TissGeneSummary for SP8 |
Gene summary |
Basic gene information | Gene symbol | SP8 |
Gene name | Sp8 transcription factor | |
Synonyms | BTD | |
Cytomap | UCSC genome browser: 7p21.2 | |
Type of gene | protein-coding | |
RefGenes | NM_182700.5, NM_198956.3, | |
Description | specificity protein 8transcription factor Sp8 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608306 | |
HGNC : HGNC | ||
HPRD : 12208 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SP8 | |
BioGPS: 221833 | ||
Pathway | NCI Pathway Interaction Database: SP8 | |
KEGG: SP8 | ||
REACTOME: SP8 | ||
Pathway Commons: SP8 | ||
Context | iHOP: SP8 | |
ligand binding site mutation search in PubMed: SP8 | ||
UCL Cancer Institute: SP8 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainProstate | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGPRAD | |
Reference showing the relevant tissue of SP8 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SP8 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -0.026473051 | -2.615406385 | 2.588933333 | 1.45E-10 | 5.36E-10 |
HNSC | -0.397658778 | -2.308623895 | 1.910965116 | 5.15E-08 | 5.32E-07 |
COAD | -0.430981498 | -2.761904575 | 2.330923077 | 4.63E-06 | 2.28E-05 |
LUAD | -0.031743301 | -2.602948474 | 2.571205172 | 2.45E-09 | 1.23E-08 |
ESCA | 0.466896824 | -2.796512267 | 3.263409091 | 0.00034 | 0.007384544 |
STAD | -0.841190392 | -2.510099767 | 1.668909375 | 7.40E-05 | 0.000591758 |
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TissGene-miRNA for SP8 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SP8 |
TissGeneSNV for SP8 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G138S | TGCT | 3 |
p.S37L | BLCA | 2 |
p.A4S | LUAD | 1 |
p.E201K | STAD | 1 |
p.R347H | UCEC | 1 |
p.G354V | HNSC | 1 |
p.D401N | STAD | 1 |
p.G156S | LIHC | 1 |
p.A331T | KIRP | 1 |
p.H270Y | STAD | 1 |
p.R414C | STAD | 1 |
p.G171R | STAD | 1 |
p.R396C | STAD | 1 |
p.G163C | TGCT | 1 |
p.D419N | STAD | 1 |
p.S371L | READ | 1 |
p.G138S | MESO | 1 |
p.A42S | READ | 1 |
p.Y367C | SKCM | 1 |
p.R417H | UCEC | 1 |
p.A375V | STAD | 1 |
p.H288Y | STAD | 1 |
p.S18F | SKCM | 1 |
p.H157R | PRAD | 1 |
p.P501A | LIHC | 1 |
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TissGeneCNV for SP8 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SP8 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SP8 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SP8 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SP8 |
TissGeneDrug for SP8 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SP8 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0005586 | Bipolar Disorder | 2 | BeFree,GAD |
umls:C0033975 | Psychotic Disorders | 1 | BeFree |
umls:C0220754 | Biotinidase Deficiency | 1 | BeFree |
umls:C0349204 | Nonorganic psychosis | 1 | BeFree |