TissGeneSummary for ETV3 |
Gene summary |
Basic gene information | Gene symbol | ETV3 |
Gene name | ets variant 3 | |
Synonyms | METS|PE-1|PE1|bA110J1.4 | |
Cytomap | UCSC genome browser: 1q21-q23 | |
Type of gene | protein-coding | |
RefGenes | NM_001145312.1, NM_005240.1, | |
Description | ETS domain transcriptional repressor PE1ETS translocation variant 3ets variant gene 3, ETS family transcriptional repressormitogenic Ets transcriptional suppressor | |
Modification date | 20141207 | |
dbXrefs | MIM : 164873 | |
HGNC : HGNC | ||
Ensembl : ENSG00000117036 | ||
HPRD : 01282 | ||
Vega : OTTHUMG00000034298 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ETV3 | |
BioGPS: 2117 | ||
Pathway | NCI Pathway Interaction Database: ETV3 | |
KEGG: ETV3 | ||
REACTOME: ETV3 | ||
Pathway Commons: ETV3 | ||
Context | iHOP: ETV3 | |
ligand binding site mutation search in PubMed: ETV3 | ||
UCL Cancer Institute: ETV3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonSkin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADSKCM | |
Reference showing the relevant tissue of ETV3 | ||
Description by TissGene annotations | Risk TissGene in RFS TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ETV3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -0.793494604 | 0.219235904 | -1.012730508 | 4.58E-05 | 0.000132898 |
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TissGene-miRNA for ETV3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUAD | hsa-miR-26b-5p | MIMAT0000083 | 0.034 | -0.28 | 60 |
LUAD | hsa-miR-148a-3p | MIMAT0000243 | 0.028 | -0.29 | 60 |
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TissGeneMut for ETV3 |
TissGeneSNV for ETV3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A93T | SARC | 2 |
p.Y96C | STAD | 1 |
p.Q58H | COAD | 1 |
p.Y97C | PRAD | 1 |
p.P472L | UCEC | 1 |
p.K2T | LUAD | 1 |
p.E12K | BRCA | 1 |
p.P253S | LIHC | 1 |
p.P166L | UCEC | 1 |
p.G15R | LUAD | 1 |
p.Q34* | UCEC | 1 |
p.S396L | TGCT | 1 |
p.K105E | SKCM | 1 |
p.R79K | LAML | 1 |
p.R317W | COAD | 1 |
p.S275P | LIHC | 1 |
p.E27V | LGG | 1 |
p.S32F | BRCA | 1 |
p.K89* | PRAD | 1 |
p.N143K | UCEC | 1 |
p.L155P | UCEC | 1 |
p.V249A | UCEC | 1 |
p.K135T | UCEC | 1 |
p.L103F | SKCM | 1 |
p.K100R | LIHC | 1 |
p.H403Y | THYM | 1 |
p.H104Y | SKCM | 1 |
p.G62A | PRAD | 1 |
p.S339* | UCEC | 1 |
p.L231R | UCEC | 1 |
p.F117L | READ | 1 |
p.Q223K | ESCA | 1 |
p.V261F | COAD | 1 |
p.K89X | PRAD | 1 |
p.L75F | SKCM | 1 |
p.R479C | ESCA | 1 |
p.P316H | UCEC | 1 |
p.D21N | BLCA | 1 |
p.M85I | LUSC | 1 |
p.G77D | PRAD | 1 |
p.T106P | LIHC | 1 |
p.V359I | BRCA | 1 |
p.P232H | UCEC | 1 |
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TissGeneCNV for ETV3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ETV3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-BH-A18T-01A | ARHGEF11-ETV3 | CDS-5UTR | Chr1:157014091 | Chr1:157106157 |
TCGAfusionPortal | PRADA | BRCA | TCGA-D8-A1JF-01A | ARHGEF11-ETV3 | Out-of-frame | Chr1:157014091 | Chr1:157095771 |
TCGAfusionPortal | PRADA | PRAD | TCGA-G9-7510-01A | ETV3-MNDA | CDS-5UTR | Chr1:157103904 | Chr1:158811924 |
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TissGeneNet for ETV3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ETV3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ETV3 |
TissGeneDrug for ETV3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ETV3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0524620 | Metabolic Syndrome X | 7 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0020538 | Hypertensive disease | 1 | BeFree |
umls:C0023434 | Chronic Lymphocytic Leukemia | 1 | BeFree |
umls:C0024301 | Lymphoma, Follicular | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |