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| TissGeneSummary for ZNF804B |
 Gene summary |
| Basic gene information | Gene symbol | ZNF804B |
| Gene name | zinc finger protein 804B | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 7q21.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_181646.2, | |
| Description | zinc finger 804B | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000182348 | ||
| HPRD : 08721 | ||
| Vega : OTTHUMG00000131037 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZNF804B | |
| BioGPS: 219578 | ||
| Pathway | NCI Pathway Interaction Database: ZNF804B | |
| KEGG: ZNF804B | ||
| REACTOME: ZNF804B | ||
| Pathway Commons: ZNF804B | ||
| Context | iHOP: ZNF804B | |
| ligand binding site mutation search in PubMed: ZNF804B | ||
| UCL Cancer Institute: ZNF804B | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Thyroid gland | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | THCA | |
| Reference showing the relevant tissue of ZNF804B | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ZNF804B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -0.352052685 | 1.742182037 | -2.094234722 | 1.24E-08 | 3.72E-08 |
| THCA | 0.158112239 | 5.781873256 | -5.623761017 | 7.96E-28 | 2.94E-25 |
| KICH | -1.830336574 | 0.866307426 | -2.696644 | 4.71E-07 | 1.88E-06 |
| KIRP | -1.836407199 | 1.989158426 | -3.825565625 | 1.24E-11 | 1.70E-10 |
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| TissGene-miRNA for ZNF804B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ZNF804B |
| TissGeneSNV for ZNF804B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P1199S | SKCM | 2 |
| p.E546K | SKCM | 2 |
| p.P962R | ESCA | 2 |
| p.E278K | SKCM | 2 |
| p.D829N | SKCM | 2 |
| p.S913A | STAD | 2 |
| p.G170E | SKCM | 2 |
| p.E92K | SKCM | 2 |
| p.R95Q | SKCM | 2 |
| p.K1157* | LUAD | 1 |
| p.P962S | LUSC | 1 |
| p.H330D | LUSC | 1 |
| p.P998S | SKCM | 1 |
| p.E278K | STAD | 1 |
| p.P338T | LUAD | 1 |
| p.T1086N | LUSC | 1 |
| p.K52N | LUAD | 1 |
| p.N784S | SKCM | 1 |
| p.D308N | STAD | 1 |
| p.R188L | ESCA | 1 |
| p.V932I | BLCA | 1 |
| p.C757Y | COAD | 1 |
| p.Q872K | READ | 1 |
| p.H400Y | STAD | 1 |
| p.K41N | LUAD | 1 |
| p.D544Y | LUAD | 1 |
| p.N655K | KIRP | 1 |
| p.S858* | LIHC | 1 |
| p.S904F | UCEC | 1 |
| p.D1094N | LUAD | 1 |
| p.S233F | CESC | 1 |
| p.L929S | HNSC | 1 |
| p.L1295X | LIHC | 1 |
| p.A213E | LUAD | 1 |
| p.H1299Q | READ | 1 |
| p.D450N | SKCM | 1 |
| p.K230X | COAD | 1 |
| p.D415H | BLCA | 1 |
| p.H1266R | STAD | 1 |
| p.S297Y | LUAD | 1 |
| p.S1227N | PRAD | 1 |
| p.K615M | LUAD | 1 |
| p.I318T | BRCA | 1 |
| p.E794K | SKCM | 1 |
| p.S389L | HNSC | 1 |
| p.E280A | HNSC | 1 |
| p.I769M | ACC | 1 |
| p.D590Y | COAD | 1 |
| p.S868T | BLCA | 1 |
| p.A986V | THYM | 1 |
| p.Q68H | COAD | 1 |
| p.K636E | LIHC | 1 |
| p.K41T | STAD | 1 |
| p.P369S | DLBC | 1 |
| p.V1198F | BLCA | 1 |
