TissGeneSummary for TBATA |
Gene summary |
Basic gene information | Gene symbol | TBATA |
Gene name | thymus, brain and testes associated | |
Synonyms | C10orf27|spatial | |
Cytomap | UCSC genome browser: 10q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_152710.2, | |
Description | protein SPATIALprotein TBATAstromal protein associated with thymii and lymph node homologthymus, brain and testes-associated protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 612640 | |
HGNC : HGNC | ||
Ensembl : ENSG00000166220 | ||
HPRD : 08500 | ||
Vega : OTTHUMG00000018413 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TBATA | |
BioGPS: 219793 | ||
Pathway | NCI Pathway Interaction Database: TBATA | |
KEGG: TBATA | ||
REACTOME: TBATA | ||
Pathway Commons: TBATA | ||
Context | iHOP: TBATA | |
ligand binding site mutation search in PubMed: TBATA | ||
UCL Cancer Institute: TBATA | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | TestisThymus | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCTTHYM | |
Reference showing the relevant tissue of TBATA | Dynamic distribution of Spatial during mouse spermatogenesis and its interaction with the kinesin KIF17b. Exp Cell Res. 2007 Feb 1;313(3):614-26. Epub 2006 Nov 29. (pmid:20937703) go to articlePeptides presented by HLA class I molecules in the human thymus. J Proteomics. 2013 Dec 6;94:23-36. doi: 10.1016/j.jprot.2013.08.023. Epub 2013 Sep 9. (pmid:24029068) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TBATA |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for TBATA |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TBATA |
TissGeneSNV for TBATA |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E321K | SKCM | 2 |
p.G181E | SKCM | 1 |
p.V293L | LUAD | 1 |
p.R51Q | SKCM | 1 |
p.E164K | SKCM | 1 |
p.P309L | STAD | 1 |
p.K39T | LGG | 1 |
p.S25* | CESC | 1 |
p.I314V | KIRC | 1 |
p.Y253H | SKCM | 1 |
p.L266M | DLBC | 1 |
p.Q206* | LUAD | 1 |
p.P132S | LUAD | 1 |
p.Q227* | SKCM | 1 |
p.R202S | BLCA | 1 |
p.R51W | BLCA | 1 |
p.E299* | SKCM | 1 |
p.E299X | SKCM | 1 |
p.S204P | LIHC | 1 |
p.E174K | SKCM | 1 |
p.R27H | CHOL | 1 |
p.I43V | KIRC | 1 |
p.G218R | SKCM | 1 |
p.P106S | LUAD | 1 |
p.P138S | LUAD | 1 |
p.S126C | BLCA | 1 |
p.E341X | STAD | 1 |
p.R27C | LGG | 1 |
p.H205L | SKCM | 1 |
p.R202L | LUAD | 1 |
p.R155W | SKCM | 1 |
p.E295D | KIRP | 1 |
p.E341* | STAD | 1 |
p.P297S | SKCM | 1 |
p.E179G | KIRP | 1 |
p.R27H | PRAD | 1 |
p.Q227X | SKCM | 1 |
p.D104Y | LUAD | 1 |
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TissGeneCNV for TBATA |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TBATA |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TBATA |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TBATA |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TBATA |
TissGeneDrug for TBATA |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TBATA |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0019693 | HIV Infections | 2 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0026769 | Multiple Sclerosis | 1 | BeFree,GAD,LHGDN |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |