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| TissGeneSummary for FGA |
 Gene summary |
| Basic gene information | Gene symbol | FGA |
| Gene name | fibrinogen alpha chain | |
| Synonyms | Fib2 | |
| Cytomap | UCSC genome browser: 4q28 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000508.3, NM_021871.2, | |
| Description | fibrinogen, A alpha polypeptide | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 134820 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000171560 | ||
| HPRD : 00619 | ||
| Vega : OTTHUMG00000150330 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FGA | |
| BioGPS: 2243 | ||
| Pathway | NCI Pathway Interaction Database: FGA | |
| KEGG: FGA | ||
| REACTOME: FGA | ||
| Pathway Commons: FGA | ||
| Context | iHOP: FGA | |
| ligand binding site mutation search in PubMed: FGA | ||
| UCL Cancer Institute: FGA | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of FGA | Cell type-specific differential induction of the human gamma-fibrinogen promoter by interleukin-6. Duan HO, Simpson-Haidaris PJ. J Biol Chem. 2006 May 5;281(18):12451-7. Epub 2006 Mar 8. (pmid:16524883) go to article | |
| Description by TissGene annotations | Cancer gene TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0007160 | cell-matrix adhesion | 10903502 | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 8100742 | GO:0043623 | cellular protein complex assembly | 8910396 | GO:0045907 | positive regulation of vasoconstriction | 15739255 | GO:0045921 | positive regulation of exocytosis | 19193866 | GO:0050714 | positive regulation of protein secretion | 19193866 | GO:0051258 | protein polymerization | 12706644 | GO:0051592 | response to calcium ion | 6777381 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10903502 | GO:0070527 | platelet aggregation | 6281794 | GO:0090277 | positive regulation of peptide hormone secretion | 19193866 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 10903502 | GO:2000352 | negative regulation of endothelial cell apoptotic process | 10903502 | GO:0007160 | cell-matrix adhesion | 10903502 | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 8100742 | GO:0043623 | cellular protein complex assembly | 8910396 | GO:0045907 | positive regulation of vasoconstriction | 15739255 | GO:0045921 | positive regulation of exocytosis | 19193866 | GO:0050714 | positive regulation of protein secretion | 19193866 | GO:0051258 | protein polymerization | 12706644 | GO:0051592 | response to calcium ion | 6777381 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10903502 | GO:0070527 | platelet aggregation | 6281794 | GO:0090277 | positive regulation of peptide hormone secretion | 19193866 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 10903502 | GO:2000352 | negative regulation of endothelial cell apoptotic process | 10903502 |
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| TissGeneExp for FGA |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 13.26049056 | 15.36875456 | -2.108264 | 4.20E-08 | 3.23E-07 |
| KICH | -3.634337441 | 0.17145456 | -3.805792 | 4.81E-07 | 1.90E-06 |
| LUSC | -0.049509205 | 3.900633932 | -3.950143137 | 4.21E-10 | 1.49E-09 |
| KIRC | 2.12570256 | 0.751537282 | 1.374165278 | 0.00904 | 0.015266496 |
| COAD | -1.970351287 | -3.42457821 | 1.454226923 | 0.000331 | 0.001068072 |
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| TissGene-miRNA for FGA |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FGA |
| TissGeneSNV for FGA |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S104L | SKCM | 3 |
| p.S845F | SKCM | 3 |
| p.S131P | UCEC | 2 |
| p.G646C | LGG | 2 |
| p.E139K | SKCM | 2 |
| p.E702K | SKCM | 2 |
| p.P636S | SKCM | 2 |
| p.A855D | UCEC | 2 |
| p.A855V | SKCM | 2 |
| p.G368V | READ | 1 |
| p.E431K | BLCA | 1 |
| p.S351I | HNSC | 1 |
| p.P636L | SKCM | 1 |
| p.P398S | SKCM | 1 |
| p.E797D | CESC | 1 |
| p.L433M | PRAD | 1 |
| p.G72W | COAD | 1 |
| p.S594F | SKCM | 1 |
| p.R443S | LUAD | 1 |
| p.P408L | SKCM | 1 |
| p.D51Y | SKCM | 1 |
| p.G329E | SKCM | 1 |
| p.S460L | SKCM | 1 |
| p.R630K | BLCA | 1 |
| p.G371V | LUAD | 1 |
| p.E111K | SKCM | 1 |
| p.R35C | HNSC | 1 |
| p.W373X | ESCA | 1 |
| p.C55F | LUAD | 1 |
| p.F237L | UCEC | 1 |
| p.K144N | BLCA | 1 |
| p.H715Q | LUAD | 1 |
| p.D133N | SKCM | 1 |
| p.L154I | STAD | 1 |
| p.A370S | ESCA | 1 |
| p.E431K | SKCM | 1 |
| p.R627C | LUSC | 1 |
| p.N832K | HNSC | 1 |
| p.L699Q | OV | 1 |
| p.S297Y | HNSC | 1 |
| p.S577P | PRAD | 1 |
| p.T320A | HNSC | 1 |
| p.E729D | CESC | 1 |
| p.R367C | READ | 1 |
| p.R857C | SKCM | 1 |
| p.G592R | THYM | 1 |
| p.G391R | READ | 1 |
| p.I152N | SKCM | 1 |
| p.A403T | UCEC | 1 |
| p.A762V | LGG | 1 |
| p.R591T | CESC | 1 |
| p.D605A | LUAD | 1 |
| p.K195N | UCEC | 1 |
| p.R181* | BLCA | 1 |
| p.E376K | UCEC | 1 |
| p.D496Y | HNSC | 1 |
| p.P349L | UCEC | 1 |
| p.R308* | STAD | 1 |
| p.L669F | SKCM | 1 |
| p.V140I | PAAD | 1 |
| p.G423E | SKCM | 1 |
| p.R830M | UCEC | 1 |
| p.G745V | BLCA | 1 |
| p.E481D | BRCA | 1 |
| p.T252R | COAD | 1 |
| p.R271P | LUAD | 1 |
| p.T761N | LUAD | 1 |
| p.S698R | COAD | 1 |
| p.T283M | READ | 1 |
| p.G301E | SKCM | 1 |
| p.S485F | HNSC | 1 |
| p.G745F | BLCA | 1 |
| p.S388F | SKCM | 1 |
| p.P514H | LUAD | 1 |
| p.E486K | SKCM | 1 |
| p.K144* | STAD | 1 |
| p.R547S | LUAD | 1 |
| p.E493D | STAD | 1 |
| p.S333R | SARC | 1 |
| p.L753I | LUAD | 1 |
| p.S102Y | UCEC | 1 |
| p.S400A | UCEC | 1 |
| p.D396N | LIHC | 1 |
| p.R459C | SKCM | 1 |
| p.S852F | SKCM | 1 |
| p.W373* | ESCA | 1 |
| p.G819R | SKCM | 1 |
| p.T341P | LIHC | 1 |
| p.V192I | GBM | 1 |
| p.G332E | SKCM | 1 |
| p.G502S | SKCM | 1 |
| p.Y428* | GBM | 1 |
| p.G72W | BLCA | 1 |
| p.M858I | SKCM | 1 |
| p.R308X | STAD | 1 |
| p.D174N | SKCM | 1 |
| p.S746Y | UCEC | 1 |
| p.R35C | STAD | 1 |
| p.P214S | SKCM | 1 |
| p.K144X | STAD | 1 |
| p.A792T | SKCM | 1 |
| p.S356I | HNSC | 1 |
| p.E447V | SARC | 1 |
