p.T172I | SKCM | 1 |
| p.L417S | SKCM | 1 |
| p.P65T | LUSC | 1 |
| p.R103L | SARC | 1 |
| p.V491F | LUAD | 1 |
| p.G426V | STAD | 1 |
| p.E444K | BLCA | 1 |
| p.E444K | LUAD | 1 |
| p.S153L | UCEC | 1 |
| p.T155M | COAD | 1 |
| p.M158I | STAD | 1 |
| p.A377T | STAD | 1 |
| p.N124Y | KIRC | 1 |
| p.G45E | LGG | 1 |
| p.N431D | HNSC | 1 |
| p.P531L | SKCM | 1 |
| p.Q62K | LUSC | 1 |
| p.A354V | LGG | 1 |
| p.D413G | BLCA | 1 |
| p.E68V | THCA | 1 |
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| TissGeneCNV for EPHX2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for EPHX2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BLCA | TCGA-HQ-A2OE-01A | EPHX2-PTK2B | In-frame | Chr8:27375589 | Chr8:27308266 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-E9-A1NA-01A | EPHX2-BNIP3L | Out-of-frame | Chr8:27401761 | Chr8:26265516 |
| TCGAfusionPortal | PRADA | OV | TCGA-23-1027-01A | ESCO2-EPHX2 | In-frame | Chr8:27646495 | Chr8:27394301 |
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| TissGeneNet for EPHX2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| EPHX2, S100A9, MVP, NIPSNAP3A (tumor) | EPHX2, S100A9, MVP, NIPSNAP3A (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| EPHX2, S100A9, MVP, NIPSNAP3A (tumor) | EPHX2, S100A9, MVP, NIPSNAP3A (normal) |
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| HNSC (tumor) | HNSC (normal) |
| EPHX2, S100A9, MVP, NIPSNAP3A (tumor) | EPHX2, S100A9, MVP, NIPSNAP3A (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| EPHX2, S100A9, MVP, NIPSNAP3A (tumor) | EPHX2, S100A9, MVP, NIPSNAP3A (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| EPHX2, S100A9, MVP, NIPSNAP3A (tumor) | EPHX2, S100A9, MVP, NIPSNAP3A (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| EPHX2, S100A9, MVP, NIPSNAP3A (tumor) | EPHX2, S100A9, MVP, NIPSNAP3A (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| EPHX2, S100A9, MVP, NIPSNAP3A (tumor) | EPHX2, S100A9, MVP, NIPSNAP3A (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| EPHX2, S100A9, MVP, NIPSNAP3A (tumor) | EPHX2, S100A9, MVP, NIPSNAP3A (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| EPHX2, S100A9, MVP, NIPSNAP3A (tumor) | EPHX2, S100A9, MVP, NIPSNAP3A (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| EPHX2, S100A9, MVP, NIPSNAP3A (tumor) | EPHX2, S100A9, MVP, NIPSNAP3A (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| EPHX2, S100A9, MVP, NIPSNAP3A (tumor) | EPHX2, S100A9, MVP, NIPSNAP3A (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| EPHX2, S100A9, MVP, NIPSNAP3A (tumor) | EPHX2, S100A9, MVP, NIPSNAP3A (normal) |
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| TissGeneProg for EPHX2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for EPHX2 |
| TissGeneDrug for EPHX2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for EPHX2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007222 | Cardiovascular Diseases | 10 | BeFree,LHGDN |
| umls:C0038454 | Cerebrovascular accident | 6 | BeFree,GAD,LHGDN,RGD |
| umls:C0948008 | Ischemic stroke | 6 | BeFree,GAD |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 6 | BeFree |
| umls:C0004153 | Atherosclerosis | 5 | BeFree,GAD,LHGDN |
| umls:C0010054 | Coronary Arteriosclerosis | 5 | BeFree,GAD |
| umls:C0003850 | Arteriosclerosis | 4 | BeFree |
| umls:C0020538 | Hypertensive disease | 4 | BeFree,LHGDN,RGD |
| umls:C0010068 | Coronary heart disease | 3 | BeFree |
| umls:C0151526 | Premature Birth | 3 | GAD |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 2 | GAD |
| umls:C0007786 | Brain Ischemia | 2 | GAD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | GAD |
| umls:C0021368 | Inflammation | 2 | GAD |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 2 | BeFree,GAD |
| umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree,GAD |
| umls:C0524620 | Metabolic Syndrome X | 2 | BeFree,RGD |
| umls:C1956346 | Coronary Artery Disease | 2 | BeFree,GAD |
| umls:C0003125 | Anorexia Nervosa | 1 | BeFree |
| umls:C0004096 | Asthma | 1 | GAD |
| umls:C0006663 | Calcinosis | 1 | GAD |
| umls:C0007273 | Carotid Artery Diseases | 1 | GAD |
| umls:C0007785 | Cerebral Infarction | 1 | RGD |
| umls:C0009782 | Connective Tissue Diseases | 1 | GAD |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0011881 | Diabetic Nephropathy | 1 | BeFree |
| umls:C0015929 | Fetal Diseases | 1 | GAD |
| umls:C0017658 | Glomerulonephritis | 1 | BeFree |
| umls:C0017661 | IGA Glomerulonephritis | 1 | BeFree |
| umls:C0018671 | Head and Neck Neoplasms | 1 | GAD |
| umls:C0018801 | Heart failure | 1 | BeFree,CTD_human |
| umls:C0018802 | Congestive heart failure | 1 | BeFree |
| umls:C0020429 | Hyperalgesia | 1 | RGD |
| umls:C0020443 | Hypercholesterolemia | 1 | BeFree |
| umls:C0020542 | Pulmonary Hypertension | 1 | RGD |
| umls:C0022661 | Kidney Failure, Chronic | 1 | GAD |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | GAD |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
| umls:C0026857 | Musculoskeletal Diseases | 1 | GAD |
| umls:C0027643 | Neoplasm Recurrence, Local | 1 | GAD |
| umls:C0032964 | Pregnancy Complications, Hematologic | 1 | GAD |
| umls:C0037274 | Dermatologic disorders | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0041755 | Adverse reaction to drug | 1 | CTD_human |
| umls:C0079745 | Lymphoma, Large-Cell, Follicular | 1 | BeFree |
| umls:C0085183 | Neoplasms, Second Primary | 1 | GAD |
| umls:C0151744 | Myocardial Ischemia | 1 | BeFree,GAD |
| umls:C0232197 | Fibrillation | 1 | BeFree |
| umls:C0242488 | Acute Lung Injury | 1 | RGD |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0947751 | Vascular inflammations | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | GAD |
| umls:C1611184 | Calcification of coronary artery | 1 | GAD |
| umls:C2609414 | Acute kidney injury | 1 | CTD_human |
| umls:C3714514 | Infection | 1 | GAD |
| umls:C0020445 | Hypercholesterolemia, Familial | 0 | CLINVAR |
| umls:C0745103 | Hyperlipoproteinemia Type IIa | 0 | CTD_human |
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