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| TissGeneSummary for FCN2 |
 Gene summary |
| Basic gene information | Gene symbol | FCN2 |
| Gene name | ficolin (collagen/fibrinogen domain containing lectin) 2 | |
| Synonyms | EBP-37|FCNL|P35|ficolin-2 | |
| Cytomap | UCSC genome browser: 9q34.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004108.2, NM_015837.2,NM_015838.1,NM_015839.1, | |
| Description | 37 kDa elastin-binding proteinL-ficolincollagen/fibrinogen domain-containing protein 2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)ficolin Bficolin-2ficolin-Bficolin-betaserum lectin p35 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601624 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000160339 | ||
| HPRD : 03376 | ||
| Vega : OTTHUMG00000020892 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FCN2 | |
| BioGPS: 2220 | ||
| Pathway | NCI Pathway Interaction Database: FCN2 | |
| KEGG: FCN2 | ||
| REACTOME: FCN2 | ||
| Pathway Commons: FCN2 | ||
| Context | iHOP: FCN2 | |
| ligand binding site mutation search in PubMed: FCN2 | ||
| UCL Cancer Institute: FCN2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of FCN2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for FCN2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 0.97179728 | 8.14463928 | -7.172842 | 1.00E-25 | 2.94E-23 |
| BRCA | -0.507940124 | 1.189686192 | -1.697626316 | 4.58E-12 | 1.97E-11 |
| KIRP | -0.99275997 | 0.01139003 | -1.00415 | 0.00216 | 0.00547819 |
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| TissGene-miRNA for FCN2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FCN2 |
| TissGeneSNV for FCN2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.A185T | STAD | 2 |
| p.R103H | UCEC | 2 |
| p.Q165* | SKCM | 1 |
| p.E152K | SKCM | 1 |
| p.P79S | SKCM | 1 |
| p.P54S | SKCM | 1 |
| p.T198A | THCA | 1 |
| p.T236A | THCA | 1 |
| p.Q224P | ESCA | 1 |
| p.C257F | STAD | 1 |
| p.V174L | LUAD | 1 |
| p.A193G | LUAD | 1 |
| p.A147T | STAD | 1 |
| p.E228V | STAD | 1 |
| p.A288G | LUAD | 1 |
| p.K106X | SKCM | 1 |
| p.S248N | SKCM | 1 |
| p.E190K | SKCM | 1 |
| p.S286N | DLBC | 1 |
| p.G217R | SKCM | 1 |
| p.D100N | PAAD | 1 |
| p.T130N | UCEC | 1 |
| p.G21D | ESCA | 1 |
| p.G255R | SKCM | 1 |
| p.G117S | READ | 1 |
| p.A13S | LUAD | 1 |
| p.K68* | SKCM | 1 |
| p.L197M | LUAD | 1 |
| p.G167S | COAD | 1 |
| p.Q146H | LUAD | 1 |
| p.Q146H | ESCA | 1 |
| p.T236M | COAD | 1 |
| p.Q203X | SKCM | 1 |
| p.L26P | LUAD | 1 |
| p.C52F | COAD | 1 |
| p.N163K | LUAD | 1 |
| p.G11V | LUSC | 1 |
| p.R154L | LUAD | 1 |
| p.P41S | SKCM | 1 |
| p.M1I | HNSC | 1 |
| p.G176W | LUAD | 1 |
| p.A65S | ESCA | 1 |
| p.E179K | SKCM | 1 |
| p.Q108H | ESCA | 1 |
| p.G247S | SKCM | 1 |
| p.M260T | COAD | 1 |
| p.Y124* | HNSC | 1 |
| p.L191I | COAD | 1 |
| p.I83M | LUAD | 1 |
| p.R119L | HNSC | 1 |
| p.W104* | SKCM | 1 |
| p.G247S | SARC | 1 |
| p.G72E | SKCM | 1 |
| p.A213V | STAD | 1 |
| p.Q262P | ESCA | 1 |
| p.G101V | KIRP | 1 |
| p.Q108H | LUAD | 1 |
| p.L15M | UCEC | 1 |
| p.I48V | LUAD | 1 |
| p.D138N | PAAD | 1 |
| p.A216V | STAD | 1 |
| p.D69N | SKCM | 1 |
| p.R71T | BRCA | 1 |
| p.G138W | LUAD | 1 |
| p.D194Y | READ | 1 |
| p.A250G | LUAD | 1 |
| p.A258S | COAD | 1 |
| p.M37V | OV | 1 |
| p.A65T | UCEC | 1 |
| p.D107N | SKCM | 1 |
| p.A28V | PAAD | 1 |
| p.D30N | BLCA | 1 |
| p.G101R | SKCM | 1 |
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| TissGeneCNV for FCN2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FCN2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for FCN2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (tumor) | FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (normal) |
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| COAD (tumor) | COAD (normal) |
| FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (tumor) | FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (tumor) | FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (normal) |
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| KICH (tumor) | KICH (normal) |
| FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (tumor) | FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (tumor) | FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (tumor) | FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (tumor) | FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (tumor) | FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (tumor) | FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (tumor) | FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (normal) |
