TissGeneSummary for CCDC129 |
Gene summary |
Basic gene information | Gene symbol | CCDC129 |
Gene name | coiled-coil domain containing 129 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 7p14.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001257967.1, NM_001257968.1,NM_194300.3,NR_047565.1, | |
Description | coiled-coil domain-containing protein 129 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000180347 | ||
HPRD : 14137 | ||
Vega : OTTHUMG00000128611 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC129 | |
BioGPS: 223075 | ||
Pathway | NCI Pathway Interaction Database: CCDC129 | |
KEGG: CCDC129 | ||
REACTOME: CCDC129 | ||
Pathway Commons: CCDC129 | ||
Context | iHOP: CCDC129 | |
ligand binding site mutation search in PubMed: CCDC129 | ||
UCL Cancer Institute: CCDC129 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCTGCT | |
Reference showing the relevant tissue of CCDC129 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CCDC129 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | -1.972148256 | 0.134072675 | -2.10622093 | 1.64E-05 | 8.89E-05 |
COAD | -1.188814445 | 0.95707017 | -2.145884615 | 1.02E-06 | 5.77E-06 |
BRCA | -0.870110801 | 1.363777795 | -2.233888596 | 7.35E-14 | 3.52E-13 |
LUAD | 0.6958833 | -1.5791667 | 2.27505 | 5.71E-08 | 2.32E-07 |
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TissGene-miRNA for CCDC129 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CCDC129 |
TissGeneSNV for CCDC129 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A272T | ESCA | 2 |
p.L552V | LUAD | 2 |
p.P609T | LUSC | 1 |
p.K460N | LUAD | 1 |
p.V193A | HNSC | 1 |
p.A344T | STAD | 1 |
p.P369R | SKCM | 1 |
p.S728R | STAD | 1 |
p.G850R | HNSC | 1 |
p.G542W | SKCM | 1 |
p.I142K | LUAD | 1 |
p.L369M | LGG | 1 |
p.G357V | LUSC | 1 |
p.D607H | HNSC | 1 |
p.S472I | PAAD | 1 |
p.P523L | BLCA | 1 |
p.T395N | SKCM | 1 |
p.S557Y | LUAD | 1 |
p.C858R | LUSC | 1 |
p.R470L | CESC | 1 |
p.R530K | HNSC | 1 |
p.E17G | STAD | 1 |
p.R175W | SKCM | 1 |
p.C339Y | LUAD | 1 |
p.A771T | STAD | 1 |
p.E183* | CESC | 1 |
p.S218Y | UCS | 1 |
p.Q107P | STAD | 1 |
p.M354T | KIRC | 1 |
p.I965T | STAD | 1 |
p.V285A | HNSC | 1 |
p.D93Y | THYM | 1 |
p.S665A | COAD | 1 |
p.D67Y | THYM | 1 |
p.R644L | CESC | 1 |
p.G611E | STAD | 1 |
p.R382K | HNSC | 1 |
p.A272T | KIRC | 1 |
p.Q692K | LIHC | 1 |
p.P399L | LGG | 1 |
p.G177E | SKCM | 1 |
p.S298I | PAAD | 1 |
p.E76K | SKCM | 1 |
p.G1036R | SKCM | 1 |
p.V351I | BLCA | 1 |
p.T710I | HNSC | 1 |
p.G408X | ESCA | 1 |
p.E272Q | LUAD | 1 |
p.H285Y | LGG | 1 |
p.D455N | SKCM | 1 |
p.V553F | LUAD | 1 |
p.Q959R | HNSC | 1 |
p.T369S | OV | 1 |
p.S264P | LUAD | 1 |
p.S216L | LUAD | 1 |
p.D56Y | KIRC | 1 |
p.T655A | LUSC | 1 |
p.G69E | UCEC | 1 |
p.K695E | KIRC | 1 |
p.S249I | COAD | 1 |
p.E599K | SKCM | 1 |
