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| TissGeneSummary for SCUBE3 |
 Gene summary |
| Basic gene information | Gene symbol | SCUBE3 |
| Gene name | signal peptide, CUB domain, EGF-like 3 | |
| Synonyms | CEGF3 | |
| Cytomap | UCSC genome browser: 6p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001303136.1, NM_152753.3, | |
| Description | CUB domain and EGF-like repeat containing 3signal peptide, CUB and EGF-like domain containing protein 3signal peptide, CUB and EGF-like domain-containing protein 3signal peptide-, CUB domain-, and EGF-like domains-containing protein 3 | |
| Modification date | 20141219 | |
| dbXrefs | MIM : 614708 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000146197 | ||
| HPRD : 18031 | ||
| Vega : OTTHUMG00000014562 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SCUBE3 | |
| BioGPS: 222663 | ||
| Pathway | NCI Pathway Interaction Database: SCUBE3 | |
| KEGG: SCUBE3 | ||
| REACTOME: SCUBE3 | ||
| Pathway Commons: SCUBE3 | ||
| Context | iHOP: SCUBE3 | |
| ligand binding site mutation search in PubMed: SCUBE3 | ||
| UCL Cancer Institute: SCUBE3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Thyroid gland | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | THCA | |
| Reference showing the relevant tissue of SCUBE3 | ||
| Description by TissGene annotations | Risk TissGene in OS Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0051260 | protein homooligomerization | 15234972 | GO:0051260 | protein homooligomerization | 15234972 |
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| TissGeneExp for SCUBE3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | 1.286431012 | -0.191308643 | 1.477739655 | 2.38E-06 | 7.48E-06 |
| KIRC | -0.326051219 | 1.674246003 | -2.000297222 | 1.37E-12 | 5.78E-12 |
| BRCA | 1.170707479 | -0.534104801 | 1.704812281 | 9.86E-13 | 4.43E-12 |
| THCA | 3.463284256 | 5.698428324 | -2.235144068 | 3.11E-14 | 3.50E-13 |
| KICH | -1.634255608 | 0.724188392 | -2.358444 | 8.11E-07 | 3.08E-06 |
| LUSC | 1.694648862 | -0.065168785 | 1.759817647 | 4.88E-07 | 1.27E-06 |
| KIRP | -1.871580733 | 1.922753642 | -3.794334375 | 6.52E-13 | 1.08E-11 |
| HNSC | -0.45947412 | -2.178567143 | 1.719093023 | 0.00047 | 0.001765442 |
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| TissGene-miRNA for SCUBE3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-182-5p | MIMAT0000259 | 0.00066 | -0.38 | 78 |
| ACC | hsa-miR-182-5p | MIMAT0000259 | 0.00066 | -0.38 | 78 |
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| TissGeneMut for SCUBE3 |
| TissGeneSNV for SCUBE3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R840H | STAD | 2 |
| p.A241T | ESCA | 1 |
| p.S419F | SKCM | 1 |
| p.P50L | COAD | 1 |
| p.R293H | ACC | 1 |
| p.R139Q | COAD | 1 |
| p.P818H | SKCM | 1 |
| p.K545N | SKCM | 1 |
| p.G512C | UCEC | 1 |
| p.C669* | LUAD | 1 |
| p.R293C | ESCA | 1 |
| p.A737T | LIHC | 1 |
| p.S406R | UCEC | 1 |
| p.R929* | LUSC | 1 |
| p.R588K | SKCM | 1 |
| p.L587I | LIHC | 1 |
| p.K947R | LIHC | 1 |
| p.R173W | LGG | 1 |
| p.T256I | HNSC | 1 |
| p.D604N | SKCM | 1 |
| p.L587V | SKCM | 1 |
| p.I503M | CESC | 1 |
| p.R990G | STAD | 1 |
| p.R532Q | COAD | 1 |
| p.H330Y | SKCM | 1 |
| p.C46Y | UCEC | 1 |
| p.G167S | STAD | 1 |
| p.G167S | UCEC | 1 |
| p.R139Q | STAD | 1 |
| p.P680A | BLCA | 1 |
| p.A560T | UCEC | 1 |
| p.R293H | UCEC | 1 |
| p.R883C | UCEC | 1 |
| p.R840C | ESCA | 1 |
| p.Q125H | BLCA | 1 |
