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| TissGeneSummary for FGB |
 Gene summary |
| Basic gene information | Gene symbol | FGB |
| Gene name | fibrinogen beta chain | |
| Synonyms | HEL-S-78p | |
| Cytomap | UCSC genome browser: 4q28 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001184741.1, NM_005141.4, | |
| Description | epididymis secretory sperm binding protein Li 78pfibrinogen, B beta polypeptide | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 134830 | |
| HGNC : HGNC | ||
| HPRD : 00620 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FGB | |
| BioGPS: 2244 | ||
| Pathway | NCI Pathway Interaction Database: FGB | |
| KEGG: FGB | ||
| REACTOME: FGB | ||
| Pathway Commons: FGB | ||
| Context | iHOP: FGB | |
| ligand binding site mutation search in PubMed: FGB | ||
| UCL Cancer Institute: FGB | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of FGB | Cell type-specific differential induction of the human gamma-fibrinogen promoter by interleukin-6. Duan HO, Simpson-Haidaris PJ. J Biol Chem. 2006 May 5;281(18):12451-7. Epub 2006 Mar 8. (pmid:16524883) go to article | |
| Description by TissGene annotations | TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0007160 | cell-matrix adhesion | 10903502 | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 8100742 | GO:0043623 | cellular protein complex assembly | 8910396 | GO:0045907 | positive regulation of vasoconstriction | 15739255 | GO:0045921 | positive regulation of exocytosis | 19193866 | GO:0050714 | positive regulation of protein secretion | 19193866 | GO:0051258 | protein polymerization | 12706644 | GO:0051592 | response to calcium ion | 6777381 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10903502 | GO:0070527 | platelet aggregation | 6281794 | GO:0090277 | positive regulation of peptide hormone secretion | 19193866 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 10903502 | GO:2000352 | negative regulation of endothelial cell apoptotic process | 10903502 | GO:0007160 | cell-matrix adhesion | 10903502 | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 8100742 | GO:0043623 | cellular protein complex assembly | 8910396 | GO:0045907 | positive regulation of vasoconstriction | 15739255 | GO:0045921 | positive regulation of exocytosis | 19193866 | GO:0050714 | positive regulation of protein secretion | 19193866 | GO:0051258 | protein polymerization | 12706644 | GO:0051592 | response to calcium ion | 6777381 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 10903502 | GO:0070527 | platelet aggregation | 6281794 | GO:0090277 | positive regulation of peptide hormone secretion | 19193866 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 10903502 | GO:2000352 | negative regulation of endothelial cell apoptotic process | 10903502 |
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| TissGeneExp for FGB |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -1.785470235 | 3.490353765 | -5.275824 | 1.97E-08 | 9.96E-08 |
| LUAD | 2.473933075 | -0.353377269 | 2.827310345 | 2.47E-05 | 6.85E-05 |
| LIHC | 14.29956577 | 16.82209977 | -2.522534 | 6.53E-09 | 6.02E-08 |
| KIRP | 1.60302564 | 3.78946939 | -2.18644375 | 0.0195 | 0.039636446 |
| COAD | -0.344473158 | -1.917769312 | 1.573296154 | 0.000522 | 0.001599583 |