p.G15D | LGG | 1 |
p.M191I | SKCM | 1 |
p.S336Y | UCS | 1 |
p.L746F | LUAD | 1 |
p.S55R | UCEC | 1 |
p.C247Y | LUAD | 1 |
p.P481Q | SKCM | 1 |
p.S566C | LUAD | 1 |
p.G290V | PAAD | 1 |
p.G408V | PAAD | 1 |
p.S29R | UCEC | 1 |
p.A333V | LGG | 1 |
p.G711S | LUSC | 1 |
p.G823D | STAD | 1 |
p.E558X | STAD | 1 |
p.G437R | LUAD | 1 |
p.E767D | HNSC | 1 |
p.D681E | SKCM | 1 |
p.P65S | SKCM | 1 |
p.A584D | UCEC | 1 |
p.K688N | COAD | 1 |
p.P307Q | SKCM | 1 |
p.T580S | LUAD | 1 |
p.G758E | SKCM | 1 |
p.I168T | ESCA | 1 |
p.A370T | STAD | 1 |
p.Q133* | LUSC | 1 |
p.I173V | SKCM | 1 |
p.E422K | COAD | 1 |
p.F195L | KIRC | 1 |
p.P251R | SKCM | 1 |
p.Q563K | LIHC | 1 |
p.T277I | LGG | 1 |
p.Q538* | LUAD | 1 |
p.E427* | BLCA | 1 |
p.R216Q | SKCM | 1 |
p.K897E | LUSC | 1 |
p.A56V | THCA | 1 |
p.E866Q | BRCA | 1 |
p.Q789H | COAD | 1 |
p.M374I | BLCA | 1 |
p.G732V | HNSC | 1 |
p.E138* | HNSC | 1 |
p.Y403F | BLCA | 1 |
p.D231G | LUAD | 1 |
p.S128R | STAD | 1 |
p.G524V | LUAD | 1 |
p.M119I | KIRP | 1 |
p.Q866K | LIHC | 1 |
p.A993T | STAD | 1 |
p.P846S | SKCM | 1 |
p.I210V | SKCM | 1 |
p.G8E | SKCM | 1 |
p.Q321* | BLCA | 1 |
p.A56V | STAD | 1 |
p.E889K | SKCM | 1 |
p.V783I | UCEC | 1 |
p.E677K | HNSC | 1 |
p.P246L | SKCM | 1 |
p.S446I | PAAD | 1 |
p.T872M | STAD | 1 |
p.I328V | SKCM | 1 |
p.A745T | UCEC | 1 |
p.G587V | UCEC | 1 |
p.E230K | SKCM | 1 |
p.S731P | LIHC | 1 |
p.E844K | SKCM | 1 |
p.S249F | SKCM | 1 |
p.Y353C | PRAD | 1 |
p.E138K | SKCM | 1 |
p.F461L | LUAD | 1 |
p.E965* | UCEC | 1 |
p.Q445H | UCEC | 1 |
p.G849D | STAD | 1 |
p.E773K | SKCM | 1 |
p.P112L | SKCM | 1 |
p.N295T | PAAD | 1 |
p.V441L | LUAD | 1 |
p.G251D | LUAD | 1 |
p.G601E | UCEC | 1 |
p.D507E | SKCM | 1 |
p.P246H | SKCM | 1 |
p.P858L | SKCM | 1 |
p.G303R | SKCM | 1 |
p.R216Q | COAD | 1 |
p.K399N | LUSC | 1 |
p.R276Q | UCS | 1 |
p.V171A | GBM | 1 |
p.K521E | KIRC | 1 |
p.Q4H | UCEC | 1 |
p.L401S | LIHC | 1 |
p.Q811R | HNSC | 1 |
p.P39S | SKCM | 1 |
p.A875T | SKCM | 1 |
p.E866V | STAD | 1 |
p.N396T | STAD | 1 |
p.V315I | SKCM | 1 |
p.R158Q | UCS | 1 |
p.N443T | PAAD | 1 |
p.L418V | BLCA | 1 |
p.N808H | UCS | 1 |
p.F215L | UCEC | 1 |
p.S263C | COAD | 1 |
p.N370T | STAD | 1 |
p.E257K | SKCM | 1 |
p.P237S | SKCM | 1 |
p.V599I | LIHC | 1 |
p.P364L | SKCM | 1 |
p.T898M | STAD | 1 |
p.R940H | DLBC | 1 |
p.E364Q | LUAD | 1 |
p.E892V | STAD | 1 |
p.E1037K | SKCM | 1 |
p.E390D | UCEC | 1 |
p.R706S | THCA | 1 |
p.E542D | LUSC | 1 |
p.E436Q | HNSC | 1 |
p.G382V | PAAD | 1 |
p.F194I | GBM | 1 |
p.C658G | STAD | 1 |
p.F532L | ESCA | 1 |
p.Q737K | LIHC | 1 |
p.G790E | SKCM | 1 |
p.G849C | LUAD | 1 |
p.V425I | LIHC | 1 |
p.L972F | CESC | 1 |
p.V894D | LUAD | 1 |
p.R203* | STAD | 1 |
p.A516V | COAD | 1 |
p.G433E | SKCM | 1 |
p.I147V | SKCM | 1 |
p.Q133P | STAD | 1 |
p.C650* | LUAD | 1 |
p.P369S | CHOL | 1 |
p.R561K | LUSC | 1 |