| p.D80Y | UCEC | 1 |
| p.E268K | BLCA | 1 |
| p.G608R | KICH | 1 |
| p.V40M | LIHC | 1 |
| p.T331N | LIHC | 1 |
| p.T283M | ESCA | 1 |
| p.E838Q | CESC | 1 |
| p.N407H | SKCM | 1 |
| p.K176N | GBM | 1 |
| p.G411S | SKCM | 1 |
| p.R854G | STAD | 1 |
| p.G825S | SKCM | 1 |
| p.P255L | STAD | 1 |
| p.T616A | UCEC | 1 |
| p.R181* | ESCA | 1 |
| p.I675M | BLCA | 1 |
| p.R308Q | SKCM | 1 |
| p.P571S | SKCM | 1 |
| p.F742L | LIHC | 1 |
| p.L669F | LIHC | 1 |
| p.E486K | READ | 1 |
| p.T464N | LUAD | 1 |
| p.Y589C | GBM | 1 |
| p.D172G | LGG | 1 |
| p.L500S | LGG | 1 |
| p.S600R | KICH | 1 |
| p.E796K | COAD | 1 |
| p.R627C | SKCM | 1 |
| p.Q153K | THYM | 1 |
| p.K651N | STAD | 1 |
| p.V34M | STAD | 1 |
| p.G272R | SKCM | 1 |
| p.I650V | LIHC | 1 |
| p.P640L | SKCM | 1 |
| p.R308Q | LGG | 1 |
| p.S299N | UCEC | 1 |
| p.D21Y | COAD | 1 |
| p.G548D | SKCM | 1 |
| p.S336P | GBM | 1 |
| p.N99K | HNSC | 1 |
| p.D49N | LUSC | 1 |
| p.S641F | SKCM | 1 |
| p.S290R | LUAD | 1 |
| p.K463Q | PRAD | 1 |
| p.G301* | LUAD | 1 |
| p.P354T | KIRC | 1 |
| p.S313F | LIHC | 1 |
| p.G670* | LUAD | 1 |
| p.G526E | SKCM | 1 |
| p.T341P | LUAD | 1 |
| p.V171M | LUAD | 1 |
| p.E836D | UCEC | 1 |
| p.K602T | UCEC | 1 |
| p.G293V | BRCA | 1 |
| p.R181X | ESCA | 1 |
| p.L728S | SKCM | 1 |
| p.V483M | LIHC | 1 |
| p.T555A | BRCA | 1 |
| p.Y835X | COAD | 1 |
| p.R857H | READ | 1 |
| p.E749K | CESC | 1 |
| p.P323L | SKCM | 1 |
| p.S300T | GBM | 1 |
| p.G25V | BRCA | 1 |
| p.S313C | BLCA | 1 |
| p.R591I | LGG | 1 |
| p.R178Q | UCEC | 1 |
| p.K249N | LIHC | 1 |
| p.A189S | BLCA | 1 |
| p.F659C | UCEC | 1 |
| p.R510C | LIHC | 1 |
| p.G438R | SKCM | 1 |
| p.P565H | OV | 1 |
| p.S215F | HNSC | 1 |
| p.G272E | SKCM | 1 |
| p.Y579C | COAD | 1 |
| p.G774W | UCEC | 1 |
| p.W248C | BLCA | 1 |
| p.S119* | LUAD | 1 |
| p.G745C | BLCA | 1 |
| p.G266E | SKCM | 1 |
| p.G337V | LUSC | 1 |
| p.D49Y | UCEC | 1 |
| p.E749Q | CESC | 1 |
| p.R573S | LUAD | 1 |
| p.G631S | LGG | 1 |
| p.D211E | BRCA | 1 |
| p.R458C | COAD | 1 |
| p.D634G | UCEC | 1 |
| p.E559K | SKCM | 1 |
| p.S102F | SKCM | 1 |
| p.D521N | READ | 1 |
| p.R216K | BLCA | 1 |
| p.P395S | PAAD | 1 |
| p.E111G | STAD | 1 |
| p.C55S | LUSC | 1 |
| p.G368R | LUSC | 1 |
| p.E706X | READ | 1 |
| p.E262K | SKCM | 1 |
| p.G646D | PAAD | 1 |
| p.D789E | OV | 1 |
| p.L88I | THYM | 1 |
| p.T457S | LUAD | 1 |
| p.G819A | HNSC | 1 |
| p.D101N | SKCM | 1 |
| p.S757P | BLCA | 1 |
| p.W373* | UCS | 1 |
| p.R190H | UCEC | 1 |
| p.F27Y | BLCA | 1 |
| p.W321X | COAD | 1 |
| p.K144* | LUAD | 1 |
| p.E147K | SKCM | 1 |
| p.R857C | UCEC | 1 |
| p.S102Y | READ | 1 |
| p.P530L | SKCM | 1 |
| p.R178* | UCEC | 1 |
| p.E477K | SKCM | 1 |
| p.R190C | KIRC | 1 |
| p.A762V | STAD | 1 |
| p.P514T | PRAD | 1 |
| p.S618N | STAD | 1 |
| p.P234A | BLCA | 1 |
| p.T587M | HNSC | 1 |
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| TissGeneCNV for FGA |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FGA |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AA345305 | FGA-NEU1 | chr4:155507818 | chr6:3159999 | |