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| TissGene-miRNA for FGB |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FGB |
| TissGeneSNV for FGB |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R47Q | SKCM | 2 |
| p.E339Q | LUAD | 2 |
| p.K328T | UCS | 1 |
| p.G444S | COAD | 1 |
| p.K211R | UCEC | 1 |
| p.R199C | SKCM | 1 |
| p.R267* | HNSC | 1 |
| p.R87I | BLCA | 1 |
| p.R72W | BLCA | 1 |
| p.D419Y | OV | 1 |
| p.Y182H | ESCA | 1 |
| p.D327N | BRCA | 1 |
| p.P90T | PAAD | 1 |
| p.G472E | OV | 1 |
| p.K471N | UCEC | 1 |
| p.V361L | LUAD | 1 |
| p.P122Q | BLCA | 1 |
| p.M468I | SKCM | 1 |
| p.R74H | STAD | 1 |
| p.D455E | THYM | 1 |
| p.L340R | STAD | 1 |
| p.A136D | PAAD | 1 |
| p.E243K | LUAD | 1 |
| p.W279L | OV | 1 |
| p.N125S | SARC | 1 |
| p.D463N | SKCM | 1 |
| p.A89D | LUAD | 1 |
| p.Q82E | BLCA | 1 |
| p.D350N | LIHC | 1 |
| p.S371L | HNSC | 1 |
| p.D164_splice | GBM | 1 |
| p.R199C | READ | 1 |
| p.R74H | KICH | 1 |
| p.A79V | KICH | 1 |
| p.M482R | BLCA | 1 |
| p.G39D | SKCM | 1 |
| p.E253D | UCEC | 1 |
| p.R124G | STAD | 1 |
| p.G248R | SARC | 1 |
| p.R224C | UCEC | 1 |
| p.D411Y | PRAD | 1 |
| p.S126T | SKCM | 1 |
| p.R87K | SKCM | 1 |
| p.Q331L | LUAD | 1 |
| p.D164Y | LUAD | 1 |
| p.S142C | LUAD | 1 |
| p.A382V | GBM | 1 |
| p.L341S | LUSC | 1 |
| p.H355Q | PAAD | 1 |
| p.T407M | GBM | 1 |
| p.V361L | UCEC | 1 |
| p.N125S | LIHC | 1 |
| p.K328N | STAD | 1 |
| p.P100S | SKCM | 1 |
| p.W323L | LUAD | 1 |
| p.S237P | UCEC | 1 |
| p.G317C | LUAD | 1 |
| p.R196C | READ | 1 |
| p.W454L | CHOL | 1 |
| p.E275K | LUSC | 1 |
| p.G402S | STAD | 1 |
| p.R44C | MESO | 1 |
| p.K471R | SKCM | 1 |
| p.G349E | LUAD | 1 |
| p.T407M | LGG | 1 |
| p.L324I | PRAD | 1 |
| p.S473T | LUAD | 1 |
| p.A98T | UCS | 1 |
| p.M397V | HNSC | 1 |
| p.D327N | SKCM | 1 |
| p.N469H | ESCA | 1 |
| p.K178N | LUSC | 1 |
| p.G450E | LUAD | 1 |
| p.Q146* | HNSC | 1 |
| p.E129D | LUSC | 1 |
| p.K313N | PAAD | 1 |
| p.C95S | LUAD | 1 |
| p.H438N | UCEC | 1 |
| p.W448C | THYM | 1 |
| p.E250* | LUAD | 1 |
| p.E343* | UCEC | 1 |
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| TissGeneCNV for FGB |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FGB |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI065122 | FGB-FGB | chr4:155491723 | chr4:155488755 | |
| Chimerdb3.0 | ChiTaRs | NA | BC020762 | FGB-GNAS | chr4:155490429 | chr20:57485039 | |
| Chimerdb3.0 | ChiTaRs | NA | AW970840 | FGB-FGB | chr4:155492174 | chr4:155492186 | |
| Chimerdb3.0 | ChiTaRs | NA | AA491846 | FGB-FGB | chr4:155492174 | chr4:155492184 | |
| Chimerdb3.0 | ChiTaRs | NA | BG568132 | ZFP36L1-FGB | chr14:69255154 | chr4:155491882 | |
| TCGAfusionPortal | PRADA | BRCA | TCGA-D8-A13Z-01A | ARFIP1-FGB | In-frame | Chr4:153750878 | Chr4:155486960 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-78-7148-01A | FGB-PLEKHA5 | NA | Chr4:155492238 | Chr12:19441012 |
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| TissGeneNet for FGB |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FGB, CDKN1A, SMN1, TK1, NID1, ANXA7, GRB7, PITX3, CALR, HNF1A, KHDRBS2, F2, SERPINA5, FGA, RORA, AIMP2, FBLN1, FGG, PIK3R3, FOXA2, KLK6 (tumor) | FGB, CDKN1A, SMN1, TK1, NID1, CEBPB, ANXA7, GRB7, CSNK2B, CALR, HNF1A, KHDRBS2, LPA, F2, FGA, AIMP2, FBLN1, FGG, PIK3R3, MIS12, KLK6 (normal) |