| p.S598N | COAD | 1 |
| p.Q147H | LUAD | 1 |
| p.G884R | SKCM | 1 |
| p.L1098I | UCEC | 1 |
| p.A269S | LUAD | 1 |
| p.Q1172K | LUAD | 1 |
| p.D1153E | HNSC | 1 |
| p.S1193L | BLCA | 1 |
| p.D385N | SKCM | 1 |
| p.K41N | COAD | 1 |
| p.L112V | LUAD | 1 |
| p.T1001M | HNSC | 1 |
| p.V516I | STAD | 1 |
| p.Q702H | OV | 1 |
| p.V97I | LUSC | 1 |
| p.G918R | SKCM | 1 |
| p.K449T | STAD | 1 |
| p.P370T | ESCA | 1 |
| p.Y583D | LUAD | 1 |
| p.S1225Y | STAD | 1 |
| p.H1259N | LUSC | 1 |
| p.L303V | STAD | 1 |
| p.E312D | LUSC | 1 |
| p.N435S | COAD | 1 |
| p.F55L | ESCA | 1 |
| p.H1234Y | CESC | 1 |
| p.E143K | SKCM | 1 |
| p.C1324R | SKCM | 1 |
| p.G918E | SKCM | 1 |
| p.I1030M | COAD | 1 |
| p.R824I | LUSC | 1 |
| p.D1126H | HNSC | 1 |
| p.E40K | SKCM | 1 |
| p.S224F | SKCM | 1 |
| p.H1177N | LUAD | 1 |
| p.Q1092E | LUAD | 1 |
| p.K1171N | LGG | 1 |
| p.E105A | STAD | 1 |
| p.R1179* | LUSC | 1 |
| p.R157I | UCS | 1 |
| p.P962L | LUAD | 1 |
| p.K935N | LUSC | 1 |
| p.L1295F | LUAD | 1 |
| p.R486Q | COAD | 1 |
| p.P536S | OV | 1 |
| p.P1278L | SKCM | 1 |
| p.T44R | LUAD | 1 |
| p.K449R | READ | 1 |
| p.I302L | DLBC | 1 |
| p.Q202K | STAD | 1 |
| p.K350N | BLCA | 1 |
| p.S366F | SKCM | 1 |
| p.P536S | ACC | 1 |
| p.A996T | HNSC | 1 |
| p.R755W | UCEC | 1 |
| p.K301N | STAD | 1 |
| p.G1084R | SARC | 1 |
| p.I1246V | UCEC | 1 |
| p.S208L | HNSC | 1 |
| p.S626Y | UCEC | 1 |
| p.G894R | UCEC | 1 |
| p.D308N | READ | 1 |
| p.E87X | COAD | 1 |
| p.K264M | ESCA | 1 |
| p.R182Q | HNSC | 1 |
| p.A269P | LUAD | 1 |
| p.Q850K | LUAD | 1 |
| p.P1253A | BLCA | 1 |
| p.N1113S | LGG | 1 |
| p.S626C | UCEC | 1 |
| p.Y552C | HNSC | 1 |
| p.R652I | UCS | 1 |
| p.C804F | LUSC | 1 |
| p.L1161I | UCEC | 1 |
| p.A1241V | BLCA | 1 |
| p.T459M | COAD | 1 |
| p.D491E | LUAD | 1 |
| p.Q1145* | LUSC | 1 |
| p.L1223I | SKCM | 1 |
| p.I150F | LUAD | 1 |
| p.V1085L | LUAD | 1 |
| p.V334I | KIRC | 1 |
| p.A1192S | ESCA | 1 |
| p.D522H | ESCA | 1 |
| p.R870I | COAD | 1 |
| p.Q984H | UCEC | 1 |
| p.E342X | STAD | 1 |
| p.K744I | SKCM | 1 |
| p.H330Y | LUAD | 1 |
| p.Q515K | LUAD | 1 |
| p.A1184S | LUAD | 1 |
| p.V688A | STAD | 1 |
| p.G906S | LUAD | 1 |
| p.P534Q | LUSC | 1 |
| p.E120A | DLBC | 1 |
| p.G690R | STAD | 1 |
| p.G319D | STAD | 1 |
| p.S858X | LIHC | 1 |
| p.K563X | READ | 1 |
| p.E988K | SKCM | 1 |
| p.T915P | SKCM | 1 |
| p.N54K | LIHC | 1 |
| p.S376N | HNSC | 1 |
| p.H851Q | LUSC | 1 |
| p.H1109Y | SKCM | 1 |
| p.Q1284* | CESC | 1 |
| p.S251P | STAD | 1 |
| p.I150M | ESCA | 1 |
| p.C591Y | LUAD | 1 |
| p.T915I | DLBC | 1 |
| p.E1090D | UCEC | 1 |
| p.E58* | LUAD | 1 |
| p.A986T | STAD | 1 |
| p.V1195A | LUSC | 1 |
| p.D1021N | SKCM | 1 |
| p.S164I | BLCA | 1 |
| p.E342K | SKCM | 1 |
| p.P1257T | ACC | 1 |
| p.P641T | SKCM | 1 |
| p.I1232M | DLBC | 1 |
| p.R95X | READ | 1 |
| p.F634I | COAD | 1 |
| p.G692R | SKCM | 1 |
| p.T295N | STAD | 1 |
| p.S1193P | COAD | 1 |
