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| TissGeneSummary for C6orf223 |
 Gene summary |
| Basic gene information | Gene symbol | C6orf223 |
| Gene name | chromosome 6 open reading frame 223 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 6p21.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001171992.1, NM_153246.4, | |
| Description | uncharacterized protein C6orf223 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000181577 | ||
| HPRD : 14640 | ||
| Vega : OTTHUMG00000014753 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_C6orf223 | |
| BioGPS: 221416 | ||
| Pathway | NCI Pathway Interaction Database: C6orf223 | |
| KEGG: C6orf223 | ||
| REACTOME: C6orf223 | ||
| Pathway Commons: C6orf223 | ||
| Context | iHOP: C6orf223 | |
| ligand binding site mutation search in PubMed: C6orf223 | ||
| UCL Cancer Institute: C6orf223 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixColonLung | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCCOADLUAD,LUSC | |
| Reference showing the relevant tissue of C6orf223 | ||
| Description by TissGene annotations | Risk TissGene in RFS Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for C6orf223 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | -2.079509546 | 1.536806079 | -3.616315625 | 8.44E-11 | 9.80E-10 |
| STAD | 1.548434204 | -1.478956421 | 3.027390625 | 3.48E-07 | 7.12E-06 |
| LUSC | 1.553029792 | 3.091063126 | -1.538033333 | 2.46E-05 | 5.42E-05 |
| COAD | 3.810905358 | -0.884475411 | 4.695380769 | 3.77E-16 | 3.18E-14 |
| KIRC | 4.071866149 | 1.252081426 | 2.819784722 | 3.52E-20 | 2.83E-19 |
| HNSC | -0.436761726 | -1.548805912 | 1.112044186 | 0.0153 | 0.035599793 |
| BLCA | -1.506093428 | -3.514361849 | 2.008268421 | 0.0024 | 0.014826667 |
| ESCA | 1.510186477 | -3.063004432 | 4.573190909 | 1.21E-06 | 0.000542656 |
| LUAD | 1.777459204 | 3.036238514 | -1.25877931 | 3.98E-05 | 0.000107426 |
| Top |
| TissGene-miRNA for C6orf223 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-27a-3p | MIMAT0000084 | 0.0073 | -0.36 | 56 |
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| TissGeneMut for C6orf223 |
| TissGeneSNV for C6orf223 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.F39C | SKCM | 1 |
| p.A124P | CESC | 1 |
| p.E32K | SKCM | 1 |
| p.S17* | BLCA | 1 |
| p.T117S | BLCA | 1 |
| p.R234C | SKCM | 1 |
| p.R221L | LUSC | 1 |
| p.P226Q | LIHC | 1 |
| p.P206S | SKCM | 1 |
| p.R234C | BLCA | 1 |
| p.D43N | SKCM | 1 |
| p.L53F | SKCM | 1 |
| p.L71P | KIRP | 1 |
| p.R221C | KIRP | 1 |
| p.R30K | SKCM | 1 |
| Top |
| TissGeneCNV for C6orf223 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for C6orf223 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for C6orf223 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for C6orf223 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for C6orf223 |
| TissGeneDrug for C6orf223 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for C6orf223 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0242383 | Age related macular degeneration | 1 | BeFree |
| umls:C0271084 | Exudative age-related macular degeneration | 1 | GWASCAT |
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