TissGeneSummary for OPN5 |
Gene summary |
Basic gene information | Gene symbol | OPN5 |
Gene name | opsin 5 | |
Synonyms | GPR136|GRP136|PGR12|TMEM13 | |
Cytomap | UCSC genome browser: 6p12.3 | |
Type of gene | protein-coding | |
RefGenes | NM_181744.3, NR_033806.1,NM_001030051.1, | |
Description | G-protein coupled receptor 136neuropsinopsin-5transmembrane protein 13 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609042 | |
HGNC : HGNC | ||
HPRD : 12358 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_OPN5 | |
BioGPS: 221391 | ||
Pathway | NCI Pathway Interaction Database: OPN5 | |
KEGG: OPN5 | ||
REACTOME: OPN5 | ||
Pathway Commons: OPN5 | ||
Context | iHOP: OPN5 | |
ligand binding site mutation search in PubMed: OPN5 | ||
UCL Cancer Institute: OPN5 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of OPN5 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for OPN5 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for OPN5 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for OPN5 |
TissGeneSNV for OPN5 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R61Q | SKCM | 2 |
p.G113R | SKCM | 1 |
p.A299V | PRAD | 1 |
p.S288F | BLCA | 1 |
p.M57K | SKCM | 1 |
p.R131Q | ESCA | 1 |
p.A276P | LUAD | 1 |
p.K147N | LUSC | 1 |
p.A213V | PRAD | 1 |
p.T212K | LUAD | 1 |
p.D11N | SKCM | 1 |
p.R61* | LGG | 1 |
p.S58Y | ACC | 1 |
p.K147N | SARC | 1 |
p.R107C | COAD | 1 |
p.D79N | SKCM | 1 |
p.S229Y | LUAD | 1 |
p.I73M | BLCA | 1 |
p.Y301* | LUAD | 1 |
p.W99C | LUAD | 1 |
p.S275* | HNSC | 1 |
p.R13H | UCEC | 1 |
p.A323S | STAD | 1 |
p.A2V | LUAD | 1 |
p.S344T | LUAD | 1 |
p.C118R | STAD | 1 |
p.K62R | HNSC | 1 |
p.K325N | UCS | 1 |
p.G50E | SKCM | 1 |
p.Q286L | LUAD | 1 |
p.A213V | LUAD | 1 |
p.A234D | LIHC | 1 |
p.H235Y | SKCM | 1 |
p.A68T | OV | 1 |
p.P211Q | LUSC | 1 |
p.E232* | LUAD | 1 |
p.T251A | LIHC | 1 |
p.Y219* | LUAD | 1 |
p.G260A | ESCA | 1 |
p.E232K | SKCM | 1 |
p.L287H | LGG | 1 |
p.A112V | STAD | 1 |
p.V337I | HNSC | 1 |
p.E69A | SKCM | 1 |
p.A254V | ESCA | 1 |
p.K62N | UCEC | 1 |
p.R61X | LGG | 1 |
p.S83L | BLCA | 1 |
p.D130Y | LUAD | 1 |
p.M71I | LUAD | 1 |
p.I203T | CESC | 1 |
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TissGeneCNV for OPN5 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for OPN5 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for OPN5 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for OPN5 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for OPN5 |
TissGeneDrug for OPN5 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for OPN5 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004936 | Mental disorders | 1 | BeFree |
umls:C0005586 | Bipolar Disorder | 1 | BeFree,LHGDN |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree |