TissGDB

Home

	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for F9

Gene summary

Basic gene information	Gene symbol	F9
	Gene name	coagulation factor IX
	Synonyms	FIX\|HEMB\|P19\|PTC\|THPH8
	Cytomap	UCSC genome browser: Xq27.1-q27.2
	Type of gene	protein-coding
	RefGenes	NM_000133.3,
	Description	Christmas factorF9 p22FIX F9factor 9factor IX F9plasma thromboplastic componentplasma thromboplastin component
	Modification date	20141219
dbXrefs	MIM : 300746
	HGNC : HGNC
	Ensembl : ENSG00000101981
	HPRD : 02385
	Vega : OTTHUMG00000022536
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_F9
	BioGPS: 2158
Pathway	NCI Pathway Interaction Database: F9
	KEGG: F9
	REACTOME: F9
	Pathway Commons: F9
Context	iHOP: F9
	ligand binding site mutation search in PubMed: F9
	UCL Cancer Institute: F9
Assigned class in TissGDB*	B
Included tissue-specific gene expression resources	HPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	LIHC
Reference showing the relevant tissue of F9
Description by TissGene annotations	TissgsKTS

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO term

PubMed ID

Top

TissGeneExp for F9

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
LIHC	10.43476208	13.78654408	-3.351782	7.09E-09	6.43E-08

Top

TissGene-miRNA for F9

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

Top

TissGeneMut for F9

TissGeneSNV for F9

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.R384*	UCEC	2
p.G442R	SKCM	2
p.R298Q	UCEC	2
p.P197S	SKCM	2
p.D378N	HNSC	1
p.E231K	SKCM	1
p.M6I	BLCA	1
p.C134Y	LUAD	1
p.E35K	SKCM	1
p.Q167*	UCS	1
p.E116K	LUAD	1
p.K109N	OV	1
p.L32F	SKCM	1
p.F55L	COAD	1
p.E142D	LGG	1
p.P239H	THCA	1
p.G106S	HNSC	1
p.G253R	SKCM	1
p.D131_splice	LUSC	1
p.N452H	KIRC	1
p.V419L	LUSC	1
p.Q167X	UCS	1
p.R226L	LUAD	1
p.R43W	SKCM	1
p.G280_splice	GBM	1
p.R75*	UCEC	1
p.F238L	HNSC	1
p.T264A	UCEC	1
p.V273I	HNSC	1
p.T381I	COAD	1
p.N113S	UCEC	1
p.C69R	BLCA	1
p.R294*	CESC	1
p.I284F	HNSC	1
p.P12T	LUAD	1
p.R46K	HNSC	1
p.I336L	COAD	1
p.A279T	GBM	1
p.G357V	COAD	1
p.N213S	LUAD	1
p.G421R	SKCM	1
p.D410N	SKCM	1
p.E61Q	LUSC	1
p.R162*	SKCM	1
p.G160R	LUSC	1
p.N48D	UCEC	1
p.K126N	UCEC	1
p.V257I	COAD	1
p.A279T	LGG	1
p.M8T	LUAD	1
p.Q219K	CESC	1
p.Q370X	SKCM	1
p.D410E	LUAD	1
p.G402A	LUAD	1
p.Y391N	BLCA	1
p.A279T	UCEC	1
p.G254S	LUAD	1
p.Q370*	SKCM	1
p.D150G	STAD	1
p.K387R	STAD	1
p.R62I	COAD	1
p.F123S	READ	1
p.C145S	LUSC	1
p.E285D	LUAD	1
p.T264N	LUAD	1
p.F395L	READ	1
p.G139S	SKCM	1
p.R298*	GBM	1
p.R162X	SKCM	1
p.E159D	STAD	1
p.C128W	GBM	1
p.R384*	LGG	1
p.R298Q	HNSC	1
p.M394L	UCEC	1
p.C108Y	THYM	1
p.E171K	SKCM	1
p.T386I	STAD	1
p.D212N	SKCM	1
p.W261L	STAD	1
p.Q143R	LUAD	1
p.S448Y	LUAD	1
p.N343I	LUAD	1
p.G363R	LUAD	1
p.S184L	SKCM	1
p.R191S	THCA	1
p.P324L	LGG	1
p.L372I	UCEC	1
p.I7M	HNSC	1
p.S411R	LUAD	1
p.L376F	STAD	1
p.P197L	SKCM	1
p.Y305H	ESCA	1
p.P177L	CESC	1
p.P172L	SKCM	1
p.N295K	LUSC	1
p.A164V	BRCA	1
p.V181F	UCEC	1
p.V257I	UCEC	1