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| STAD (tumor) | STAD (normal) |
| FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (tumor) | FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (normal) |
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| THCA (tumor) | THCA (normal) |
| FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (tumor) | FCN2, PITX3, CRP, MASP2, PTX3, MASP1 (normal) |
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| TissGeneProg for FCN2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FCN2 |
| TissGeneDrug for FCN2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FCN2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0035243 | Respiratory Tract Infections | 4 | BeFree,GAD |
| umls:C0524851 | Neurodegenerative Disorders | 4 | BeFree |
| umls:C0004623 | Bacterial Infections | 2 | BeFree,GAD |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | BeFree |
| umls:C0019163 | Hepatitis B | 2 | BeFree |
| umls:C0023343 | Leprosy | 2 | BeFree,GAD |
| umls:C0024141 | Lupus Erythematosus, Systemic | 2 | BeFree |
| umls:C0024198 | Lyme Disease | 2 | BeFree |
| umls:C0024530 | Malaria | 2 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
| umls:C0036323 | Schistosomiasis | 2 | BeFree |
| umls:C0042769 | Virus Diseases | 2 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 2 | BeFree |
| umls:C3280586 | Mannose-Binding Protein Deficiency | 2 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | GAD |
| umls:C0004096 | Asthma | 1 | BeFree |
| umls:C0004114 | Astrocytoma | 1 | BeFree |
| umls:C0004943 | Behcet Syndrome | 1 | BeFree,GAD |
| umls:C0006111 | Brain Diseases | 1 | BeFree |
| umls:C0006267 | Bronchiectasis | 1 | BeFree |
| umls:C0009447 | Common Variable Immunodeficiency | 1 | BeFree |
| umls:C0010346 | Crohn Disease | 1 | BeFree |
| umls:C0010823 | Cytomegalovirus Infections | 1 | BeFree |
| umls:C0019196 | Hepatitis C | 1 | BeFree |
| umls:C0023281 | Leishmaniasis | 1 | BeFree |
| umls:C0023283 | Leishmaniasis, Cutaneous | 1 | BeFree |
| umls:C0023290 | Leishmaniasis, Visceral | 1 | BeFree |
| umls:C0025202 | melanoma | 1 | BeFree |
| umls:C0026847 | Spinal Muscular Atrophy | 1 | BeFree |
| umls:C0027765 | nervous system disorder | 1 | BeFree |
| umls:C0027819 | Neuroblastoma | 1 | BeFree |
| umls:C0029463 | Osteosarcoma | 1 | BeFree |
| umls:C0030524 | Paratuberculosis | 1 | BeFree |
| umls:C0031154 | Peritonitis | 1 | BeFree |
| umls:C0032269 | Pneumococcal Infections | 1 | BeFree |
| umls:C0032787 | Postoperative Complications | 1 | GAD |
| umls:C0035204 | Respiration Disorders | 1 | BeFree |
| umls:C0035242 | Respiratory Tract Diseases | 1 | BeFree |
| umls:C0035436 | Rheumatic Fever | 1 | BeFree,GAD |
| umls:C0035439 | Rheumatic Heart Disease | 1 | BeFree,GAD |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0036916 | Sexually Transmitted Diseases | 1 | BeFree |
| umls:C0038395 | Streptococcal Infections | 1 | BeFree,GAD |
| umls:C0038454 | Cerebrovascular accident | 1 | BeFree |
| umls:C0041296 | Tuberculosis | 1 | BeFree |
| umls:C0041327 | Tuberculosis, Pulmonary | 1 | BeFree |
| umls:C0041341 | Tuberous Sclerosis | 1 | BeFree |
| umls:C0158944 | Infections specific to perinatal period | 1 | BeFree |
| umls:C0175708 | Chronic rheumatic heart disease | 1 | BeFree |
| umls:C0220756 | Niemann-Pick Disease, Type C | 1 | BeFree |
| umls:C0233794 | Memory impairment | 1 | BeFree |
| umls:C0276609 | Acute type B viral hepatitis | 1 | BeFree |
| umls:C0333186 | Restenosis | 1 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
| umls:C0700095 | Central neuroblastoma | 1 | BeFree |
| umls:C0863094 | Recurrent respiratory tract infections | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | BeFree |
| umls:C1292769 | Precursor B-cell lymphoblastic leukemia | 1 | BeFree |
| umls:C1562908 | Leprosy, Paucibacillary | 1 | BeFree |
| umls:C1704430 | Urinary Schistosomiasis | 1 | BeFree |
| umls:C1846064 | Recurrent infections (sinusitis and bacterial pneumonia and meningitis) | 1 | BeFree |
| umls:C1848199 | X-Linked Lissencephaly | 1 | BeFree |
| umls:C2607914 | Allergic rhinitis (disorder) | 1 | BeFree |
| umls:C3665346 | Unspecified visual loss | 1 | BeFree |
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