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| COAD (tumor) | COAD (normal) |
| FGB, CDKN1A, SMN1, TK1, NID1, ANXA7, GRB7, PITX3, CSNK2B, CALR, KHDRBS2, LPA, F2, SERPINA5, FGA, RORA, FBLN1, FGG, PIK3R3, MIS12, KLK6 (tumor) | FGB, CDKN1A, SMN1, TK1, CEBPB, ANXA7, PITX3, CALR, HNF1A, KHDRBS2, LPA, F2, SERPINA5, FGA, RORA, AIMP2, FBLN1, FGG, PIK3R3, FOXA2, KLK6 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| FGB, CDKN1A, SMN1, TK1, NID1, CEBPB, ANXA7, PITX3, CSNK2B, CALR, HNF1A, KHDRBS2, F2, SERPINA5, FGA, AIMP2, FBLN1, FGG, MIS12, FOXA2, KLK6 (tumor) | FGB, CDKN1A, SMN1, NID1, CEBPB, ANXA7, PITX3, CSNK2B, HNF1A, LPA, F2, SERPINA5, FGA, RORA, AIMP2, FBLN1, FGG, PIK3R3, MIS12, FOXA2, KLK6 (normal) |
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| KICH (tumor) | KICH (normal) |
| FGB, CDKN1A, TK1, NID1, CEBPB, ANXA7, GRB7, PITX3, CSNK2B, CALR, HNF1A, KHDRBS2, LPA, F2, FGA, FBLN1, FGG, PIK3R3, MIS12, FOXA2, KLK6 (tumor) | FGB, CDKN1A, SMN1, TK1, NID1, ANXA7, GRB7, CSNK2B, CALR, HNF1A, KHDRBS2, SERPINA5, FGA, RORA, AIMP2, FBLN1, FGG, PIK3R3, MIS12, FOXA2, KLK6 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| FGB, SMN1, TK1, NID1, CEBPB, ANXA7, GRB7, PITX3, CSNK2B, CALR, HNF1A, KHDRBS2, LPA, F2, SERPINA5, FGA, FGG, PIK3R3, MIS12, FOXA2, KLK6 (tumor) | FGB, CDKN1A, TK1, NID1, CEBPB, GRB7, PITX3, CSNK2B, CALR, HNF1A, KHDRBS2, LPA, F2, SERPINA5, FGA, AIMP2, FBLN1, FGG, PIK3R3, FOXA2, KLK6 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| FGB, TK1, NID1, CEBPB, ANXA7, GRB7, PITX3, CALR, HNF1A, KHDRBS2, LPA, F2, SERPINA5, FGA, RORA, AIMP2, FBLN1, FGG, PIK3R3, FOXA2, KLK6 (tumor) | FGB, CDKN1A, NID1, CEBPB, GRB7, PITX3, CSNK2B, CALR, KHDRBS2, LPA, F2, SERPINA5, FGA, RORA, AIMP2, FBLN1, FGG, PIK3R3, MIS12, FOXA2, KLK6 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| FGB, CDKN1A, TK1, NID1, CEBPB, GRB7, PITX3, CALR, HNF1A, KHDRBS2, LPA, F2, SERPINA5, FGA, RORA, AIMP2, FBLN1, FGG, PIK3R3, MIS12, FOXA2 (tumor) | FGB, CDKN1A, SMN1, TK1, NID1, CEBPB, ANXA7, PITX3, CALR, HNF1A, KHDRBS2, LPA, F2, SERPINA5, FGA, RORA, FBLN1, FGG, PIK3R3, FOXA2, KLK6 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| FGB, CDKN1A, SMN1, TK1, NID1, CEBPB, ANXA7, GRB7, PITX3, CSNK2B, CALR, HNF1A, F2, SERPINA5, FGA, RORA, AIMP2, FGG, PIK3R3, MIS12, FOXA2 (tumor) | FGB, CDKN1A, TK1, NID1, CEBPB, ANXA7, GRB7, PITX3, CSNK2B, CALR, HNF1A, F2, FGA, RORA, AIMP2, FBLN1, FGG, PIK3R3, MIS12, FOXA2, KLK6 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| FGB, CDKN1A, SMN1, TK1, NID1, CEBPB, GRB7, PITX3, CSNK2B, CALR, HNF1A, KHDRBS2, F2, FGA, RORA, AIMP2, FBLN1, FGG, PIK3R3, FOXA2, KLK6 (tumor) | FGB, CDKN1A, TK1, CEBPB, ANXA7, PITX3, CSNK2B, CALR, HNF1A, KHDRBS2, LPA, F2, SERPINA5, FGA, RORA, AIMP2, FBLN1, FGG, PIK3R3, FOXA2, KLK6 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| FGB, CDKN1A, SMN1, NID1, CEBPB, GRB7, PITX3, CSNK2B, CALR, HNF1A, KHDRBS2, F2, SERPINA5, FGA, RORA, AIMP2, FBLN1, FGG, PIK3R3, FOXA2, KLK6 (tumor) | FGB, CDKN1A, TK1, CEBPB, ANXA7, GRB7, PITX3, CSNK2B, CALR, HNF1A, KHDRBS2, LPA, F2, SERPINA5, FGA, RORA, AIMP2, FGG, MIS12, FOXA2, KLK6 (normal) |
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| STAD (tumor) | STAD (normal) |
