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| TissGeneSummary for ESRRB |
 Gene summary |
| Basic gene information | Gene symbol | ESRRB |
| Gene name | estrogen-related receptor beta | |
| Synonyms | DFNB35|ERR2|ERRb|ESRL2|NR3B2 | |
| Cytomap | UCSC genome browser: 14q24.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004452.3, | |
| Description | ERR beta-2ERR-betaERRbeta-2estrogen receptor-like 2estrogen-related nuclear receptor betanuclear receptor ERRB2nuclear receptor subfamily 3 group B member 2orphan nuclear receptorsteroid hormone receptor ERR2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602167 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000119715 | ||
| HPRD : 03700 | ||
| Vega : OTTHUMG00000160457 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ESRRB | |
| BioGPS: 2103 | ||
| Pathway | NCI Pathway Interaction Database: ESRRB | |
| KEGG: ESRRB | ||
| REACTOME: ESRRB | ||
| Pathway Commons: ESRRB | ||
| Context | iHOP: ESRRB | |
| ligand binding site mutation search in PubMed: ESRRB | ||
| UCL Cancer Institute: ESRRB | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyEye | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHUVM | |
| Reference showing the relevant tissue of ESRRB | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006355 | regulation of transcription, DNA-templated | 23836911 | GO:0006355 | regulation of transcription, DNA-templated | 23836911 |
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| TissGeneExp for ESRRB |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | 0.688529631 | 5.748253631 | -5.059724 | 1.25E-10 | 9.34E-10 |
| KIRP | -1.353722119 | 5.358893506 | -6.712615625 | 2.77E-28 | 5.65E-26 |
| KIRC | -1.208265869 | 5.319574409 | -6.527840278 | 7.56E-54 | 1.41E-51 |
| ESCA | -1.770051096 | 2.456667085 | -4.226718182 | 0.00107 | 0.015352774 |
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| TissGene-miRNA for ESRRB |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-9-5p | MIMAT0000441 | 0.011 | -0.34 | 56 |
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| TissGeneMut for ESRRB |
| TissGeneSNV for ESRRB |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.C12R | LUAD | 1 |
| p.E144K | STAD | 1 |
| p.K124N | SKCM | 1 |
| p.H32Y | GBM | 1 |
| p.A219D | LUSC | 1 |
| p.R101H | PAAD | 1 |
| p.S25T | OV | 1 |
| p.P467S | SKCM | 1 |
| p.S11N | SKCM | 1 |
| p.D308A | GBM | 1 |
| p.T343M | UCEC | 1 |
| p.L164I | BLCA | 1 |
| p.R101H | STAD | 1 |
| p.R400Q | UCEC | 1 |
| p.G82S | LUAD | 1 |
| p.A226V | PRAD | 1 |
| p.S268F | SKCM | 1 |
| p.D57Y | LUAD | 1 |
| p.C103F | LUAD | 1 |
| p.P491L | ESCA | 1 |
| p.G64D | READ | 1 |
| p.Q367K | LUAD | 1 |
| p.P386S | BRCA | 1 |
| p.A122S | LUAD | 1 |
| p.S449R | STAD | 1 |
| p.A403T | SKCM | 1 |
| p.P386L | SKCM | 1 |
| p.R150Q | COAD | 1 |
| p.E340K | SKCM | 1 |
| p.A406V | SKCM | 1 |
| p.F45S | OV | 1 |
| p.F456L | DLBC | 1 |
| p.R182C | LUAD | 1 |
| p.C12F | LUAD | 1 |
| p.A125S | KIRC | 1 |
| p.H383Y | SKCM | 1 |
| p.T402M | GBM | 1 |
| p.E192D | SKCM | 1 |
| p.R101H | UCEC | 1 |
| p.P482T | LUAD | 1 |
| p.P472L | SKCM | 1 |
| p.P60L | BLCA | 1 |
| p.C106Y | LUSC | 1 |
| p.A157V | UCEC | 1 |
| p.R101C | STAD | 1 |
| p.S473F | SKCM | 1 |
| p.L396P | SKCM | 1 |
| p.S441C | HNSC | 1 |
| p.D108Y | LUAD | 1 |
| p.K211T | ESCA | 1 |
| p.R73L | LUAD | 1 |
| p.R313H | READ | 1 |
| p.R455Q | LUAD | 1 |
| p.K207T | UCEC | 1 |
| p.E487K | SKCM | 1 |
| p.T148I | SKCM | 1 |
| p.T142S | STAD | 1 |
| p.R150Q | SKCM | 1 |
| p.Q416R | LUAD | 1 |
| p.E442* | LUAD | 1 |
| p.R476S | LUAD | 1 |
| p.P386L | LUSC | 1 |
| p.A141V | PRAD | 1 |
| p.E192K | HNSC | 1 |
| p.G44S | LGG | 1 |
| p.M447R | UCEC | 1 |
| p.E372K | SKCM | 1 |
| p.G434D | ESCA | 1 |
| p.R249X | COAD | 1 |
| p.L314F | HNSC | 1 |
| p.I285M | HNSC | 1 |
| p.A315T | COAD | 1 |
| p.W257R | HNSC | 1 |
| p.V117M | UCEC | 1 |
| p.V474L | THYM | 1 |
| p.C163* | BLCA | 1 |
| p.T507I | SKCM | 1 |
| p.R177L | LUAD | 1 |
| p.L102P | LUSC | 1 |
| p.W476L | LUAD | 1 |
| p.K207M | LUAD | 1 |
| p.S38L | SKCM | 1 |