Top

TissGeneCNV for F9

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

Top

TissGeneFusions for F9

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database

Src

Cancer type

Sample

Fusion gene

ORF

5'-gene BP

3'-gene BP

Top

TissGeneNet for F9

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (tumor)	F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (normal)

COAD (tumor)	COAD (normal)
F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (tumor)	F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (normal)

HNSC (tumor)	HNSC (normal)
F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (tumor)	F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (normal)

KICH (tumor)	KICH (normal)
F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (tumor)	F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (normal)

KIRC (tumor)	KIRC (normal)
F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (tumor)	F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (normal)

KIRP (tumor)	KIRP (normal)
F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (tumor)	F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (normal)

LIHC (tumor)	LIHC (normal)
F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (tumor)	F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (normal)

LUAD (tumor)	LUAD (normal)
F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (tumor)	F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (normal)

LUSC (tumor)	LUSC (normal)
F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (tumor)	F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (normal)

PRAD (tumor)	PRAD (normal)
F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (tumor)	F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (normal)

STAD (tumor)	STAD (normal)
F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (tumor)	F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (normal)

THCA (tumor)	THCA (normal)
F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (tumor)	F9, HNF4A, ONECUT1, AR, CEBPA, NR2F1, F2, LRP1, NR2F2, FLG, GGCX, SERPINC1, F8, F7 (normal)

Top

TissGeneProg for F9

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Top

TissGeneClin for F9

TissGeneDrug for F9

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID	Drug name	Drug activity	Drug type	Drug status
DB13150	Coagulation factor VII human	Activator	Biotech	Approved