| FGB, CDKN1A, TK1, NID1, ANXA7, GRB7, CSNK2B, CALR, HNF1A, LPA, F2, SERPINA5, FGA, RORA, AIMP2, FBLN1, FGG, PIK3R3, MIS12, FOXA2, KLK6 (tumor) | FGB, NID1, CEBPB, ANXA7, GRB7, PITX3, CSNK2B, CALR, HNF1A, KHDRBS2, LPA, F2, SERPINA5, FGA, RORA, AIMP2, FGG, PIK3R3, MIS12, FOXA2, KLK6 (normal) |
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| THCA (tumor) | THCA (normal) |
| FGB, CDKN1A, TK1, NID1, CEBPB, ANXA7, GRB7, PITX3, CALR, HNF1A, KHDRBS2, LPA, F2, SERPINA5, FGA, RORA, FBLN1, FGG, MIS12, FOXA2, KLK6 (tumor) | FGB, SMN1, TK1, NID1, CEBPB, ANXA7, GRB7, PITX3, CSNK2B, HNF1A, KHDRBS2, LPA, F2, SERPINA5, FGA, RORA, AIMP2, FGG, PIK3R3, MIS12, KLK6 (normal) |
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| TissGeneProg for FGB |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FGB |
| TissGeneDrug for FGB |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FGB |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0027051 | Myocardial Infarction | 22 | BeFree,GAD,LHGDN |
| umls:C1561955 | Fibrinogen Adverse Event | 21 | GAD,GWASCAT |
| umls:C0038454 | Cerebrovascular accident | 16 | BeFree,GAD,LHGDN |
| umls:C0948008 | Ischemic stroke | 12 | BeFree,GAD |
| umls:C0007222 | Cardiovascular Diseases | 11 | BeFree,GAD,LHGDN |
| umls:C0020538 | Hypertensive disease | 10 | BeFree,GAD,LHGDN |
| umls:C0040053 | Thrombosis | 8 | GAD,LHGDN |
| umls:C0007786 | Brain Ischemia | 7 | GAD |
| umls:C0004153 | Atherosclerosis | 6 | BeFree,GAD |
| umls:C0001733 | Afibrinogenemia | 5 | BeFree,CTD_human,LHGDN |
| umls:C0007785 | Cerebral Infarction | 5 | GAD,LHGDN |
| umls:C0010068 | Coronary heart disease | 4 | BeFree,GAD |
| umls:C0019250 | Hereditary factor I deficiency disease | 4 | BeFree |
| umls:C0042373 | Vascular Diseases | 4 | GAD,LHGDN |
| umls:C0042487 | Venous Thrombosis | 4 | GAD |
| umls:C0149871 | Deep Vein Thrombosis | 4 | BeFree,GAD |
| umls:C0151744 | Myocardial Ischemia | 4 | GAD |
| umls:C1956346 | Coronary Artery Disease | 4 | BeFree,GAD,LHGDN |
| umls:C2584774 | Congenital hypofibrinogenemia | 4 | ORPHANET,UNIPROT |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 4 | BeFree |
| umls:C0004238 | Atrial Fibrillation | 3 | GAD |
| umls:C0007789 | Cerebral Palsy | 3 | GAD |
| umls:C0010054 | Coronary Arteriosclerosis | 3 | BeFree,GAD |
| umls:C0028754 | Obesity | 3 | GAD |
| umls:C0034065 | Pulmonary Embolism | 3 | GAD,RGD |
| umls:C0398623 | Thrombophilia | 3 | GAD |
| umls:C0948089 | Acute Coronary Syndrome | 3 | GAD |
| umls:C1861172 | Venous Thromboembolism | 3 | GAD |
| umls:C0001925 | Albuminuria | 2 | GAD |
| umls:C0002895 | Anemia, Sickle Cell | 2 | GAD |
| umls:C0007273 | Carotid Artery Diseases | 2 | BeFree,GAD |
| umls:C0010072 | Coronary Thrombosis | 2 | GAD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | GAD |
| umls:C0021368 | Inflammation | 2 | GAD |
| umls:C0022661 | Kidney Failure, Chronic | 2 | BeFree,GAD |
| umls:C0024143 | Lupus Nephritis | 2 | BeFree,GAD,LHGDN |
| umls:C0031099 | Periodontitis | 2 | GAD |
| umls:C0035326 | Retinal vascular occlusion | 2 | GAD |
| umls:C0085096 | Peripheral Vascular Diseases | 2 | GAD |
| umls:C0243026 | Sepsis | 2 | GAD,LHGDN |
| umls:C0266929 | Chronic Periodontitis | 2 | GAD |
