TissGeneSummary for ALDH3A1 |
Gene summary |
Basic gene information | Gene symbol | ALDH3A1 |
Gene name | aldehyde dehydrogenase 3 family, member A1 | |
Synonyms | ALDH3|ALDHIII | |
Cytomap | UCSC genome browser: 17p11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_000691.4, NM_001135167.1,NM_001135168.1, | |
Description | aldehyde dehydrogenase isozyme 3aldehyde dehydrogenase type IIIaldehyde dehydrogenase, dimeric NADP-preferringstomach aldehyde dehydrogenase | |
Modification date | 20141207 | |
dbXrefs | MIM : 100660 | |
HGNC : HGNC | ||
Ensembl : ENSG00000108602 | ||
HPRD : 00004 | ||
Vega : OTTHUMG00000059469 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ALDH3A1 | |
BioGPS: 218 | ||
Pathway | NCI Pathway Interaction Database: ALDH3A1 | |
KEGG: ALDH3A1 | ||
REACTOME: ALDH3A1 | ||
Pathway Commons: ALDH3A1 | ||
Context | iHOP: ALDH3A1 | |
ligand binding site mutation search in PubMed: ALDH3A1 | ||
UCL Cancer Institute: ALDH3A1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | EsophagusStomachEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCASTADUVM | |
Reference showing the relevant tissue of ALDH3A1 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006081 | cellular aldehyde metabolic process | 1737758 | GO:0055114 | oxidation-reduction process | 1737758 | GO:0006081 | cellular aldehyde metabolic process | 1737758 | GO:0055114 | oxidation-reduction process | 1737758 |
Top |
TissGeneExp for ALDH3A1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
PRAD | -1.737327455 | 0.433678314 | -2.171005769 | 1.05E-13 | 7.35E-12 |
BRCA | -3.311503264 | 0.093144981 | -3.404648246 | 2.03E-27 | 2.29E-26 |
LUSC | 3.950613609 | 2.464744981 | 1.485868627 | 0.0158 | 0.024221647 |
HNSC | 4.964834128 | 7.024796919 | -2.059962791 | 0.00178 | 0.005585774 |
Top |
TissGene-miRNA for ALDH3A1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for ALDH3A1 |
TissGeneSNV for ALDH3A1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P139L | SKCM | 2 |
p.E97K | SKCM | 2 |
p.V345M | UCS | 1 |
p.T205S | LIHC | 1 |
p.R314H | STAD | 1 |
p.V324M | PAAD | 1 |
p.E70K | SKCM | 1 |
p.F336L | STAD | 1 |
p.A32T | SKCM | 1 |
p.G193R | SKCM | 1 |
p.K202E | STAD | 1 |
p.S328P | CESC | 1 |
p.N119S | SKCM | 1 |
p.A47G | PRAD | 1 |
p.A131V | SKCM | 1 |
p.S102L | BLCA | 1 |
p.I71T | STAD | 1 |
p.Q257* | SKCM | 1 |
p.R231H | ESCA | 1 |
p.D70N | UCEC | 1 |
p.E6K | LUAD | 1 |
p.G188D | HNSC | 1 |
p.W57L | SKCM | 1 |
p.L433V | LUAD | 1 |
p.V219M | COAD | 1 |
p.E380D | BLCA | 1 |
p.I75L | THYM | 1 |
p.G438D | OV | 1 |
p.N239I | LUAD | 1 |
p.A130V | UCEC | 1 |
p.Q257X | SKCM | 1 |
p.E537K | GBM | 1 |
p.V378G | OV | 1 |
p.Q94* | BLCA | 1 |
p.E56K | SKCM | 1 |
p.G191A | CHOL | 1 |
p.P215L | UCEC | 1 |
p.R314H | COAD | 1 |
p.A83V | UCEC | 1 |
p.S17L | BLCA | 1 |
p.T190M | COAD | 1 |
p.D96E | ESCA | 1 |
p.A151T | LUAD | 1 |
p.E6K | BLCA | 1 |
p.M74I | SKCM | 1 |
p.T198M | LGG | 1 |
p.E88D | UCEC | 1 |
p.P329A | COAD | 1 |
p.E333Q | BLCA | 1 |
p.A350T | GBM | 1 |
p.V110I | STAD | 1 |
p.I195V | LGG | 1 |
p.T208M | STAD | 1 |
p.G193E | SKCM | 1 |
p.W81C | LUAD | 1 |
p.F237L | UCEC | 1 |
p.R289Q | COAD | 1 |
p.S27* | UCEC | 1 |
p.D390N | SKCM | 1 |
p.G273E | SKCM | 1 |
Top |
TissGeneCNV for ALDH3A1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for ALDH3A1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CV572132 | MSI2-ALDH3A1 | chr17:55335694 | chr17:19641303 | |
Chimerdb3.0 | ChiTaRs | NA | BQ331769 | DDX55-ALDH3A1 | chr12:124101096 | chr17:19643649 | |
Chimerdb3.0 | ChiTaRs | NA | BU679486 | ALDH3A1-ASPH | chr17:19641367 | chr8:62574298 | |
Chimerdb3.0 | ChiTaRs | NA | BU685263 | ALDH3A1-ASPH | chr17:19641367 | chr8:62574243 | |
Chimerdb3.0 | FusionScan | LUSC | TCGA-33-6737-01A | ALDH3A1-MYH9 | 5'UTR-CDS | chr17:19651571 | chr22:36723533 |
Top |
TissGeneNet for ALDH3A1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for ALDH3A1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for ALDH3A1 |
TissGeneDrug for ALDH3A1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for ALDH3A1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C2239176 | Liver carcinoma | 5 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree,GAD |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
umls:C0024121 | Lung Neoplasms | 2 | BeFree,LHGDN |
umls:C0033999 | Pterygium | 2 | BeFree |
umls:C0152013 | Adenocarcinoma of lung (disorder) | 2 | BeFree |
umls:C0004352 | Autistic Disorder | 1 | GAD |
umls:C0011570 | Mental Depression | 1 | BeFree |
umls:C0011581 | Depressive disorder | 1 | BeFree |
umls:C0017636 | Glioblastoma | 1 | BeFree |
umls:C0023903 | Liver neoplasms | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0027658 | Neoplasms, Germ Cell and Embryonal | 1 | GAD |
umls:C0036341 | Schizophrenia | 1 | BeFree,GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0085692 | Hemorrhagic cystitis | 1 | BeFree |
umls:C0086543 | Cataract | 1 | BeFree |
umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
umls:C0155158 | Recurrent pterygium | 1 | BeFree |
umls:C0206669 | Hepatocellular Adenoma | 1 | BeFree |
umls:C0220603 | childhood brain tumor | 1 | GAD |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
umls:C0521707 | Bilateral cataracts (disorder) | 1 | BeFree |
umls:C0600139 | Prostate carcinoma | 1 | BeFree |
umls:C0858252 | Breast adenocarcinoma | 1 | BeFree |
umls:C0919267 | ovarian neoplasm | 1 | GAD |
umls:C1458155 | Mammary Neoplasms | 1 | GAD |