TissGeneSummary for F11 |
Gene summary |
Basic gene information | Gene symbol | F11 |
Gene name | coagulation factor XI | |
Synonyms | FXI | |
Cytomap | UCSC genome browser: 4q35 | |
Type of gene | protein-coding | |
RefGenes | NM_000128.3, NM_019559.2, | |
Description | PTAplasma thromboplastin antecedent | |
Modification date | 20141207 | |
dbXrefs | MIM : 264900 | |
HGNC : HGNC | ||
HPRD : 07524 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_F11 | |
BioGPS: 2160 | ||
Pathway | NCI Pathway Interaction Database: F11 | |
KEGG: F11 | ||
REACTOME: F11 | ||
Pathway Commons: F11 | ||
Context | iHOP: F11 | |
ligand binding site mutation search in PubMed: F11 | ||
UCL Cancer Institute: F11 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of F11 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0031639 | plasminogen activation | 89876 | GO:0051919 | positive regulation of fibrinolysis | 89876 | GO:0031639 | plasminogen activation | 89876 | GO:0051919 | positive regulation of fibrinolysis | 89876 |
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TissGeneExp for F11 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 1.738842384 | 8.133449328 | -6.394606944 | 2.57E-38 | 9.29E-37 |
KICH | 1.474337773 | 8.184045773 | -6.709708 | 8.90E-12 | 8.65E-11 |
KIRP | 0.380856273 | 8.273106273 | -7.89225 | 2.71E-30 | 7.59E-28 |
LIHC | 9.311905773 | 10.94186577 | -1.62996 | 8.18E-07 | 4.44E-06 |
LUSC | 0.355842793 | 6.388648675 | -6.032805882 | 5.64E-31 | 2.89E-29 |
LUAD | 1.471521359 | 6.384957566 | -4.913436207 | 4.89E-23 | 1.54E-21 |
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TissGene-miRNA for F11 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for F11 |
TissGeneSNV for F11 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R326H | UCEC | 2 |
p.P288Q | SKCM | 1 |
p.I485T | LUAD | 1 |
p.E453Q | BLCA | 1 |
p.D160N | BLCA | 1 |
p.D255N | SKCM | 1 |
p.R391H | ESCA | 1 |
p.I217F | HNSC | 1 |
p.I107V | BLCA | 1 |
p.P234S | SKCM | 1 |
p.R443H | UCEC | 1 |
p.M506K | SKCM | 1 |
p.G478V | STAD | 1 |
p.A94V | DLBC | 1 |
p.E491* | HNSC | 1 |
p.G251R | SKCM | 1 |
p.Q464X | SKCM | 1 |
p.L254I | COAD | 1 |
p.R443H | ESCA | 1 |
p.L118I | STAD | 1 |
p.E135D | SKCM | 1 |
p.E613X | THYM | 1 |
p.E305D | COAD | 1 |
p.R139K | SKCM | 1 |
p.Q199E | BLCA | 1 |
p.K547N | LUAD | 1 |
p.G591S | BLCA | 1 |
p.R268C | CESC | 1 |
p.P182S | SKCM | 1 |
p.E68D | LUAD | 1 |
p.I269F | HNSC | 1 |
p.P41S | LUSC | 1 |
p.S459Y | UCEC | 1 |
p.R274C | BLCA | 1 |
p.Q451X | SKCM | 1 |
p.P236Q | SKCM | 1 |
p.E613K | KICH | 1 |
p.D164E | BLCA | 1 |
p.G539S | SKCM | 1 |
p.G342E | OV | 1 |
p.V129I | UCEC | 1 |
p.P70S | SKCM | 1 |
p.S137L | LUAD | 1 |
p.L254I | UCEC | 1 |
p.A199S | PRAD | 1 |
p.S523L | BLCA | 1 |
p.S503C | LUSC | 1 |
p.C136W | LUAD | 1 |
p.T267I | COAD | 1 |
p.E543* | HNSC | 1 |
p.H292R | LUAD | 1 |
p.G539S | BLCA | 1 |
p.F239C | STAD | 1 |
p.G591S | SKCM | 1 |
p.G339R | SKCM | 1 |
p.S191F | SKCM | 1 |
p.A43S | LUAD | 1 |
p.H531L | LUAD | 1 |
p.R216H | KIRC | 1 |
p.E249* | UCEC | 1 |
p.T51P | LUAD | 1 |
p.K495N | LUAD | 1 |
p.S99F | SKCM | 1 |
p.W467S | LUAD | 1 |
p.V490A | UCEC | 1 |
p.H583L | LUAD | 1 |
p.A171D | LUAD | 1 |
p.Q399* | SKCM | 1 |
p.G365S | LIHC | 1 |