| Chimerdb3.0 | ChiTaRs | NA | AI110732 | FGA-PIK3IP1 | chr4:155506812 | chr22:31678626 | |
| Chimerdb3.0 | ChiTaRs | NA | AI114445 | RPS16-FGA | chr19:39926560 | chr4:155506702 |
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| TissGeneNet for FGA |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FGA, SUMO2, THBS1, CDH5, PITX3, CEBPA, ALB, ITGB3, PLAT, HNF1A, F13A1, KHDRBS2, F2, KRT18, SERPINA5, FGG, MIS12, ITGA2B, FGB, KLK6, SERPINF2 (tumor) | FGA, HRG, THBS1, CDH5, PITX3, CEBPA, ALB, PLAT, HNF1A, F13A1, KHDRBS2, F2, SPARC, KRT18, SERPINA5, FGG, MIS12, ITGA2B, FGB, KLK6, SERPINF2 (normal) |
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| COAD (tumor) | COAD (normal) |
| FGA, SUMO2, NID1, HRG, THBS1, CDH5, PITX3, ALB, ITGB3, PLAT, HNF1A, F13A1, KHDRBS2, F2, KRT18, SERPINA5, FGG, MIS12, FGB, KLK6, SERPINF2 (tumor) | FGA, SUMO2, HRG, THBS1, CDH5, PITX3, CEBPA, ALB, ITGB3, PLAT, HNF1A, KHDRBS2, F2, SPARC, KRT18, SERPINA5, FGG, MIS12, ITGA2B, FGB, SERPINF2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| FGA, SUMO2, NID1, HRG, THBS1, PITX3, CEBPA, ALB, ITGB3, PLAT, KHDRBS2, F2, SPARC, KRT18, SERPINA5, FGG, MIS12, ITGA2B, FGB, KLK6, SERPINF2 (tumor) | FGA, SUMO2, NID1, HRG, THBS1, CDH5, PITX3, CEBPA, ALB, HNF1A, F13A1, KHDRBS2, F2, SPARC, KRT18, SERPINA5, FGG, MIS12, ITGA2B, FGB, KLK6 (normal) |
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| KICH (tumor) | KICH (normal) |
| FGA, SUMO2, NID1, THBS1, PITX3, CEBPA, ALB, ITGB3, PLAT, HNF1A, F13A1, KHDRBS2, F2, SPARC, KRT18, FGG, MIS12, ITGA2B, FGB, KLK6, SERPINF2 (tumor) | FGA, SUMO2, NID1, THBS1, CDH5, PITX3, CEBPA, ITGB3, PLAT, HNF1A, F13A1, KHDRBS2, F2, SPARC, KRT18, FGG, MIS12, ITGA2B, FGB, KLK6, SERPINF2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| FGA, SUMO2, NID1, HRG, THBS1, CDH5, PITX3, CEBPA, ALB, ITGB3, PLAT, HNF1A, F13A1, KHDRBS2, F2, SPARC, FGG, ITGA2B, FGB, KLK6, SERPINF2 (tumor) | FGA, SUMO2, NID1, HRG, CDH5, PITX3, CEBPA, ALB, ITGB3, PLAT, HNF1A, F13A1, KHDRBS2, F2, SPARC, KRT18, SERPINA5, FGG, ITGA2B, FGB, SERPINF2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| FGA, SUMO2, NID1, HRG, THBS1, CDH5, PITX3, CEBPA, ALB, ITGB3, HNF1A, F13A1, KHDRBS2, F2, SPARC, SERPINA5, FGG, ITGA2B, FGB, KLK6, SERPINF2 (tumor) | FGA, NID1, HRG, THBS1, CDH5, PITX3, CEBPA, ALB, ITGB3, PLAT, HNF1A, F13A1, KHDRBS2, F2, SERPINA5, FGG, MIS12, ITGA2B, FGB, KLK6, SERPINF2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| FGA, NID1, HRG, THBS1, PITX3, CEBPA, ALB, ITGB3, PLAT, HNF1A, F13A1, KHDRBS2, F2, SPARC, KRT18, SERPINA5, FGG, MIS12, ITGA2B, FGB, SERPINF2 (tumor) | FGA, SUMO2, NID1, HRG, THBS1, CDH5, PITX3, CEBPA, ALB, PLAT, HNF1A, KHDRBS2, F2, SPARC, KRT18, SERPINA5, FGG, ITGA2B, FGB, KLK6, SERPINF2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| FGA, HRG, THBS1, CDH5, PITX3, CEBPA, ITGB3, PLAT, HNF1A, F13A1, KHDRBS2, F2, SPARC, KRT18, SERPINA5, FGG, MIS12, ITGA2B, FGB, KLK6, SERPINF2 (tumor) | FGA, SUMO2, NID1, HRG, THBS1, CDH5, CEBPA, ALB, ITGB3, PLAT, HNF1A, F13A1, KHDRBS2, F2, KRT18, FGG, MIS12, ITGA2B, FGB, KLK6, SERPINF2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| FGA, SUMO2, NID1, HRG, THBS1, PITX3, CEBPA, ALB, ITGB3, PLAT, F13A1, KHDRBS2, F2, SPARC, KRT18, SERPINA5, FGG, ITGA2B, FGB, KLK6, SERPINF2 (tumor) | FGA, SUMO2, NID1, HRG, THBS1, CDH5, PITX3, ALB, ITGB3, PLAT, HNF1A, F13A1, KHDRBS2, F2, SPARC, KRT18, SERPINA5, FGG, ITGA2B, FGB, SERPINF2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| FGA, SUMO2, NID1, HRG, THBS1, CDH5, PITX3, CEBPA, ALB, ITGB3, HNF1A, KHDRBS2, F2, SPARC, SERPINA5, FGG, MIS12, ITGA2B, FGB, KLK6, SERPINF2 (tumor) | FGA, SUMO2, HRG, THBS1, PITX3, ALB, ITGB3, PLAT, HNF1A, F13A1, KHDRBS2, F2, SPARC, KRT18, SERPINA5, FGG, MIS12, ITGA2B, FGB, KLK6, SERPINF2 (normal) |
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| STAD (tumor) | STAD (normal) |
| FGA, SUMO2, NID1, HRG, THBS1, PITX3, CEBPA, ALB, ITGB3, PLAT, HNF1A, F13A1, F2, SPARC, KRT18, SERPINA5, FGG, MIS12, FGB, KLK6, SERPINF2 (tumor) | FGA, SUMO2, NID1, HRG, THBS1, PITX3, CEBPA, ALB, ITGB3, PLAT, HNF1A, F13A1, KHDRBS2, F2, SPARC, SERPINA5, FGG, MIS12, ITGA2B, FGB, SERPINF2 (normal) |
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| THCA (tumor) | THCA (normal) |
| FGA, SUMO2, NID1, HRG, THBS1, CDH5, ALB, ITGB3, PLAT, HNF1A, F13A1, KHDRBS2, SPARC, KRT18, SERPINA5, FGG, MIS12, ITGA2B, FGB, KLK6, SERPINF2 (tumor) | FGA, SUMO2, NID1, HRG, CDH5, PITX3, ALB, ITGB3, PLAT, HNF1A, F13A1, KHDRBS2, F2, SPARC, KRT18, SERPINA5, FGG, MIS12, ITGA2B, FGB, SERPINF2 (normal) |
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| TissGeneProg for FGA |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Top |
| TissGeneClin for FGA |
| TissGeneDrug for FGA |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00009 | Alteplase | Biotech | Approved | |
| DB00015 | Reteplase | Biotech | Approved | |
| DB00029 | Anistreplase | Biotech | Approved | |
| DB00031 | Tenecteplase | Biotech | Approved |
| Top |
| TissGeneDisease for FGA |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0019250 | Hereditary factor I deficiency disease | 10 | BeFree |
| umls:C0001733 | Afibrinogenemia | 8 | BeFree,CTD_human,LHGDN |
| umls:C0027051 | Myocardial Infarction | 8 | BeFree,GAD,LHGDN |
| umls:C0038454 | Cerebrovascular accident | 7 | BeFree,GAD,LHGDN |
| umls:C0007786 | Brain Ischemia | 5 | GAD |
| umls:C0040053 | Thrombosis | 5 | CTD_human,GAD |
| umls:C1561955 | Fibrinogen Adverse Event | 5 | GAD,GWASCAT |
| umls:C0020538 | Hypertensive disease | 4 | BeFree,GAD |
| umls:C0948008 | Ischemic stroke | 4 | BeFree,GAD |
| umls:C1861172 | Venous Thromboembolism | 4 | CTD_human,GAD,LHGDN |
| umls:C0002726 | Amyloidosis | 3 | BeFree,LHGDN |
| umls:C0004153 | Atherosclerosis | 3 | BeFree,GAD |
| umls:C0007222 | Cardiovascular Diseases | 3 | BeFree,GAD,LHGDN |
