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| TissGeneSummary for LAMB4 |
 Gene summary |
| Basic gene information | Gene symbol | LAMB4 |
| Gene name | laminin, beta 4 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 7q31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_007356.2, | |
| Description | laminin beta-1-related proteinlaminin subunit beta-4 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000091128 | ||
| HPRD : 11224 | ||
| Vega : OTTHUMG00000154874 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LAMB4 | |
| BioGPS: 22798 | ||
| Pathway | NCI Pathway Interaction Database: LAMB4 | |
| KEGG: LAMB4 | ||
| REACTOME: LAMB4 | ||
| Pathway Commons: LAMB4 | ||
| Context | iHOP: LAMB4 | |
| ligand binding site mutation search in PubMed: LAMB4 | ||
| UCL Cancer Institute: LAMB4 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
| Reference showing the relevant tissue of LAMB4 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for LAMB4 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| HNSC | -0.062874275 | 2.911142004 | -2.974016279 | 5.34E-07 | 4.35E-06 |
| KIRC | -0.021082899 | 3.023457379 | -3.044540278 | 7.65E-33 | 1.75E-31 |
| THCA | -1.269477744 | -0.122672659 | -1.146805085 | 4.65E-06 | 1.58E-05 |
| KIRP | 0.939237934 | 3.153653559 | -2.214415625 | 2.07E-07 | 1.19E-06 |
| ESCA | -1.274264339 | 1.415753843 | -2.690018182 | 0.00136 | 0.017922824 |
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| TissGene-miRNA for LAMB4 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for LAMB4 |
| TissGeneSNV for LAMB4 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.F956L | UCEC | 2 |
| p.S926F | SKCM | 2 |
| p.E1492K | SKCM | 2 |
| p.R1585P | HNSC | 2 |
| p.P205S | SKCM | 2 |
| p.Q1741* | SKCM | 1 |
| p.G1465R | BRCA | 1 |
| p.E395K | OV | 1 |
| p.G796R | LUAD | 1 |
| p.V358M | KIRP | 1 |
| p.A391V | UCEC | 1 |
| p.Q1635* | STAD | 1 |
| p.S107Y | LUAD | 1 |
| p.D119H | BLCA | 1 |
| p.T1519N | ESCA | 1 |
| p.S1187Y | UCEC | 1 |
| p.I676N | KIRC | 1 |
| p.Y899H | STAD | 1 |
| p.D1520N | LUAD | 1 |
| p.S933R | LUSC | 1 |
| p.A1648V | PRAD | 1 |
| p.K1671N | UCEC | 1 |
| p.R1585Q | SKCM | 1 |
| p.P917S | GBM | 1 |
| p.K232N | BRCA | 1 |
| p.E64K | SKCM | 1 |
| p.Y254H | COAD | 1 |
| p.V1743I | UCEC | 1 |
| p.P459L | SKCM | 1 |
| p.P693T | BRCA | 1 |
| p.G1009C | LUAD | 1 |
| p.R1437H | UCEC | 1 |
| p.R1229K | SKCM | 1 |
| p.Q1580E | BLCA | 1 |
| p.C508Y | UCEC | 1 |
| p.R986W | SKCM | 1 |
| p.L711I | THYM | 1 |
| p.S953F | SKCM | 1 |
| p.T231N | LUAD | 1 |
| p.H1510Q | ACC | 1 |
| p.G883V | BLCA | 1 |
| p.F598S | STAD | 1 |
| p.G1239R | ESCA | 1 |
| p.E273K | GBM | 1 |
| p.P1036S | SKCM | 1 |
| p.E1500K | COAD | 1 |
| p.S1320P | LIHC | 1 |
| p.H818D | HNSC | 1 |
| p.S1297Y | LUAD | 1 |
| p.M44T | COAD | 1 |
| p.V591F | COAD | 1 |
| p.E557K | BRCA | 1 |
| p.C274F | LUAD | 1 |
| p.A1215S | ESCA | 1 |
| p.P98T | COAD | 1 |
| p.E1753K | SKCM | 1 |
| p.E1663K | GBM | 1 |
| p.H1316Y | BLCA | 1 |
| p.R849H | GBM | 1 |
| p.D189N | SKCM | 1 |
| p.C984R | LIHC | 1 |
| p.V1494L | OV | 1 |
| p.E627K | THYM | 1 |
| p.G263E | SKCM | 1 |
| p.A1192V | UCEC | 1 |
| p.G796R | GBM | 1 |
| p.Q2* | LGG | 1 |
| p.A565E | LUAD | 1 |
| p.D180E | LGG | 1 |
| p.R262W | UCEC | 1 |
| p.G1097S | LUAD | 1 |
| p.Q1592K | LUAD | 1 |
| p.G511R | COAD | 1 |
| p.G883E | SKCM | 1 |
| p.G497E | SKCM | 1 |
| p.E1260K | SKCM | 1 |
