TissGeneSummary for RNF152 |
Gene summary |
Basic gene information | Gene symbol | RNF152 |
Gene name | ring finger protein 152 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 18q21.33 | |
Type of gene | protein-coding | |
RefGenes | NM_173557.2, | |
Description | E3 ubiquitin-protein ligase RNF152 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
HPRD : 11514 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RNF152 | |
BioGPS: 220441 | ||
Pathway | NCI Pathway Interaction Database: RNF152 | |
KEGG: RNF152 | ||
REACTOME: RNF152 | ||
Pathway Commons: RNF152 | ||
Context | iHOP: RNF152 | |
ligand binding site mutation search in PubMed: RNF152 | ||
UCL Cancer Institute: RNF152 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of RNF152 | ||
Description by TissGene annotations | Protective TissGene in OS Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0070936 | protein K48-linked ubiquitination | 21203937 | GO:0070936 | protein K48-linked ubiquitination | 21203937 |
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TissGeneExp for RNF152 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | -0.327807115 | 1.575772885 | -1.90358 | 1.29E-16 | 5.62E-15 |
KIRP | -1.38728074 | 2.475559885 | -3.862840625 | 1.07E-12 | 1.71E-11 |
COAD | -2.448211269 | 0.140715654 | -2.588926923 | 1.63E-16 | 1.49E-14 |
KIRC | 0.743418218 | 2.362025163 | -1.618606944 | 2.62E-14 | 1.26E-13 |
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TissGene-miRNA for RNF152 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
UCS | hsa-miR-181a-5p | MIMAT0000256 | 0.049 | -0.27 | 56 |
UCS | hsa-miR-181b-5p | MIMAT0000257 | 0.045 | -0.27 | 56 |
UVM | hsa-miR-96-5p | MIMAT0000095 | 0.0082 | -0.31 | 80 |
UCS | hsa-miR-137 | MIMAT0000429 | 0.031 | -0.33 | 56 |
UCS | hsa-miR-218-5p | MIMAT0000275 | 0.014 | -0.33 | 56 |
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TissGeneMut for RNF152 |
TissGeneSNV for RNF152 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P95S | SKCM | 6 |
p.E153K | SKCM | 2 |
p.S194C | BLCA | 1 |
p.S194Y | UCEC | 1 |
p.G168E | SKCM | 1 |
p.E149K | SKCM | 1 |
p.K108M | LUAD | 1 |
p.P70L | UCEC | 1 |
p.Q6X | SKCM | 1 |
p.S67L | UCEC | 1 |
p.A80T | PAAD | 1 |
p.Q155H | LUAD | 1 |
p.R120H | ESCA | 1 |
p.P21L | SKCM | 1 |
p.P136S | SKCM | 1 |
p.S125T | BLCA | 1 |
p.R110G | KIRP | 1 |
p.E2K | SKCM | 1 |
p.E154K | SKCM | 1 |
p.R158Q | LUAD | 1 |
p.D116N | SKCM | 1 |
p.I185V | CESC | 1 |
p.G98W | LUAD | 1 |
p.D48N | SKCM | 1 |
p.G184S | SKCM | 1 |
p.M117I | SKCM | 1 |
p.S20N | SKCM | 1 |
p.Q6* | SKCM | 1 |
p.G144V | STAD | 1 |
p.D72N | SKCM | 1 |
p.A111V | COAD | 1 |
p.E2D | LUAD | 1 |
p.E109K | SKCM | 1 |
p.S85F | SKCM | 1 |
p.V133A | LIHC | 1 |
p.G144S | LUAD | 1 |
p.A80T | LIHC | 1 |
p.R50W | STAD | 1 |
p.P21S | SKCM | 1 |
p.V178I | PAAD | 1 |
p.Q40H | KIRP | 1 |
p.S36L | LUSC | 1 |
p.R50P | SKCM | 1 |
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TissGeneCNV for RNF152 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for RNF152 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | HNSC | TCGA-CV-6954-01A | RNF152-PIGN | 5UTR-CDS | Chr18:59560028 | Chr18:59774318 |
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TissGeneNet for RNF152 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for RNF152 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for RNF152 |
TissGeneDrug for RNF152 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for RNF152 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0153638 | Malignant neoplasm of occipital lobe | 1 | GAD |