| p.D277Y | UCEC | 1 |
| p.F977L | BLCA | 1 |
| p.G286E | SKCM | 1 |
| p.F952L | COAD | 1 |
| p.V845M | COAD | 1 |
| p.C672G | LUAD | 1 |
| p.G386S | BRCA | 1 |
| p.M130L | SKCM | 1 |
| p.R76* | STAD | 1 |
| p.I180T | STAD | 1 |
| p.E504K | SKCM | 1 |
| p.R840C | BLCA | 1 |
| p.A539S | HNSC | 1 |
| p.S249N | ESCA | 1 |
| p.A826T | SKCM | 1 |
| p.T37I | STAD | 1 |
| p.V796M | PRAD | 1 |
| p.D676N | SKCM | 1 |
| p.R764C | UCEC | 1 |
| p.R532Q | SKCM | 1 |
| p.I311M | LIHC | 1 |
| p.T444K | LUSC | 1 |
| p.Q960H | UCEC | 1 |
| p.S952F | CESC | 1 |
| p.D670N | HNSC | 1 |
| p.T261N | SARC | 1 |
| p.N462S | UCEC | 1 |
| p.E617K | SKCM | 1 |
| p.D670N | SKCM | 1 |
| p.S853Y | BLCA | 1 |
| p.G158E | SKCM | 1 |
| p.L427V | SKCM | 1 |
| p.R907S | KIRP | 1 |
| p.R293C | COAD | 1 |
| p.D701Y | STAD | 1 |
| p.Q960H | ESCA | 1 |
| p.E280K | SKCM | 1 |
| p.R618* | STAD | 1 |
| p.R76X | STAD | 1 |
| p.R389W | HNSC | 1 |
| p.P437S | LUSC | 1 |
| p.S249N | STAD | 1 |
| p.R282H | THYM | 1 |
| p.R663T | LUSC | 1 |
| p.N819Y | SKCM | 1 |
| p.N147K | STAD | 1 |
| p.R929Q | STAD | 1 |
| p.R720W | ESCA | 1 |
| p.R840H | UCEC | 1 |
| p.H224Q | LUSC | 1 |
| p.R595H | THYM | 1 |
| p.R618X | STAD | 1 |
| p.G178E | SKCM | 1 |
| p.G647D | SKCM | 1 |
| p.T211M | COAD | 1 |
| p.A255V | PRAD | 1 |
| p.N417K | READ | 1 |
| p.I291V | BLCA | 1 |
| p.G121C | KIRP | 1 |
| p.R907S | PRAD | 1 |
| p.D773N | ESCA | 1 |
| p.Q648R | SARC | 1 |
| p.L851P | HNSC | 1 |
| p.A104V | LIHC | 1 |
| p.N334K | LGG | 1 |
| p.I171V | UCEC | 1 |
| p.G674E | SKCM | 1 |
| p.R173W | STAD | 1 |
| p.K841N | UCEC | 1 |
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| TissGeneCNV for SCUBE3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SCUBE3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BI868521 | SCUBE3-SCUBE3 | chr6:35192094 | chr6:35191433 | |
| Chimerdb3.0 | ChiTaRs | NA | BI013178 | MUC16-SCUBE3 | chr19:8969304 | chr6:35197380 |
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| TissGeneNet for SCUBE3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (tumor) | SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (normal) |
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| COAD (tumor) | COAD (normal) |
| SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (tumor) | SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (tumor) | SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (normal) |
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| KICH (tumor) | KICH (normal) |
| SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (tumor) | SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (tumor) | SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (tumor) | SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (tumor) | SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (tumor) | SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (tumor) | SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (tumor) | SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (tumor) | SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (tumor) | SCUBE3, MMP2, SCUBE1, TGFBR2, MMP9 (normal) |
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| TissGeneProg for SCUBE3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SCUBE3 |
| TissGeneDrug for SCUBE3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SCUBE3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
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