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| TissGeneSummary for SPERT |
 Gene summary |
| Basic gene information | Gene symbol | SPERT |
| Gene name | spermatid associated | |
| Synonyms | CBY2|NURIT | |
| Cytomap | UCSC genome browser: 13q14.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001286341.1, NM_001286342.1,NM_152719.2, | |
| Description | novel leucine zipper testicular proteinprotein chibby homolog 2spermatid flower-like structure proteinspermatid-associated proteintestis-specific leucine zipper protein nurit | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000174015 | ||
| HPRD : 14856 | ||
| Vega : OTTHUMG00000016861 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SPERT | |
| BioGPS: 220082 | ||
| Pathway | NCI Pathway Interaction Database: SPERT | |
| KEGG: SPERT | ||
| REACTOME: SPERT | ||
| Pathway Commons: SPERT | ||
| Context | iHOP: SPERT | |
| ligand binding site mutation search in PubMed: SPERT | ||
| UCL Cancer Institute: SPERT | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of SPERT | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SPERT |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -2.100950623 | -0.059290623 | -2.04166 | 2.00E-07 | 8.64E-07 |
| KIRP | -2.317503373 | -0.600306498 | -1.717196875 | 5.76E-10 | 5.61E-09 |
| COAD | 0.591815377 | -2.745030777 | 3.336846154 | 2.31E-11 | 4.15E-10 |
| LUAD | -0.670815658 | -2.44376221 | 1.772946552 | 1.01E-07 | 3.94E-07 |
| HNSC | 0.914730493 | -1.231032298 | 2.145762791 | 1.29E-11 | 3.30E-10 |
| LUSC | 0.861018318 | -2.388564035 | 3.249582353 | 1.41E-21 | 2.09E-20 |
| KIRC | -2.020805457 | -0.606204068 | -1.414601389 | 3.77E-12 | 1.53E-11 |
| STAD | -0.308640873 | -2.629462748 | 2.320821875 | 8.88E-07 | 1.48E-05 |
| ESCA | -0.28279826 | -2.508025533 | 2.225227273 | 0.0017 | 0.020888398 |
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| TissGene-miRNA for SPERT |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SPERT |
| TissGeneSNV for SPERT |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.K329E | COAD | 7 |
| p.S286X | ACC | 5 |
| p.K329E | READ | 3 |
| p.E217K | SKCM | 2 |
| p.S286X | COAD | 2 |
| p.A72T | READ | 2 |
| p.S170L | SKCM | 1 |
| p.A256T | BRCA | 1 |
| p.A110D | STAD | 1 |
| p.R240H | UCEC | 1 |
| p.R79W | STAD | 1 |
| p.R58S | LUAD | 1 |
| p.P55L | SKCM | 1 |
| p.R411S | HNSC | 1 |
| p.V48A | LUAD | 1 |
| p.W164R | LUAD | 1 |
| p.R79Q | STAD | 1 |
| p.L106M | STAD | 1 |
| p.V98M | COAD | 1 |
| p.A235T | GBM | 1 |
| p.A307T | LUAD | 1 |
| p.P179S | SKCM | 1 |
| p.A110V | THYM | 1 |
| p.L214F | SKCM | 1 |
| p.R141H | COAD | 1 |
| p.R105C | HNSC | 1 |
| p.A235T | UCEC | 1 |
| p.R355M | LUAD | 1 |
| p.A36T | SARC | 1 |
| p.R69C | HNSC | 1 |
| p.R120W | COAD | 1 |
| p.M48I | SKCM | 1 |
| p.P109S | SKCM | 1 |
| p.S286X | THCA | 1 |
| p.K206M | SKCM | 1 |
| p.S216L | STAD | 1 |
| p.A235T | STAD | 1 |
| p.R213Q | LIHC | 1 |
| p.R94H | COAD | 1 |
| p.S170W | BLCA | 1 |
| p.R173Q | SKCM | 1 |
| p.E57K | PAAD | 1 |
| p.A49V | LGG | 1 |
| p.A76V | GBM | 1 |
| p.R151W | LGG | 1 |
| p.Q367X | KIRP | 1 |
| p.P55S | SKCM | 1 |
| p.P45L | PAAD | 1 |
| p.E5K | SKCM | 1 |
| p.R187Q | UCEC | 1 |
| p.R447S | HNSC | 1 |
| p.M390I | LUAD | 1 |
| p.V417M | READ | 1 |
| p.N28Y | BLCA | 1 |
| p.S206L | SKCM | 1 |
| p.A256V | KICH | 1 |
| p.K242M | SKCM | 1 |
| p.E142K | SKCM | 1 |
| p.Q87X | STAD | 1 |
| p.P91S | SKCM | 1 |
| p.R134H | COAD | 1 |
| p.I378V | LUAD | 1 |
| p.D75N | PRAD | 1 |
| p.L42V | LUAD | 1 |
| p.S89F | LUSC | 1 |
| p.S53Y | HNSC | 1 |
| p.P409L | SKCM | 1 |
| p.A199T | BLCA | 1 |
| p.N57K | LUAD | 1 |
| p.E156K | SKCM | 1 |
| p.N186S | STAD | 1 |
| p.Q87* | STAD | 1 |
| p.P145L | HNSC | 1 |
| p.R219H | SKCM | 1 |
| p.E216K | SKCM | 1 |
| p.P109L | HNSC | 1 |
| p.E396K | LUSC | 1 |
| p.A343T | LUAD | 1 |
| p.A72T | STAD | 1 |
| p.L142M | STAD | 1 |
| p.G352S | COAD | 1 |
| p.R219C | SKCM | 1 |
| p.V192G | LUAD | 1 |
| p.E21K | PAAD | 1 |
| p.E341G | LIHC | 1 |
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| TissGeneCNV for SPERT |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SPERT |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SPERT |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SPERT, TUBGCP4, NINL (tumor) | SPERT, TUBGCP4, NINL (normal) |
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| COAD (tumor) | COAD (normal) |
| SPERT, TUBGCP4, NINL (tumor) | SPERT, TUBGCP4, NINL (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SPERT, TUBGCP4, NINL (tumor) | SPERT, TUBGCP4, NINL (normal) |
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| KICH (tumor) | KICH (normal) |
| SPERT, TUBGCP4, NINL (tumor) | SPERT, TUBGCP4, NINL (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SPERT, TUBGCP4, NINL (tumor) | SPERT, TUBGCP4, NINL (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SPERT, TUBGCP4, NINL (tumor) | SPERT, TUBGCP4, NINL (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SPERT, TUBGCP4, NINL (tumor) | SPERT, TUBGCP4, NINL (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SPERT, TUBGCP4, NINL (tumor) | SPERT, TUBGCP4, NINL (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SPERT, TUBGCP4, NINL (tumor) | SPERT, TUBGCP4, NINL (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SPERT, TUBGCP4, NINL (tumor) | SPERT, TUBGCP4, NINL (normal) |
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| STAD (tumor) | STAD (normal) |
| SPERT, TUBGCP4, NINL (tumor) | SPERT, TUBGCP4, NINL (normal) |
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| THCA (tumor) | THCA (normal) |
| SPERT, TUBGCP4, NINL (tumor) | SPERT, TUBGCP4, NINL (normal) |
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| TissGeneProg for SPERT |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SPERT |
| TissGeneDrug for SPERT |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SPERT |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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