| umls:C0553681 | Hypofibrinogenemia | 2 | BeFree |
| umls:C0687675 | Pregnancy loss | 2 | GAD |
| umls:C0852077 | Blood Coagulation Disorders, Inherited | 2 | GAD |
| umls:C0000809 | Abortion, Habitual | 1 | GAD |
| umls:C0002382 | Alveolar Bone Loss | 1 | GAD |
| umls:C0002395 | Alzheimer's Disease | 1 | GAD |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | GAD |
| umls:C0002962 | Angina Pectoris | 1 | GAD |
| umls:C0002965 | Angina, Unstable | 1 | BeFree |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | GAD |
| umls:C0005283 | beta Thalassemia | 1 | GAD |
| umls:C0007282 | Carotid Stenosis | 1 | GAD |
| umls:C0007820 | Cerebrovascular Disorders | 1 | GAD |
| umls:C0008495 | Chorioamnionitis | 1 | GAD |
| umls:C0015944 | Fetal Membranes, Premature Rupture | 1 | GAD |
| umls:C0017327 | Generalized atherosclerosis | 1 | GAD |
| umls:C0019080 | Hemorrhage | 1 | GAD |
| umls:C0020542 | Pulmonary Hypertension | 1 | GAD |
| umls:C0021361 | Female infertility | 1 | GAD |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | GAD |
| umls:C0022116 | Ischemia | 1 | GAD |
| umls:C0022658 | Kidney Diseases | 1 | GAD |
| umls:C0022876 | Premature Obstetric Labor | 1 | GAD |
| umls:C0023234 | Legg-Calve-Perthes Disease | 1 | GAD,LHGDN |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
| umls:C0024131 | Lupus Vulgaris | 1 | GAD |
| umls:C0024138 | Lupus Erythematosus, Discoid | 1 | GAD |
| umls:C0024141 | Lupus Erythematosus, Systemic | 1 | GAD |
| umls:C0026269 | Mitral Valve Stenosis | 1 | GAD |
| umls:C0026691 | Mucocutaneous Lymph Node Syndrome | 1 | GAD |
| umls:C0026837 | Muscle Rigidity | 1 | BeFree |
| umls:C0029456 | Osteoporosis | 1 | CTD_human |
| umls:C0030305 | Pancreatitis | 1 | RGD |
| umls:C0030567 | Parkinson Disease | 1 | CTD_human |
| umls:C0031094 | Periodontal Pocket | 1 | GAD |
| umls:C0031106 | Periodontitis, Juvenile | 1 | GAD |
| umls:C0032914 | Pre-Eclampsia | 1 | GAD |
| umls:C0035078 | Kidney Failure | 1 | BeFree |
| umls:C0036421 | Systemic Scleroderma | 1 | GAD |
| umls:C0040038 | Thromboembolism | 1 | GAD |
| umls:C0151526 | Premature Birth | 1 | GAD |
| umls:C0151942 | Arterial thrombosis | 1 | BeFree |
| umls:C0155626 | Acute myocardial infarction | 1 | BeFree |
| umls:C0155668 | Old myocardial infarction | 1 | BeFree |
| umls:C0206114 | Periodontal Attachment Loss | 1 | GAD |
| umls:C0242383 | Age related macular degeneration | 1 | GAD |
| umls:C0272350 | Dysfibrinogenemia, Congenital | 1 | ORPHANET,UNIPROT |
| umls:C0333186 | Restenosis | 1 | GAD |
| umls:C0340293 | Anterior myocardial infarction | 1 | BeFree |
| umls:C0342257 | Complications of Diabetes Mellitus | 1 | GAD |
| umls:C0409974 | Lupus Erythematosus | 1 | GAD |
| umls:C0524620 | Metabolic Syndrome X | 1 | GAD |
| umls:C0856169 | Endothelial dysfunction | 1 | BeFree |
| umls:C0856761 | Budd-Chiari Syndrome | 1 | GAD |
| umls:C1261287 | Stenosis | 1 | LHGDN |
| umls:C1272641 | Systemic arterial pressure | 1 | GAD |
| umls:C1842372 | ASPIRIN RESISTANCE | 1 | GAD |
| umls:C2919032 | Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 1 | GAD |
| umls:C2921106 | Recurrent pregnancy loss | 1 | GAD |
| umls:C3178801 | Stroke, Lacunar | 1 | GAD |
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