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| TissGeneSummary for CLCA4 |
 Gene summary |
| Basic gene information | Gene symbol | CLCA4 |
| Gene name | chloride channel accessory 4 | |
| Synonyms | CaCC|CaCC2 | |
| Cytomap | UCSC genome browser: 1p22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_012128.3, NR_024602.1, | |
| Description | caCC-2calcium-activated chloride channel family member 4calcium-activated chloride channel protein 2calcium-activated chloride channel regulator 4chloride channel regulator 4chloride channel, calcium activated, family member 4hCLCA4hCaCC-2 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000016602 | ||
| HPRD : 16719 | ||
| Vega : OTTHUMG00000010260 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CLCA4 | |
| BioGPS: 22802 | ||
| Pathway | NCI Pathway Interaction Database: CLCA4 | |
| KEGG: CLCA4 | ||
| REACTOME: CLCA4 | ||
| Pathway Commons: CLCA4 | ||
| Context | iHOP: CLCA4 | |
| ligand binding site mutation search in PubMed: CLCA4 | ||
| UCL Cancer Institute: CLCA4 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BladderColonEsophagus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BLCACOADESCA | |
| Reference showing the relevant tissue of CLCA4 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CLCA4 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| HNSC | 4.341809402 | 8.584790797 | -4.242981395 | 5.77E-09 | 7.55E-08 |
| LUSC | 2.685252403 | -1.155400539 | 3.840652941 | 1.85E-10 | 6.77E-10 |
| COAD | 3.394528722 | 11.03933641 | -7.644807692 | 1.58E-11 | 2.96E-10 |
| BRCA | -1.153691251 | 2.769923662 | -3.923614912 | 6.39E-37 | 1.37E-35 |
| PRAD | 1.408426799 | 2.996819107 | -1.588392308 | 0.0021 | 0.006119766 |
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| TissGene-miRNA for CLCA4 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CLCA4 |
| TissGeneSNV for CLCA4 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R679W | SKCM | 5 |
| p.T886A | KIRC | 3 |
| p.E252K | SKCM | 3 |
| p.G315E | SKCM | 2 |
| p.G682E | SKCM | 2 |
| p.E145K | SKCM | 2 |
| p.E824* | BLCA | 1 |
| p.I843N | LUAD | 1 |
| p.I771S | UCEC | 1 |
| p.G620V | THYM | 1 |
| p.L411M | LUAD | 1 |
| p.P881S | SKCM | 1 |
| p.D222Y | UCEC | 1 |
| p.D482N | LUAD | 1 |
| p.F333I | SKCM | 1 |
| p.H155Y | SKCM | 1 |
| p.E68Q | LUAD | 1 |
| p.W774C | LUAD | 1 |
| p.T453A | UCEC | 1 |
| p.G345E | SKCM | 1 |
| p.D782N | SKCM | 1 |
| p.M503I | SKCM | 1 |
| p.T290I | THCA | 1 |
| p.E50X | THYM | 1 |
| p.A573V | COAD | 1 |
| p.P608S | SKCM | 1 |
| p.S384F | HNSC | 1 |
| p.S847C | BRCA | 1 |
| p.E156K | BLCA | 1 |
| p.P748S | SKCM | 1 |
| p.G563C | LUSC | 1 |
| p.A501D | LUAD | 1 |
| p.N628K | LUAD | 1 |
| p.F71L | SKCM | 1 |
| p.E711K | SKCM | 1 |
| p.F269I | UCS | 1 |
| p.L311I | COAD | 1 |
| p.N713S | STAD | 1 |
| p.D653H | CESC | 1 |
| p.E491K | HNSC | 1 |
| p.I286V | UCEC | 1 |
| p.T522K | LUAD | 1 |
| p.E709K | SKCM | 1 |
| p.D166H | BLCA | 1 |
| p.V562M | STAD | 1 |
| p.D54N | SKCM | 1 |
| p.S298L | SKCM | 1 |
| p.L520F | STAD | 1 |
| p.T61M | ESCA | 1 |
| p.A699V | LGG | 1 |
| p.V740L | BRCA | 1 |
| p.L79* | LUSC | 1 |
| p.T726N | LUAD | 1 |
| p.M288T | KIRC | 1 |
| p.H766Y | SKCM | 1 |
| p.P135L | KIRC | 1 |
| p.T669K | LUAD | 1 |
| p.I265M | SKCM | 1 |
| p.S60F | SKCM | 1 |
| p.M240I | COAD | 1 |
| p.A101V | SKCM | 1 |
| p.R325* | SKCM | 1 |
| p.E425X | UCS | 1 |
| p.Q465* | CESC | 1 |
| p.E835D | KIRC | 1 |
| p.P295L | LUAD | 1 |
| p.T61M | PAAD | 1 |
| p.E425* | UCS | 1 |
| p.K142N | BLCA | 1 |
| p.D802G | PRAD | 1 |
| p.E115* | UCEC | 1 |
| p.E718K | SKCM | 1 |
| p.G736R | SKCM | 1 |
| p.P868S | SKCM | 1 |
| p.G163A | STAD | 1 |
| p.C386R | LUAD | 1 |
| p.E491K | COAD | 1 |
| p.G202E | LUAD | 1 |
| p.G563V | LUSC | 1 |
| p.L625I | UCEC | 1 |
| p.D443A | STAD | 1 |
| p.P593L | SKCM | 1 |
| p.V433D | LUAD | 1 |
| p.S179L | BLCA | 1 |
| p.E82D | UCEC | 1 |
| p.T352A | STAD | 1 |
| p.A66V | UCEC | 1 |
| p.A177T | STAD | 1 |
| p.P714L | GBM | 1 |
| p.A59T | BLCA | 1 |
| p.E233K | LUAD | 1 |
| p.G112V | OV | 1 |
| p.R788H | COAD | 1 |
| p.L800I | UCEC | 1 |
| p.Q328E | BLCA | 1 |
| p.G682R | SKCM | 1 |
| p.S342F | SKCM | 1 |
| p.G494R | SKCM | 1 |
| p.G405R | SKCM | 1 |
| p.L262I | LUAD | 1 |
| p.G737C | UCEC | 1 |
| p.G345W | LUAD | 1 |
| p.A501T | UCEC | 1 |
| p.N357S | LUAD | 1 |
| p.V909L | OV | 1 |
| p.H681D | BLCA | 1 |
| p.V810L | DLBC | 1 |
| p.T377I | COAD | 1 |
| p.D471N | BLCA | 1 |
| p.Q257K | UCEC | 1 |
| p.G563C | LUAD | 1 |
| p.S825N | LIHC | 1 |
| p.G708R | STAD | 1 |
| p.S364I | PAAD | 1 |
| p.V347I | SKCM | 1 |
| p.L399I | LUAD | 1 |
| p.L526V | HNSC | 1 |
| p.S635* | LUAD | 1 |
| p.R325X | SKCM | 1 |
| p.S499I | LUAD | 1 |
| p.E491K | ESCA | 1 |
| p.D505Y | SARC | 1 |
| p.I302T | HNSC | 1 |
| p.P717L | SKCM | 1 |
| p.N811S | OV | 1 |
| p.D166H | STAD | 1 |
| p.K127E | LIHC | 1 |
| p.L625H | THYM | 1 |
| p.A870S | LUAD | 1 |
| p.D647H | LUAD | 1 |
| p.N324D | LUAD | 1 |
| p.G514E | SKCM | 1 |
| p.L79X | COAD | 1 |
| p.T58S | LUAD | 1 |
| p.E728K | SKCM | 1 |
| p.L900V | LUAD | 1 |
| p.D603N | SKCM | 1 |
| p.E129K | UCEC | 1 |
| p.Q787* | BLCA | 1 |
| p.A627T | SKCM | 1 |
| p.V8A | HNSC | 1 |
| p.E96K | SKCM | 1 |
| p.R176C | SKCM | 1 |
| p.D54N | UCEC | 1 |
| p.H255Y | SKCM | 1 |
| p.G397A | LUAD | 1 |
| p.P43S | DLBC | 1 |
| p.D534N | LIHC | 1 |
| p.D799V | SKCM | 1 |
| p.F23L | READ | 1 |
| p.T764I | STAD | 1 |
| p.S421Y | CESC | 1 |
| p.H840N | LUAD | 1 |
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| TissGeneCNV for CLCA4 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CLCA4 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-D8-A27W-01A | ZZZ3-CLCA4 | 5'UTR-5'UTR | chr1:78148269 | chr1:87025614 |
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| TissGeneNet for CLCA4 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for CLCA4 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CLCA4 |
| TissGeneDrug for CLCA4 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CLCA4 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0010674 | Cystic Fibrosis | 2 | BeFree,LHGDN,ORPHANET |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0019151 | Hepatic Encephalopathy | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
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