| umls:C0042487 | Venous Thrombosis | 3 | GAD |
| umls:C0149871 | Deep Vein Thrombosis | 3 | BeFree,GAD |
| umls:C0007785 | Cerebral Infarction | 2 | BeFree,GAD |
| umls:C0007820 | Cerebrovascular Disorders | 2 | GAD,LHGDN |
| umls:C0022658 | Kidney Diseases | 2 | CTD_human |
| umls:C0034065 | Pulmonary Embolism | 2 | CTD_human,RGD |
| umls:C0040038 | Thromboembolism | 2 | BeFree,GAD |
| umls:C0042373 | Vascular Diseases | 2 | GAD,LHGDN |
| umls:C0268382 | Amyloid nephropathy | 2 | BeFree,GAD |
| umls:C0272350 | Dysfibrinogenemia, Congenital | 2 | ORPHANET,UNIPROT |
| umls:C0740340 | Amyloidosis, Familial | 2 | CTD_human |
| umls:C1260903 | Dysfibrinogenemia | 2 | BeFree,CLINVAR |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 2 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 1 | GAD |
| umls:C0002895 | Anemia, Sickle Cell | 1 | GAD |
| umls:C0002962 | Angina Pectoris | 1 | GAD |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0007273 | Carotid Artery Diseases | 1 | GAD |
| umls:C0007282 | Carotid Stenosis | 1 | GAD |
| umls:C0008370 | Cholestasis | 1 | CTD_human |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |
| umls:C0014175 | Endometriosis | 1 | BeFree |
| umls:C0015499 | Factor V Deficiency | 1 | LHGDN |
| umls:C0016522 | Foramen Ovale, Patent | 1 | GAD |
| umls:C0019080 | Hemorrhage | 1 | GAD |
| umls:C0020542 | Pulmonary Hypertension | 1 | LHGDN |
| umls:C0022116 | Ischemia | 1 | GAD |
| umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
| umls:C0026640 | Mouth Neoplasms | 1 | CTD_human |
| umls:C0026837 | Muscle Rigidity | 1 | BeFree |
| umls:C0027726 | Nephrotic Syndrome | 1 | BeFree |
| umls:C0027819 | Neuroblastoma | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | GAD |
| umls:C0029456 | Osteoporosis | 1 | CTD_human |
| umls:C0030305 | Pancreatitis | 1 | RGD |
| umls:C0041755 | Adverse reaction to drug | 1 | CTD_human |
| umls:C0151942 | Arterial thrombosis | 1 | BeFree |
| umls:C0151950 | Deep thrombophlebitis | 1 | BeFree |
| umls:C0206246 | Amyloidosis, Hereditary | 1 | BeFree |
| umls:C0242383 | Age related macular degeneration | 1 | GAD |
| umls:C0243026 | Sepsis | 1 | RGD |
| umls:C0268389 | Amyloidosis, familial visceral | 1 | CLINVAR,CTD_human,UNIPROT |
| umls:C0398623 | Thrombophilia | 1 | CTD_human |
| umls:C0472803 | Hypodysfibrinogenemia | 1 | BeFree |
| umls:C0553681 | Hypofibrinogenemia | 1 | BeFree |
| umls:C0700095 | Central neuroblastoma | 1 | BeFree |
| umls:C0860207 | Drug-Induced Liver Injury | 1 | CTD_human |
| umls:C0948089 | Acute Coronary Syndrome | 1 | GAD |
| umls:C1956346 | Coronary Artery Disease | 1 | GAD |
| umls:C2584774 | Congenital hypofibrinogenemia | 1 | ORPHANET,UNIPROT |
| umls:C2609414 | Acute kidney injury | 1 | RGD |
| umls:C2937358 | Cerebral Hemorrhage | 1 | GAD |
| umls:C1859970 | Hypodysfibrinogenemia, Congenital | 0 | CLINVAR |
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