Top

TissGeneDisease for F9

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0008533	Hemophilia B	315	BeFree,CLINVAR,CTD_human,GAD,LHGDN,MGD,UNIPROT
umls:C0019069	Hemophilia A	82	BeFree,CTD_human,GAD
umls:C0549473	Thyroid carcinoma	77	BeFree
umls:C0684275	Hemophilia, NOS	53	BeFree
umls:C0238463	Papillary thyroid carcinoma	44	BeFree
umls:C0005779	Blood Coagulation Disorders	42	BeFree
umls:C0007115	Malignant neoplasm of thyroid	32	BeFree
umls:C0007133	Carcinoma, Papillary	26	BeFree
umls:C0206659	Embryonal Carcinoma	26	BeFree
umls:C0596263	Carcinogenesis	22	BeFree
umls:C0040136	Thyroid Neoplasm	13	BeFree
umls:C0206682	Follicular thyroid carcinoma	12	BeFree
umls:C0040137	Thyroid Nodule	10	BeFree
umls:C0023493	Adult T-Cell Lymphoma/Leukemia	8	BeFree
umls:C0205647	Follicular adenoma	8	BeFree
umls:C0238461	Anaplastic thyroid carcinoma	8	BeFree
umls:C0027627	Neoplasm Metastasis	7	BeFree
umls:C0018021	Goiter	6	BeFree
umls:C0398623	Thrombophilia	6	BeFree,LHGDN
umls:C0686619	Secondary malignant neoplasm of lymph node	6	BeFree
umls:C0016667	Fragile X Syndrome	5	BeFree
umls:C0019087	Hemorrhagic Disorders	5	BeFree
umls:C0019693	HIV Infections	5	BeFree
umls:C0042487	Venous Thrombosis	5	GAD,LHGDN
umls:C0005586	Bipolar Disorder	4	BeFree
umls:C0023903	Liver neoplasms	4	BeFree
umls:C0149871	Deep Vein Thrombosis	4	BeFree
umls:C0151468	Thyroid Gland Follicular Adenoma	4	BeFree
umls:C2239176	Liver carcinoma	4	BeFree
umls:C0002793	Anaplasia	3	BeFree
umls:C0003873	Rheumatoid Arthritis	3	BeFree
umls:C0004779	Basal Cell Nevus Syndrome	3	BeFree
umls:C0023418	leukemia	3	BeFree
umls:C0023895	Liver diseases	3	BeFree
umls:C0025202	melanoma	3	BeFree
umls:C0027666	Neoplasms, Radiation-Induced	3	BeFree
umls:C0040128	Thyroid Diseases	3	BeFree
umls:C0040147	Thyroiditis	3	BeFree
umls:C0205696	Anaplastic carcinoma	3	BeFree
umls:C0206664	Teratocarcinoma	3	BeFree
umls:C0235290	Taste bitter	3	BeFree
umls:C0238462	Medullary carcinoma of thyroid	3	BeFree
umls:C0242225	Color blindness	3	BeFree
umls:C0340708	Deep vein thrombosis of lower limb	3	BeFree
umls:C0850803	Anaphylaxis (non medication)	3	BeFree
umls:C1337013	Differentiated Thyroid Gland Carcinoma	3	BeFree
umls:C1839839	MAJOR AFFECTIVE DISORDER 2	3	BeFree
umls:C0001973	Alcoholic Intoxication, Chronic	2	BeFree
umls:C0004364	Autoimmune Diseases	2	BeFree
umls:C0006142	Malignant neoplasm of breast	2	BeFree
umls:C0008626	Congenital chromosomal disease	2	BeFree
umls:C0010674	Cystic Fibrosis	2	BeFree
umls:C0015523	Factor XI Deficiency	2	GAD,LHGDN
umls:C0018023	Nodular Goiter	2	BeFree
umls:C0023492	Leukemia, T-Cell	2	BeFree
umls:C0027726	Nephrotic Syndrome	2	BeFree
umls:C0029408	Degenerative polyarthritis	2	BeFree
umls:C0032580	Adenomatous Polyposis Coli	2	BeFree
umls:C0033626	Protein Deficiency	2	BeFree
umls:C0079474	Hallopeau-Siemens Disease	2	BeFree
umls:C0086692	Benign Neoplasm	2	BeFree
umls:C0178874	Tumor Progression	2	BeFree
umls:C0272322	Severe hereditary factor VIII deficiency disease	2	BeFree
umls:C0311361	Adenomatous goiter	2	BeFree
umls:C0342208	Multinodular goiter	2	BeFree
umls:C0476073	Papillary neoplasm	2	BeFree
umls:C0600433	Activated Protein C Resistance	2	BeFree
umls:C0678222	Breast Carcinoma	2	BeFree
umls:C1136249	Mental Retardation, X-Linked	2	BeFree
umls:C1266050	Poorly Differentiated Thyroid Carcinoma	2	BeFree
umls:C1527249	Colorectal Cancer	2	BeFree
umls:C1861171	THROMBOPHILIA DUE TO ACTIVATED PROTEIN C RESISTANCE (disorder)	2	BeFree
umls:C0001175	Acquired Immunodeficiency Syndrome	1	BeFree
umls:C0002736	Amyotrophic Lateral Sclerosis	1	BeFree
