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| TissGeneSummary for FGL1 |
 Gene summary |
| Basic gene information | Gene symbol | FGL1 |
| Gene name | fibrinogen-like 1 | |
| Synonyms | HFREP1|HP-041|LFIRE-1|LFIRE1 | |
| Cytomap | UCSC genome browser: 8p22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004467.3, NM_147203.2,NM_201552.1,NM_201553.1, | |
| Description | fibrinogen-like protein 1hepassocinhepatocellular carcinoma-related sequencehepatocyte-derived fibrinogen-related protein 1liver fibrinogen-related protein 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605776 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000104760 | ||
| HPRD : 09312 | ||
| Vega : OTTHUMG00000096989 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_FGL1 | |
| BioGPS: 2267 | ||
| Pathway | NCI Pathway Interaction Database: FGL1 | |
| KEGG: FGL1 | ||
| REACTOME: FGL1 | ||
| Pathway Commons: FGL1 | ||
| Context | iHOP: FGL1 | |
| ligand binding site mutation search in PubMed: FGL1 | ||
| UCL Cancer Institute: FGL1 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of FGL1 | ||
| Description by TissGene annotations | TissgsKTS Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for FGL1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -3.132125723 | -1.786689723 | -1.345436 | 2.03E-06 | 7.26E-06 |
| LUAD | 1.969140967 | -1.719534895 | 3.688675862 | 1.17E-10 | 6.92E-10 |
| LIHC | 10.72710028 | 12.77751828 | -2.050418 | 7.06E-07 | 3.94E-06 |
| KIRC | -2.976303334 | -1.804907501 | -1.171395833 | 8.01E-10 | 2.64E-09 |
| PRAD | 0.959118354 | -1.566618185 | 2.525736538 | 1.32E-09 | 2.00E-08 |
| STAD | -1.341926598 | -2.603189098 | 1.2612625 | 0.0109 | 0.036918825 |
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| TissGene-miRNA for FGL1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for FGL1 |
| TissGeneSNV for FGL1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S130R | READ | 1 |
| p.R38L | COAD | 1 |
| p.E68K | LUAD | 1 |
| p.N146H | COAD | 1 |
| p.Q124R | STAD | 1 |
| p.K138E | UCEC | 1 |
| p.D128Y | CESC | 1 |
| p.Q124* | BLCA | 1 |
| p.W275* | UCEC | 1 |
| p.Q103K | LUAD | 1 |
| p.W237X | SKCM | 1 |
| p.S109F | SKCM | 1 |
| p.T70A | LGG | 1 |
| p.A13T | THCA | 1 |
| p.E201Q | CESC | 1 |
| p.A266V | GBM | 1 |
| p.R231S | PAAD | 1 |
| p.W155S | STAD | 1 |
| p.S263C | HNSC | 1 |
| p.F5I | COAD | 1 |
| p.D189E | UCEC | 1 |
| p.F147S | LUAD | 1 |
| p.G273C | LUAD | 1 |
| p.R184H | BLCA | 1 |
| p.E131* | UCEC | 1 |
| p.R32Q | SKCM | 1 |
| p.R126Q | SKCM | 1 |
| p.T236M | STAD | 1 |
| p.V110F | ESCA | 1 |
| p.N190K | COAD | 1 |
| p.W225* | UCEC | 1 |
| p.S272R | STAD | 1 |
| p.W237* | SKCM | 1 |
| p.Q124* | SARC | 1 |
| p.G282R | BLCA | 1 |
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| TissGeneCNV for FGL1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for FGL1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BM910902 | PCM1-FGL1 | chr8:17780697 | chr8:17749190 | |
| Chimerdb3.0 | ChiTaRs | NA | BM914108 | PCM1-FGL1 | chr8:17780697 | chr8:17739588 | |
| Chimerdb3.0 | FusionScan | LUAD | TCGA-55-8094-01A | MTUS1-FGL1 | In-Frame | chr8:17570722 | chr8:17726513 |
| Chimerdb3.0 | TopHat-Fusion | LUAD | TCGA-55-8094-01A | MTUS1-FGL1 | In-Frame | chr8:17570722 | chr8:17726512 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-55-8094-01A | MTUS1-FGL1 | In-frame | Chr8:17570723 | Chr8:17726513 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-55-8508-01A | MTUS1-FGL1 | CDS-5UTR | Chr8:17570723 | Chr8:17743080 |
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| TissGeneNet for FGL1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| FGL1, HNF1A, BCL2L11 (tumor) | FGL1, HNF1A, BCL2L11 (normal) |
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| COAD (tumor) | COAD (normal) |
| FGL1, HNF1A, BCL2L11 (tumor) | FGL1, HNF1A, BCL2L11 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| FGL1, HNF1A, BCL2L11 (tumor) | FGL1, HNF1A, BCL2L11 (normal) |
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| KICH (tumor) | KICH (normal) |
| FGL1, HNF1A, BCL2L11 (tumor) | FGL1, HNF1A, BCL2L11 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| FGL1, HNF1A, BCL2L11 (tumor) | FGL1, HNF1A, BCL2L11 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| FGL1, HNF1A, BCL2L11 (tumor) | FGL1, HNF1A, BCL2L11 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| FGL1, HNF1A, BCL2L11 (tumor) | FGL1, HNF1A, BCL2L11 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| FGL1, HNF1A, BCL2L11 (tumor) | FGL1, HNF1A, BCL2L11 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| FGL1, HNF1A, BCL2L11 (tumor) | FGL1, HNF1A, BCL2L11 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| FGL1, HNF1A, BCL2L11 (tumor) | FGL1, HNF1A, BCL2L11 (normal) |
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| STAD (tumor) | STAD (normal) |
| FGL1, HNF1A, BCL2L11 (tumor) | FGL1, HNF1A, BCL2L11 (normal) |
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| THCA (tumor) | THCA (normal) |
| FGL1, HNF1A, BCL2L11 (tumor) | FGL1, HNF1A, BCL2L11 (normal) |
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| TissGeneProg for FGL1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for FGL1 |
| TissGeneDrug for FGL1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for FGL1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C2239176 | Liver carcinoma | 5 | BeFree,GAD |
| umls:C0019196 | Hepatitis C | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 1 | BeFree |
| umls:C1318485 | Liver regeneration disorder | 1 | BeFree |
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