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| TissGeneSummary for FABP4 |
 Gene summary |
| Basic gene information | Gene symbol | FABP4 |
| Gene name | fatty acid binding protein 4, adipocyte | |
| Synonyms | A-FABP|AFABP|ALBP|HEL-S-104|aP2 | |
| Cytomap | UCSC genome browser: 8q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001442.2, | |
| Description | adipocyte lipid-binding proteinadipocyte-type fatty acid-binding proteinepididymis secretory protein Li 104fatty acid-binding protein 4fatty acid-binding protein, adipocyte | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 600434 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000170323 | ||
| HPRD : 02698 | ||
| Vega : OTTHUMG00000164602 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FABP4 | |
| BioGPS: 2167 | ||
| Pathway | NCI Pathway Interaction Database: FABP4 | |
| KEGG: FABP4 | ||
| REACTOME: FABP4 | ||
| Pathway Commons: FABP4 | ||
| Context | iHOP: FABP4 | |
| ligand binding site mutation search in PubMed: FABP4 | ||
| UCL Cancer Institute: FABP4 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BladderBreastSoft tissue | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BLCABRCASARC | |
| Reference showing the relevant tissue of FABP4 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for FABP4 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| PRAD | -3.88409767 | -2.40677267 | -1.477325 | 9.03E-08 | 8.61E-07 |
| KIRP | -3.464901516 | 0.576623484 | -4.041525 | 4.89E-13 | 8.37E-12 |
| LUSC | -0.550253967 | 5.101520543 | -5.65177451 | 3.02E-23 | 5.36E-22 |
| STAD | -1.104292141 | 1.844092234 | -2.948384375 | 1.57E-07 | 3.84E-06 |
| BRCA | 1.915620853 | 7.882868221 | -5.967247368 | 9.84E-42 | 3.36E-40 |
| THCA | -0.502136685 | 2.868195518 | -3.370332203 | 2.70E-14 | 3.08E-13 |
| LUAD | -0.584500654 | 5.363402795 | -5.947903448 | 1.06E-35 | 2.97E-33 |
| COAD | -1.56172267 | 1.878704253 | -3.440426923 | 2.66E-06 | 1.36E-05 |
| BLCA | 1.753973484 | 4.780741905 | -3.026768421 | 0.00232 | 0.014412514 |
| LIHC | 0.690865484 | -0.729204516 | 1.42007 | 0.00223 | 0.005602749 |
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| TissGene-miRNA for FABP4 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FABP4 |
| TissGeneSNV for FABP4 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.M41I | SKCM | 1 |
| p.W9* | HNSC | 1 |
| p.M1V | CESC | 1 |
| p.A4D | UCEC | 1 |
| p.G89V | LUAD | 1 |
| p.Q96H | COAD | 1 |
| p.G100E | SKCM | 1 |
| p.T126M | ESCA | 1 |
| p.A76S | BRCA | 1 |
| p.E110D | PAAD | 1 |
| p.G27R | HNSC | 1 |
| p.A4T | SARC | 1 |
| p.R109* | UCEC | 1 |
| p.M41I | HNSC | 1 |
| p.V81A | LGG | 1 |
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| TissGeneCNV for FABP4 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FABP4 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BP317019 | FABP4-PMP22 | chr8:82395468 | chr17:15143726 | |
| Chimerdb3.0 | ChiTaRs | NA | BG290021 | FABP4-SEMA3C | chr8:82391672 | chr7:80371856 | |
| Chimerdb3.0 | ChiTaRs | NA | BG992392 | METTL17-FABP4 | chr14:21464977 | chr8:82391102 |
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| TissGeneNet for FABP4 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (tumor) | FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (normal) |
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| COAD (tumor) | COAD (normal) |
| FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (tumor) | FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (tumor) | FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (normal) |
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| KICH (tumor) | KICH (normal) |
| FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (tumor) | FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (tumor) | FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (tumor) | FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (tumor) | FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (tumor) | FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (tumor) | FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (tumor) | FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (normal) |
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| STAD (tumor) | STAD (normal) |
| FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (tumor) | FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (normal) |
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| THCA (tumor) | THCA (normal) |
| FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (tumor) | FABP4, CHD3, USP15, ZBED1, LIPE, ACTB, INSR, PGAM1, SNCG, PRKCI, VIM, TNK2, ACP1, OSTF1, EXT2 (normal) |
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| TissGeneProg for FABP4 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FABP4 |
| TissGeneDrug for FABP4 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FABP4 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0028754 | Obesity | 13 | BeFree,GAD |
| umls:C0003850 | Arteriosclerosis | 7 | BeFree |
| umls:C0004153 | Atherosclerosis | 7 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 4 | BeFree,GAD |
| umls:C0524620 | Metabolic Syndrome X | 4 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 3 | BeFree |
| umls:C0577631 | Carotid Atherosclerosis | 3 | BeFree |
| umls:C0600139 | Prostate carcinoma | 3 | BeFree |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 2 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 2 | BeFree |
| umls:C0010068 | Coronary heart disease | 2 | BeFree,LHGDN |
| umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 2 | BeFree |
| umls:C2362324 | Pediatric Obesity | 2 | BeFree |
| umls:C0004096 | Asthma | 1 | BeFree |
| umls:C0007138 | Carcinoma, Transitional Cell | 1 | LHGDN |
| umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
| umls:C0011616 | Contact Dermatitis | 1 | CTD_human |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0020443 | Hypercholesterolemia | 1 | GAD |
| umls:C0021655 | Insulin Resistance | 1 | RGD |
| umls:C0023787 | Lipodystrophy | 1 | BeFree |
| umls:C0024236 | Lymphedema | 1 | BeFree,GAD |
| umls:C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| umls:C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| umls:C0025149 | Medulloblastoma | 1 | BeFree |
| umls:C0027051 | Myocardial Infarction | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0029928 | Ovarian Diseases | 1 | BeFree |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | BeFree |
| umls:C0032914 | Pre-Eclampsia | 1 | LHGDN |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0040021 | Thromboangiitis Obliterans | 1 | BeFree |
| umls:C0153690 | Secondary malignant neoplasm of bone | 1 | BeFree |
| umls:C0242339 | Dyslipidemias | 1 | LHGDN |
| umls:C0242350 | Erectile dysfunction | 1 | RGD |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 1 | BeFree |
| umls:C0520679 | Sleep Apnea, Obstructive | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0948008 | Ischemic stroke | 1 | BeFree |
| umls:C0948089 | Acute Coronary Syndrome | 1 | BeFree |
| umls:C1301700 | Cardiovascular morbidity | 1 | BeFree |
| umls:C1370507 | Cerebellar Liponeurocytoma | 1 | BeFree |
| umls:C1536220 | ST segment elevation myocardial infarction | 1 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 1 | BeFree |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 1 | BeFree |
| umls:C3539878 | Triple Negative Breast Neoplasms | 1 | BeFree |
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