p.R284K | SKCM | 1 |
p.S394Y | UCEC | 1 |
p.L115P | LUAD | 1 |
p.F186L | ESCA | 1 |
p.E341K | UCEC | 1 |
p.G510S | BLCA | 1 |
p.T557I | SKCM | 1 |
p.E401Q | BLCA | 1 |
p.D307N | SKCM | 1 |
p.T609I | SKCM | 1 |
p.E253K | BLCA | 1 |
p.M324I | SKCM | 1 |
p.S294* | LUSC | 1 |
p.I307T | PRAD | 1 |
p.S140F | SKCM | 1 |
p.R396C | READ | 1 |
p.R232K | SKCM | 1 |
p.E465* | UCEC | 1 |
p.L254V | COAD | 1 |
p.C275Y | PRAD | 1 |
p.T60N | LUAD | 1 |
p.E84* | UCEC | 1 |
p.G391R | SKCM | 1 |
p.C547F | SKCM | 1 |
p.A43T | ESCA | 1 |
p.A223D | LUAD | 1 |
p.V257F | SKCM | 1 |
p.A561V | ESCA | 1 |
p.Q412* | SKCM | 1 |
p.E341G | UCEC | 1 |
p.G122S | SKCM | 1 |
p.D130N | SKCM | 1 |
p.E197K | SKCM | 1 |
p.M376I | SKCM | 1 |
p.W399X | KIRC | 1 |
p.P169S | SKCM | 1 |
p.E305K | BLCA | 1 |
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TissGeneCNV for F11 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for F11 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AW951415 | F11-ANKH | chr4:187208898 | chr5:14711173 | |
Chimerdb3.0 | TopHat-Fusion | HNSC | TCGA-DQ-5631-01A | F11-FAT1 | Out-of-Frame | chr4:187197536 | chr4:187532539 |
Chimerdb3.0 | TopHat-Fusion | HNSC | TCGA-DQ-5631-01A | F11-FAT1 | Out-of-Frame | chr4:187202579 | chr4:187531428 |
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TissGeneNet for F11 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for F11 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for F11 |
TissGeneDrug for F11 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB06404 | C1 Esterase Inhibitor (Human) | Inhibitor | Biotech | Approved |
DB09228 | C1 Esterase Inhibitor (Recombinant) | Inhibitor | Biotech | Approved |
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TissGeneDisease for F11 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0015523 | Factor XI Deficiency | 35 | BeFree,CLINVAR,CTD_human,GAD,LHGDN,MGD,ORPHANET,UNIPROT |
umls:C0005779 | Blood Coagulation Disorders | 9 | BeFree |
umls:C1861172 | Venous Thromboembolism | 4 | GAD,GWASCAT |
umls:C0042487 | Venous Thrombosis | 3 | GAD |
umls:C0149871 | Deep Vein Thrombosis | 3 | BeFree,GAD |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | BeFree |
umls:C0042974 | von Willebrand Disease | 2 | BeFree |
umls:C0151950 | Deep thrombophlebitis | 2 | BeFree |
umls:C0398623 | Thrombophilia | 2 | BeFree,GAD,LHGDN |
umls:C0005129 | Bernard-Soulier Syndrome | 1 | BeFree |
umls:C0008533 | Hemophilia B | 1 | LHGDN |
umls:C0011269 | Dementia, Vascular | 1 | BeFree |
umls:C0020538 | Hypertensive disease | 1 | CTD_human |
umls:C0021368 | Inflammation | 1 | LHGDN |
umls:C0031256 | Petechiae | 1 | BeFree |
umls:C0040053 | Thrombosis | 1 | LHGDN |
umls:C0162872 | Aortic Aneurysm, Thoracic | 1 | BeFree |
umls:C0220992 | Histidinemia | 1 | BeFree |
umls:C0272340 | High molecular weight kininogen deficiency | 1 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 1 | GAD |
umls:C0497327 | Dementia | 1 | BeFree |
umls:C0600139 | Prostate carcinoma | 1 | BeFree |
umls:C0852036 | Pregnancy associated hypertension | 1 | GAD |
umls:C0948008 | Ischemic stroke | 1 | BeFree |
umls:C1956346 | Coronary Artery Disease | 1 | LHGDN |
umls:C3272363 | Ischemic Cerebrovascular Accident | 1 | BeFree |