| p.A1273T | KIRC | 1 |
| p.V688A | ESCA | 1 |
| p.Q362R | COAD | 1 |
| p.E1340* | CESC | 1 |
| p.D1126E | LUSC | 1 |
| p.L582I | UCEC | 1 |
| p.T467R | LUSC | 1 |
| p.G690R | LUSC | 1 |
| p.D385E | OV | 1 |
| p.K901N | UCS | 1 |
| p.S835F | SARC | 1 |
| p.L1283R | STAD | 1 |
| p.R188X | READ | 1 |
| p.L173I | COAD | 1 |
| p.R182W | HNSC | 1 |
| p.S942R | HNSC | 1 |
| p.W545C | LUAD | 1 |
| p.P998S | BRCA | 1 |
| p.A1184E | STAD | 1 |
| p.D78H | ESCA | 1 |
| p.H1032Y | UCEC | 1 |
| p.E280G | KIRC | 1 |
| p.E342* | STAD | 1 |
| p.T1261S | SKCM | 1 |
| p.R707K | HNSC | 1 |
| p.H228N | ESCA | 1 |
| p.E289* | UCEC | 1 |
| p.P1278T | LUAD | 1 |
| p.M1169I | LUSC | 1 |
| p.F548L | COAD | 1 |
| p.L384Q | LUAD | 1 |
| p.I1307V | LUAD | 1 |
| p.H1211N | STAD | 1 |
| p.G971V | STAD | 1 |
| p.Q108H | PRAD | 1 |
| p.H1109Y | BRCA | 1 |
| p.K264T | STAD | 1 |
| p.C161F | LUSC | 1 |
| p.S376I | LUAD | 1 |
| p.D622E | DLBC | 1 |
| p.E386K | SKCM | 1 |
| p.Y1118D | COAD | 1 |
| p.L390Q | LUAD | 1 |
| p.E1090Q | BLCA | 1 |
| p.S1306Y | READ | 1 |
| p.S717I | UCEC | 1 |
| p.K603N | UCEC | 1 |
| p.H1010Y | LUAD | 1 |
| p.K563T | PRAD | 1 |
| p.P458T | LUSC | 1 |
| p.V97A | HNSC | 1 |
| p.P534L | UCEC | 1 |
| p.Q515* | SKCM | 1 |
| p.Y64C | LUSC | 1 |
| p.L461I | UCS | 1 |
| p.K615E | ESCA | 1 |
| p.T295A | LUSC | 1 |
| p.H1201Y | LUSC | 1 |
| p.S557R | HNSC | 1 |
| p.P458L | HNSC | 1 |
| p.A1272S | SARC | 1 |
| p.Q872K | LIHC | 1 |
| p.Q1215K | HNSC | 1 |
| p.D37H | STAD | 1 |
| p.P1293S | LIHC | 1 |
| p.E873K | HNSC | 1 |
| p.S397N | SKCM | 1 |
| p.H1325N | LUAD | 1 |
| p.Y473S | LUAD | 1 |
| p.T849P | ESCA | 1 |
| p.S160L | CESC | 1 |
| p.V1110I | SKCM | 1 |
| p.T273A | ACC | 1 |
| p.Y64C | LUAD | 1 |
| p.P477Q | LUSC | 1 |
| p.V750A | LUAD | 1 |
| p.H492Y | LUAD | 1 |
| p.Q1321H | STAD | 1 |
| p.E69K | UCEC | 1 |
| p.G894R | STAD | 1 |
| p.A363E | ESCA | 1 |
| p.R196H | ESCA | 1 |
| p.P962L | LIHC | 1 |
| p.A98D | STAD | 1 |
| p.G971R | LUAD | 1 |
| p.P1152L | SKCM | 1 |
| p.A269S | ESCA | 1 |
| p.E604K | SKCM | 1 |
| p.K41T | ESCA | 1 |
| p.N201K | UCEC | 1 |
| p.G502C | HNSC | 1 |
| p.K867E | HNSC | 1 |
| p.E751Q | SKCM | 1 |
| p.G894R | PRAD | 1 |
| p.S472C | HNSC | 1 |
| p.K82T | STAD | 1 |
| p.L1286M | LUSC | 1 |
| p.H330Y | LUSC | 1 |
| p.I302L | STAD | 1 |
| p.P641L | SKCM | 1 |
| p.H1168Y | KIRC | 1 |
| p.Q1170H | STAD | 1 |
| p.D1019E | LUAD | 1 |
| p.C60G | LUSC | 1 |
| p.K326T | COAD | 1 |
| p.T184I | CESC | 1 |
| p.T453N | HNSC | 1 |
| p.R974K | BRCA | 1 |
| p.R419K | LUAD | 1 |
| p.R707I | STAD | 1 |
| p.V446G | STAD | 1 |
| p.R870I | UCEC | 1 |
| p.G149X | STAD | 1 |
| p.G1075R | HNSC | 1 |
| p.K890T | ESCA | 1 |
| p.K638T | UCEC | 1 |
| p.L444F | SKCM | 1 |
| p.H669L | STAD | 1 |
| p.K935N | UCEC | 1 |
| p.E1133* | LUAD | 1 |
| p.C127_splice | LUSC | 1 |
| p.E919G | ESCA | 1 |
| p.V961F | LUAD | 1 |
| p.D620N | CESC | 1 |
| p.N1041H | UCEC | 1 |
| p.A119T | UCEC | 1 |
| p.K841E | UCEC | 1 |
| p.D1156Y | ESCA | 1 |
| p.H359Y | BLCA | 1 |
| p.Q447E | COAD | 1 |
| p.E58D | STAD | 1 |
| p.Q1170X | THYM | 1 |
| p.P477T | HNSC | 1 |
| p.E574* | LUSC | 1 |
| p.I1042T | UCEC | 1 |
| p.S1249W | LUAD | 1 |
| p.N1024K | LUSC | 1 |
| p.S953G | LUAD | 1 |
| p.E521D | READ | 1 |
| p.T459M | HNSC | 1 |
| p.S659G | STAD | 1 |
| p.R607T | LUAD | 1 |
| p.R379S | BRCA | 1 |
| p.S1249W | BLCA | 1 |
| p.H116R | STAD | 1 |
| p.L740I | STAD | 1 |
| p.I769M | STAD | 1 |
| p.Q872* | CESC | 1 |
| p.N562S | HNSC | 1 |
| p.S317* | UCEC | 1 |
| p.S893Y | LUAD | 1 |
| p.L173F | SKCM | 1 |
| p.C1328Y | HNSC | 1 |
| p.R550M | ESCA | 1 |
| p.L883P | SKCM | 1 |
| p.P1253A | LUSC | 1 |
| p.D530E | KIRC | 1 |
| p.E789K | LUAD | 1 |
| p.G451V | LIHC | 1 |
| p.E794X | STAD | 1 |
| p.Q1170* | LUSC | 1 |
| p.I983M | COAD | 1 |
| p.G149* | STAD | 1 |
| p.H445D | HNSC | 1 |
| p.S327T | SKCM | 1 |
| p.R512I | LIHC | 1 |
| p.T1086I | PAAD | 1 |
| p.D209Y | READ | 1 |
| p.K798* | HNSC | 1 |
| p.F1262L | COAD | 1 |
| p.W457S | HNSC | 1 |
| p.G971S | SKCM | 1 |
| p.H452R | SARC | 1 |
| p.T1254A | LUAD | 1 |
| p.N1343H | ESCA | 1 |
| p.I769T | ACC | 1 |
| p.E58* | HNSC | 1 |
| p.N949K | LUAD | 1 |
| p.I74M | UCEC | 1 |
| p.E278X | READ | 1 |
| p.G149E | SARC | 1 |
| p.N761T | LGG | 1 |
| p.K30N | UCS | 1 |
| p.K885E | STAD | 1 |
| p.E794* | STAD | 1 |
| p.E574K | SKCM | 1 |
| p.R614I | ESCA | 1 |
| p.Q1051E | LUSC | 1 |
| p.G737D | LGG | 1 |
| p.L1238I | STAD | 1 |
| p.Q816H | ESCA | 1 |
| p.R91W | BRCA | 1 |
| p.Q938X | STAD | 1 |
| p.R188Q | STAD | 1 |
| p.A1273V | LUAD | 1 |
| p.T1083A | LUSC | 1 |
| p.Y77* | BLCA | 1 |
| p.P641S | SKCM | 1 |
| p.L441I | LUAD | 1 |
| p.M575I | SKCM | 1 |
| p.F151I | STAD | 1 |
| p.H321R | UCS | 1 |
| p.S868N | PRAD | 1 |
| p.S1225Y | UCEC | 1 |
| p.E529K | SKCM | 1 |
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| TissGeneCNV for ZNF804B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ZNF804B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BM671376 | DOLPP1-ZNF804B | chr9:131851607 | chr7:88556176 | |
| Chimerdb3.0 | ChiTaRs | NA | BF447908 | ZNF804B-KCNA6 | chr7:88409002 | chr12:4923266 | |
| Chimerdb3.0 | ChiTaRs | NA | BI001044 | ZNF804B-PLG | chr7:88507168 | chr6:161152048 | |
| Chimerdb3.0 | ChiTaRs | NA | BG748632 | RPL28-ZNF804B | chr19:55899746 | chr7:88482050 |
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| TissGeneNet for ZNF804B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for ZNF804B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ZNF804B |
| TissGeneDrug for ZNF804B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ZNF804B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0003125 | Anorexia Nervosa | 1 | GAD |
| umls:C0020676 | Hypothyroidism | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
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