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| TissGeneCNV for ESRRB |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ESRRB |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AF094517 | IFT57-ESRRB | chr3:107938313 | chr14:76837724 | |
| TCGAfusionPortal | PRADA | PRAD | TCGA-VP-A875-01A | PARVA-ESRRB | CDS-5UTR | Chr11:12399330 | Chr14:76905684 |
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| TissGeneNet for ESRRB |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (tumor) | ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (normal) |
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| COAD (tumor) | COAD (normal) |
| ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (tumor) | ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (tumor) | ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (normal) |
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| KICH (tumor) | KICH (normal) |
| ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (tumor) | ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (tumor) | ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (tumor) | ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (tumor) | ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (tumor) | ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (tumor) | ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (tumor) | ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (normal) |
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| STAD (tumor) | STAD (normal) |
| ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (tumor) | ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (normal) |
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| THCA (tumor) | THCA (normal) |
| ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (tumor) | ESRRB, NCOA3, UBC, SP1, NRIP1, NCOA2, PARK2, DPF2 (normal) |
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| TissGeneProg for ESRRB |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ESRRB |
| TissGeneDrug for ESRRB |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ESRRB |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 12 | BeFree |
| umls:C0678222 | Breast Carcinoma | 12 | BeFree |
| umls:C0220766 | Congenital hypoplasia of adrenal gland | 8 | BeFree |
| umls:C0032002 | Pituitary Diseases | 5 | BeFree |
| umls:C0596263 | Carcinogenesis | 5 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 4 | BeFree,GAD |
| umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
| umls:C0271623 | Hypogonadotropic hypogonadism | 3 | BeFree |
| umls:C0600139 | Prostate carcinoma | 3 | BeFree |
| umls:C0006118 | Brain Neoplasms | 2 | BeFree |
| umls:C0022735 | Klinefelter Syndrome | 2 | BeFree |
| umls:C0035309 | Retinal Diseases | 2 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 2 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 2 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 2 | BeFree |
| umls:C1275278 | Extraskeletal Myxoid Chondrosarcoma | 2 | BeFree |
| umls:C1527249 | Colorectal Cancer | 2 | BeFree |
| umls:C2239176 | Liver carcinoma | 2 | BeFree |
| umls:C3711374 | Nonsyndromic Deafness | 2 | BeFree |
| umls:C0003130 | Anoxia | 1 | LHGDN |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0003864 | Arthritis | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | BeFree |
| umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
| umls:C0020443 | Hypercholesterolemia | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0029408 | Degenerative polyarthritis | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0263912 | Rotator cuff syndrome | 1 | BeFree |
| umls:C0345905 | Intrahepatic Cholangiocarcinoma | 1 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
| umls:C0553580 | Ewings sarcoma | 1 | BeFree |
| umls:C0752120 | Spinocerebellar Ataxia Type 1 | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1384666 | hearing impairment | 1 | LHGDN |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C1837857 | DEAFNESS, AUTOSOMAL RECESSIVE 35 | 1 | CLINVAR,CTD_human,UNIPROT |
| umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |
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