| p.T366S | LUSC | 1 |
| p.D372N | SARC | 1 |
| p.P587H | ESCA | 1 |
| p.D79G | STAD | 1 |
| p.Q1435H | LUAD | 1 |
| p.G1410S | BRCA | 1 |
| p.T1350N | COAD | 1 |
| p.R1713K | UCS | 1 |
| p.N589S | SKCM | 1 |
| p.G511R | LUAD | 1 |
| p.C267F | LUAD | 1 |
| p.G813S | UCEC | 1 |
| p.G443R | SKCM | 1 |
| p.W153X | COAD | 1 |
| p.A662V | UCEC | 1 |
| p.M44T | DLBC | 1 |
| p.E1539K | SKCM | 1 |
| p.H10Y | KIRC | 1 |
| p.V1224L | HNSC | 1 |
| p.T1018A | STAD | 1 |
| p.D79N | SKCM | 1 |
| p.R1461K | SKCM | 1 |
| p.H1510Y | COAD | 1 |
| p.A1026T | STAD | 1 |
| p.K1240N | SKCM | 1 |
| p.E1168K | SKCM | 1 |
| p.R1612S | COAD | 1 |
| p.F1241L | HNSC | 1 |
| p.H1409Q | HNSC | 1 |
| p.I1325M | READ | 1 |
| p.V591F | BRCA | 1 |
| p.P858S | SKCM | 1 |
| p.P520S | LGG | 1 |
| p.Q325H | UCEC | 1 |
| p.P585S | UCEC | 1 |
| p.G778* | STAD | 1 |
| p.L1005I | LUAD | 1 |
| p.V1029M | PRAD | 1 |
| p.Q218* | SKCM | 1 |
| p.R534H | UCEC | 1 |
| p.S660P | LUAD | 1 |
| p.K1555R | STAD | 1 |
| p.A1549T | PAAD | 1 |
| p.G1407C | UCEC | 1 |
| p.R1437C | BLCA | 1 |
| p.L871I | LUAD | 1 |
| p.C790R | UCEC | 1 |
| p.S1111I | LUAD | 1 |
| p.V178A | UCEC | 1 |
| p.A446T | STAD | 1 |
| p.G1106S | UCEC | 1 |
| p.E570K | SKCM | 1 |
| p.K1279N | HNSC | 1 |
| p.D1219Y | READ | 1 |
| p.G877W | LIHC | 1 |
| p.S1023Y | LUAD | 1 |
| p.P287H | UCEC | 1 |
| p.R1723T | HNSC | 1 |
| p.A140G | LUAD | 1 |
| p.D808N | SKCM | 1 |
| p.G1684E | BLCA | 1 |
| p.N1504K | SKCM | 1 |
| p.G897D | PAAD | 1 |
| p.M1032L | LUAD | 1 |
| p.G1067R | SKCM | 1 |
| p.D1288N | SKCM | 1 |
| p.S824L | SKCM | 1 |
| p.R909H | STAD | 1 |
| p.D315H | LUAD | 1 |
| p.V1436F | LUAD | 1 |
| p.G765W | LUAD | 1 |
| p.R1339M | UCEC | 1 |
| p.V1385L | LUAD | 1 |
| p.E487K | BLCA | 1 |
| p.G1465E | SKCM | 1 |
| p.D1249N | LUAD | 1 |
| p.D980N | UCEC | 1 |
| p.N522S | HNSC | 1 |
| p.H772Q | LUAD | 1 |
| p.R262W | COAD | 1 |
| p.A1278T | UCEC | 1 |
| p.C798Y | LUAD | 1 |
| p.E875K | BLCA | 1 |
| p.L1703S | HNSC | 1 |
| p.P389S | SKCM | 1 |
| p.R1401M | STAD | 1 |
| p.D726G | STAD | 1 |
| p.R262Q | ESCA | 1 |
| p.N152K | ESCA | 1 |
| p.I209S | COAD | 1 |
| p.P590S | KIRC | 1 |
| p.P547T | THYM | 1 |
| p.P1054L | ESCA | 1 |
| p.R909C | COAD | 1 |
| p.L709R | BRCA | 1 |
| p.R1437S | UCEC | 1 |
| p.Q1530X | STAD | 1 |
| p.S188L | STAD | 1 |
| p.H1657Q | LUAD | 1 |
| p.V94L | LUAD | 1 |
| p.S903F | SKCM | 1 |
| p.T674A | SARC | 1 |
| p.F550S | UCEC | 1 |
| p.G810W | LUAD | 1 |
| p.P713S | SKCM | 1 |
| p.N1223S | UCEC | 1 |
| p.G497V | UCEC | 1 |
| p.R137Q | SKCM | 1 |
| p.P389S | LUAD | 1 |
| p.G1691E | SKCM | 1 |
| p.N1441D | LIHC | 1 |
| p.Q1254H | STAD | 1 |
| p.Y898X | READ | 1 |
| p.P1142S | HNSC | 1 |
| p.M1032I | SKCM | 1 |
| p.E273V | LUAD | 1 |
| p.D189Y | BRCA | 1 |
| p.A27V | PRAD | 1 |
| p.G1145V | STAD | 1 |
| p.G778E | SKCM | 1 |
| p.T41K | LUAD | 1 |
| p.C1158Y | KIRC | 1 |
| p.G785E | SKCM | 1 |
| p.Q1530* | STAD | 1 |
| p.E870K | CESC | 1 |
| p.S418F | STAD | 1 |
| p.R1430C | SKCM | 1 |
| p.E64* | LUAD | 1 |
| p.P215S | SKCM | 1 |
| p.E273K | SKCM | 1 |
| p.G26C | LUAD | 1 |
| p.L35I | LUAD | 1 |
| p.T1416M | HNSC | 1 |
| p.S1681N | STAD | 1 |
| p.D589N | UCEC | 1 |
| p.Y390N | LUSC | 1 |
| p.D509N | SKCM | 1 |
| p.R373H | READ | 1 |
| p.G813D | SKCM | 1 |
| p.N997Y | LUAD | 1 |
| p.S1079L | BLCA | 1 |
| p.E627K | SKCM | 1 |
| p.G492R | SKCM | 1 |
| p.E1424K | SKCM | 1 |
| p.V94I | LGG | 1 |
| p.P168S | SKCM | 1 |