p.R190Q | SKCM | 1 |
p.P138L | SKCM | 1 |
p.A829T | COAD | 1 |
p.E256K | SKCM | 1 |
p.G259E | SKCM | 1 |
p.Q686* | LUAD | 1 |
p.S649N | COAD | 1 |
p.T85N | LUAD | 1 |
p.E576D | COAD | 1 |
p.G477R | SKCM | 1 |
p.D924E | PRAD | 1 |
p.A754E | LUAD | 1 |
p.S25Y | LIHC | 1 |
p.D457E | UCEC | 1 |
p.M188T | KIRC | 1 |
p.G437E | STAD | 1 |
p.R250Q | UCEC | 1 |
p.E43G | STAD | 1 |
p.S249Y | HNSC | 1 |
p.I939T | STAD | 1 |
p.Y235C | PRAD | 1 |
p.E964G | UCEC | 1 |
p.Q785H | LUAD | 1 |
p.R276Q | READ | 1 |
p.R293W | SKCM | 1 |
p.D126Y | READ | 1 |
p.D604E | KIRP | 1 |
p.T562I | HNSC | 1 |
p.R532S | THCA | 1 |
p.R866W | LUAD | 1 |
p.G850V | HNSC | 1 |
p.D750E | PRAD | 1 |
p.G888R | SKCM | 1 |
p.Q786K | LUAD | 1 |
p.F609V | STAD | 1 |
p.Q615K | BLCA | 1 |
p.S154R | STAD | 1 |
p.R682S | LUAD | 1 |
p.C592S | LUAD | 1 |
p.G978D | UCEC | 1 |
p.D673N | UCEC | 1 |
p.A745T | STAD | 1 |
p.Q469* | BLCA | 1 |
p.G584E | SKCM | 1 |
p.C835Y | COAD | 1 |
p.E467* | BLCA | 1 |
p.V405F | LUAD | 1 |
p.A558T | UCEC | 1 |
p.L540I | LUAD | 1 |
p.T111A | PAAD | 1 |
p.P1044R | DLBC | 1 |
p.C832G | STAD | 1 |
p.F358L | ESCA | 1 |
p.G8* | LUAD | 1 |
p.Y652H | STAD | 1 |
p.N469T | PAAD | 1 |
p.A606E | LUAD | 1 |
p.E60K | UCEC | 1 |
p.T680N | LUSC | 1 |
p.A30V | THCA | 1 |
p.S902R | STAD | 1 |
p.E231K | SKCM | 1 |
p.T277N | SKCM | 1 |
p.G584V | HNSC | 1 |
p.L566V | BLCA | 1 |
p.E532* | STAD | 1 |
p.R982S | STAD | 1 |
p.E641D | DLBC | 1 |
p.C998Y | LUSC | 1 |
p.S132I | UCEC | 1 |
p.F635V | STAD | 1 |
p.E825K | HNSC | 1 |
p.D493E | COAD | 1 |
p.R276Q | COAD | 1 |
p.D459H | HNSC | 1 |
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TissGeneCNV for CCDC129 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CCDC129 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AW891032 | CCDC129-CCDC129 | chr7:31695019 | chr7:31695172 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-AN-A0FV-01A | URGCP-MRPS24-CCDC129 | CDS-3'UTR | chr7:43927013 | chr7:31681789 |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-AN-A0FV-01A | URGCP-CCDC129 | In-Frame | chr7:43927013 | chr7:31681789 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A0D4-01A | URGCP-CCDC129 | 5UTR-CDS | Chr7:43927014 | Chr7:31681790 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AN-A0FV-01A | URGCP-CCDC129 | 5UTR-CDS | Chr7:43927014 | Chr7:31681790 |
TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A150-01A | CCDC129-DEFB118 | Out-of-frame | Chr7:31618048 | Chr20:29960660 |
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TissGeneNet for CCDC129 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CCDC129 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CCDC129 |
TissGeneDrug for CCDC129 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CCDC129 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |