TissGeneSummary for F13B |
Gene summary |
Basic gene information | Gene symbol | F13B |
Gene name | coagulation factor XIII, B polypeptide | |
Synonyms | FXIIIB | |
Cytomap | UCSC genome browser: 1q31-q32.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001994.2, | |
Description | TGasecoagulation factor XIII B chainfibrin-stabilizing factor B subunitprotein-glutamine gamma-glutamyltransferase B chaintransglutaminase B chain | |
Modification date | 20141207 | |
dbXrefs | MIM : 134580 | |
HGNC : HGNC | ||
Ensembl : ENSG00000143278 | ||
HPRD : 00605 | ||
Vega : OTTHUMG00000036519 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_F13B | |
BioGPS: 2165 | ||
Pathway | NCI Pathway Interaction Database: F13B | |
KEGG: F13B | ||
REACTOME: F13B | ||
Pathway Commons: F13B | ||
Context | iHOP: F13B | |
ligand binding site mutation search in PubMed: F13B | ||
UCL Cancer Institute: F13B | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of F13B | ||
Description by TissGene annotations | TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for F13B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 10.07359419 | 11.28868419 | -1.21509 | 0.00276 | 0.006788439 |
Top |
TissGene-miRNA for F13B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for F13B |
TissGeneSNV for F13B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R438C | SKCM | 2 |
p.K190N | UCEC | 2 |
p.E179K | UCEC | 2 |
p.G410R | READ | 2 |
p.G33E | SKCM | 2 |
p.P386R | LUAD | 1 |
p.S446F | SKCM | 1 |
p.A119T | STAD | 1 |
p.T322I | STAD | 1 |
p.G319R | LUAD | 1 |
p.Q635* | STAD | 1 |
p.T75M | UCEC | 1 |
p.Y39H | ESCA | 1 |
p.L136I | UCEC | 1 |
p.G508R | SKCM | 1 |
p.R438H | UCEC | 1 |
p.E473K | SKCM | 1 |
p.R217K | SKCM | 1 |
p.G561E | SKCM | 1 |
p.R438H | LUAD | 1 |
p.P497S | LUSC | 1 |
p.Q177K | STAD | 1 |
p.E590G | OV | 1 |
p.W140S | LUAD | 1 |
p.Y626C | SKCM | 1 |
p.R617I | PRAD | 1 |
p.G442E | SKCM | 1 |
p.Q441P | SKCM | 1 |
p.E467K | SKCM | 1 |
p.R438H | HNSC | 1 |
p.E588K | BRCA | 1 |
p.A119V | CESC | 1 |
p.P527S | BLCA | 1 |
p.V334A | STAD | 1 |
p.P262A | HNSC | 1 |
p.S434L | SKCM | 1 |
p.C267S | SKCM | 1 |
p.N32Y | STAD | 1 |
p.R315S | LUAD | 1 |
p.G249* | BLCA | 1 |
p.Y643N | SKCM | 1 |
p.A36V | HNSC | 1 |
p.E232K | SKCM | 1 |
p.K365* | HNSC | 1 |
p.L492V | ESCA | 1 |
p.T145A | PRAD | 1 |
p.P648S | SKCM | 1 |
p.T574I | STAD | 1 |
p.Y246D | READ | 1 |
p.P448L | SKCM | 1 |
p.G188A | LUAD | 1 |
p.P265S | SKCM | 1 |
p.W140* | LUAD | 1 |
p.L304P | SKCM | 1 |
p.K93N | BRCA | 1 |
p.C267W | LUAD | 1 |
p.E220X | SKCM | 1 |
p.Q70* | BLCA | 1 |
p.E440K | KIRC | 1 |
p.S50N | STAD | 1 |
p.R603I | UCEC | 1 |
p.G367S | SKCM | 1 |
p.G479E | SKCM | 1 |
p.G433E | LUSC | 1 |
p.E17X | COAD | 1 |
p.I35S | STAD | 1 |
p.A187S | HNSC | 1 |
p.E220* | SKCM | 1 |
p.G639V | LUAD | 1 |
p.P94L | SKCM | 1 |
p.Q111E | HNSC | 1 |
p.V237I | DLBC | 1 |
p.G33V | BLCA | 1 |
p.R380C | SKCM | 1 |
p.E179K | SKCM | 1 |
p.P83L | SKCM | 1 |
p.T322A | BLCA | 1 |
p.H371Q | STAD | 1 |
p.S446F | COAD | 1 |
p.E427K | SKCM | 1 |
p.S142F | BLCA | 1 |
p.E232D | LUAD | 1 |
p.Q635X | STAD | 1 |
p.A119S | HNSC | 1 |
p.K173Q | LUSC | 1 |
p.R293C | STAD | 1 |
p.E157K | SKCM | 1 |
p.E337D | STAD | 1 |
p.F42C | BRCA | 1 |
p.E301* | UCEC | 1 |
p.F170I | HNSC | 1 |
p.Y429H | SARC | 1 |
p.Q229H | BLCA | 1 |
p.A119T | LGG | 1 |
p.P144L | BLCA | 1 |
p.C135S | COAD | 1 |
p.R603K | LUSC | 1 |
p.T145A | HNSC | 1 |
p.E388V | STAD | 1 |
p.P494L | SKCM | 1 |
p.C454Y | LUAD | 1 |
p.G189R | SKCM | 1 |
p.G522V | COAD | 1 |
p.E394D | UCEC | 1 |
p.K53R | SKCM | 1 |