umls:C0003499	Supravalvular aortic stenosis	1	BeFree
umls:C0004943	Behcet Syndrome	1	BeFree
umls:C0007570	Celiac Disease	1	BeFree
umls:C0008354	Cholera	1	BeFree
umls:C0009402	Colorectal Carcinoma	1	BeFree
umls:C0010346	Crohn Disease	1	BeFree
umls:C0013336	Dwarfism	1	BeFree
umls:C0014072	Experimental Autoimmune Encephalomyelitis	1	BeFree
umls:C0014743	Erythema Nodosum	1	BeFree
umls:C0015503	Factor VII Deficiency	1	BeFree
umls:C0019080	Hemorrhage	1	GAD
umls:C0019158	Hepatitis	1	BeFree
umls:C0019159	Hepatitis A	1	BeFree
umls:C0021051	Immunologic Deficiency Syndromes	1	BeFree
umls:C0021655	Insulin Resistance	1	GAD
umls:C0022408	Arthropathy	1	BeFree
umls:C0023890	Liver Cirrhosis	1	GAD
umls:C0025149	Medulloblastoma	1	BeFree
umls:C0025269	Multiple Endocrine Neoplasia Type 2b	1	BeFree
umls:C0025362	Mental Retardation	1	BeFree
umls:C0026705	Mucopolysaccharidosis II	1	BeFree
umls:C0026769	Multiple Sclerosis	1	BeFree
umls:C0026850	Muscular Dystrophy	1	BeFree
umls:C0027051	Myocardial Infarction	1	BeFree
umls:C0028259	Nodule	1	BeFree
umls:C0031511	Pheochromocytoma	1	BeFree
umls:C0033860	Psoriasis	1	BeFree
umls:C0034065	Pulmonary Embolism	1	BeFree
umls:C0035335	Retinoblastoma	1	BeFree
umls:C0037286	Skin Neoplasms	1	BeFree
umls:C0039103	Synovitis	1	BeFree
umls:C0040038	Thromboembolism	1	BeFree
umls:C0040053	Thrombosis	1	CTD_human
umls:C0042769	Virus Diseases	1	BeFree
umls:C0042974	von Willebrand Disease	1	BeFree
umls:C0085110	Severe Combined Immunodeficiency	1	BeFree
umls:C0085669	Acute leukemia	1	BeFree
umls:C0151779	Cutaneous Melanoma	1	BeFree
umls:C0151942	Arterial thrombosis	1	BeFree
umls:C0151950	Deep thrombophlebitis	1	BeFree
umls:C0206693	Medullary carcinoma	1	BeFree
umls:C0206716	Ganglioglioma	1	BeFree
umls:C0235782	Gallbladder Carcinoma	1	BeFree
umls:C0242379	Malignant neoplasm of lung	1	BeFree
umls:C0242666	Protein S Deficiency	1	BeFree
umls:C0263361	Psoriasis vulgaris	1	BeFree
umls:C0265325	Turcot syndrome (disorder)	1	BeFree
umls:C0272317	Hereditary factor II deficiency disease	1	BeFree
umls:C0272375	Antithrombin III Deficiency	1	BeFree
umls:C0276275	Disease due to Parvoviridae	1	BeFree
umls:C0280100	Solid tumour	1	BeFree
umls:C0349639	Juvenile Myelomonocytic Leukemia	1	BeFree
umls:C0375019	Human T-cell lymphotrophic virus, type I [HTLV-I]	1	BeFree
umls:C0376288	Amaurosis	1	BeFree
umls:C0398625	Protein C Deficiency	1	BeFree
umls:C0432291	Mandibuloacral dysostosis	1	BeFree
umls:C0474808	Follicular neoplasm	1	BeFree
umls:C0497550	Benign neurologic neoplasms	1	BeFree
umls:C0524851	Neurodegenerative Disorders	1	BeFree
umls:C0584960	Factor V Leiden mutation	1	BeFree
umls:C0587248	Costello syndrome (disorder)	1	BeFree
umls:C0600452	Hepatopulmonary Syndrome	1	GAD
umls:C0684249	Carcinoma of lung	1	BeFree
umls:C0699885	Carcinoma of bladder	1	BeFree
umls:C0744310	gastritis h pylori	1	BeFree
umls:C0795801	trisomy 2	1	BeFree
umls:C0850666	Helicobacter pylori infection	1	BeFree
umls:C0852077	Blood Coagulation Disorders, Inherited	1	BeFree
umls:C0920420	cancer recurrence	1	BeFree
umls:C0948216	Ovarian adenocarcinoma	1	BeFree
umls:C1096488	Hereditary factor IX deficiency disease without inhibitor	1	BeFree
umls:C1292769	Precursor B-cell lymphoblastic leukemia	1	BeFree
umls:C1318500	Non-toxic nodular goiter	1	BeFree
umls:C1561955	Fibrinogen Adverse Event	1	GAD
umls:C2608079	WARFARIN SENSITIVITY (disorder)	1	GAD
umls:C2749016	Thrombophilia, X-Linked, Due To Factor Ix Defect	1	CLINVAR,CTD_human,UNIPROT
umls:C3811653	Experimental Organism Basal Cell Carcinoma	1	BeFree
umls:C0750384	Coumarin Resistance	0	CTD_human