TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for PPP1R32

Gene summary

Basic gene information	Gene symbol	PPP1R32
	Gene name	protein phosphatase 1, regulatory subunit 32
	Synonyms	C11orf66\|IIIG9
	Cytomap	UCSC genome browser: 11q12.2
	Type of gene	protein-coding
	RefGenes	NM_001170753.1, NM_145017.2,
	Description	protein phosphatase 1 regulatory subunit 32
	Modification date	20141207
dbXrefs	HGNC : HGNC
	Ensembl : ENSG00000162148
	HPRD : 16933
	Vega : OTTHUMG00000168176
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PPP1R32
	BioGPS: 220004
Pathway	NCI Pathway Interaction Database: PPP1R32
	KEGG: PPP1R32
	REACTOME: PPP1R32
	Pathway Commons: PPP1R32
Context	iHOP: PPP1R32
	ligand binding site mutation search in PubMed: PPP1R32
	UCL Cancer Institute: PPP1R32
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	TGCT
Reference showing the relevant tissue of PPP1R32
Description by TissGene annotations

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO term

PubMed ID

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TissGeneExp for PPP1R32

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type

Mean(exp) in tumor

Mean(exp) in matched normal

Log2FC

P-val.

FDR

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TissGene-miRNA for PPP1R32

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for PPP1R32

TissGeneSNV for PPP1R32

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.E77K	THYM	1
p.S17G	LIHC	1
p.S11F	SKCM	1
p.R340Q	SKCM	1
p.P282S	LUAD	1
p.R173C	READ	1
p.D241H	COAD	1
p.T22M	LUAD	1
p.R269*	BLCA	1
p.A29T	CESC	1
p.P332L	SKCM	1
p.R129W	COAD	1
p.R38W	HNSC	1
p.R108C	LUAD	1
p.V10I	PRAD	1
p.S205I	ESCA	1
p.Q235H	THYM	1
p.S177L	COAD	1
p.T176M	HNSC	1
p.Q195H	LUAD	1
p.E311K	SKCM	1
p.P123S	SKCM	1
p.R395W	CESC	1
p.M2L	LIHC	1
p.E137Q	BLCA	1
p.S382T	COAD	1
p.R269Q	BLCA	1
p.R364Q	SKCM	1
p.K355E	STAD	1
p.Q136X	COAD	1
p.Q141R	DLBC	1
p.S198L	COAD	1
p.V61L	HNSC	1
p.T238N	DLBC	1
p.R38W	COAD	1
p.S85F	UCEC	1
p.P12L	SKCM	1
p.H155Y	PAAD	1
p.R44C	LIHC	1
p.H101Q	LUAD	1
p.S198L	STAD	1
p.G320W	PRAD	1
p.Q156H	LIHC	1
p.R129Q	UCEC	1
p.V49I	LUAD	1
p.P104S	SKCM	1
p.L67P	BLCA	1
p.R310W	STAD	1

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TissGeneCNV for PPP1R32

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for PPP1R32

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	CD723237	NUB1-PPP1R32		chr7:151073084	chr11:61258348
Chimerdb3.0	ChiTaRs	NA	BG399714	SDHAF2-PPP1R32		chr11:61205247	chr11:61256424
Chimerdb3.0	FusionScan	LUAD	TCGA-49-4512-01A	SDHAF2-PPP1R32	CDS-5'UTR	chr11:61197654	chr11:61249253
Chimerdb3.0	FusionScan	LUAD	TCGA-55-6980-11A	SDHAF2-PPP1R32	CDS-5'UTR	chr11:61197654	chr11:61249253
Chimerdb3.0	FusionScan	LUAD	TCGA-55-7284-01B	SDHAF2-PPP1R32	CDS-5'UTR	chr11:61197654	chr11:61249253
Chimerdb3.0	FusionScan	LUAD	TCGA-69-8253-01A	SDHAF2-PPP1R32	CDS-5'UTR	chr11:61197654	chr11:61249253
Chimerdb3.0	FusionScan	LUAD	TCGA-86-8281-01A	SDHAF2-PPP1R32	Out-of-Frame	chr11:61197654	chr11:61249782
Chimerdb3.0	FusionScan	LAML	TCGA-AB-2820-03A	SDHAF2-PPP1R32	CDS-5'UTR	chr11:61197654	chr11:61249253
Chimerdb3.0	FusionScan	LUAD	TCGA-44-6776-01A	SDHAF2-PPP1R32	CDS-5'UTR	chr11:61197654	chr11:61249253
Chimerdb3.0	FusionScan	LUSC	TCGA-85-8276-01A	SDHAF2-PPP1R32	CDS-5'UTR	chr11:61197654	chr11:61249253
Chimerdb3.0	FusionScan	LUSC	TCGA-92-7340-01A	SDHAF2-PPP1R32	CDS-5'UTR	chr11:61197654	chr11:61249253
Chimerdb3.0	FusionScan	LUSC	TCGA-33-6737-11A	SDHAF2-PPP1R32	CDS-5'UTR	chr11:61197654	chr11:61249253

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TissGeneNet for PPP1R32

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

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TissGeneProg for PPP1R32

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for PPP1R32

TissGeneDrug for PPP1R32

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for PPP1R32

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID

Disease name

# pubmeds

Source