p.G561* | SKCM | 1 |
p.P156S | SKCM | 1 |
p.L136H | LUSC | 1 |
p.E157Q | SKCM | 1 |
p.P453S | GBM | 1 |
p.P325S | SKCM | 1 |
p.G410W | LUAD | 1 |
p.P24L | SKCM | 1 |
p.V334L | HNSC | 1 |
p.V503L | LUAD | 1 |
p.M468I | STAD | 1 |
p.S373L | SKCM | 1 |
p.D129Y | UCEC | 1 |
p.S419F | SKCM | 1 |
p.E313K | SKCM | 1 |
p.S215F | SKCM | 1 |
p.D483Y | UCEC | 1 |
p.D318N | LUAD | 1 |
p.L514S | LUSC | 1 |
p.G26R | LUAD | 1 |
p.R273K | KICH | 1 |
p.S373X | ESCA | 1 |
p.G357R | UCEC | 1 |
p.A416E | UCEC | 1 |
p.M403K | HNSC | 1 |
p.C454R | LGG | 1 |
p.I253V | KIRC | 1 |
p.N393S | LUAD | 1 |
p.Y428F | LUSC | 1 |
p.D619Y | UCEC | 1 |
p.C389F | LUAD | 1 |
p.A565G | COAD | 1 |
p.T75M | LUAD | 1 |
p.I466V | STAD | 1 |
p.G319R | SKCM | 1 |
p.K591N | UCEC | 1 |
p.T587I | SKCM | 1 |
p.S215F | LGG | 1 |
p.L136F | LUSC | 1 |
p.E564K | SKCM | 1 |
p.L370V | CESC | 1 |
p.D491Y | READ | 1 |
p.E149K | LUAD | 1 |
p.Y40C | LIHC | 1 |
p.G561X | SKCM | 1 |
p.G188R | LUSC | 1 |
p.L247P | SKCM | 1 |
p.P575L | LUSC | 1 |
p.E544K | SKCM | 1 |
p.Y39H | STAD | 1 |
p.S82F | SKCM | 1 |
p.L96M | LUAD | 1 |
p.I13V | HNSC | 1 |
p.T92S | STAD | 1 |
p.N506K | LUSC | 1 |
p.G249E | SKCM | 1 |
p.E500* | LUAD | 1 |
p.A61V | PAAD | 1 |
p.E422* | LUAD | 1 |
p.G618* | PRAD | 1 |
p.E196Q | LUSC | 1 |
p.R463T | HNSC | 1 |
p.G62S | SKCM | 1 |
p.W444L | LUAD | 1 |
p.Q504R | LGG | 1 |
p.R315C | UCEC | 1 |
p.P658T | ESCA | 1 |
p.E17K | SKCM | 1 |
p.G561V | LUSC | 1 |
p.C327R | LUAD | 1 |
Top |
TissGeneCNV for F13B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for F13B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LGG | TCGA-DU-6542-01A | KIF21B-F13B | Out-of-frame | Chr1:200992471 | Chr1:197032187 |
Top |
TissGeneNet for F13B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for F13B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for F13B |
TissGeneDrug for F13B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for F13B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007786 | Brain Ischemia | 4 | GAD |
umls:C0027051 | Myocardial Infarction | 3 | GAD,LHGDN |
umls:C0004153 | Atherosclerosis | 2 | GAD |
umls:C0015530 | Factor XIII Deficiency | 2 | BeFree,CTD_human |
umls:C0038454 | Cerebrovascular accident | 2 | GAD |
umls:C0242383 | Age related macular degeneration | 2 | BeFree,GAD |
umls:C0339526 | Autosomal recessive retinitis pigmentosa | 2 | BeFree |
umls:C2750481 | Factor XIII, B Subunit, Deficiency Of | 2 | CLINVAR,CTD_human,UNIPROT |
umls:C0007282 | Carotid Stenosis | 1 | GAD |
umls:C0008495 | Chorioamnionitis | 1 | GAD |
umls:C0010054 | Coronary Arteriosclerosis | 1 | GAD |
umls:C0015944 | Fetal Membranes, Premature Rupture | 1 | GAD |
umls:C0021390 | Inflammatory Bowel Diseases | 1 | GAD |
umls:C0022876 | Premature Obstetric Labor | 1 | GAD |
umls:C0023487 | Acute Promyelocytic Leukemia | 1 | BeFree |
umls:C0025149 | Medulloblastoma | 1 | BeFree |
umls:C0032914 | Pre-Eclampsia | 1 | GAD |
umls:C0040053 | Thrombosis | 1 | GAD |
umls:C0042344 | Varicose Ulcer | 1 | LHGDN |
umls:C0042373 | Vascular Diseases | 1 | GAD |
umls:C0042487 | Venous Thrombosis | 1 | CTD_human,GAD |
umls:C0151526 | Premature Birth | 1 | GAD |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
umls:C0600139 | Prostate carcinoma | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0751530 | Subarachnoid Hemorrhage, Aneurysmal | 1 | GAD |
umls:C1285162 | Degenerative disorder | 1 | BeFree |
umls:C1527249 | Colorectal Cancer | 1 | GAD |
umls:C2919032 | Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 1 | GAD |