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| TissGeneSummary for TFEC |
 Gene summary |
| Basic gene information | Gene symbol | TFEC |
| Gene name | transcription factor EC | |
| Synonyms | TCFEC|TFE-C|TFEC-L|TFECL|bHLHe34|hTFEC-L | |
| Cytomap | UCSC genome browser: 7q31.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001018058.2, NM_001244583.1,NM_012252.3, | |
| Description | class E basic helix-loop-helix protein 34 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604732 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000105967 | ||
| HPRD : 05294 | ||
| Vega : OTTHUMG00000023518 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TFEC | |
| BioGPS: 22797 | ||
| Pathway | NCI Pathway Interaction Database: TFEC | |
| KEGG: TFEC | ||
| REACTOME: TFEC | ||
| Pathway Commons: TFEC | ||
| Context | iHOP: TFEC | |
| ligand binding site mutation search in PubMed: TFEC | ||
| UCL Cancer Institute: TFEC | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLung | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLUAD,LUSC | |
| Reference showing the relevant tissue of TFEC | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for TFEC |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | 0.056671986 | 1.310959917 | -1.254287931 | 1.38E-07 | 5.29E-07 |
| KIRC | 2.542080655 | 1.182275099 | 1.359805556 | 1.70E-05 | 3.90E-05 |
| LUSC | -0.828990995 | 1.273383514 | -2.10237451 | 2.90E-14 | 1.60E-13 |
| KICH | -1.49528229 | 0.29127771 | -1.78656 | 0.000638 | 0.001426118 |
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| TissGene-miRNA for TFEC |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for TFEC |
| TissGeneSNV for TFEC |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G103E | SKCM | 4 |
| p.G36E | SKCM | 2 |
| p.H5Y | SKCM | 2 |
| p.S330F | SKCM | 2 |
| p.D291N | SKCM | 1 |
| p.R219W | SKCM | 1 |
| p.S263F | SKCM | 1 |
| p.P10Q | LUAD | 1 |
| p.E187K | SKCM | 1 |
| p.G25E | SKCM | 1 |
| p.H70Y | LUAD | 1 |
| p.R152K | SKCM | 1 |
| p.D242N | SKCM | 1 |
| p.L165F | SKCM | 1 |
| p.H60Y | STAD | 1 |
| p.Q16K | SKCM | 1 |
| p.A114V | LUSC | 1 |
| p.K123T | SKCM | 1 |
| p.K207T | STAD | 1 |
| p.L33V | BLCA | 1 |
| p.S272G | ESCA | 1 |
| p.C262* | LUAD | 1 |
| p.R158* | LGG | 1 |
| p.R149K | SKCM | 1 |
| p.Q78* | BLCA | 1 |
| p.P320T | LUAD | 1 |
| p.A281D | LUAD | 1 |
| p.I225S | HNSC | 1 |
| p.G79R | SKCM | 1 |
| p.E155K | SKCM | 1 |
| p.P187L | SKCM | 1 |
| p.G270R | SKCM | 1 |
| p.D63G | PAAD | 1 |
| p.M122I | SKCM | 1 |
| p.R91X | LGG | 1 |
| p.L12V | HNSC | 1 |
| p.H230Y | BLCA | 1 |
| p.E78K | SKCM | 1 |
| p.R152Q | SKCM | 1 |
| p.E120K | SKCM | 1 |
| p.D96E | LUAD | 1 |
| p.R219Q | SKCM | 1 |
| p.G79E | SKCM | 1 |
| p.E346K | SKCM | 1 |
| p.T266A | STAD | 1 |
| p.M197I | LUAD | 1 |
| p.I8M | CESC | 1 |
| p.D171N | GBM | 1 |
| p.D291H | BLCA | 1 |
| p.L98F | SKCM | 1 |
| p.R88K | GBM | 1 |
| p.E125* | UCEC | 1 |
| p.G203R | SKCM | 1 |
| p.I88T | COAD | 1 |
| p.E77V | LUAD | 1 |
| p.R85K | SKCM | 1 |
| p.G92E | SKCM | 1 |
| p.A236V | SKCM | 1 |
| p.R228C | SKCM | 1 |
| p.D130N | LUSC | 1 |
| p.Y98N | BLCA | 1 |
| p.S169F | STAD | 1 |
| p.H28N | LUAD | 1 |
| p.L12V | KIRC | 1 |
| p.S258L | SKCM | 1 |
| p.R82K | SKCM | 1 |
| p.P233T | BRCA | 1 |
| p.D224N | SKCM | 1 |
| p.T266I | UCEC | 1 |
| p.A236T | STAD | 1 |
| p.Q78E | BLCA | 1 |
| p.R219W | PRAD | 1 |
| p.D173Y | UCEC | 1 |
| p.A29E | THYM | 1 |
| p.P254L | SKCM | 1 |
| p.E201* | UCEC | 1 |
| p.F282L | CESC | 1 |
| p.V247A | PAAD | 1 |
| p.L8F | SARC | 1 |
| p.R161C | SKCM | 1 |
| p.T62I | SKCM | 1 |
| p.S82C | LGG | 1 |
| p.Q263K | LUAD | 1 |
| p.T129I | SKCM | 1 |
| p.E279K | SKCM | 1 |
| p.P172_splice | LUSC | 1 |
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| TissGeneCNV for TFEC |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TFEC |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for TFEC |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (tumor) | TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (normal) |
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| COAD (tumor) | COAD (normal) |
| TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (tumor) | TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (normal) |
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| HNSC (tumor) | HNSC (normal) |
| TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (tumor) | TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (normal) |
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| KICH (tumor) | KICH (normal) |
| TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (tumor) | TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (normal) |
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| KIRC (tumor) | KIRC (normal) |
| TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (tumor) | TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (normal) |
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| KIRP (tumor) | KIRP (normal) |
| TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (tumor) | TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (normal) |
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| LIHC (tumor) | LIHC (normal) |
| TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (tumor) | TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (normal) |
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| LUAD (tumor) | LUAD (normal) |
| TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (tumor) | TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (normal) |
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| LUSC (tumor) | LUSC (normal) |
| TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (tumor) | TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (normal) |
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| PRAD (tumor) | PRAD (normal) |
| TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (tumor) | TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (normal) |
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| STAD (tumor) | STAD (normal) |
| TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (tumor) | TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (normal) |
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| THCA (tumor) | THCA (normal) |
| TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (tumor) | TFEC, HNRNPA1, DCK, MITF, TFE3, ZMAT2, TFEB (normal) |
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| TissGeneProg for TFEC |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TFEC |
| TissGeneDrug for TFEC |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TFEC |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
| umls:C0026010 | Microphthalmos | 1 | BeFree |
| umls:C1956346 | Coronary Artery Disease | 1 | BeFree |
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