TissGeneSummary for FDXR |
Gene summary |
Basic gene information | Gene symbol | FDXR |
Gene name | ferredoxin reductase | |
Synonyms | ADXR | |
Cytomap | UCSC genome browser: 17q25.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001258012.3, NM_001258013.3,NM_001258014.3,NM_001258015.2,NM_001258016.3, NM_004110.5,NM_024417.4,NR_047576.2, | |
Description | ARNADPH:adrenodoxin oxidoreductase, mitochondrialadrenodoxin reductaseadrenodoxin-NADP(+) reductaseferredoxin--NADP(+) reductase | |
Modification date | 20141212 | |
dbXrefs | MIM : 103270 | |
HGNC : HGNC | ||
Ensembl : ENSG00000161513 | ||
HPRD : 00060 | ||
Vega : OTTHUMG00000179026 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FDXR | |
BioGPS: 2232 | ||
Pathway | NCI Pathway Interaction Database: FDXR | |
KEGG: FDXR | ||
REACTOME: FDXR | ||
Pathway Commons: FDXR | ||
Context | iHOP: FDXR | |
ligand binding site mutation search in PubMed: FDXR | ||
UCL Cancer Institute: FDXR | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixAdrenal gland | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCPCPG,ACC | |
Reference showing the relevant tissue of FDXR | ||
Description by TissGene annotations | Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FDXR |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | 1.232863631 | -0.482736369 | 1.7156 | 2.89E-14 | 6.89E-13 |
KIRC | 0.243843492 | -0.995524563 | 1.239368056 | 3.75E-19 | 2.74E-18 |
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TissGene-miRNA for FDXR |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-150-5p | MIMAT0000451 | 0.028 | -0.26 | 78 |
ACC | hsa-miR-150-5p | MIMAT0000451 | 0.028 | -0.26 | 78 |
LUAD | hsa-miR-24-3p | MIMAT0000080 | 0.0038 | -0.37 | 60 |
ACC | hsa-miR-107 | MIMAT0000104 | 0.0014 | -0.38 | 78 |
ACC | hsa-miR-107 | MIMAT0000104 | 0.0014 | -0.38 | 78 |
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TissGeneMut for FDXR |
TissGeneSNV for FDXR |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R123Q | BRCA | 2 |
p.V73A | COAD | 1 |
p.S475C | BLCA | 1 |
p.R227C | PRAD | 1 |
p.S363F | PAAD | 1 |
p.P474L | LUAD | 1 |
p.G65A | ACC | 1 |
p.C108Y | CESC | 1 |
p.H94Y | LUAD | 1 |
p.H534Y | SKCM | 1 |
p.Q87H | PAAD | 1 |
p.F32L | ESCA | 1 |
p.R352Q | STAD | 1 |
p.R219X | COAD | 1 |
p.G90R | SKCM | 1 |
p.G270V | LUSC | 1 |
p.A324T | SKCM | 1 |
p.H94Y | SKCM | 1 |
p.R341H | STAD | 1 |
p.P100S | SKCM | 1 |
p.T351A | SARC | 1 |
p.H57R | ACC | 1 |
p.P525H | THYM | 1 |
p.R95W | BLCA | 1 |
p.I163S | KIRP | 1 |
p.A342V | STAD | 1 |
p.R384H | STAD | 1 |
p.P431L | LUAD | 1 |
p.H138Y | SKCM | 1 |
p.A192T | STAD | 1 |
p.G90E | SKCM | 1 |
p.D307Y | LUSC | 1 |
p.P43S | SKCM | 1 |
p.S254L | BLCA | 1 |
p.A255V | STAD | 1 |
p.Y438H | STAD | 1 |
p.R166Q | PCPG | 1 |
p.D505N | KIRP | 1 |
p.R309Q | STAD | 1 |
p.Q483E | HNSC | 1 |
p.R322W | COAD | 1 |
p.Y481H | STAD | 1 |
p.R236H | UCEC | 1 |
p.S298L | BLCA | 1 |
p.P144S | SKCM | 1 |
p.C152Y | CESC | 1 |
p.K369T | UCEC | 1 |
p.R288K | SKCM | 1 |
p.R238Q | UCS | 1 |
p.W331C | HNSC | 1 |
p.V78A | STAD | 1 |
p.S497F | SKCM | 1 |
p.S256F | BLCA | 1 |
p.D307E | KIRP | 1 |
p.P307R | BRCA | 1 |
p.V136M | LGG | 1 |
p.M454I | BLCA | 1 |
p.R364L | LUSC | 1 |
p.G369V | HNSC | 1 |
p.V111M | HNSC | 1 |
p.D220E | KIRP | 1 |
p.D216E | THYM | 1 |
p.P358L | SKCM | 1 |
p.M411I | BLCA | 1 |
p.S300F | BLCA | 1 |
p.P474H | CHOL | 1 |
p.D500E | LIHC | 1 |
p.A482T | PRAD | 1 |
p.K58T | UCEC | 1 |
p.Q526E | HNSC | 1 |
p.I250S | KIRP | 1 |
p.V187M | UCEC | 1 |
p.P87S | SKCM | 1 |
p.D411N | SARC | 1 |
p.E349Q | HNSC | 1 |
p.A235T | STAD | 1 |
p.P395S | SKCM | 1 |
p.F51V | COAD | 1 |
p.V371M | STAD | 1 |
p.D362G | LIHC | 1 |
p.E79K | SKCM | 1 |
p.A280T | SKCM | 1 |
p.V67M | HNSC | 1 |
p.V414M | STAD | 1 |
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TissGeneCNV for FDXR |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FDXR |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FDXR |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FDXR |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FDXR |
TissGeneDrug for FDXR |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FDXR |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C0948380 | Colorectal cancer metastatic | 1 | BeFree |