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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for EREG
check button Gene summary
Basic gene informationGene symbolEREG
Gene nameepiregulin
SynonymsER
CytomapUCSC genome browser: 4q13.3
Type of geneprotein-coding
RefGenesNM_001432.2,
Descriptionproepiregulin
Modification date20141207
dbXrefs MIM : 602061
HGNC : HGNC
Ensembl : ENSG00000124882
HPRD : 03638
Vega : OTTHUMG00000130005
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_EREG
BioGPS: 2069
PathwayNCI Pathway Interaction Database: EREG
KEGG: EREG
REACTOME: EREG
Pathway Commons: EREG
ContextiHOP: EREG
ligand binding site mutation search in PubMed: EREG
UCL Cancer Institute: EREG
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesHPA,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Bone marrowSkin
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LAMLSKCM
Reference showing the relevant tissue of EREG
Description by TissGene annotationsCancer gene
Have significant anti-correlated miRNA
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0007267cell-cell signaling14581411
GO:0008284positive regulation of cell proliferation10681561
GO:0009299mRNA transcription10681561
GO:0019221cytokine-mediated signaling pathway9419975
GO:0042108positive regulation of cytokine biosynthetic process10681561
GO:0042327positive regulation of phosphorylation10681561
GO:0043616keratinocyte proliferation10681561
GO:0045740positive regulation of DNA replication10681561
GO:0045860positive regulation of protein kinase activity14581411
GO:0045892negative regulation of transcription, DNA-templated14581411
GO:0048146positive regulation of fibroblast proliferation12702554
GO:0051151negative regulation of smooth muscle cell differentiation14581411
GO:0007267cell-cell signaling14581411
GO:0008284positive regulation of cell proliferation10681561
GO:0009299mRNA transcription10681561
GO:0019221cytokine-mediated signaling pathway9419975
GO:0042108positive regulation of cytokine biosynthetic process10681561
GO:0042327positive regulation of phosphorylation10681561
GO:0043616keratinocyte proliferation10681561
GO:0045740positive regulation of DNA replication10681561
GO:0045860positive regulation of protein kinase activity14581411
GO:0045892negative regulation of transcription, DNA-templated14581411
GO:0048146positive regulation of fibroblast proliferation12702554
GO:0051151negative regulation of smooth muscle cell differentiation14581411


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TissGeneExp for EREG

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
BRCA-1.564265714-0.157091153-1.4071745611.59E-053.85E-05
THCA-1.196716309-3.2298061392.0330898315.69E-072.23E-06
KIRP-1.421108258-2.5097645081.088656250.02530.049975859
LIHC-2.561841258-1.434257258-1.1275840.01070.022419528
KICH-3.206517258-2.010609258-1.1959080.008110.014870582
LUSC0.2944687032.118353017-1.8238843140.0001030.000213195


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TissGene-miRNA for EREG

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
ACChsa-miR-130b-3pMIMAT00006910.0013-0.3678
ACChsa-miR-130b-3pMIMAT00006910.0013-0.3678


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TissGeneMut for EREG
TissGeneSNV for EREG

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R147*SKCM3
p.R147XSKCM2
p.E155KSKCM2
p.G79ESKCM1
p.A120SUCEC1
p.R6KSKCM1
p.R147*UCEC1
p.Q53ELUSC1
p.R147XCOAD1
p.V85LESCA1
p.L125RUCEC1
p.L26PLUAD1
p.S69IESCA1
p.L31FSKCM1
p.R145KREAD1
p.S161*BLCA1
p.Q62KSKCM1
p.R102LESCA1
p.S161LLUAD1
p.A61SSTAD1
p.Y139SLUAD1
p.V110IHNSC1
p.S69ILUAD1
p.K150ISKCM1
p.E8KLGG1


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TissGeneCNV for EREG

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for EREG

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for EREG

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
EREG, ERBB4, SCN9A, EGFR (tumor)EREG, ERBB4, SCN9A, EGFR (normal)
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COAD (tumor)COAD (normal)
EREG, ERBB4, SCN9A, EGFR (tumor)EREG, ERBB4, SCN9A, EGFR (normal)
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HNSC (tumor)HNSC (normal)
EREG, ERBB4, SCN9A, EGFR (tumor)EREG, ERBB4, SCN9A, EGFR (normal)
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KICH (tumor)KICH (normal)
EREG, ERBB4, SCN9A, EGFR (tumor)EREG, ERBB4, SCN9A, EGFR (normal)
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KIRC (tumor)KIRC (normal)
EREG, ERBB4, SCN9A, EGFR (tumor)EREG, ERBB4, SCN9A, EGFR (normal)
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KIRP (tumor)KIRP (normal)
EREG, ERBB4, SCN9A, EGFR (tumor)EREG, ERBB4, SCN9A, EGFR (normal)
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LIHC (tumor)LIHC (normal)
EREG, ERBB4, SCN9A, EGFR (tumor)EREG, ERBB4, SCN9A, EGFR (normal)
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LUAD (tumor)LUAD (normal)
EREG, ERBB4, SCN9A, EGFR (tumor)EREG, ERBB4, SCN9A, EGFR (normal)
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LUSC (tumor)LUSC (normal)
EREG, ERBB4, SCN9A, EGFR (tumor)EREG, ERBB4, SCN9A, EGFR (normal)
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PRAD (tumor)PRAD (normal)
EREG, ERBB4, SCN9A, EGFR (tumor)EREG, ERBB4, SCN9A, EGFR (normal)
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STAD (tumor)STAD (normal)
EREG, ERBB4, SCN9A, EGFR (tumor)EREG, ERBB4, SCN9A, EGFR (normal)
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THCA (tumor)THCA (normal)
EREG, ERBB4, SCN9A, EGFR (tumor)EREG, ERBB4, SCN9A, EGFR (normal)
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TissGeneProg for EREG

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for EREG
TissGeneDrug for EREG

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for EREG

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0027627Neoplasm Metastasis4BeFree
umls:C0009402Colorectal Carcinoma3BeFree
umls:C0596263Carcinogenesis3BeFree
umls:C0948380Colorectal cancer metastatic3BeFree
umls:C1527249Colorectal Cancer3BeFree
umls:C0006142Malignant neoplasm of breast2BeFree
umls:C0007131Non-Small Cell Lung Carcinoma2BeFree
umls:C0024623Malignant neoplasm of stomach2BeFree
umls:C0699791Stomach Carcinoma2BeFree
umls:C2239176Liver carcinoma2BeFree
umls:C0001418Adenocarcinoma1BeFree
umls:C0002793Anaplasia1BeFree
umls:C0003864Arthritis1BeFree
umls:C0003873Rheumatoid Arthritis1BeFree
umls:C0007137Squamous cell carcinoma1BeFree,LHGDN
umls:C0008373Cholesteatoma1BeFree
umls:C0009319Colitis1BeFree
umls:C0010606Adenoid Cystic Carcinoma1BeFree
umls:C0015230Exanthema1BeFree
umls:C0017636Glioblastoma1BeFree
umls:C0017638Glioma1BeFree
umls:C0017661IGA Glomerulonephritis1CTD_human
umls:C0024121Lung Neoplasms1LHGDN
umls:C0027809Neurilemmoma1BeFree
umls:C0029463Osteosarcoma1BeFree
umls:C0029925Ovarian Carcinoma1BeFree
umls:C0038356Stomach Neoplasms1BeFree
umls:C0041296Tuberculosis1BeFree
umls:C0041327Tuberculosis, Pulmonary1BeFree
umls:C0152013Adenocarcinoma of lung (disorder)1BeFree
umls:C0153676Secondary malignant neoplasm of lung1BeFree
umls:C0153690Secondary malignant neoplasm of bone1BeFree
umls:C0155490Middle Ear Cholesteatoma1BeFree
umls:C0162557Liver Failure, Acute1BeFree
umls:C0162568Erythropoietic Protoporphyria1CTD_human
umls:C0206698Cholangiocarcinoma1BeFree
umls:C0238198Gastrointestinal Stromal Tumors1BeFree
umls:C0334463Malignant Fibrous Histiocytoma1LHGDN
umls:C0494165Secondary malignant neoplasm of liver1BeFree
umls:C0520679Sleep Apnea, Obstructive1BeFree
umls:C0555198Malignant Glioma1BeFree
umls:C0585442Osteosarcoma of bone1BeFree
umls:C0919267ovarian neoplasm1CTD_human
umls:C1140680Malignant neoplasm of ovary1BeFree
umls:C1167791Skin toxicity1BeFree
umls:C1263846Attention deficit hyperactivity disorder1GAD
umls:C1318485Liver regeneration disorder1BeFree
umls:C1458155Mammary Neoplasms1LHGDN
umls:C1512981Mammary Tumorigenesis1BeFree