| p.R1541M | UCEC | 1 |
| p.C1110R | HNSC | 1 |
| p.N975K | LUAD | 1 |
| p.R1404S | ESCA | 1 |
| p.G443E | SKCM | 1 |
| p.L1015I | LUAD | 1 |
| p.R1160S | LUAD | 1 |
| p.S859C | LIHC | 1 |
| p.E210K | LUSC | 1 |
| p.D707N | SKCM | 1 |
| p.G805R | SKCM | 1 |
| p.R1585L | STAD | 1 |
| p.R53T | LUSC | 1 |
| p.A1549D | UCEC | 1 |
| p.T954A | STAD | 1 |
| p.G1377R | SKCM | 1 |
| p.A1001T | HNSC | 1 |
| p.N1596K | THYM | 1 |
| p.Q1610* | SKCM | 1 |
| p.P1100S | SKCM | 1 |
| p.C69Y | OV | 1 |
| p.G65W | SKCM | 1 |
| p.P394S | UCEC | 1 |
| p.P547L | LUAD | 1 |
| p.G1380E | SKCM | 1 |
| p.S698F | UCEC | 1 |
| p.G1377R | LUSC | 1 |
| p.L561P | THYM | 1 |
| p.D1129Y | ESCA | 1 |
| p.K1670R | HNSC | 1 |
| p.A446V | STAD | 1 |
| p.R262W | KIRP | 1 |
| p.A700T | KICH | 1 |
| p.G958E | SKCM | 1 |
| p.T235I | SKCM | 1 |
| p.M758L | HNSC | 1 |
| p.W105* | THCA | 1 |
| p.L1289P | LGG | 1 |
| p.P816A | LUAD | 1 |
| p.Q948* | HNSC | 1 |
| p.D1740N | KIRC | 1 |
| p.S723R | LUAD | 1 |
| p.D1066H | BLCA | 1 |
| p.P617L | SKCM | 1 |
| p.D896Y | LIHC | 1 |
| p.P1496A | HNSC | 1 |
| p.L1300F | SKCM | 1 |
| p.A45V | SKCM | 1 |
| p.G1584E | SKCM | 1 |
| p.L43I | UCEC | 1 |
| p.R1712K | BRCA | 1 |
| p.C1175Y | HNSC | 1 |
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| TissGeneCNV for LAMB4 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for LAMB4 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AK075165 | LAMB4-COBLL1 | chr7:107677931 | chr2:165541255 | |
| Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A6BH-01A | UTRN-LAMB4 | Out-of-Frame | chr6:144769905 | chr7:107678040 |
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| TissGeneNet for LAMB4 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| LAMB4, KCTD13 (tumor) | LAMB4, KCTD13 (normal) |
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| COAD (tumor) | COAD (normal) |
| LAMB4, KCTD13 (tumor) | LAMB4, KCTD13 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| LAMB4, KCTD13 (tumor) | LAMB4, KCTD13 (normal) |
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| KICH (tumor) | KICH (normal) |
| LAMB4, KCTD13 (tumor) | LAMB4, KCTD13 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| LAMB4, KCTD13 (tumor) | LAMB4, KCTD13 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| LAMB4, KCTD13 (tumor) | LAMB4, KCTD13 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| LAMB4, KCTD13 (tumor) | LAMB4, KCTD13 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| LAMB4, KCTD13 (tumor) | LAMB4, KCTD13 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| LAMB4, KCTD13 (tumor) | LAMB4, KCTD13 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| LAMB4, KCTD13 (tumor) | LAMB4, KCTD13 (normal) |
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| STAD (tumor) | STAD (normal) |
| LAMB4, KCTD13 (tumor) | LAMB4, KCTD13 (normal) |
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| THCA (tumor) | THCA (normal) |
| LAMB4, KCTD13 (tumor) | LAMB4, KCTD13 (normal) |
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| TissGeneProg for LAMB4 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for LAMB4 |
| TissGeneDrug for LAMB4 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for LAMB4 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0004352 | Autistic Disorder | 1 | GAD |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
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